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| Number | Title | Issue Date |
| 7799941 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative There is provided a process for efficiently producing an anti form of an optically active β-hydroxy-α-aminocarboxylic acid derivative that is useful as an intermediate for pharmaceuticals and agrochemicals. The process for producing optically active β-hydroxy-α-... | 09/21/2010 |
| 7781609 | Process for producing optically active β-hydroxy-α-aminocarboxylic acid derivative There is provided a process for efficiently producing an anti form of an optically active β-hydroxy-α-aminocarboxylic acid derivative that is useful as an intermediate for pharmaceuticals and agrochemicals. The process for producing optically active β-hydroxy-α-... | 08/24/2010 |
| 7598412 | Modulators of ATP-binding cassette transporters The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE... | 10/06/2009 |
| 7560586 | Acid and ester compounds and methods of using the same Disclosed is a compound of having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, ... | 07/14/2009 |
| 7402692 | Intermediates in producing phenoxyacetic acid derivatives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity... | 07/22/2008 |
| 7323585 | Levodopa prodrugs, and compositions and uses thereof Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. ... | 01/29/2008 |
| 7319104 | hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated w... | 01/15/2008 |
| 7208520 | Crystals of hydroxynorephedrine derivative The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent β3 | 04/24/2007 |
| 7199239 | Chemical compounds A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, Wherein: R1 and R2 are independently hydrogen or C... | 04/03/2007 |
| 7153869 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molec... | 12/26/2006 |
| 7151191 | Compounds and compositions for delivering active agents Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 12/19/2006 |
| 7138538 | Process for the separation of enantiomers and enantiopure reagent Process for the separation of enantiomers comprising at least one free functional group, in which process a reagent based on an enantiopure amino acid is reacted in basic medium with a mixture comprising enantiomers. ... | 11/21/2006 |
| 7015346 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides a process for preparing a compound useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 03/21/2006 |
| 6995286 | Process for preparing isomers of salbutamol A process for making optically pure (R) and (S) salbutamol comprises obtaining the (R) or (S) isomer of either salbutamol or a salbutamol precursor in substantially optically pure form by resolving a racemic or optically impure mixture of enantiomers of salbutamol o... | 02/07/2006 |
| 6919343 | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/19/2005 |
| 6916956 | Calcium receptor antagonist A compound of the formula [I] wherein R1 is optionally substituted aryl group or optionally substituted heteroaryl group; R2 is optionally substituted C1-6 alkyl group, C3-7 c... | 07/12/2005 |
| 6894076 | Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the production of a medicament with analgesic properties. These new pro... | 05/17/2005 |
| 6884821 | Carboxylic acid derivatives and drugs containing the same Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydro... | 04/26/2005 |
| 6870065 | Bifunctional boronic compound complexing reagents and complexes A reagent having the general formula of General Formula I: wherein group R is an electrophilic or a nucleophilic moiety suitable for reaction of the reagent with a biologically active species; group R2 is on... | 03/22/2005 |
| 6861561 | Substituted aromatic policyclic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aromatic polycyclic tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and o... | 03/01/2005 |
| 6800771 | Stabilization of amido acids with antioxidants The invention relates to stabilized amido acid compositions. More particularly, the invention relates to compositions of amido acids, such as 6-nonanoylamidohexanoic acid, stabilized with antioxidants. The stabilized amido acid compositions are useful in the manufac... | 10/05/2004 |
| 6787562 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists Compounds of the formula I; useful for the treatment of pain wherein A, Z, B, R1, X and D are as defined in the specification, methods of making such compounds, methods of using such compounds and pharmaceutical c... | 09/07/2004 |
| 6696600 | L-DOPA ethyl ester salts and uses thereof The present invention provides non-hygroscopic, crystalline salts of levodopa ethyl ester (LDEE), wherein the salt is the octanoate salt, the myristate salt, the succinate salt, the succinate dihydrate salt, the fumarate salt or the fumarate dihydrate sal... | 02/24/2004 |
| 6689902 | Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L--aspartyl]-L-ph ... | 02/10/2004 |
| 6673794 | Substituted aminomethyl-phenyl-cyclohexane derivatives A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, ##STR1## and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are method for preparing the substituted aminomethyl-pheny... | 01/06/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6649639 | Antipicornaviral compounds, compositions containing them, and methods for their use Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treatin... | 11/18/2003 |
| 6632836 | Carbocyclic potassium channel inhibitors The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like. ##STR1##... | 10/14/2003 |
| 6590119 | Methods for the synthesis of dioxoalkanoic acid compounds The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of benzoylcyclohexanone ketal compounds.... | 07/08/2003 |
| 6583177 | Leukotriene B4 antagonist compounds and method for treatment Novel amidinophenol derivatives of formula (IB) ##STR1## and processes for the preparation thereof; compositions containing a compound of formula (IB) as active ingredient useful as antagonists of leukotine B4 and inhibitors of phospholipase A | 06/24/2003 |
| 6538152 | Phenoxyacetic acid derivatives and medicinal compositions containing the same The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: ##STR1## wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino g... | 03/25/2003 |
| 6514925 | O-substituted N,N-diacylhydroxylamine bleach activators and compositions employing the same N,N diacyl O-substituted imide bleach activators and compositions employing them are provided. The activators have the general formula: ##STR1## wherein X is selected from O, NR16 and S; e is 0 or 1; f is 0 or 1; R16 is selected from... | 02/04/2003 |
| 6482855 | Diamine alkylene diacetic or triacetic acid derivatives, preparation method, use in cosmetic and pharmaceutical compositions and compositions containing them Novel alkylenediaminediacetic acid or alkylenediaminetriacetic derivatives of formula (I): ##STR1## or an organic or inorganic salt thereof, their process of preparation, and their use in cosmetic and pharmaceutical compositions, such as for protecti... | 11/19/2002 |
| 6451289 | Albuterol formulations Albuterol formulations packaged in an oxygen-permeable plastic container have a long shelf life at room temperature. The formulations consist essentially of albuterol or a pharmaceutically acceptable salt thereof, sodium chloride, and water, have a pH of ... | 09/17/2002 |
| 6417368 | Amine derivative fixed to resin and method for synthesizing ଲ-aminocarbonyl compound in a solid phase The invention provides a resin-immobilized imine represented by the following formula: P--Q--N--.dbd.CH--R I [in the formula, P represents the principal chain of a resin polymer; Q represents a substituted or unsubstituted hydrocarbon side chain or a su... | 07/09/2002 |
| 6414122 | Bifunctional boronic compound complexing reagents and complexes Embodiments include reagents to modify a bioactive species for incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different or same bioactive species having pendant phenylboronic acid moieties of General Formul... | 07/02/2002 |
| 6410600 | Azine used as fungicides The invention relates to novel azines, to a process for their preparation and to their use as fungicides.... | 06/25/2002 |
| 6410790 | 3-amin3-arylpropan-1-ol compounds, their preparation and use 3-amino-3-arylpropan-1-ol compounds of formula I: ##STR1## R1 and R2 independently denoting C1-6 alkyl, or together denoting a (CH2)2-6 ring optionally substituted by phenyl, R3 denoting C3... | 06/25/2002 |
| 6410585 | Inhibitors of protein tyrosine phosphatase The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).... | 06/25/2002 |
| 6388122 | Tryptase inhibitor and novel guanidino derivatives A tryptase inhibitor comprising as an active ingredient at least one member selected from among guanidinoaliphatic acid derivatives of the formula (I), guanidinobenzoic acid derivatives of the formula (II), guanidinophenol derivatives of the formula (III)... | 05/14/2002 |
