Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7429674 | Process for preparing fluoroleucine alkyl esters This invention relates to a stereoselective preparation of fluoroleucine alkyl esters. ... | 09/30/2008 |
| 7385077 | Fluoroalkyl surfactants Surfactants of formula (I) wherein each R is independently hydrogen or a C1 to C4 alkyl group; A is independently hydrogen or —C(O)—O—B; ... | 06/10/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7323589 | Intermediates for use in retinoid synthesis The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH3)2—, —N(C2H5)2-group or N-pyrrolidine: n is an integer equal to 1 or 2: R1, R2 and R3... | 01/29/2008 |
| 7256289 | Process for making chiral 1,4-disubstituted piperazines A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula: wherein R, Ar, and Q are defined as set f... | 08/14/2007 |
| 7148372 | Intermediates for use in retinoid synthesis The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH3)2—, —N(C2H5)2-group or N-pyrrolidine: n is an integer equal to 1 or 2: R1, R2 and R3... | 12/12/2006 |
| 7141695 | Methods for producing substituted acrylic acid esters and use of the latter for producing substituted γ-amino acids The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted γ-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination ... | 11/28/2006 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7015349 | Reduction of hair growth Compositions including a conjugate of α-difluoromethylornithine can be applied topically to reduce hair growth. ... | 03/21/2006 |
| 7009069 | Intermediates for use in retinoid synthesis The invention concerns compounds of formula (1) wherein in particular G represents the —N(CH3)2—, —N(C2H5)2— group or N-pyrrolidine: n is an integer equal to 1 or 2: R1, R2 and R | 03/07/2006 |
| 7002038 | Method for producing 3-amino-4,4,4-trifluorocrotonic acid esters A process is described for preparing 3-amino-4,4,4-trifluorocrotonic esters of the formula (I) or the E/Z isomers or tautomeric forms thereof where R1 and R2 are each independently hydrogen, an opt... | 02/21/2006 |
| 6979748 | Method for preparing amino alkyl(meth)acrylates A process for the preparation of aminoalkyl (meth)acrylates by transesterification from C1-C4-alkyl (meth)acrylates and aminoalcohols is described, in which process the transesterification is carried out in the presence of at least one distanno... | 12/27/2005 |
| 6974879 | Process for preparing single enantiomers of 5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs A process for synthesizing L and D-5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-as... | 12/13/2005 |
| 6787664 | Process for preparing single enantiomers of 5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs A process for synthesizing L and D-5,5,5,5′,5′,5′-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-as... | 09/07/2004 |
| 6692728 | Polyesters based on hydroxy fatty acids and lower hydroxy alkyl acids and uses thereof The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants... | 02/17/2004 |
| 6646156 | (Meth)acryloyl-group-containing carbamoyl halides and production process therefor The present invention provides a (meth)acryloyl-group-containing carbamoyl halide represented by the following formula (1): ##STR1## where R1 represents a hydrogen atom or a methyl group; R2 represents a linear or branched C1-C10 alk... | 11/11/2003 |
| 6562963 | Process for the preparation of macrocyclic metalloprotease inhibitors The present invention is directed to a process for the preparation of a compound of formula (X-a) ##STR1## or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted wi... | 05/13/2003 |
| 6540987 | Polyesters based on hydroxy fatty acids and lower hydroxy alkyl acids and uses thereof The present invention provides biodegradable polyesters based on lower hydroxy acids and hydroxy fatty acids. The resulting polyesters are useful as cosmetic vehicles for sunscreens, skin lotions and by themselves are also useful as milder skin exfoliants... | 04/01/2003 |
| 6486344 | Polymer coatings with improved adhesion properties on metallic surfaces The present invention is based on a series of acrylic cross-linking agents containing two or more dehydroalanine moieties (H2 C.dbd.C(NHCOR')COOR) per monomer. Monomers of the general structure H2 C.dbd.C(NHCOCH3)COO(CH | 11/26/2002 |
| 6476243 | Perfluorinated esters of alkanoyl L-carnitine for the preparation of cationic lipids for the intracellular delivery of pharmacologically active compounds Perfluorinated esters of alkanoyl-L-carnitine of the formula (I): ##STR1## are useful as cationic lipids for the intracellular delivery of pharmacologically active compounds.... | 11/05/2002 |
| 6465686 | Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.... | 10/15/2002 |
| 6452038 | Fluoroalkyloxy dispersant The present invention provides a compound according to the formula: CH2.dbd.C(R1)--C(O)--R6 --NHCO2 (CH2)p (CF2)q --O--((CF2)a CFXO)m (CF | 09/17/2002 |
| 6451854 | -amino acid phenyl ester derivatives The present invention relates to -amino acid phenyl ester derivatives having general formula (I) wherein R1 is (C1-3)alkyloxy; R2 is (C1-3)alkyl, (C1-3)alkyloxy or (C2-3)alkenyl; R | 09/17/2002 |
| 6423866 | Production of aminohalogencrotonates Lower alkyl esters of 3-amino crotonates substituted by halogen in the C-4 position, e.g. ethyl 3-amino-4,4,4-trifluoro-crotonate, in which the amino group optionally may be substituted by one or two C1 to C3 alkyl groups or by one or two aryl groups, e.g... | 07/23/2002 |
| 6355713 | ଲ-ketoesters for use as polymer stabilizers ଲ-Ketoesters and their enamines derived from alcohols or polyols are suitable for stabilizing polymers, and are represented by formulae: A[(O--CHR4 --Z--CHR5)m --O--CO--CHR1 --CO--R3 ]n | 03/12/2002 |
| 6307103 | Process for the preparation of 1,1,1-trifluoro-2-aminoalkanes An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I ##STR1## wherein R1 represents an optionally substituted alkyl group; which comprises hydrogenating the corresponding oxime of formula II ##STR2## wherein R... | 10/23/2001 |
| 6166259 | Process for preparing a 1,1,1-trifluoro-2-aminoalkane The invention relates to a process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I ##STR1## wherein R1 represents an optionally substituted alkyl group; which comprises heating a mixture consisting essentially of a comp... | 12/26/2000 |
| 5952316 | 2-amino-1,3-propanediol compound and immunosuppressant 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R2, R3 | 09/14/1999 |
| 5952458 | Process for preparing a vinyl terminated polymer Synthesis of a vinyl terminated polymer by reacting a cationically polymerizable monomer in the form of a cyclic ether with an acid chloride in a suitable solvent and in the presence of a Lewis acid. The vinyl-terminated polymers can be polymerized with o... | 09/14/1999 |
| 5945558 | Method of making amino acid acrylic monoesters A method is disclosed for making dibasic amino acid monoesters useful in repair of teeth in which a dibasic amino acid is partially esterified with an allylic acrylic compound in the presence of an acidic ion-exchange resin at ambient temperature. The inv... | 08/31/1999 |
| 5910602 | Method for preparing 3-amino substituted crotonates The present invention relates to methods for preparing 3-amino-4,4,4-trihalocrotonates and their derivatives from a 4,4,4-trihaloacetoacetate derivative and an amine or ammonium salt.... | 06/08/1999 |
| 5902887 | Process for producing 3-amino-2-oxo-1-halogenopropane derivatives Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl ha... | 05/11/1999 |
| 5840961 | Asymmetric synthesis of chiral beta-amiNo acids The invention herein is directed to a process for the preparation of ethyl 3S-amino-4-pentynoate which involves treating 3-(trimethylsilyl)-2-propynal with L-phenylglycinol in toluene to produce S-3-(trimethylsilyl)-2-propynylidene amino!benzen... | 11/24/1998 |
| 5777184 | Preparation of fluoroalkyl compounds and their derivatives A process for producing a fluorinated olefin having the formula: CH3-a Fa CH.dbd.CHCl where a=1,2 or 3, said process comprising catalytically reacting a chlorinated organic compound with a fluorination agent under conditions sufficient to... | 07/07/1998 |
| 5777154 | Method for preparing 3-amino substituted crotonates The present invention relates to methods for preparing 3-amino-4,4,4-trihalocrotonates and their derivatives from a 4,4,4-trihaloacetoacetate derivative and an amine or ammonium salt.... | 07/07/1998 |
| 5750492 | Surfactants based on quaternary ammonium compounds preparation processes softening bases and compositions derived Cationic surfactant compound comprising, in the form of a quaternary ammonium salt, a product of condensation between, on the one hand a fraction of saturated or unsaturated fatty acids, or of derivatives of said acids chosen from the group comprising est... | 05/12/1998 |
| 5714517 | Fluoroalkenyl compounds and their use as pest repellents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful ... | 02/03/1998 |
| 5712411 | N-vinylformamidopropionates and process for their synthesis A process is provided for the synthesis of N-vinylformamidopropionates by the reaction of NVF with acrylic and methacrylic acid esters in the presence of a metal hydride catalyst. This process allows for the improved production of mono-functional monomers... | 01/27/1998 |
| 5672731 | N-vinylformamide/alkyl acrylate Michael adducts Novel unsaturated compounds comprising the 3-(N-vinylformamido)propionates and 2-methyl-3-(N-vinylformamido)propionates, or the corresponding propionamides, are obtained by the Michael addition reaction of N-vinylformamide with an acrylic or methacrylic a... | 09/30/1997 |
| 5637743 | Quaternary ammonium surfactants derived from tertiary amines and fabric softeners containing quaternary ammonium surfactants Cationic surfactant compound comprising, in the form of a quaternary ammonium salt, a product of condensation between, on the one hand a fraction of saturated or unsaturated fatty acids, or of derivatives of said acids chosen from the group comprising est... | 06/10/1997 |
