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| Number | Title | Issue Date |
| 7566795 | Preparation of retinyl esters Long-chain esters of retinol are prepared via a chemoenzymatic process from short-chain retinyl esters and an appropriate long-chain acid or ester in the presence of an enzyme. Use of various additives enhance the yield of the desired ester and facilitated its purif... | 07/28/2009 |
| 7355064 | Method for preparing 15-keto-prostaglandin E derivative Disclosed is an improved method for preparing 15-keto-prostaglandin E derivative. According to the invention, the deprotection of protected hydroxy group required in manufacturing a 15-keto-prostaglandin derivative is conducted under the presence of a phosphoric aci... | 04/08/2008 |
| 6933289 | Inhibition of irritating side effects associated with use of a topical ophthalmic medication This invention relates to a method of reducing an irritating or adverse side effect associated with the topical use of an active ophthalmic drug comprising incorporating an effective amount of a cyclodextrin or cyclodextrin derivative into a formulation to complex t... | 08/23/2005 |
| 6395786 | Sleep inducing agent A sleep-inducing preparation which comprises as an effective ingredient a prostaglandin derivative represented by the formula: ##STR1## wherein X is a halogen atom, Y is a group represented by (CH2)m, a cis-vinylene group or a phenyl... | 05/28/2002 |
| 6329539 | Prostagladin derivatives A prostaglandin derivative represented by the formula: ##STR1## wherein X is a halogen atom, n is an integer of 1 to 5, R1 is a C3-10 cycloalkyl group, a C3-10 cycloalkyl group substituted with C1-4 alkyl group(... | 12/11/2001 |
| 6251931 | Inhibitors of gap junction communication Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agents can serve both ... | 06/26/2001 |
| 6083501 | Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases A drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation, as well as a model animal of fibrinoid formation or thrombus formation in the lung is disclosed. The drug for preventing and treating diseases caused by fib... | 07/04/2000 |
| 6072081 | Optically active bisoxazoline compounds, production and use thereof An optically active bisoxazoline compound of the formula [I]: ##STR1## wherein R1 represents alkyl group, cycloalkyl group, aralkyl group, phenyl group which may be substituted or alkoxy group and two geminal alkyl groups may be joined tog... | 06/06/2000 |
| 5990329 | Retinoids Compounds of the formula: ##STR1## wherein R2 and X are as described, are disclosed. The compounds are useful for treating dermatological disorders which are accompanied by epithelial lesions, e.g., acne and psoriasis, as well as malignant... | 11/23/1999 |
| 5990346 | Prostaglandins and processes for production thereof A prostaglandin having formula (I), (II), or (III): ##STR1## a process of production thereof, and inhibitors of cell migration caused by chemokines containing (I) or (II) as an active ingredient.... | 11/23/1999 |
| 5731450 | Oil adduct conditioners This invention relates to the synthesis of vegetable and synthetic oil adducts and to the adduct products having the formula ##STR1##... | 03/24/1998 |
| 5639899 | Prostaglandin E1 analogues Object: To provide novel prostaglandin E1 analogues which have more excellent pharmaceutical effects, longer duration of the effects and less side-effects than the prior art prostaglandin E1 's. Constitution: A PGE1 analogue re... | 06/17/1997 |
| 5616607 | Hepoxilin analogs Compounds of the general structure ##STR1## are disclosed, wherein X is O, Cn, NH, or S, wherein n is 1, 2, 3 or 4; R1 is OH, CH3, CH2 OH, N3 or CH2 N3 ; R3 is H or CH3 ; R5... | 04/01/1997 |
| 5434281 | Process for the stereospecific synthesis of leukotriene B4 in its 6Z, 8E, 10E configuration and intermediates Process for the stereospecific synthesis of leukotriene B4 (LTB4) of 6Z, 8E, 10E configuration of formula ##STR1## in which a dibenzoate triether is prepared which is subjected to a reductive elimination according to the diagram... | 07/18/1995 |
| 5262437 | Homo-prostaglandin derivatives as ocular hypotensives The invention relates to homo-prostaglandin derivatives. More particularly, the present invention concerns 1a-homo derivatives of naturally occurring and synthetic prostaglandins, the corresponding bis- and trishomo-prostaglandin compounds, and their 1-es... | 11/16/1993 |
| 5218138 | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one and a sterically hindered dialkylated borane to form a complex at about -50° C. to about 0° C., and reducing th... | 06/08/1993 |
| 5094783 | Retinoid compounds Retinoid compounds with bioactive properties and their synthesis are described. The compounds are useful as chemopreventive or cancer-treating agents and dermatological agents. The novel retinoids are members of either of the two general structures: ... | 03/10/1992 |
| 5055230 | Corrosion inhibiting compositions A composition, in contact with a corrodable metal surface, comprising: a) an aqueous-based or oil-based system; and b) as an inhibitor for protecting the metal surface against corrosion, at least one compound having the formula I or II: ##STR1## in which... | 10/08/1991 |
| 5041694 | Substituted glutaric acid lactones in the treatment of hyperlipidemia Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit ଲ-hydroxy-ଲ-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthes... | 08/20/1991 |
| 4764528 | 2,4-pentadienoic acid derivatives and platelet aggregation inhibitors containing the same Novel 2,4-pentadienoic acid derivatives are disclosed. As the examples are mentioned 3-(4-carboxy-trans, trans-1,3-butadienyl)-6-exo-(3-hydroxy-trans-1-octenyl)-7-endo-hydr oxybicyclo[3.3.0]oct-2-ene, 3-(5-carboxy-trans, trans-2,4-pentadienyl)-... | 08/16/1988 |
| 4526723 | Biocidal enol esters of non-ortho substituted 2-aryl-1-3-cycloalkanedione compounds Non-ortho substituted 2-aryl-1,3-cycloalkanedione enol ester compounds exhibit outstanding acaricidal and herbicidal activity.... | 07/02/1985 |
| 4523042 | Derivatives of alpha-alkyl polyolefinic carboxylic acid useful in the treatment of psoriasis This invention relates to novel compounds having pharmaceutical activity and having the general structure ##STR1## wherein the Z, R1, R2, R3, R4, n and m are defined within.... | 06/11/1985 |
| 4505930 | Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses Polyolefinic compounds represented by the general formula ##STR1## in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, a... | 03/19/1985 |
| 4472430 | Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula ##STR1## in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is ... | 09/18/1984 |
| 4450149 | Radiohalogenation method Organoborane compounds are halogenated by reacting an organoborane with iodinemonochloride, brominemono-chloride or a halide salt in the presence of a mild oxidizing agent.... | 05/22/1984 |
| 4404393 | 15-Deoxy-16-hydroxy-16-(1'fluorovinyl) prostaglandins and derivatives 15-Deoxy-16-(halovinyl)-16-hydroxy prostaglandins have been prepared.... | 09/13/1983 |
| 4347379 | Synthesis of alpha-alkoxycarboxylic acids Numerous alpha-carboxylic acids are prepared in a liquid medium by the reaction of an organic compound having at least one reactive hydroxyl or thiol group, with a monoketone, and a haloform, in the presence of a phase transfer catalyst and an alkali meta... | 08/31/1982 |
| 4338457 | Composition and process The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologica... | 07/06/1982 |
| 4328359 | 15-Deoxy-16-substituted-19-chloro-20-nor-prostane derivatives of the E and F series The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E and F series wherein C-16 is substituted with hydrogen, methyl, vinyl or ethynyl and C-19 substituted with chloro and the ଲ-chain consists of 7 car... | 05/04/1982 |
| 4322546 | 15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series This invention disclosed herein relates to pharmacologically active 15-deoxy-16-hydroxy prostaglandin derivatives of the E and F series wherein C16 is substituted with allenyl. These compounds are active as hypotensives, antisecretory, bronchodilati... | 03/30/1982 |
| 4284795 | 19,20-Didehydro-PG2 compounds The present invention provides novel 19,20-didehydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 08/18/1981 |
| 4281153 | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.... | 07/28/1981 |
| 4276428 | 19,20-Didehydro-13,14-dihydro-PG1 compounds The present invention provides novel 19,20-didehydro-13,14-dihydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/30/1981 |
| 4276427 | 19,20-Didehydro-PG1 compounds The present invention provides novel 19,20-didehydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/30/1981 |
| 4275231 | 19-Hydroxy-19-methyl-13,14-dihydro-PG1 compounds The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/23/1981 |
| 4275233 | 19-Hydroxy-19-methyl-13,14-dihydro-PG2 compounds The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/23/1981 |
| 4269995 | 19,20-Didehydro-13,14-dihydro-PG2 compounds The present invention provides novel 19,20-didehydro-13,14-dihydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 05/26/1981 |
| 4259514 | 19-Hydroxy-13,14-dihydro-PG2 compounds The present invention provides novel 19-hydroxy-13,14-dihydro-PG2 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 03/31/1981 |
| 4257971 | 19-Hydroxy-PG2 analogs The present invention provides novel 19-hydroxy PG2 analogs, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 03/24/1981 |
| 4237307 | 15-Deoxy-16-hydroxy-16-methyl-Ɗ19-prostaglandins of the E and F series The inventions disclosed herein relates to pharmacologically active Ɗ19 prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and methyl as well as the pharmacologically acceptable, non toxic lower alkyl esters and salts thereof... | 12/02/1980 |
