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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8013181 | Preparation of rivastigmine and its salts There are provided processes for making rivastigmine. In one embodiment, the process includes reacting S-(−)-[1-(3-hydroxyphenyl)ethyl]dimethylamine with N-ethyl-N-methyl carbamoyl chloride in the presence of an organic base to obtain a free base of rivastigmine. | 09/06/2011 |
| 7683205 | Process for the preparation of Rivastigmine The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H... | 03/23/2010 |
| 7405239 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyp... | 07/29/2008 |
| 7385076 | Process for the preparation of phenylcarbamates A process for the preparation of compound of formula (I); wherein R1 is hydrogen, linear, branched or cyclic lower alkyl, cyclohexyl, allyl, propargyl or benzyl; R2 is hydrogen, methyl, ethyl or propyl; or R1 and R2 togeth... | 06/10/2008 |
| 7319160 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl ... | 01/15/2008 |
| RE39616 | Aminoindan derivatives This invention is directed to compounds of the following formula: wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is... | 05/08/2007 |
| 6927303 | Tetrafluorobenzyl derivatives and pharmaceutical composition for preventing and treating acute and chronic neurodegenerative diseases in central nervous system containing the same The present invention relates to a tetrafluorobenzyl derivative and a pharmaceutical composition for prevention and treatment of acute and chronic neurodegenerative disease in central nervous system and ophthalmic diseases containing the same. The tetrafluorobenzyl ... | 08/09/2005 |
| 6835748 | Treatment of ocular disorders The present invention is in particular related to the use of rivastigmine in the manufacture of a medicament for the treatment of ocular disorders. ... | 12/28/2004 |
| 6730700 | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclose... | 05/04/2004 |
| 6573297 | (2-substituted oxyphenyl)alkanamide derivative, hair growth promoter and external composition for skin using the same A (2-substituted oxyphenyl)alkanamide derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C3-30 expressed by R1 and the other is --(CH2)n-NR2 | 06/03/2003 |
| 6534541 | Treatment of ocular disorders The present invention is in particular related to the use of rivastigmine in the manufacture of a medicament for the treatment of ocular disorders.... | 03/18/2003 |
| 6512136 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them New compounds of formula I are described ##STR1## The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a reduction in the O-methylation of catecholamines may be o... | 01/28/2003 |
| 6342523 | 3,4,5-trisubstituted aryl nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have the formula: ##STR1## where R1 -R4 are as defined in the specif... | 01/29/2002 |
| 6303650 | Aminoindan derivatives This invention is directed to compounds of the following formula ##STR1## wherein when a is O, b is 1 or 2; when a is 1, b is 1, m is from 0-3 X is O or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-... | 10/16/2001 |
| 6251938 | Phenylethylamine derivatives This invention is directed to compounds of the following formula: ##STR1## wherein m is from 0-4; X is O or S; Y is halogeno; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-4 alkyl or optionally substituted pr... | 06/26/2001 |
| 6153646 | Binuclear platinum complexes, method for preparing same and pharmaceutical compositions containing said complexes A family of platinum complexes which are stable and exhibit anticancer activity.... | 11/28/2000 |
| 6022989 | Process for the preparation of an activated amino acid A process is disclosed for the preparation of an N-acylated activated derivative of an amino acid or a salt thereof.... | 02/08/2000 |
| 6013606 | Substituted cinnamic oxime and hydroxamide derivatives Substituted cinnamic oxime derivatives I and cinnamic hydroxamide derivatives II ##STR1## (R1= halogen, NO2, CN, CF3 ; R2 =H, halogen; R3= H, halogen, C1 -C6 -alkyl, C1... | 01/11/2000 |
| 5981791 | High purity N-(4-[N,N-bis(2-iodoethyl)amino]phenoscycarbonyl)-L-glutamic acid A new salt of a prodrug useful in antibody directed enzyme prodrug therapy (ADEPT) is disclosed. A hydrogen iodide salt of the prodrug N-(4-[N,N-bis(2-iodoethyl)amino]phenoxycarbonyl)-L-glutamic acid is prepared which can be obtained in crystalline form. ... | 11/09/1999 |
| 5958971 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.... | 09/28/1999 |
| 5714148 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.... | 02/03/1998 |
| 5660829 | Process for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.... | 08/26/1997 |
| 5602176 | Phenyl carbamate The (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methyl-phenylncarbamate in free base or acid addition salt form is useful as pharmaceutical, particularly for systemic transdermal administration.... | 02/11/1997 |
| 5587161 | Prodrugs for antibody directed enzyme prodrug therapy Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs substrates for carboxypeptidase G2 (CPG2) and yield more cytotoxic drugs than known products of CPG2 catalysed... | 12/24/1996 |
| 5565490 | P-hydroxyaniline derivatives, their preparation and their use p-Hydroxyaniline derivatives of the formula I ##STR1## where the substituents have the following meanings: R1 is hydrogen, or unsubstituted or substituted alkyl; R2 and R3 independently of one another are halogen, alkyl, ... | 10/15/1996 |
| 5466862 | Low molecular weight polyacetals and polyaldehydes Low molecular weight polyaldehydes are prepared by converting the acetal groups of the low molecular weight polyacetal to aldehyde groups or by reacting an aldehyde-containing reagent (e.g., glyoxal) with a polyamide.... | 11/14/1995 |
| 5446194 | Pharmacologically active catechol derivatives A compound according to formula 1 ##STR1## wherein R1 and R2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represe... | 08/29/1995 |
| 5405990 | Chemical compounds Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.... | 04/11/1995 |
| 5371271 | Pesticidal substituted aminophenyl carbamates Fungicidal substituted aminophenyl carbamates of the formula ##STR1## in which X represents --CO--NR8 R9 ; --CO--OR9 ; --CO--SR9 ; --CO--R10 ; --SO2 R9 or hydrogen, in which R | 12/06/1994 |
| 5206417 | Radiation-sensitive, ethylenically unsaturated copolymerizable compounds and their preparation The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R1, and R1 is a radical ##STR2## where R2 to R6 are each H, alkyl, OH, Oalkyl, SH, Sal... | 04/27/1993 |
| 5206418 | Amino-tetrahydronaphthalene derivatives The invention relates to aminotetrahydronaphthalene derivatives which are intermediates for the preparation of sulfonylaminotetrahydronaphthalenes.... | 04/27/1993 |
| 5189058 | Iminodicarbonic, iminodicarbonodithioic, and thiocarbonylcarbamic acid esters useful as ACAT inhibitors The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R1 and R2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, ara... | 02/23/1993 |
| 5176914 | Fungicidal carbocyclic anilide carbamates Fungicidal carbocyclic anilide carbamates of the formula ##STR1## in which X represents optionally alkyl-substituted cycloalkyl or optionally alkyl-substituted cycloalkenyl, Hal represents halogen, and Y1, Y2 and Y3 indepe... | 01/05/1993 |
| 5066674 | Carbamate inhibitors of cholesterol esterase and their use as hypolipidemic and hypocaloric agents Certain carbamate esters are used as inhibitors as cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intes... | 11/19/1991 |
| 5066819 | Process for the preparation of aryl esters of N-alkyl carbamic acids The invention relates to a process for the preparation of aryl esters of N-alkyl carbamic acids. The process comprises reacting an alkyl N-alkyl carbamate of the general formula: R1 --NH--COO--R3 wherein R1 and R3 ar... | 11/19/1991 |
| 5021590 | Process for producing N-alkyl-carbamates A process is provided for the preparation of N-alkyl-carbamates by directly reacting low-molecular weight alkyl-isocyanates, in particular methyl isocyanate, and a substituted phenolic precursor in solution in the presence of a basic catalyst compound sel... | 06/04/1991 |
| 5013753 | Prodrugs of dopamine Compounds of formula ##STR1## (wherein R, R1, R2 and X have the meanings reported in the specification), the processes for their preparation and the pharmaceutical compositions containing them as active ingredient are described.... | 05/07/1991 |
| 4960881 | -chlorinated carbonates, their method of manufacture and application in the protection of the amine functions of amino acids The invention relates to carbonates of formula: ##STR1## in which X is a fluorine, chlorine or bromine atom and R1 is different from the ##STR2## group and represents: a substituted or non-substituted, saturated or unsaturated, a... | 10/02/1990 |
| 4948807 | Phenyl carbamates Phenyl carbamates of the general formula ##STR1## wherein R1 to R5 are as defined in the claims, are useful as pharmaceuticals.... | 08/14/1990 |
| 4925971 | Method for producing aliphatic o-arylurethanes A method for producing aliphatic O-arylurethanes by the reaction of an aliphatic primary amine with an aromatic hydroxyl compound and urea. Ammonia produced as a by-product in the reaction is removed during the reaction so that the ammonia concentration o... | 05/15/1990 |
