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| Number | Title | Issue Date |
| 8044231 | Method for producing dihalo acetoacetic alkyl esters The invention relates to a process for preparing alkyl dihaloacetoacetates of the formula (I) by reacting α,α-dihaloamines of the formula (III) with acetic esters of the formula (II) in the presence of bases. ... | 10/25/2011 |
| 7754913 | Synthesis of isotopically labeled alpha-keto acids and esters Isotopically labeled alpha-keto acids and esters are disclosed herein. Also disclosed are methods of synthesizing isotopically labeled alpha-keto acids and esters. ... | 07/13/2010 |
| 7585998 | Method for producing difluoro-acetyl-acetic acid alkylesters The present invention relates to a three-step method for the preparation of alkyl esters of 4,4-difluoroacetoacetic acid in which in the first step alkyl esters of 4-chloro-4,4-difluoroacetic acid are reacted with trialkylphosphites of formula (III) P(OR | 09/08/2009 |
| 7485743 | Oligomeric ketone compounds A novel keto8enic compound is provided having general: Formula R(OCH(CH3)CH2C(O))n—O-A wherein n is an integer of 3 to 10, A is the residue of a 3-keto alkan-1-ol and R is selected from the group consisting of H, C1-C6 alkyl and ac... | 02/03/2009 |
| 7420079 | Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided. ... | 09/02/2008 |
| 7378549 | Process for the reactive extractive extraction of levulinic acid A process for the reactive extraction of levulinic acid from an aqueous mixture having levulinic acid, wherein the aqueous mixture is contacted with a liquid esterifying alcohol, the alcohol having at least four carbon atoms and is substantially water-immiscible, at... | 05/27/2008 |
| 7351850 | Process for producing alphaoxocarbonyl compound A process by which an α-oxocarbonyl compound useful as an intermediate for pharmaceuticals/agricultural chemicals can be industrially advantageously and efficiently produced in a high yield. The process, which is for producing an α-oxocarbonyl compound represented... | 04/01/2008 |
| 7351851 | Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters A method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters of formula (I): in addition to the enols thereof and E and Z isomers, wherein X independently represents fluorine, chlorine or bromine... | 04/01/2008 |
| 7348450 | Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters A method for the production of 6,6,6-trihalo-3,5-dioxhexanoic acid esters of formula (I): in addition to the enols thereof and E and Z isomers, wherein X independently represents fluorine, chlorine or bromine ... | 03/25/2008 |
| 7339073 | Method for obtaining 5-halogenolaevulinic acid alkyl esters A method for obtaining a 5-bromolevulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester from either a bromination mixture or a chlorination mixture, containing either a 5-bromo-levulinic acid methyl ester or a 5-chlorolevulinic acid methyl ester, respec... | 03/04/2008 |
| 7329774 | Method and plant for the manufacture of carboxylic acid ester by means of a reactive distillation Carboxylic acid ester is produced by esterification of carboxylic acid and an alcohol in a catalytic reaction zone of a first column at a pressure not greater than ambient pressure. The resultant sump product is distilled in a reaction zone of a second column at a p... | 02/12/2008 |
| 7300921 | Polyene polyketides and methods of production Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant... | 11/27/2007 |
| 7287646 | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherei... | 10/30/2007 |
| 7279605 | Synthesis of cyclopentenones The invention relates to a process for the preparation, in a single step, of substituted 2-cyclopenten-1-ones by reacting a substituted enone with an aldehyde in the presence of a catalytic system. The catalytic system consists of a metal complex, such as a Ti(Cl) | 10/09/2007 |
| 7268250 | Process for producing optically active compound A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.... | 09/11/2007 |
| 7268258 | Process for producing muscone and its intermediate The present invention provides a process for producing a muscone represented by (1) by subjecting a citronellic acid derivative and an undecenoate to a Claisen condensation reaction to produce a keto ester compound represented by (2) decarboxylating the keto ester c... | 09/11/2007 |
| 7265239 | Process for the conversion of furfuryl alcohol into levulinic acid or alkyl levulinate A process for the conversion of furfuryl alcohol into levulinic acid or alkyl levulinate comprising contacting furfuryl alcohol and water or an alkyl alcohol with a porous heterogeneous catalyst comprising strong acid ion-exchange resin, wherein the catalyst has por... | 09/04/2007 |
| 7253192 | Phenyl derivatives comprising an acetylene group This invention is concerned with compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2 | 08/07/2007 |
| 7235698 | Enantioselective, catalytic allylation of ketones and olefins Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. C... | 06/26/2007 |
| 7229657 | Dulce de leche-flavored fat-based confection, method for making the same and confectionery candies making use of the same A dulce-flavored fat-based confection possessing a smooth and creamy mouthfeel and a thermally generated flavor and suitable for use in candy-shelling is provided. A method of making such a dulce-flavored fat-based confection is also disclosed. ... | 06/12/2007 |
| 7211681 | Ester production method by transesterification reaction using solid acid catalyst It is an object of this invention to provide a method for producing an ester by a transesterification reaction in which the reaction can be stably performed in a short time at a pressure approximately equal to normal pressure. The ester is produced by a transesterif... | 05/01/2007 |
| 7195792 | Browning agent A browning agent for foodstuffs having at least two carbonyl groups is disclosed. A method for using the browning agent in or on a substrate is also disclosed. The browning agent may be coated onto foodstuffs such as biscuits, pizza, pie coverings or hash brown pota... | 03/27/2007 |
| 7166648 | Photoinitiator, novel compound, and photocurable composition A photoinitiator is provided which exhibits excellent photosensitivity, yields colorless products, and is usable in thick layer UV curable coating. A novel chemical compound is also provided which is usable for the photoinitator. Photocurable composition is also pro... | 01/23/2007 |
| 7160925 | Decomposing surfactant Use of a compound having a hydrophobic moiety attached to a hydrophilic moiety, wherein the hydrophilic moiety comprises a β-keto acid group and the hydrophobic moiety is attached via a bond from a carbon or an oxygen of the hydrophobic moiety to a carbon of the β... | 01/09/2007 |
| 7157255 | Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises ei... | 01/02/2007 |
| 7153996 | Preparation of levulinic acid esters and formic acid esters from biomass and olefins This invention relates to a process for producing a mixture of levulinic acid esters and formic acid esters from biomass and olefins, and the composition prepared therefrom. This invention also relates to usage of the mixture of these esters as fuel and as fuel addi... | 12/26/2006 |
| 7141694 | Enzymatic resolution of aryl and thio-substituted acids Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C6 or C10 aromatic group that can be substituted with H, C1 ... | 11/28/2006 |
| RE39333 | Process for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low-temperature ... | 10/10/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7097823 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/29/2006 |
| 7094885 | Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/22/2006 |
| 7091375 | Method for the production of 2=-keto-l-gulonic acid CCalkyl esters The invention relates to a method for producing 2-keto-L-gulonic acid-C4–C10 alkyl ester by esterifying 2-keto-L-gulonic acid (KGS) with an unsaturated, branched or unbranched C4–C10 alcohol. The inventive method is ch... | 08/15/2006 |
| 7081546 | Process for preparing a 5-hydroxy-3-oxo-hexanoic acid derivative The present invention is related to a novel process for preparing an optically active 5-hydroxy-3-oxo-hexanoic acid derivative or its tautomer which is useful intermediate for preparing statins such as atorvastatin and rosuvastatin. Blaise reaction of (S)-4-halo-3-h... | 07/25/2006 |
| 7074952 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound... | 07/11/2006 |
| 7060859 | Use of a solid hydrotalcite structure incorporating fluorides for basic catalysis of Michael or Knoevenagel reactions The invention concerns the use of a solid basic catalyst comprising a hydrotalcite structure wherein part at least of the compensating anions are fluoride anions F− for producing Knoevenagel of Michael condensation reactions. The invention also concerns... | 06/13/2006 |
| 7049461 | Treatment of leukemia A preferred embodiment of the invention encompasses a compounds having the property of anti-carcinogenic activity against human leukemia comprising the use of 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid methyl ester (OF-13),... | 05/23/2006 |
| 7045116 | Treatment of osteomyelitis with radiopharmaceuticals This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharm... | 05/16/2006 |
| 6972335 | Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth... | 12/06/2005 |
| 6965034 | Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates ... | 11/15/2005 |
| 6965029 | Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by means of asymmetric, catalytic hydrogenation The invention relates to a process for the preparation of compounds of the general formula I in which R1 represents a C1-C20-alkyl group, a C3-C12-cycloalkyl group... | 11/15/2005 |
