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| Number | Title | Issue Date |
| 8063240 | Prostaglandin E1 and E2 analogs for the treatment of various medical conditions A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone fracture, bone disease, glaucoma, ocular hypertension, dysmenorrhoea, ... | 11/22/2011 |
| 7563924 | 9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems. ... | 07/21/2009 |
| 7476755 | Therapeutic compounds Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein. ... | 01/13/2009 |
| 7449595 | Nitrosated and nitrosylated prostaglandins, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevate... | 11/11/2008 |
| 7425651 | Jasmonate derivative compounds, pharmaceuticals compounds and methods of use thereof The present invention provides novel jasmonate derivative compounds, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for treatment of ca... | 09/16/2008 |
| 7388103 | Cyclopentane carboxylate compounds, process and intermediates for preparing the same and use thereof The present invention discloses cyclopentane carboxylate compounds. The 1-hydrocarbyl-2-acyloxy-cyclopentane carboxylates according to the invention have a general formula (I): wherein groups R1, R2 an... | 06/17/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7285613 | Free-radical curable polyesters and methods for use thereof The invention is based on the discovery that certain polyester compounds bearing free-radical curable moieties are useful as b-stageable adhesives for the microelectonic packaging industry. ... | 10/23/2007 |
| 7271283 | High refractive index, UV-curable monomers and coating compositions prepared therefrom Disclosed herein are high refractive index monomers that are curable by ultraviolet light. These monomers may be a component of curable compositions useful in the preparation of optical articles. Also disclosed is a method of synthesizing the monomers. ... | 09/18/2007 |
| 7214813 | Preparation of chiral cyclic amino acids and derivatives Cyclic β-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic β-aminoacids in high yield and enantioselectivity according to the reaction scheme: | 05/08/2007 |
| 7214400 | Flavor enhancing oils Disclosed are flavor enhancing oils comprising at least one edible liquid oil and at least one water soluble flavor enhancer. The water soluble flavor enhancer is uniformly dispersed throughout the edible liquid oil. Delivery of water soluble flavor enhancers via a ... | 05/08/2007 |
| 7176238 | Nitrostated and nitrosylated prostaglandins, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide,... | 02/13/2007 |
| 7163959 | Prostagladin derivatives for the treatment of glaucoma or ocular hypertension The invention relates to ophthalmological compositions for topical treatment of glaucoma or ocular hypertension comprising an effective intraocular pressure reducing amount of a prostaglandin derivative of PGA, PGB, PGD, PGE or PGF, in which the omega chain contains... | 01/16/2007 |
| 7129272 | Apoptosis inhibitor Disclosed is a method for treatment of a subject having a disease or condition associated with apoptosis, which comprises administering to the subject an effective amount of a 15-keto-prostaglandin compound represented by the following formula (I): | 10/31/2006 |
| 7094586 | Transglutaminase from oomycetes The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes and unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strai... | 08/22/2006 |
| 7091231 | 12-Aryl prostaglandin analogs Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted pheny... | 08/15/2006 |
| 7084178 | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's... | 08/01/2006 |
| 7045653 | Pharmaceuticals The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R1 is C1–C6alkyl, C1–C6alkoxyC1–C3alkyl or... | 05/16/2006 |
| 7005437 | Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R | 02/28/2006 |
| 6998111 | Storage stable polymerizable compositions A composition is adapted to be stored for at least 24 hours at between 0° C. to 40° C. and between 0 percent and 100 percent humidity. The composition includes from 0.2 to 5 percent by weight of a peroxide, from 0.2 to 3 percent by weight of a metal containing mat... | 02/14/2006 |
| 6956057 | EP4 agonists as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound which is a EP4 agonist. ... | 10/18/2005 |
| 6956056 | Method for providing a cathartic effect The present invention relates to a novel method for providing a cathartic effect to a patient in need of cathartic induction, which comprises administering to the patient a cathartic-inducing effective amount of halogenated bioactive lipid comprising the following p... | 10/18/2005 |
| 6909014 | Intermediates for the synthesis of ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 06/21/2005 |
| 6903067 | Fragrance composition containing 3-(3-hexenyl)-2-cyclopentenone An excellent fragrance compound having high palatability. A 3-(3-hexenyl)-2-cyclopentenone represented by a general formula (1) (wherein wavy line represents a double bond cis-form and/or trans-form) is used as an acti... | 06/07/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6852876 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/08/2005 |
| 6753443 | Preparing method of chiral ester The present invention relates to a process for preparing a chiral ester according to the formula (100): by reacting (i) a racemic alcohol, (ii) a selected ruthenium complex to activate racemization of the racemic alcohol... | 06/22/2004 |
| 6750363 | Olefination process to itaconate and succinate derivatives An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. wh... | 06/15/2004 |
| 6740772 | Prostaglandin derivatives A prostaglandin derivative represented by the formula: wherein X is a halogen atom in the α- or β-position, Y is an ethylene group, a vinylene group or an ethynylene group, A is a group represented by the formul... | 05/25/2004 |
| 6710081 | Erection insufficiency remedies Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I) (wherein symbols have the same meanings as described in the description), nontoxic salts thereof, o... | 03/23/2004 |
| 6680339 | 15-fluoro prostaglandins as ocular hypotensives 15-fluoro substituted analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 01/20/2004 |
| 6649653 | 15-fluoro prostaglandins as ocular hypotensives 15-Fluoro substituted analogs of PGF2 and methods of their use in treating glaucoma and ocular hypertension are disclosed.... | 11/18/2003 |
| 6642274 | Methods and compositions for preventing and treating prostate disorders The present invention relates to methods, compositions, devices and kits for the prevention and treatment of prostate disorders in mammals, including, but not limited to, benign prostatic hypertrophy, carcinoma of the prostate, prostadynia, prostatitis, a... | 11/04/2003 |
| 6632958 | Process for producing a purified prostaglandin derivative An alkene (1) is added to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reagent to form an adduct, said adduct is reacted with e.g. a carboxylic anhydride (4) to obtain a prostaglandin derivative (6), which is then treated ... | 10/14/2003 |
| 6576786 | Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) ##STR1## wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceut... | 06/10/2003 |
| 6541655 | Catalytic compositions and methods for asymmetric allylic alkylation Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates.... | 04/01/2003 |
| 6531485 | Prostaglandin agonists This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 03/11/2003 |
| 6528688 | Prostacyclin derivatives An improved method is described for making 9-deoxy-PGF1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.... | 03/04/2003 |
| 6512139 | Oxidation inhibitors in prostane derivatives The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before co... | 01/28/2003 |
| 6495725 | Process for the preparation of optically active enones and intermediates thereof The present invention provides a simplified and convenient process for the preparation of an optically active enone such as 7,7-dimethyl-6,8-dioxabicyclo-[3,3,0]oct-3-en-2-one. The invention further provides novel optically active intermediate compounds. ... | 12/17/2002 |
