Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7326685 | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof Disclosed are peptide agents and uses thereof that are analogs of biologically active peptides such as somatostatin and bombesin. The compounds of the invention have the general formula X-Y-Z-Q, where X is a cytotoxic agent, therapeutic agent, detectable label or ch... | 02/05/2008 |
| 7160975 | Methacrylates as stabilizers for polymer polyols This invention relates to ethylenically unsaturated macromers which contain reactive unsaturation, and to a process for preparing these ethylenicallly unsaturated macromers which contain reactive unsaturation. The process of preparing these ethylenically unsaturated... | 01/09/2007 |
| 7033676 | Binding agent mixtures and their use in coating materials cured by actinic radiation and/or heat A binder mixture comprises at least one polymer (A) with saturated main chain that is not a polyester and at least one polyester (B) with a saturated and/or unsaturated main chain, where (i) one of the two components (A) or (B) con... | 04/25/2006 |
| 6495719 | Histone deacetylase inhibitors Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of h... | 12/17/2002 |
| 6184412 | Process for manufacture of N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives in the presence of N,N-dialkylarylamine catalyst and aqueous solvent The present invention provides a process for making N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives by reacting a chloroformate with a thiocyanate, in the presence of an aqueous solvent and a catalytic amount of a N,N-dialkylarylamine, to produce ... | 02/06/2001 |
| 6156895 | Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxamide, an intermediate for an HIV protease inhibitor.... | 12/05/2000 |
| 6143917 | Process for producing aryl carbamates A process for producing an aryl carbamate of a high purity at a high yield by reacting a diaryl carbonate with an amine compound having one or more hydrogen atoms bonded to the N position in the presence of carboxylic acid(s) of the following general form... | 11/07/2000 |
| 6066754 | Process for manufacturing N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives using N,N-dialkylarylamine as catalyst The present invention provides a process for making N-alkoxy(or aryloxy)carbonyl isothiocyanate derivatives by reacting a chloroformate with a thiocyanate, in the presence of an organic solvent and a catalytic amount of a N,N-dialkylarylamine, to produce ... | 05/23/2000 |
| 5977364 | Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide An improved process using chiral hydrogenation is described for the synthesis in high yields of a 4-protected-(S)-piperazine-2-tert-butylcarboxaimide, an intermediate for an HIV protease inhibitor.... | 11/02/1999 |
| 5958971 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.... | 09/28/1999 |
| 5817863 | Process and novel intermediates for preparing triazolinones The present invention relates to a novel process for preparing triazolinones of the general formula (I) ##STR1## in which R1 represents halogenoalkyl, and R2 represents hydrogen, hydroxyl or amino, or represents alkyl, alkenyl, ... | 10/06/1998 |
| 5714148 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.... | 02/03/1998 |
| 5660829 | Process for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.... | 08/26/1997 |
| 5587161 | Prodrugs for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs substrates for carboxypeptidase G2 (CPG2) and yield more cytotoxic drugs than known products of CPG2 catalysed... | 12/24/1996 |
| 5523463 | Method of producing halogenated and alpha-aminoalchohols A process for the manufacture of N-protected -aminoketones and N-protected -aminoalcohols of the formula ##STR1## wherein X is halogen, one of Q1 and Q2 is hydrogen and the other is hydroxy or Q1 and Q | 06/04/1996 |
| 5405990 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.... | 04/11/1995 |
| 5315032 | Method of producing an N-hydroxycarbamate compound An N-hydroxycarbamate compound of the formula ROCONHOH in which R is C1-8 alkyl, C3-12 cycloalkyl, aryl or aralkyl group, is produced by reacting a carbonic acid diester of the formula ROCOOR in which R is as defined above, with hydr... | 05/24/1994 |
| 5254715 | Aminosulfonyl carbamates A compound of the following general formula which is useful in treating hypocholesterolemia and atherosclerosis: ##STR1## wherein X is oxygen or sulfur; R is hydrogen, alkyl having from 1 to 8 carbon atoms, or benzyl; R1 is phenyl, substit... | 10/19/1993 |
| 5209930 | Preparation and use of N-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents Antimicrobial compounds of the formula ##STR1## wherein R1 is selected from the group consisting of H, lower (C1 -C4)alkyl, alkyl aryl, CH2 OR, CH2 SR, and CH(CH3)OR; and R, R2 | 05/11/1993 |
| 5206417 | Radiation-sensitive, ethylenically unsaturated copolymerizable compounds and their preparation The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R1, and R1 is a radical ##STR2## where R2 to R6 are each H, alkyl, OH, Oalkyl, SH, Sal... | 04/27/1993 |
| 5194673 | Process of alkoxy and aryloxy isothiocyanate preparation Alkoxy and aryloxy isothiocyanates are produced by the reaction of a haloformate and an alkali or alkaline earth metal thiocyanate in the presence of water and (i) a catalyst comprising a six membered mononuclear or ten membered fused polynuclear aromatic... | 03/16/1993 |
| 5189058 | Iminodicarbonic, iminodicarbonodithioic, and thiocarbonylcarbamic acid esters useful as ACAT inhibitors The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R1 and R2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, ara... | 02/23/1993 |
| 5072020 | Aliphatic polyamines from polynitro compounds Disclosed is a novel route to diamines and triamines comprising reacting nitroalcohols with isocyanates to prepare di- and trinitro compounds which are subsequently reduced over a metal hydrogenation catalyst to the corresponding polyamino compound.... | 12/10/1991 |
| 5043474 | Optically active rhodium complexes of 3,4-bis(diarylphosphino)pyrrolidines and their use for the preparation of phosphinothricin by asymmetric hydrogenation The invention relates to rhodium complexes of the formula [A--O--(CH2 CH2 O)n --A]2+ 2X- (Ia) and [A--O--(CH2 CH2 O)m --CH3 ]+ X-(Ib) in which n=5... | 08/27/1991 |
| 4985587 | Reaction products of p-vinylphenol and polyisocyanates Polyunsaturated compounds useful in radiation curable compositions are made by reacting p-vinylphenol and a polyisocyanate in the ratio of one mole of p-vinylphenol for each isocyanate group of the polyisocyanate.... | 01/15/1991 |
| 4935413 | Carbamate physical property-improving reagent A physical property-improving reagent which comprises an alkenoylcarbamate compound of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is an oxygen atom (--O--), a sulfur atom (--S--) or a substituted or unsubstituted imi... | 06/19/1990 |
| 4927965 | N-(N-succinyl-L-leucyl)agmatine, related compounds and use in pharmacology Compounds having the formula: ##STR1## wherein R1 is --NH(C.dbd.O)OR5, --NH(C.dbd.NH)NH2 or --NH(C.dbd.N--NO2)HN2 ; R2 is hydrogen, C1-8 alkyl or C6-8 aryl; n is ... | 05/22/1990 |
| 4925971 | Method for producing aliphatic o-arylurethanes A method for producing aliphatic O-arylurethanes by the reaction of an aliphatic primary amine with an aromatic hydroxyl compound and urea. Ammonia produced as a by-product in the reaction is removed during the reaction so that the ammonia concentration o... | 05/15/1990 |
| 4921996 | Isocyanato-acylurethanes, a process for their preparation and their use The present invention relates to isocyanto-acylurethanes corresponding to Formula I ##STR1## wherein R has a valency of m+n and is a hydrocarbon group, R' is a hydrocarbon group and m and n may be identical or different, and each have a value of 1 or 2. T... | 05/01/1990 |
| 4914124 | N-organooxycarbamic acid esters for combating endoparasites A method of combating endoparasites which comprises applying thereto or to an endoparasite habitat an endoparasiticidally effective amount of an N-organooxycarbamic acid ester of the formula ##STR1## in which R1 represents alkyl, cycloalky... | 04/03/1990 |
| 4883903 | Novel procedure for the preparation of activated nitrosocarbamates The subject of the invention is a novel procedure for the preparation of the compounds of formula I: ##STR1## in which n varies in particular from 2 to 5 and R represents Cl, Br or F Z represents in particular hydrogen, characterized in that the halo... | 11/28/1989 |
| 4870203 | Preparation of geminal dicarbamates Prepare , ଲ-saturated geminal biscarbamates by contacting an ,ଲ-unsaturated ether with a carbamate under reaction conditions, optionally in the presence of a catalyst.... | 09/26/1989 |
| 4812590 | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma Derivatives of 4-hydroxyanisole carbamate are suitable as prodrugs for the delivery and concentration of 4-hydroxyanisole in melanomas.... | 03/14/1989 |
| 4782175 | Urethanes composed of aliphatic fluoroalcohols, isocyanates and aromatic compounds, a process for their preparation and their use The molecule of the new urethanes contains an aliphatic fluoroalcohol, an isocyanate and an aromatic dihydroxy, diamino, aminohydroxy, aminocarboxy or hydroxycarboxy compound. They are prepared by reacting an aliphatic fluoroalcohol with a diisocyanate or... | 11/01/1988 |
| 4778921 | Novel process of alkoxy and aryloxy isothiocyanate preparation Alkoxy and aryloxy isothiocyanates are produced by the reaction of a haloformate and an alkali or alkaline earth metal thiocyanate in the presence of water and a catalyst comprising a six membered mononuclear or ten membered fused polynuclear aromatic, he... | 10/18/1988 |
| 4776875 | Functional acetic acid derivatives containing phosphorus and herbicidal, growth-regulating agents containing them Compounds of the formula ##STR1## in which R1 and R2 denote alkyl, OH, CF3 or cyanoethyl, A preferably denotes --COOH, R3 denotes inter alia alkoxycarbonylalkoxy, fairly high-molecular (>C12) alk... | 10/11/1988 |
| 4704470 | Polymerizable antioxidants from isocyanatoalkyl esters of unsaturated carboxylic acids An addition polymerizable antioxidant is prepared by reacting an isocyanatoalkyl ester of an addition polymerizable carboxylic acid (2-isocyanatoethyl methacrylate) with an antioxidant functionality bearing an active hydrogen moiety which is reactive with... | 11/03/1987 |
| 4665228 | Alkenyl acetamides Compounds of the formula: ##STR1## wherein R1, R2, and R3 are independently hydrogen, halogen, C1-6 alkyl, or haloalkyl; R4 is hydrogen; C1-4 alkyl, alkenyl, alkoxy, haloalkyl; C1... | 05/12/1987 |
| 4663475 | Ethylenically unsaturated N-(halosulfonyl) carbamyl monomers A stable copolymer dispersion is prepared by addition copolymerization of (1) a monomeric adduct of an active hydrogen compound, e.g., a polyether polyol or polyether monool, and an ethylenically unsaturated N-chlorosulfonyl carbamyl compound such as ... | 05/05/1987 |
| 4610827 | Amino acid complex and a method for optical resolution of a DL-amino acid A method for optical resolution of a DL-amino acid comprising reacting the DL-amino acid with an optically active N-acyl aspartic acid in a solvent or mixture of solvents, and separating the resulting two diasteromeric salts by way of the difference betwe... | 09/09/1986 |
