Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8124803 | Salt suitable for an acid generator and a chemically amplified resist composition containing the same The present invention provides a salt of the formula (L) A salt of the formula (L): wherein Q represents —CO— group or —C(OH)— group; ring X represents monocyclic or polycyclic hydrocarbon group having 3 to 3... | 02/28/2012 |
| 6949670 | Fluorocompound, silver halide photographic light-sensitive material, surfactant, and water-based coating composition employing same A fluorocompound denoted by general formula (1) below (wherein R1 denotes a substituted or unsubstituted alkyl group having a total of at least six carbon atoms, with R1 not being an alkyl group s... | 09/27/2005 |
| 6939855 | Anti-inflammatory compositions and method The disclosed invention includes pharmaceutical compositions and methods for treating inflammatory conditions, particularly those that are characterized by increased binding of alpha-9 integrin to one or more of its ligands. Also disclosed are methods for selecting ... | 09/06/2005 |
| 6613937 | S-nitroso- and S-nitro-N-acyl-L-cysteine ester derivatives as pharmalogically active agents and pharmaceutical compositions containing said compounds SNACE derivatives as pharmacological active agents and pharmacological compositions containing these compounds, in particular for transdermal, oral, rectal and inhalational application, are described.... | 09/02/2003 |
| 6593376 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups on a di-,oligo- or polyene base A process for preparing amphiphilic compounds having at least two hydrophilic and at least two hydrophobic groups by reacting an olefinic substrate having at least two double bonds with an organic hydroperoxide to form an oxirane ring, opening, the oxiran... | 07/15/2003 |
| 6441036 | Fatty analogues for the treatment of obesity, hypertension and fatty liver The present invention relates to novel fatty acid analogous of the general forumla I: CH3 --[CH2 ]m --[xi --CH2 ]n --COOR, as defined in the specification, which can be used for the treatme... | 08/27/2002 |
| 6323363 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups based on dicarboxylic acid diamides The invention concerns amphiphilic compounds of general formula (I) ##STR1## with at least two hydrophilic and at least two hydrophobic groups based on dicarboxylic acid diamides. The disclosed amphiphilic compounds mostly have a surfactant activity and a... | 11/27/2001 |
| 6288267 | Thioamide derivatives It has been discovered that compounds of the formula: ##STR1## and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined below, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated wit... | 09/11/2001 |
| 6180667 | Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, staight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and ... | 01/30/2001 |
| 6159988 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R1 -R4 have the meanings given in the specifications and show an activity against inflammatory conditions.... | 12/12/2000 |
| 5997610 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups based on dicarboxylic acid diamides The invention concerns amphiphilic compounds of general formula (I) ##STR1## with at least two hydrophilic and at least two hydrophobic groups based on diacarboxylic acid diamides. The amphiphilic compounds according to the invention are mostly surfa... | 12/07/1999 |
| 5670684 | Process and intermediates for the preparation of excitatory amino acid receptor antagonists The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activ... | 09/23/1997 |
| 5625085 | Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, straight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and... | 04/29/1997 |
| 5616782 | Method of producing alkyl sulfoacetate compositions Disclosed are alkyl sulfoacetate compositions comprising a sulfonated ester of the formula: RO(CH2 CHR1 O)n COCH2 SO3 M where R represents straight chain alkyl having from about 6 to 20 carbon atoms; R1 | 04/01/1997 |
| 5587499 | (Meth) acrylic compounds, process for their preparation and their application to the synthesis of new polymers These compounds are denoted by the following formula (I): ##STR1## in which: Z denotes H or a linear or branched alkyl radical, X denotes O or S, each of A and B independently denotes an alkylene radical, it being possible for this radical to be substitut... | 12/24/1996 |
| 5525629 | Inhibition of cytokine production Hydroxamic acid derivatives of formula (I): ##STR1## wherein R1 represents hydrogen or an (C1 -C6)alkyl, (C1 -C6)alkoxycarbonyl(C1 -C6)alkyl, phenyl, substituted phenyl, phe... | 06/11/1996 |
| 5491170 | ଲ-carboxy sulfonamide ACAT inhibitors ଲ-Carboxy sulfonyl compounds of the formula ##STR1## wherein R1 is aryl, R3 is hydrogen or alkyl, R3 and R4 are hydrogen or alkyl, Y is --O--, --S--, or --NR2 --, and R5 is alkyl... | 02/13/1996 |
| 5489705 | Sodium salt of 1-menthyloxycarbonyl 1-hydroxy methanesulphonic acid, its preparation process and its use for obtaining L(-)menthyl glyoxylate Sodium salt of 1-menthyloxycarbonyl 1-hydroxy methanesulphonic acid, its preparation process and its use for obtaining L(-)menthyl glyoxylate. Product of formula (I). ##STR1## preparation process and use of the product of formula (I) according to cla... | 02/06/1996 |
| 5476966 | Method for depletion of glutathione This invention relates to certain S-substituted homocysteine sulfoximines and their uses. Buthionine sulfoximine (BSO) appears to have significant uses for chemotherapy and radio therapy, especially combination chemotherapy and radiation therapy and for t... | 12/19/1995 |
| 5442094 | Sodium salt of 1-menthyloxycarbonyl 1-hydroxy methanesulphonic acid, its preparation process and its use for obtaining L(-)menthyl glyoxylate Product of formula (I) ##STR1## preparation process and use of the product of formula (I) according to claim 1 for obtaining the product of formula (II).... | 08/15/1995 |
| 5166373 | Acyclic terpenes The present invention provides novel acyclic terpenes of the formula: ##STR1## which are useful as intermediates for the industrially advantageous production of sarcophytol A.... | 11/24/1992 |
| 5138091 | 1,4-dihydropyridine-threonine derivatives with cardiovascular activity Cardioactive dihydropyridines of the formula ##STR1## in which Y is ##STR2## A is H or CH3, B is --NH, --NH--CO--, --NH--CS--, --NH--COO--, --NH--SO2 --or --NH--CO--NH-- or --NH--CS--NH--, and R13 and R14 | 08/11/1992 |
| 5097049 | Process and intermediates for chiral epoxides Chiral epoxybutyrates are prepared in high yield from novel dihydro-3R-substituted sulfonyloxy-4R-hydroxy-2-(3H)furanones via based catalyzed alcoholysis. The product chiral epoxy butyrates are useful intermediates for the synthesis of 1-carba-1-dethia ce... | 03/17/1992 |
| 5010189 | Processes for the preparation of 5-amino-4-hydroxy-valeric acid derivatives The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower... | 04/23/1991 |
| 5010105 | Antihypercholesterolemic compounds Compounds of Formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.... | 04/23/1991 |
| 5008442 | Surface-active compounds on the basis of arylated fatty substances and their use A compound of the formula A[(Y-O)x - Y - Z]m in which A is the radical of an arylated fatty alcohol, Y are identical or different groups of the formulae --CH2 --CH2 -- or --CH2 --CH(CH3)--, Z are ide... | 04/16/1991 |
| 4973732 | Polymer containing a polyisobutylene-derived backbone Polymers, such as polysiobutylene or ethylene-propylene copolymers, are functionalized by reaction with an activated imine to yield novel polymers.... | 11/27/1990 |
| 4973733 | Method of functionalizing polymers Polymers, such as polyisobutylene or ethylene-propylene copolymers, are functionalized by reaction with an activated imine to yield novel polymers.... | 11/27/1990 |
| 4968599 | Photographic composition containing a fluorinated sulfosuccinate Fluoroalkyl surface active agents are provided as effective coating aids for hydrophilic colloid coating compositions for photographic materials. These coating aids are of the formula: ##STR1## where M is a cation, x and y are each independently 0 or... | 11/06/1990 |
| 4929736 | Latent isocynate derivatives useful for deactivating enzymes Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norle... | 05/29/1990 |
| 4736055 | Oxime sulfonates containing reactive groups Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR5, --COOH, COOR6, --COCl, --CH2 Hal, --SO2 Cl or --NCO group, Z is an (x+y)-valent con... | 04/05/1988 |
| 4643990 | N-acyl peptide, processes for their preparation and pharmaceutical compositions thereof N-acylpeptides are disclosed of the formula: ##STR1## wherein R1 is alkanoyloxy or alkenoyloxy; R2 is alkyl or alkenyl; R3 and R4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carbox... | 02/17/1987 |
| 4600774 | Cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides and amide derivatives thereof Cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides, amide derivatives thereof, a process for making the same, curable compositions containing cyclic sulfoperfluoroaliphaticcarboxylic acid anhydrides or amide derivatives thereof and cationically-sens... | 07/15/1986 |
| 4584196 | Perfluorinated surface-active oligomers and compositions for treating hair containing these oligomers Perfluorinated surface-active block or random oligomers of the formula ##STR1## where R denotes a C2 -C18 -hydrocarbon or -hydrofluorocarbon radical, Y denotes a C6 -C13 -fluorocarbon or -hydrofluorocarbon radic... | 04/22/1986 |
| 4567004 | Process for the preparation of monomethyl-substituted methylene compounds Monomethyl-substituted methylene compounds are obtained by reacting methylene compounds of the formula ##STR1## in which R1 and R2 independently of one another represent --CN, --CO--R3, --SO2 --R3 | 01/28/1986 |
| 4546198 | Asymmetric synthesis of esters and acids Stereoisomerically-enriched esters are prepared by treating a non-symmetrical ketene with a racemic or chiral tertiary-base-substituted alkylcarbinol. Optional hydrolysis of the esters gives the corresponding optically-active carboxylic acids correspondin... | 10/08/1985 |
| 4522764 | Process for the production of , ଲ-unsaturated carboxylic acid alkyl esters sulfonated in the -position and compounds obtainable by this process The title compounds are obtained by reacting compounds corresponding to the following formula: wherein R1 represents hydrogen or a methyl group and R2 represents a primary or secondary C1 to C4 alkyl group, with ... | 06/11/1985 |
| 4444682 | Method of sulfation A method for sulfating a hydroxy amino acid or a residue of such an amino acid in a peptide by reaction with a reagent which is a tertiaryammonium salt of acetylsulfuric acid having the formula: wherein R is triethylamine, ethyldiisopropylamine, pyridine, ... | 04/24/1984 |
| 4430271 | Energy transfer This invention relates to a process for neutralizing detergent acid mixes containing unreacted sulfating agent such as sulfuric acid with an alkaline component such as sodium hydroxide. The neutralization process is highly exothermic and contains as a by-... | 02/07/1984 |
| 4404143 | Process for producing high concentration solution of salt of alpha-sulfo fatty acid ester A high concentration aqueous solution of the salt of an alpha-sulfo fatty acid ester is produced by (a) neutralizing the sulfonated product of a fatty acid ester with an aqueous caustic alkali solution having a concentration of 15 through 50% by weight, i... | 09/13/1983 |