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| Number | Title | Issue Date |
| 7285676 | Synthesis of chiral 2-alkyl amino acids Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves reacting cysteine (or a salt or an ester thereof) and ... | 10/23/2007 |
| 7115769 | Synthesis of 2-alkylcysteine via phase transfer catalysis Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention provides methods of preparing 2-alkylcysteine derivatives. In ano... | 10/03/2006 |
| 6972340 | Selective protein tyrosine phosphatatase inhibitors Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of di... | 12/06/2005 |
| 6927236 | Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations and/or variants, and che... | 08/09/2005 |
| 6916850 | Pyruvate derivatives Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, but are not limited to oximes... | 07/12/2005 |
| 6903220 | Synthesis of chiral 2-alkyl amino acids Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves reacting cysteine (or a salt or an ester thereof) and ... | 06/07/2005 |
| 6878845 | Oligomers from multifunctional acrylates Oligomers from multifunctional acrylates and organonitro compounds are provided. Films obtained from crosslinked oligomers of the present invention are useful as protective or decorative coatings as well as components in adhesives and composites. ... | 04/12/2005 |
| 6770776 | Synthesis of fluorocarbon compounds Fluorocarbon compounds are synthesized by reacting a substrate hydrocarbyl compound containing at least one sp3-hybridized halophoric carbon atom bearing at least two halogen atom substituents, at least one of which is a halogen atom having an atomic numb... | 08/03/2004 |
| 6747169 | Fluorine compound, surfactant, aqueous coating composition and silver halide photographic light-sensitive material using them Disclosed is a silver halide photographic light-sensitive material having one or more layers including a light-sensitive silver halide emulsion layer on a support, wherein any of the layers contains the specific fluorine compound. The silver halide photographic ligh... | 06/08/2004 |
| 6586474 | Amidino compounds useful as nitric oxide synthase inhibitors The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment... | 07/01/2003 |
| 6559334 | Polymers chromatographic separation of enantiomers The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.... | 05/06/2003 |
| 6495680 | Helices and nanotubes on folding compositions and method of making same Helical oligomer and polymer compositions that form nanotubes are described. The compositions comprise a plurality of aromatic substituents linked by at least one amide group. The compositions have a curved backbone due to intramolecular hydrogen bonds th... | 12/17/2002 |
| 6407281 | Process for producing optically active cysteine derivatives A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided. A process for producing an optically active cysteine ... | 06/18/2002 |
| 6316636 | Synthesis of fluorocarbon compounds Fluorocarbon compounds are synthesized by reacting a substrate hydrocarbyl compound containing at least one sp3 -hybridized halophoric carbon atom bearing at least two halogen atom substituents, at least one of which is a halogen atom having an... | 11/13/2001 |
| 6180667 | Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, staight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and ... | 01/30/2001 |
| 6172057 | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase... | 01/09/2001 |
| 6051733 | Sulfur-containing compounds for optical grade polymeric casting compositions Polymeric compositions for the preparation of optical grade materials, and the optical materials prepared thereby, are provided. The compositions include a class of reactive and non-reactive additives, referred to as additive, in combination with a polyme... | 04/18/2000 |
| 5994539 | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases Compounds of formula ##STR1## wherein R, R1, R2, R3, R4, m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as active i... | 11/30/1999 |
| 5981511 | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 11/09/1999 |
| 5945548 | Process for the synthesis of -substituted acrylic acids and their application Process for the synthesis of -substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II). ##STR1##... | 08/31/1999 |
| 5945408 | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.... | 08/31/1999 |
| 5945451 | Fluorobutenyl(thio)ethers used as pesticides The present invention relates to new fluorobutenyl (thio)ethers of the formula (I) ##STR1## in which R1 represents hydrogen or halogen, R2 and R3 independently of one another represent hydrogen or in each case optiona... | 08/31/1999 |
| 5935988 | Tolerability of pharmaceutically active ଲ-amino acids The present invention relates to mixtures of -amino acids and/or derivatives thereof and cyclopentane-ଲ-amino acids and/or derivatives thereof, dipeptides of the abovementioned -amino acids and cyclopentane-ଲ-amino acids and mixt... | 08/10/1999 |
| 5863931 | Amidino derivatives and their use as nitric oxide synthase inhibitors Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group,... | 01/26/1999 |
| 5739140 | Selected novel aryl acrylics Novel compounds of Formula I and methods of making and using the compounds which are useful as fungicides, particularly in the agricultural field: ##STR1## wherein C1 and C2 are carbon atoms which are part of an aromatic ring; W... | 04/14/1998 |
| 5637616 | Method for treating diseases mediated by proteases A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the ... | 06/10/1997 |
| 5625085 | Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, straight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and... | 04/29/1997 |
| 5620977 | Retroviral protease inhibitors Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 04/15/1997 |
| 5616563 | Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth A compound of the formula ##STR1## with R being hydrogen, alkyl, cycloalkyl or aryl, which may be substituted with halogen or alkyl, and R' and Ra being hydroxyl, or --O-alkyl, pharmaceutically acceptable salts thereof; or mixtures thereof... | 04/01/1997 |
| 5514794 | Antibody-drug conjugates Derivatized drugs are prepared with a linker consisting of a malonate, wherein the drug is linked through a methylene to the 2-position carbon of the malonate.... | 05/07/1996 |
| 5503776 | N-acylcarnosines and their use as antioxidants An N-acylamino acid compound represented by the general formula (1): R--CO--(NH--X--CO)n --OR1 (1) wherein (NH--X--CO) is an amino acid residue, X in (NX--X--CO) is variable with the kind of amino acid to be used, R--CO ... | 04/02/1996 |
| 5503758 | Antiwear and antioxidant additives A lubricant additive having antiwear and antioxidant properties is the reaction product of a sulfur-containing carboxylic acid and an etheramine, preferably 3,3'-thiodipropionic acid and N-isoeicosyloxypropyl-1,3-diaminopropane which is post reacted with ... | 04/02/1996 |
| 5491261 | Poly-perfluoroalkyl-substituted alcohols and acids, and derivatives thereof Di-, tri- and poly-perfluoroalkyl-substituted alcohols and acids and derivatives thereof are described which are prepared from perfluoroalkyl iodides and di-, tri- or polyallyl alcohols or acids. These compounds contain two or more perfluoroalkyl-iodoalky... | 02/13/1996 |
| 5491169 | Amino acid derivatives and their therapeutical applications Compounds having the properties of morphinic substances, particularly anasia, with beneficial effects on behaviour and with peripheral effects without their major drawbacks (tolerence, addiction), the blood-brain barrier and having the following formula ... | 02/13/1996 |
| 5481026 | Optically active amino acid sulphoxide and amino acid sulphone derivatives The invention relates to new optically active amino acid derivatives of the general formula (I) ##STR1## in which n, R, R1, R2, R3, X and A have the meaning given in the description, which amino acid derivatives conta... | 01/02/1996 |
| 5466862 | Low molecular weight polyacetals and polyaldehydes Low molecular weight polyaldehydes are prepared by converting the acetal groups of the low molecular weight polyacetal to aldehyde groups or by reacting an aldehyde-containing reagent (e.g., glyoxal) with a polyamide.... | 11/14/1995 |
| 5382679 | Process for the preparation of glutathione S-acyl derivatives, compounds obtained from said process and an intermediate useful for the preparation thereof A selective and high yield process for S-acylating glutathione, comprising the eaction between glutathione and an acyl chloride or a carboxylic anhydride in trifluoroacetic acid is described.... | 01/17/1995 |
| 5374765 | Method for extracting an amino acid ester from a hydrous solution of a mineral acid salt thereof Disclosed is a method for extracting an amino acid ester from a hydrous solution which comprises adding thereto a water-insoluble organic solvent and then an amount of a base effective to liberate only a portion of the amino acid ester in free base form, ... | 12/20/1994 |
| 5359128 | Malic acid derivatives and compositions for the treatment of psoriasis The invention comprises compositions and methods for the treatment of psoriasis. The compositions comprise compounds of the formula: ##STR1##... | 10/25/1994 |
| 5347042 | Optically active sulphur-containing amino acid derivatives, their preparation, their polymerisation to give optically active polymers and the use thereof The invention relates to new optically active sulphur-containing amino acid derivatives, a process for their preparation, their polymerisation to give optically active polymers and the use of these optically active polymers as adsorbents for chromatograph... | 09/13/1994 |
