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| Number | Title | Issue Date |
| 7423176 | Bicyclic aromatic sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith. ... | 09/09/2008 |
| 7368591 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of: a) contacting a pro-chiral sulphide of formula (II... | 05/06/2008 |
| 7297817 | Thio-substituted arylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein ... | 11/20/2007 |
| 7285678 | Purification of 2-nitro-4-methylsulphonylbenzoic acid A method for removing impurities from 2-nitro-4-methylsulfonylbenzoic acid which comprises at least two of the following steps, in any order, (a) dissolving 2-nitro-4-methylsulfonylbenzoic acid in water at a pH of about 2 to 10, followed by filtration; (b) contactin... | 10/23/2007 |
| 7262317 | Freeze-dried preparation of n[o-(p-pivaloyloxybenzenasulfonylamino) benzoyl] glycine monosodium salt tetrahydrate and process for producing same A method for the preparation of a freeze-dried product of N-[o-(p-pivaloyloxybenzenesulfonylamino)benzoyl]glycine monosodium salt tetra-hydrate dissolved in a mixed solvent of water and ethanol, and the freeze-dried product obtained by the method. According t... | 08/28/2007 |
| 7217831 | Insecticide and method of controlling insects An insecticide of formula 1 and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of: the group OR5 wherein R... | 05/15/2007 |
| 7208630 | Heat shock protein 90 inhibitors Novel compounds useful for inhibiting the 90 kDa heat shock proteins containing a quinone-like moiety and a di-hydroxy phenol like moiety, similar to geldanamycin and radicicol. ... | 04/24/2007 |
| 7186854 | Process for making bicalutamide and intermediates thereof Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ... | 03/06/2007 |
| 7153993 | Process for making polymorphic form A of 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid Process for making a pharmaceutical composition, comprising: a compound of formula (1) in crystalline form: together with a pharmaceutically acceptable carrier or excipient, whe... | 12/26/2006 |
| 7138521 | Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]be... | 11/21/2006 |
| 7094919 | Preparation of substituted aromatic carboxylic acid esters Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: Additionally the inventio... | 08/22/2006 |
| 7009055 | Preparation of Sulfonyl quinoline A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic acid salt. ... | 03/07/2006 |
| 6998490 | Process for the preparation of organic compounds containing a sulfinyl or sulfonyl group A process for the oxidation of thioethers to sulfoxides or sulfones or for the oxidation of sulfoxides to sulfones by treatment of thioethers or sulfoxides with an oxidizing amount of ε-phthalimidoperhexanoic acid is particularly useful for the preparation of compo... | 02/14/2006 |
| 6998415 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. ... | 02/14/2006 |
| RE38921 | Phenoxyalkylcarboxylic acid derivatives and process for their preparations Phenoxyalkylcarboxylic acid derivative represented by the following formula, wherein R1 indicates hydrogen atom, methyl group or ethyl group, m is an integer from 2 to 5, and n is an integer from 3 to 8, X1 ... | 12/13/2005 |
| 6936719 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents. ... | 08/30/2005 |
| 6875895 | Bis (diphenylvinyl) arene compound Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R | 04/05/2005 |
| 6860905 | Anionic phthalic acid ester compounds and stain resistant compositions This invention relates to compounds of formula: wherein A is an unsaturated alkylene moiety; B the residue of a polyol wherein one hydroxyl moiety is esterified with one carboxyl moiety of the phthalic acid moiety; D i... | 03/01/2005 |
| 6818766 | Process for making bicalutamide and intermediates thereof Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ... | 11/16/2004 |
| 6777442 | Diphenyl derivatives The present invention relates to compounds of the general formula (I) in which X represents O, S, SO, SO2, CH2, CHF, CF2 or NR8, and Z represents a group of the formula | 08/17/2004 |
| 6699994 | Biaryl compounds as serine protease inhibitors Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating a... | 03/02/2004 |
| 6677473 | Plasminogen activator inhibitor antagonists Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers, benzils, benzyl et... | 01/13/2004 |
| 6664291 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac ... | 12/16/2003 |
| 6660183 | Self-doped conductive polymer, monomer for synthesizing self-doped conductive polymer, and processes of producing the same A process for producing an aromatic monomer for synthesizing a self-doped conductive polymer, the process comprising: introducing an alkoxysulfonic acid group as a self-doping group to a benzene or naphthalene derivative having a hydroxyl group bonded to a... | 12/09/2003 |
| 6630600 | 3-aryl propionic acid derivatives and analogs Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.... | 10/07/2003 |
| 6627656 | Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: ##STR1## in an amount that is effective to treat or prevent said prostaglandin ... | 09/30/2003 |
| 6566547 | Fungicides This invention relates to derivatives of acrylic acid useful as fungicides, to processes for preparing them, to fungicidal compositions containing them, and to methods of combating fungi, especially fungal infections in plants, using them.... | 05/20/2003 |
| 6562994 | Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I that exhibit antiandrogenic activity and are useful ... | 05/13/2003 |
| 6525093 | Compounds to treat diabetes and associated conditions Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-γ by adipose tissue.... | 02/25/2003 |
| 6492550 | Alpha-substituted thio, -oxo trifluoromethylketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1## where X, Z, X1, R1, ... | 12/10/2002 |
| 6337418 | Preparation of C1-C5 alkyl esters of nitro or thioether substituted aromatic carboxylic acids Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester: ##STR1## Additionally the invention relates to a method for pr... | 01/08/2002 |
| 6337306 | Phenoxyacetic acid derivatives and their use as herbicides Phenoxyacetic acid derivatives of the formula: ##STR1## wherein R1, R2, Xn and A are as defined herein, and a process for preparing the derivatives. The derivatives are used as herbicides.... | 01/08/2002 |
| 6300514 | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient Pharmaceutical composition containing aryl (sulfide, sulfoxide, sulfone) derivatives of the formula (1) and the salts thereof as active ingredient (wherein R1 is H, alkyl; R2 is COOR7, CONHOR8 ; E is --CONR... | 10/09/2001 |
| 6248781 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ... | 06/19/2001 |
| 6211403 | Process for preparing 2-chloro-3-alkoxy-4-alkylsulfonyl-benzoic acids and esters 1-Halo-2-chloro-3-alkoxy-4-alkylsulfonylbenzene and 1-halo-2,3-dichloro-4-alkylsulfonylbenzene compounds were converted to compounds having hydroxycarbonyl or alkoxycarbonyl substituents in place of the 1-halo substituent by reaction with carbon monoxide ... | 04/03/2001 |
| 6201019 | Bi-aromatic compounds bound by a heteroethynylene radical and pharmaceutical and cosmetic compositions containing same Bi-aromatic compounds linked via a heteroethynylene radical are provided along with pharmaceutical and cosmetic compositions containing these compounds and methods for their use.... | 03/13/2001 |
| 6147111 | Phenyl derivatives useful as endothelin receptor antagonists Novel phenyl derivatives which are useful as endothelin receptor antagonists.... | 11/14/2000 |
| 6143917 | Process for producing aryl carbamates A process for producing an aryl carbamate of a high purity at a high yield by reacting a diaryl carbonate with an amine compound having one or more hydrogen atoms bonded to the N position in the presence of carboxylic acid(s) of the following general form... | 11/07/2000 |
| 6100266 | Hydroxamic and carboxylic acid derivatives For the treatment of cancer, inflammation, and other conditions associated with matrix metalloproteinases or that are mediated by TNF or enzymes involved in the shedding of L-selectin, CD23, the TNF receptors, IL-1 receptors, or IL-6 receptors, dis... | 08/08/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
