Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7427610 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization. ... | 09/23/2008 |
| 7381718 | Method for preparing oestrogen derivatives A process for the preparation of compounds of formula (I) in which R1, R2, R3 and n are defined as indicated in the description, use of said compoun... | 06/03/2008 |
| 7378404 | 8β-hydrocarbyl-substituted estratrienes for use as selective estrogens This invention describes the new 8β-substituted estratrienes of general formula I in which R2, R3, R6, R6′, R7, R7′, R9, R11, R11′, R12, R14 | 05/27/2008 |
| 7375098 | 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes This invention relates to 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes of general formula I with ERβ-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparat... | 05/20/2008 |
| 7371741 | Estradiol derivatives and pharmaceutical compositions using same Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ... | 05/13/2008 |
| 7119081 | Oestrogen-17-sulphamates as inhibitors of steroid sulphatase There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R | 10/10/2006 |
| 7109360 | 16-hydroxyestratrienes as selectively active estrogens The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rat... | 09/19/2006 |
| 7067683 | Industrially applicable process for the sulfamoylation of alcohols and phenols This invention describes a safe method for the production of sulfamoyl chloride from chlorosulfonyl isocyanate and formic acid in the presence of a amide catalyst, taming the hazardous nature of this reaction by circumventing heat accumulation processes, as well as ... | 06/27/2006 |
| 7018994 | 17α-ALKYL-17β-OXY-ESTRATRIENES AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, USE OF THE 17α-ALKYL-17β-OXY-ESTRATRIENES FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS AS WELL AS PHARMACEUTICAL PREPARATIONS The invention relates to 17α-alkyl-17β-oxy-estra-1,3,5(10)-trienes that have an antiestrogenic action with general formula I. In addition, the invention also relates to 17-oxo-estra-1,3,5(10)-trienes as well as 17β-hydroxy-estra-1,3,5(10)-trienes as intermediate ... | 03/28/2006 |
| 6995278 | Antiangiogenic agents Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the spec... | 02/07/2006 |
| 6903084 | Steroid sulphatase inhibitors A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring to w... | 06/07/2005 |
| 6858597 | Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase A compound is described. The compound has the formula (Ia) as presented in the FIG. 1; wherein: X is a ring having at least 4 atoms in the ring; K is hydrocarbyl group; Rh1 is an optional halo group; Rh2 is an optional halo group; at least one of Rh1 and Rh2 ... | 02/22/2005 |
| 6794409 | Use of ERβ-selective ligands for regulating fertility and compounds useful therefor The present invention discloses the use of ERβ-selective ligands for production of medicaments for regulating fertility without additional use of a progestin. ERβ-agonists are used for treatment of infertility and ERβ-antagonists for contraception. ... | 09/21/2004 |
| 6790842 | 11β LONG-CHAIN SUBSTITUTED ESTRATRIENES, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11β LONG-CHAIN SUBSTITUTED ESTATRIENES, AND THEIR USE FOR PRODUCING MEDICAMENTS This invention describes a 11β-long-chain-substituted estratriene of general formula (I), in which R11 is a long-chain radical that has a nitrogen atom and optionally a sulfur atom, which in addition can be functionalized in the terminal position with a ... | 09/14/2004 |
| 6780855 | 11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11β-HALOGEN-7α-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS This invention describes the new 11β-halogen-7α-substituted estratrienes of general formula I in which R11 is a fluorine or chlorine atom, and the other substituents have the meanings that are explain... | 08/24/2004 |
| 6693090 | 19-norsteroids substituted in position 11ଲ, preparation process and intermediates, application as medicines and pharmaceutical compositions containing them A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as set forth in the specification which compounds are useful for the treatment of osteoporosis.... | 02/17/2004 |
| 6689768 | Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy The pharmaceutical preparations for treating side effects, such as hot flashes, prostate enlargement and gynecomastia, during and/or after treatment with analogs or antagonists of gonadotropin-releasing hormone (GnRHa therapy) contain an effective amount ... | 02/10/2004 |
| 6642397 | Steroid sulphatase inhibitors A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring ... | 11/04/2003 |
| 6596885 | 19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions Novel compounds having a formula selected from the group consisting of ##STR1## wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-prolife... | 07/22/2003 |
| 6541464 | Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them Compounds of the formula ##STR1## Where the substituents are defined in the application.... | 04/01/2003 |
| 6479476 | 19-nor steroids substituted in position 11ଲ, preparation method and intermediates, application as medicines and pharmaceutical compositions containing them A compound selected from the group consisting of the compounds of the formula ##STR1## wherein the substituents are defined as in the specification and their addition salts with non-toxic, pharmaceutically acceptable acids and bases having estrogenic... | 11/12/2002 |
| 6472382 | 4-halogenated steroids, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, ... | 10/29/2002 |
| 6436917 | Non-estrogenic estradiol derivative compounds with anti-oxidative activity New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, esp... | 08/20/2002 |
| 6399766 | 4-halogenated steroids, their preparation process and intermediates, their use as medicaments and the pharmaceutical compositions containing them A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, ... | 06/04/2002 |
| 6339079 | Steroid sulfamates, method for the production and use thereof A novel class of gonane type and D-homo-gonane type steroids having sulfatase-inhibiting and/or estrogenic activity is presented for application in the pharmaceutical industry. The number and location of sulfamoyloxy groups on the steroids provides for su... | 01/15/2002 |
| 6271403 | 7-(xi-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(xi-aminoalkyl-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(&3xb5;-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## The new compounds represent compounds with very strong antiestrogenic ac... | 08/07/2001 |
| 6239121 | 4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, ... | 05/29/2001 |
| 6201141 | Determination of steroids by competitive immunoassay A method and kit for measurement of a steroid by means of a competitive immunoassay, preferably a competitive enzyme immunoassay. The method and kit involve the use of a steroid analogue conjugated to a label. The steroids that are amenable to detection b... | 03/13/2001 |
| 6169082 | Salts of 8,9-dehydroestrone sulfate ester This invention presents alkali metal salts of 8,9-dehydroestrone, salts of its sulfate ester, and stable compositions thereof, as well as processes for their production and use in estrogen replacement therapy and cardiovascular protection.... | 01/02/2001 |
| 6080735 | Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds This invention is relating to new estra-1,3,5(10)-trien-sulfamates carrying at the 3-position an R--SO2 --O--group, with R being an R1 R2 N--group in which R1 and R2, independently of each other, repr... | 06/27/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 5998639 | Sulfatation of estrogen mixtures The invention relates to a method for the preparation of a mixture of sulfated estrogens containing delta(8,9)-dehydro estrone [delta(8,9)DHE] or derivatives thereof.... | 12/07/1999 |
| 5986115 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 11/16/1999 |
| 5977096 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel... | 11/02/1999 |
| 5914325 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Disclosed are estrane derivatives having a radical-attracting aromatic substituent of the general formula --(CH2)n X attached to the 17-position of the steroid nucleus, wherein X and n are as defined by the specification. The compoun... | 06/22/1999 |
| 5892069 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found belo... | 04/06/1999 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5707982 | 19-nor-steroids A 19-nor-steroid having a formula selected from the group consisting of ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2##... | 01/13/1998 |
| 5705495 | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds The invention relates to new sulfamate derivatives of 1,3,5(10)-estratriene derivatives of the general formula I ##STR1## wherein the 3-sulfamate moiety is acylated, sulfonated or amidosulfonated. Furthermore, methods for the production of the compou... | 01/06/1998 |
| 5679788 | 11 beta-substituted-19 nor-steroids Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the substituents are defined in the specification.... | 10/21/1997 |
