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| Number | Title | Issue Date |
| 7589229 | T-butyl cascade polymers A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2═CHCO2— TBu by nucleophilic addition to f... | 09/15/2009 |
| 7423170 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 09/09/2008 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7304092 | Compounds and methods for treating tumors, cancer and hyperproliferative diseases The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratin... | 12/04/2007 |
| 7285600 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitriles, and isocyanates. The present invention is also... | 10/23/2007 |
| 7193101 | Esters with antimicrobial, bioresistant and fungal resistant properties A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s, coatings, plastics, and medical devices. The mo... | 03/20/2007 |
| 7183426 | T-butyl cascade polymers A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2═CHCO2-TBu by nucleophilic addit... | 02/27/2007 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7012153 | Process for preparing benzoic acids An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent. ... | 03/14/2006 |
| 7012152 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino gr... | 03/14/2006 |
| 6979748 | Method for preparing amino alkyl(meth)acrylates A process for the preparation of aminoalkyl (meth)acrylates by transesterification from C1-C4-alkyl (meth)acrylates and aminoalcohols is described, in which process the transesterification is carried out in the presence of at least one distanno... | 12/27/2005 |
| 6858748 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/22/2005 |
| 6852876 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/08/2005 |
| 6835841 | Asymmetric catalytic hydrogenation process for preparation of chiral cyclic β-aminoesters A novel process for the asymmetric synthesis of substituted cyclic β-amino-carboxylates of the type shown in the specification from appropriate β-enamino-ester starting materials is described. These compounds are useful as intermediates for MMP and TACE inhibitors... | 12/28/2004 |
| 6664412 | Method for producing lysine derivative The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or ... | 12/16/2003 |
| 6355838 | Reagents for heat activated polymer crosslinking The present invention is directed to nitrile-oxide precursor compounds, and their preparation and use as an irreversible cross-linking agent in polymers having appropriate functionality, i.e., alkenes, alkynes nitrites, and isocyanates. The present invent... | 03/12/2002 |
| 6316421 | Pentaerythritol lipid derivatives and nuleic-acid complexes This invention relates to pentaerythritol lipid derivatives which are useful for the intracellular delivery of polynucleotides. These cationic lipids are useful in the preparation of liposomes and other lipid vesicles for the delivery of nucleic acids int... | 11/13/2001 |
| 6051590 | Immunosuppressant tricyclic compounds The compounds of Formula I are useful as immunosuppressive agents.... | 04/18/2000 |
| 6043390 | Pentaerythritol lipid derivatives and nucleic-acid complexes This invention relates to pentaerythritol lipid derivatives which are useful for the intracellular delivery of polynucleotides. These cationic lipids are useful in the preparation of liposomes and other lipid vesicles for the delivery of nucleic acids int... | 03/28/2000 |
| 5985859 | Methods of inhibiting bacterial sialidase A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO2 H, PO2 H, or SO2 H; B is N; R1 and R | 11/16/1999 |
| 5981511 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5977387 | Process for preparing pharmaceutical compounds This invention provides processes for preparing cryptophycin compounds and novel intermediates which are useful in such processes.... | 11/02/1999 |
| 5959122 | Process for making derivatized polymers of maleic anhydride A process for making derivatized polymers of maleic anhydride containing maleamic acid and its corresponding cyclic imide repeat units, in alcohol solution, at a temperature of about 60-160° C., during a reaction period of about 1-25 hours. The product i... | 09/28/1999 |
| 5955629 | Energetic binders Liquid nitromalonate polyesters and methods for their preparation are disclosed. Solid propellants are provided which employ as the binder a nitromalonate polyester. These propellants are resistant to plasticizer syneresis and crystallization and provide ... | 09/21/1999 |
| 5948415 | Ornithine derivatives, a process for their preparation, methods of their use and a composition comprising them The present invention relates to new compounds, which are Nδ -substituted ornithine derivatives, having the formula (I) HOOC--CH(NH2)--(CH2)3 --NH--(X)h --(CH2)j --(CHOH)k... | 09/07/1999 |
| 5945408 | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 08/31/1999 |
| 5886213 | Preparation of carbocyclic compounds The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the syn... | 03/23/1999 |
| 5859295 | Canavanine analogs and their use as chemotherapeutic agents This invention relates to canvanine analogs, their pharmaceutical compositions, and a method for treatment of cancer, particularly pancreatic cancer.... | 01/12/1999 |
| 5847198 | Process for the preparation of esters A process for the preparation of an ester, especially fluorinated esters R1 O.OC--CHR2 --CO.OR3, R1 and R3 are each independently selected from alkyl, cycloalkyl and aryl. R2 is selected fr... | 12/08/1998 |
| 5844165 | Energetic nitro malonate polyester binders Liquid nitromalonate polyesters and methods for their preparation are disclosed. Solid propellants are provided which employ as the binder a nitromalonate polyester. These propellants are resistant to plasticizer syneresis and crystallization and provide ... | 12/01/1998 |
| 5728182 | Polyalkyl esters of substituted polyphenyl ethers and fuel compositions containing the same A polyalkyl ester of a substituted polyphenylether having the formula: ##STR1## wherein A is amino, aminomethyl, cyano, nitro, N-alkylamino or N-alkylaminomethyl wherein the alkyl group contains about 1 to about 6 carbon atoms, or N,N-dialkylamino or... | 03/17/1998 |
| 5714517 | Fluoroalkenyl compounds and their use as pest repellents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds, for example, 3,4,4-trifluoro-3-butene-1-amine or 3,4,4-trifluoro-3-butenoic acid, are particularly useful ... | 02/03/1998 |
| 5639904 | 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition The 1-aryloxy-3-alkylamino-2-propanol nitrate esters, having formula I: ##STR1## the enantiomers and diastereoisomers and the therapeutically acceptable salts thereof, wherein R1 is a chain of general formula II --(CH2)m | 06/17/1997 |
| 5587509 | Caged caboxyl compounds and use thereof A method of releasing a caged carboxylic acid in which a 2-alkoxy-5-nitro-phenyl photosensitive group blocks a carboxyl function and the compositions so produced are disclosed.... | 12/24/1996 |
| 5536868 | Opiate receptor ligands Compounds of Formula 1 bind to the opioid receptors: ##STR1## wherein R1 is a group of the formula ##STR2## where W is --(CH2)a -- (where a is 0, 1, or 2), --O--, --NH--, --S--, --SO--, or --SO2 --, an... | 07/16/1996 |
| 5502237 | 1-aryloxy-3-alkylamino-2-propanol-nitrate esters, the use thereof and corresponding pharmaceutical composition The 1-aryloxy-3-alkylamino-2-propanol nitrate esters of general formula I ##STR1## the enantiomers and diastereoisomers and the therapeutically acceptable salts thereof wherein R1 is a chain of general formula II-- (CH)m,--Z--R | 03/26/1996 |
| 5482979 | Compounds containing tertiary amino groups, a process for their production and their use as catalysts Compounds containing ester groups and tertiary amino groups and optionally hydroxyl groups are made by reacting optionally hydroxyfunctional acetoacetic acid esters of monofunctional or polyfunctional alcohols (particularly polyfunctional polyether polyol... | 01/09/1996 |
| 5453535 | Preparation of ,ω-dicarboxylic acid diesters A process for the preparation of a ,ω-dicarboxylic acid diester of the general formula I ##STR1## in which R1, R2, R3, R4, R5 denotes hydrogen, C1 -C20 alkyl, C... | 09/26/1995 |
| 5453533 | Inhibitors of influenza virus neuraminidase and methods of making and using the same An influenza virus neuraminidase inhibitor, its analogs, its pharmaceutically acceptable salts, derivatives, and mixtures thereof having the following formula: ##STR1## where A is CO2 H, CO2 H3, NO2, SO | 09/26/1995 |
| 5430175 | Caged carboxyl compounds and use thereof Caged carboxyl compounds in which a 2-alkoxy-5-nitrophenyl photosensitive group blocks a carboxyl function are disclosed. Preferably the compounds are neuroactive amino acids. The compounds are photolyzable by laser pulses at wavelengths above about nm wi... | 07/04/1995 |
