Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7208026 | Heat-resistant filter To provide a heat resistant filter of which the reduction of tensile strength and folding endurance is small even when used as a filter material for a filter used at high temperatures, failure of the filter material is difficult even when used at high temperatures, ... | 04/24/2007 |
| 7166647 | Multi-functional photoinitiators Compounds of formula (I): {where n is a number from 1 to 6; R3 is hydrogen, methyl or ethyl; A represents a group of formula —[O(CHR2CHR1)a]y—, —[O(CH | 01/23/2007 |
| 7125442 | Lightfast additive having UV-absorbing moiety and ink composition including the same A lightfast additive and an ink composition including the same include a benzophenone moiety for lightfastness and a moiety for wettability and the ability to stabilize a colorant, wherein the two moieties are covalently bonded. The lightfast additive may exhibit ef... | 10/24/2006 |
| 7112430 | Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon Provided herein are type II transmembrane serine protease 10 (MTSP10) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds... | 09/26/2006 |
| 7105566 | Methods of treatment during vascular procedures The invention provides in one embodiment a method for treating vascular trauma. The method can include administering to an individual undergoing vascular trauma an effective amount of a retinoic acid receptor (RAR) antagonist or an RAR inhibitor. The methods can be ... | 09/12/2006 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6903232 | Process for the preparation of a highly pure pharmaceutical intermediate, 4-(cyclopropylcarbonyl)-α, α-dimethylphenylacetic acid This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-α,α-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesi... | 06/07/2005 |
| 6784292 | Method for the production of imidazo-(1,2-C)(2,3)-benzodiazepines and intermediates in the production thereof The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1). ... | 08/31/2004 |
| 6677473 | Plasminogen activator inhibitor antagonists Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl et... | 01/13/2004 |
| 6369026 | Slow release of fragrant compounds in perfumery using 2-benzoyl benzoates, 2-alkanoyl benzoates or alpha-keto esters The present invention describes a fragrance delivery system which releases fragrant alcohols upon exposure to light. Said system comprises 2-benzoyl benzoates of general formulae ##STR1## which can comprise various subtituents R1 -R5... | 04/09/2002 |
| 6297260 | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least o... | 10/02/2001 |
| 6235923 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 05/22/2001 |
| 6225494 | Trisubstituted phenyl derivatives having retinoid agonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 05/01/2001 |
| 6143918 | Compounds based on dibenzoylresorcinol and related compositions and articles Methods for preparing novel dibenzoylresorcinol-based compounds are disclosed, wherein the dibenzoylresorcinol is bonded to the residue of either an alcohol or a carboxylic acid group, via a methylene carboxylate linking group; and wherein the dibenzoylre... | 11/07/2000 |
| 6133228 | Slow release of fragrant compounds in perfumery using 2-benzoyl benzoates, 2-alkanoyl benzoates or -keto esters A fragrance delivery system which releases fragrant alcohols upon exposure to light. The system comprises 2-benzoyl benzoates of general formulae ##STR1## which can comprise various subtituents R1 -R5 as defined in the applicati... | 10/17/2000 |
| 6121255 | Phloroglucide derivatives and their pharmceutical use A phloroglucide derivative having the following formula: ##STR1## wherein Q is halogen; X is CH2 or C.dbd.O; Y is cephalosporin having a formula of ##STR2## wherein Ph is phenyl, Ac is acetoxy, or pharmaceutically acceptable salts ... | 09/19/2000 |
| 6110955 | Metabolically stabilized oxyalkylene esters and uses thereof This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating b... | 08/29/2000 |
| 6107517 | Thyroid hormone analogues and methods for their preparation Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.... | 08/22/2000 |
| 6096920 | Preparation of carboxylic compounds and their derivatives Palladium-catalyzed arylation of an olefin (e.g., ethylene) with an aromatic halide (e.g., 2-bromo-6-methoxynaphthalene, m-bromobenzophenone, or 4-isobutyl-1-bromobenzene) is conducted in specified media. After a special acid or base phase separation proc... | 08/01/2000 |
| 6063815 | Benzopenones useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein Y is ##STR2## R1 and R2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloal... | 05/16/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6037488 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 03/14/2000 |
| 6027747 | Process for the production of dry pharmaceutical forms and the thus obtained pharmaceutical compositions A process for the production of a solid dispersion of at least one therapeutic agent in a hydrophilic carrier having enhanced solubility in an aqueous media comprising dissolving at least one therapeutic agent in a volatile organic solvent containing a ve... | 02/22/2000 |
| 5945557 | Benzyloxy substituted aromatics and their use as fungicides and insecticides Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein A is N or CH; V is O or NH; m and n are the integers 0 and 1, provided that m+n is 0 or 1; X is independently selected from hydrogen, halo, (C1 -C4... | 08/31/1999 |
| 5886022 | Substituted cycloalkanecarboxylic acid derivatives as matrix metalloprotease inhibitors Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula ##STR1## wherein each T... | 03/23/1999 |
| 5883125 | Benzyloxy substituted aromatics and their use as fungicides and insecticides Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein A is N or CH; V is O or NH; m and n are integers 0 and 1 provided that m+n is 1; X is independently selected from hydrogen, halo, (C1 -C4)alkyl, ... | 03/16/1999 |
| 5883294 | Selective thyroid hormone analogs Selective thyroid hormone agonists are disclosed that are highly selective for the TRଲ subtype with high binding affinity. Methods of using such agonists and pharmaceutical compositions containing them are also disclosed, as are novel procedures for... | 03/16/1999 |
| 5863688 | Naphthoquinone derivative The present invention provides a naphthoquinone derivative represented by the general formula (I): ##STR1## wherein R1 and R2 are as defined in the specification. An electrophotosensitive material containing this naphthoquinone ... | 01/26/1999 |
| 5801272 | Preparation of mixtures of (R)- and (S)-2-(4-alkanoylphenoxy)- or (R)- and (S)-2-(4-aroylphenoxy)propionic esters A mixture of (R)- and (S)-2-(4-alkanoylphenoxy)- or (R)- and (S)-2-(4-aroylphenoxy)propionic esters I ##STR1## with an enantiomeric excess of at least 90% is prepared by reacting a mixture of (R) and (S) enantiomer of a 2-phenoxypropionic ester II ... | 09/01/1998 |
| 5716954 | Benzopyridazinone and pyridopyridazinone compounds Benzo or pyridopyridazinones and pyridazinthiones of the formula ##STR1## wherein: X and Y are nitrogen or carbon, provided that at least one is carbon, and Z is oxygen or sulfur; R1 is hydrogen, lower alkyl, aryl, aralkyl, heterocyclo, heteroc... | 02/10/1998 |
| 5663412 | Aromatic ketones The present invention relates to substantially pure piperidine derivative compounds of the formulae: ##STR1## wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond bet... | 09/02/1997 |
| 5583221 | Substituted fused and bridged bicyclic compounds as therapeutic agents Compounds having the formula ##STR1## methods for using such compounds to inhibit protein kinase C in animals, including man are useful as inhibitors of protein kinase C. Also disclosed are pharmaceutical compositions including such compounds and com... | 12/10/1996 |
| 5504244 | Alkylarylketo acids Disclosed are novel alkylarylketocarboxylic acids and 5-substituted tetrazoles represented by the formula ##STR1## wherein Z is aryl or an alkyl of the structure ##STR2## W is a carboxyl moiety or a tetrazole moiety bound to Z at the 5-position... | 04/02/1996 |
| 5492917 | Endothelin antagonists incorporating a cyclobutane Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cere... | 02/20/1996 |
| 5488134 | Preparation of compounds of lignan series This invention relates to a process for preparation of the compounds of lignan series in a regioselective manner. This invention provide a process for preparing a compound of the formula (I): which process is characterized by that a lactone compound represente... | 01/30/1996 |
| 5468904 | Fluorine-containing benzophenone derivatives and use thereof A fluorine-containing benzophenone derivative of the formula (1), (2) or (3): .PHI.1 (--X1 --Q1 --Rf1)n (1) .PHI.2 --X2 --Q2 --Rf2 --Q3 | 11/21/1995 |
| 5432198 | Vicinal-substituted carbocyclic compounds as therapeutic agents Compounds having the formula ##STR1## are useful as inhibitors of protein kinase C. Also disclosed are pharmaceutical compositions including such compounds and methods for using such compounds to inhibit protein kinase C in animals, including man.... | 07/11/1995 |
| 5334607 | Methods for treating mycoses Antimycotics containing a compound of the formula ##STR1## where .dbd.Y is .dbd.CH--OCH3, .dbd.CH--CH3, .dbd.CH--CH2 --CH3, .dbd.CH--SCH3 or .dbd.N--OCH3, and X is oxygen, or X may als... | 08/02/1994 |
| 5322794 | Fluorescent phospholipid analogs and fatty acid derivatives Fluorescence probes are described comprising coronene fluorophores chemically attached to lipids or membrane-mimetic molecules via hydrocarbon spacers of defined length. Also described is a method for determining lipid packing and dynamics in membranes, a... | 06/21/1994 |
