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| Number | Title | Issue Date |
| 7271294 | Cyclopropanecarboxaldehydes and their use in perfume compositions The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 6 to 30 carbon atoms and contai... | 09/18/2007 |
| 7265143 | C-4 substituted retinoids C-4 substituted retinoic acid analogs, synthesis methods of C-4 substituted retinoic acid analogs and methods of using C-4 substituted retinoic acid analogs to treat various cancers and dermatological diseases and conditions. The C-4 substituted retinoic acid analog... | 09/04/2007 |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7252981 | Method for the preparation of stable and reusable biosensing granules The present invention provides a process for the preparation of stable and reusable biosensing granules useful in the assessment of biodegradability of effluents. The biosensing granules are prepared by culturing active aerobic microbial consortia in synthetic mediu... | 08/07/2007 |
| 7220874 | Esterification of xanthophylls Lutein and zeaxanthin, the main carotenoids in marigold flowers, and capsanthin and capsorubin, the main carotenoids in red peppers are esterified mainly with C-18 fatty acids. The pigments were re-esterified without isolating them from the natural saponified extrac... | 05/22/2007 |
| 7166730 | Process for the preparation of prostaglandin derivatives The invention provides a novel process for the preparation of prostaglandins and analogues thereof, and new crystalline intermediates in the process. ... | 01/23/2007 |
| 7056954 | Means for the modulation of processes mediated by retinoid receptors and compounds useful therefor In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which ... | 06/06/2006 |
| 6927300 | Process for the preparation of Latanoprost Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process. ... | 08/09/2005 |
| 6881854 | Conjugated unsaturated glyceride mixtures and a method for producing the same The invention relates to a process for conjugating two double bonds separated by a methylene bridge in a long-chain alkene, in which the long-chain alkene is isomerized with an a) imino base, or b) iminophosphorane... | 04/19/2005 |
| 6720438 | Process for the preparation of Latanoprost Disclosed is a process for the preparation of the anti-glaucoma drug Latanoprost, in good yield, in large amounts and with desired purity. Also disclosed are novel intermediates for the above process. ... | 04/13/2004 |
| 6706259 | Hydrolytically stable esters The present invention deals with the certain novel esters derived from a specific 36 carbon diol and fatty acids, which unlike other esters are surprisingly stable to hydrolysis and consequently of interest in high and low pH applications. ... | 03/16/2004 |
| 6537531 | Hydrolytically stable esters The present invention deals with the certain novel esters derived from a specific 36 carbon diol and guerbet acids, which unlike other esters are surprisingly stable to hydrolysis and consequently of interest in high and low pH applications.... | 03/25/2003 |
| 6506917 | Compounds and compositions useful for modulation of processes mediated by RXR In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided lig... | 01/14/2003 |
| 6399105 | Sea cucumber carotenoid lipid fraction products and methods of use Methods and compositions of matter are described for treatment of inflammatory autoimmune and other diseases by administration of lipid fractions of sea cucumber tissue. Compositions of matter useful for inclusion in aquatic and human diets are also discl... | 06/04/2002 |
| 6239298 | Fuel lubricity additives There is disclosed a fuel lubricity additive, made by a two-step process wherein the first step is co-reacting an unsaturated base oil, predominantly from vegetable oil sources, and a compound having a diene structure and a carboxylic acid group, wherein ... | 05/29/2001 |
| 6225486 | Isomer enriched conjugated linoleic acid compositions Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:... | 05/01/2001 |
| 6072081 | Optically active bisoxazoline compounds, production and use thereof An optically active bisoxazoline compound of the formula [I]: ##STR1## wherein R1 represents alkyl group, cycloalkyl group, aralkyl group, phenyl group which may be substituted or alkoxy group and two geminal alkyl groups may be joined tog... | 06/06/2000 |
| 6048989 | Furyl containing fatty acids, glycosyl phosphatidylinositol (GPI) analogues used for inhibiting parasitic activity A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myrist... | 04/11/2000 |
| 6040342 | Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising admi... | 03/21/2000 |
| 6031015 | Dental materials based on liquid crystalline monomers A dental material based on polymerizable monomers is described which contains at least one polymerizable monomer which has liquid crystalline properties. Compared with traditional materials, the dental material displays a lower decrease in volume upon pol... | 02/29/2000 |
| 5837728 | 9-cis retinoic acid esters and amides and uses thereof Esters and amides of 9-cis-retinoic acid are synthesized, formulated into pharmaceutically acceptable carriers and administered for the treatment of acne vulgaris, cystic acne, hyper-pigmentation, hypo-pigmentation, psoriasis, dermal and epidermal hypopla... | 11/17/1998 |
| 5817845 | Methods for stereospecific synthesis of 11,13-cis polyene esters Methods for stereospecific synthesis of 9-cis olefins and retinoids. In one particular aspect, a cis olefin is generated via a lactol ring opening with complete retention of double bond configuration.... | 10/06/1998 |
| 5808120 | Method of synthesis of retinoic acid A method of synthesizing 9-cis-retinoic acid, all-trans-retinoic acid or 9-nor-retinoic acid is disclosed. The method comprises the steps of adding a Grignard reagent of ##STR1## to 2,2,6 trimethyl cyclohexanone is disclosed. R is a methyl group or H... | 09/15/1998 |
| 5780676 | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to members of the subclass... | 07/14/1998 |
| 5731450 | Oil adduct conditioners This invention relates to the synthesis of vegetable and synthetic oil adducts and to the adduct products having the formula ##STR1##... | 03/24/1998 |
| 5710176 | Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising admi... | 01/20/1998 |
| 5658942 | Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond, or an alkylene, alkenylene, alkynylene or alkadienyle... | 08/19/1997 |
| 5639899 | Prostaglandin E1 analogues Object: To provide novel prostaglandin E1 analogues which have more excellent pharmaceutical effects, longer duration of the effects and less side-effects than the prior art prostaglandin E1 's. Constitution: A PGE1 analogue re... | 06/17/1997 |
| 5625067 | Cyclopentane ether derivatives, processes for their production, and their pharmaceutical use The invention relates to cyclopentane ether derivatives of Formula I ##STR1## their salts with physiologically compatible bases, as well as the -, ଲ- or γ-cyclodextrin clathrates, and also the liposome-encapsulated compounds of Formula ... | 04/29/1997 |
| 5514821 | Ring-labeled retinoids and intermediates, and methods for their synthesis and use Methods for the synthesis of dideuterium and/or ditritium ring-labeled retinoids and intermediates, and their use in the discovery of Retinoid X Receptor ligands are provided. In addition, dideuterium and/or ditritium ring-labeled retinoids and novel inte... | 05/07/1996 |
| 5508456 | 9-cis tritium-labeled retinoids and intermediates, methods for their synthesis and methods for their use in discovering retinoid X receptor ligands Methods for the synthesis of 9-cis monotritium-labeled retinoids, and their use in the discovery of Retinoid X Receptor ligands are provided. In addition, 9-cis monotritium-labeled retinoids, as well as novel intermediates and tritium-labeled intermediate... | 04/16/1996 |
| 5508444 | Cyclic compounds Novel substituted cis-1,2-dihydroxy-cyclohexadiene compounds, useful as intermediates in the production of compounds for use as intermediates in the production of agrochemicals and pharmaceuticals, and a microbial process for the preparation thereof.... | 04/16/1996 |
| 5504230 | Preparation of 9-(Z)-retinoic acid A process for preparing 9-(Z)-retinoic acid from mother liquors from the industrial preparation of C15 -triarylphosphonium salts of the general formula I ##STR1## where R1 to R3 are each aryl and X.crclbar.... | 04/02/1996 |
| 5235076 | Azulenic retinoid compounds, compositions and methods Novel azulenic retinoid compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents. The compositions of the present invention will also find use in treating dermatologic... | 08/10/1993 |
| 5158773 | Retinoid esters Retinoids of the formula R1 --OCH(R2)OC(O)R3 wherein R1 signifies 13-cis-retinoyl, R2 signifies hydrogen or lower-alkyl and R3 signifies straight-chain lower-alkyl can be used as medicaments in ... | 10/27/1992 |
| 5094783 | Retinoid compounds Retinoid compounds with bioactive properties and their synthesis are described. The compounds are useful as chemopreventive or cancer-treating agents and dermatological agents. The novel retinoids are members of either of the two general structures: ... | 03/10/1992 |
| 5025017 | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroar... | 06/18/1991 |
| 4900478 | Novel retinoids The novel compounds of the formula Ret-OA I wherein Ret is the acyl residue of a retinoid carboxylic acid, A is a residue (--CHR)--CH2 O)n R1, (--CH2)m SR | 02/13/1990 |
| 4885311 | Topical transretinoids for treatment of acne and skin diseases Esters and amides of 13-trans-retinoic acid are disclosed which are used for the treatment of acne and skin diseases.... | 12/05/1989 |
| 4778630 | Microbial desaturase enzyme inhibitors and their use in a method of producing lipids The invention provides novel cyclopropene fatty acid compounds of formula (I) ##STR1## wherein R is a straight chain aliphatic group of 1 to 6 carbon atoms, n is an integer of from 10 to 15; Z is a hydrogen atom, or an alkyl group of 1 to 6 carb... | 10/18/1988 |
