"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7456310 | Dispersant for dispersing carbon nanotubes and carbon nanotube composition comprising the same Disclosed herein is a cyclic dispersant having a rigid block which has a high affinity for carbon nanotubes, and a flexible block which has a high affinity for a solvent, with a linkage created therebetween. Having a structure that is advantageous with respect to ad... | 11/25/2008 |
| 7214716 | Agonists specific for the peripheral cannabinoid receptor The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bi... | 05/08/2007 |
| 7041740 | Heat-settable resins Heat-settable epoxy resin mixtures are provided that can be used alone or in combination with fibers to form large composite material structures without the need for high consolidation pressures. The heat-settable resin mixture is composed of a resin component, curi... | 05/09/2006 |
| 6903137 | Agonists specific for the peripheral cannabinoid receptor The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bi... | 06/07/2005 |
| 6527690 | Purification of phenyl ester salts The invention relates to a process for purifying and decolorizing a phenyl ester salt. The process combines a phenyl ester salt with a solvent to form a mixture and then stirs the mixture to form a slurry. The phenyl ester salt is substantially insoluble ... | 03/04/2003 |
| 6468487 | Nitration or carboxylation catalysts In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the following formula (1): ##STR1## wherein R1 and R2 represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group and a cycloalkyl group, and R | 10/22/2002 |
| 6448442 | Contrast media The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula I ##STR1## wherein n is 0 or 1, and where n is 1 each C6 R5 moiety may be the same or different; X denotes a bond or a group pr... | 09/10/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6355673 | Substituted diaminocarboxylic acids Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved... | 03/12/2002 |
| 6337420 | Liquid crystal compounds, mixtures and devices An electroclinic device having two spaced cell walls each bearing electrode structures and treated on at least one facing surface with an alignment layer, a layer of a smectic liquid crystal material enclosed between the cell walls, where the liquid cryst... | 01/08/2002 |
| 6310243 | Iodinated x-ray contrast media The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6 R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said comp... | 10/30/2001 |
| 6235851 | Polymerizable adamantane derivatives and process for producing the same A compound shown by the following formula: ##STR1## wherein each of R1a, R2a, R3a and R4a represents a substituent selected from a non-reactive atom, a non-reactive group, a hydroxyl group and an amino group, an... | 05/22/2001 |
| 5993780 | Contrast media The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C6 R5 moeity may be the same or different; each group R is a hydro... | 11/30/1999 |
| 5882628 | Contrast media The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C6 R5 moeity may be the same or different; each group R is a hydro... | 03/16/1999 |
| 5637614 | 6,7-disubstituted-2-aminotetralines and pharmaceutical compositions containing the same 6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R1, ... | 06/10/1997 |
| 5494605 | P-terphenyl derivatives and liquid crystalline compositions The p-terphenyl derivatives of the formula shown below are useful in preparing practical ferroelectric liquid crystalline compositions. The derivatives exhibit excellent chemical stability and display the chiral smectic C or smectic C phase over a wide te... | 02/27/1996 |
| 5488137 | Acrylic acid ester derivative having a triphenyl amine skeleton An electrophotographic photoconductor is composed of a substrate and a photoconductive layer formed thereon. The photoconductive layer is composed of a polymer including an acrylic acid ester moiety of formula (I) as repeat unit: ##STR1## wherei... | 01/30/1996 |
| 5447659 | Optically active benzene derivatives, process for producing the same and liquid-crystalline substances containing said derivatives as active ingredient and optical switching elements Disclosed are novel active benzene derivatives represented by the general formula (I): ##STR1## (wherein X represents --CCO--, --OCO--, --CH2 C-- or --OCH2 --; A represents a hydrogen atom, a halogen atom or an alkyl or alkoxyl ... | 09/05/1995 |
| 5434295 | Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds The present invention provides certain novel 4-phenylpinene derivatives, and teaches how to use said novel derivatives and related compounds in pharmaceutical compositions that have utility in treating various pathological conditions associated with damag... | 07/18/1995 |
| 5397504 | Biphenyl compound A new biphenyl compound which is chemically stable and possesses practically excellent properties as a component for preparing ferroelectric smetic liquid crystalline compositions as well as a new liquid crystalline composition containing this compound.... | 03/14/1995 |
| 5382380 | P-terphenyl derivatives and liquid crystalline compositions New p-terphenyl derivatives useful as components for preparing practical ferroelectric liquid crystalline compositions and excellent in chemical stability, as well as liquid crystalline compositions containing at least one of the p-terphenyl derivatives.... | 01/17/1995 |
| 5354511 | Unsymmetrically substituted fluorenes for non-linear optical applications Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R1 and R2 are aromatic bridging groups, X and Y are preferably groups capable of ... | 10/11/1994 |
| 5347041 | Molecular composites Monomers containing two diacetylene segments each of which is connected on one end through a spacer segment to a central mesogen segment, and on the other end to an additional spacer segment, are topochemically polymerized in a molecularly ordered phase t... | 09/13/1994 |
| 5338484 | Optically active benzene derivatives, process for producing the same and liquid-crystalline substances containing said derivatives as active ingredient and optical switching elements Disclosed are novel active benzene derivatives represented by the general formula (I): ##STR1## (wherein X represents --COO--, --OCO--, --CH2 O-- or --OCH2 --; A represents a hydrogen atom, a halogen atom or an alkyl or alkoxyl ... | 08/16/1994 |
| 5334766 | Process for the resolution of racemic diphosphine oxides A process for the resolution of racemic diphosphine oxides into the optically active antipodes by reacting the racemate with a resolving agent comprising using a carbamate or thiocarbamate of an optically active -hydroxycarboxylic acid or -a... | 08/02/1994 |
| 5328643 | Optically active compounds, liquid crystal composition containing said compounds, and liquid crystal optical modulator using said composition The invention relates to optically active compounds represented by the general formula I ##STR1## wherein R1, R2, R3, R4, Q1, Q2, Q3, and M are defined as in the specificati... | 07/12/1994 |
| 5312975 | Process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid A process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid comprising the reaction of an organometallic derivative with a suitable substituted benzene in the presence of a transition-metal based catalyst is described.... | 05/17/1994 |
| 5242619 | Liquid crystalline mixtures having a chiral tilted smectic phase Optically active compounds of the formula ##STR1## wherein rings A, B and C each independently are unsubstituted or each are 1,4-phenylene substituted with at least one of halogen-, cyano-, methyl- or methoxy in which optionally 1 CH group or 2 CH gr... | 09/07/1993 |
| 5238602 | Liquid crystals Compounds of the formula ##STR1## wherein n stands for the number 0 or 1; the rings A1, A2 and A3 represent 1,4-phenylene, 2-fluoro-1,4-phenylene or trans-1,4-cyclohexylene or one of these rings also represents a ... | 08/24/1993 |
| 5235068 | Process for producing acylaromatic compounds Acylaromatic compounds ##STR1## (Q: aromatic compound residue; R: straight, branched or cyclic aliphatic group, aromatic group or araliphatic group) are prepared in high yield by a reaction, in the presence of a boron trifluoride complex catalyst, of... | 08/10/1993 |
| 5210279 | Process for manufacturing aromatic diacetates A continuous process for the production of diacetate derivatives of aromatic compounds, comprising feeding at any convenient temperature an oxygen-containing gas and feedstock comprising a diisopropyl ring substituted aromatic compound and the recycled mo... | 05/11/1993 |
| 5208263 | Anti-androgen compounds Disclosed are novel classes of anti-androgen including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.... | 05/04/1993 |
| 5191124 | Sulfonium salts having acid-labile groups Sulfonium salts of the general formula ##STR1## where R1, R2 and R3 are identical or different and are aliphatic and/or aromatic radicals which may contain heteroatoms, or two of the radicals R1 and R3... | 03/02/1993 |
| 5167863 | Optically active compound, liquid crystal composition containing said compound, and liquid crystal optical modulator using said composition There are disclosed an optically active compound represented by the general formula: ##STR1## wherein n, R1, R2, R3, R4, Q1, Q2, Q3, and M are defined as in the detailed exp... | 12/01/1992 |
| 5064569 | Optically active compounds Optically active compounds of the formula I can be used as components of chiral titled smectic liquid crystal phases: R1 --C*HX--Q--A4 --Z1 --A2 --(Z2 --A3)n --X'--Q'--C*HY'--R5 | 11/12/1991 |
| 5025036 | Catechol carboxylic acids The invention relates to catechol carboxylic acid derivatives of the formula ##STR1## wherein, R1 is ##STR2## acetyl, hydrogen, hydroxy or alkanoyloxy, R2 is ##STR3## hydroxy, hydrogen or alkanoyloxy, wherein R ... | 06/18/1991 |
| 5002693 | Novel optically active benzene derivatives, process for producing the same and liquid-crystalline substances containing said derivatives as active ingredient and optical switching elements Disclosed are novel active benzene derivatives represented by the general formula (I): ##STR1## (wherein X represents --COO--, --OCO--, --CH2 O-- or --OCH2 --; A represents a hydrogen atom, a halogen atom or an alkyl or alkoxyl ... | 03/26/1991 |
| 4973426 | Optically active compound having a plurality of asymmetric carbon atoms An optically active compound having particularly a specific feature of increasing spontaneous polarization value as one of important specific features for ferroelectric liquid crystal compositions, and a ferroelectric liquid crystal composition containing... | 11/27/1990 |
| 4970023 | Biphenyl compounds, method of producing the same as well as liquid crystal compositions and light switch elements each containing the same This invention provides novel biphenyl compounds represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from the single bond, --COO--, --OCO--, --OCOO-- and --CO--, and each of m and n is an integer of ... | 11/13/1990 |
| 4962192 | Chemiluminescent 1,2-dioxetane compounds Novel light producing 1,2-dioxetanes are described of the formula ##STR1## wherein ArOX is an aryl ring substituted with an X oxy group and A are passive organic groups which allow the 1,2-dioxetane to produce light when triggered by removing X. X is... | 10/09/1990 |