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| Number | Title | Issue Date |
| 8148557 | Method of producing tibolone metabolites by fermentation with Method of producing Δ5-Tibolone (C21H28O2), 6β-Hydroxy-Δ4-tibolone (C21H28O3), 6α-Hydroxy-Δ4-tibolone (C21H28O3), 15α-Hydroxy-Δ... | 04/03/2012 |
| 8148556 | Method of producing tibolone metabolites by fermentation with A new method of producing metabolites of tibolone comprising fermenting tibolone with Rhizopus stolonifer (ATCC 12938) resulting in the formation of Δ4-Tibolone (C21H28O2), 6β-Hydroxytibolone, and 15β-Hydroxytibo... | 04/03/2012 |
| 7300926 | Steroidal quinols and their use for estrogen replacement therapy The present invention relates to novel estrogen-related steroidal quinols and their use as drugs for estrogen replacement therapy. The quinols of the present invention provide improved physicochemical properties, increased bioavailability, and improved distribution ... | 11/27/2007 |
| 7186707 | Prodrugs for use as ophthalmic agents The subject invention provides a mechanism by which steroidal quinol compounds confer beneficial ophthalmic effects. The subject compounds possess a lipophilic-hydrophilic balance for transcorneal penetration and are readily reduced into parent phenolic A-ring stero... | 03/06/2007 |
| 7026306 | Steroidal quinols and their use for antioxidant therapy The present invention relates to novel estrogen-related steroidal quinols and their use as prodrugs for phenolic estrogens and estrogen analogs. The quinols of the present invention provide improved physicochemical properties, increased bioavailability, and improved... | 04/11/2006 |
| 7002028 | 5-androsten-3β-ol steroid intermediates and processes for their preparation The present invention provides 5-androsten-3β-ol steroid intermediates and processes for their preparation. ... | 02/21/2006 |
| 6982329 | Process improvements in steroid chemistry Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding α,β-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the α,β-unsaturated ketone structure is efficiently converted to the corres... | 01/03/2006 |
| 6072068 | 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives The present invention relates to certain 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medicinal therapy, particularly in the treatmen... | 06/06/2000 |
| 5977096 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel... | 11/02/1999 |
| 5843933 | 11ଲ-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents Compounds of formula I ##STR1## wherein X, R1, R2, R3 and R4 have the meanings indicated in the description, are described, as well as processes for their production, pharmaceutical preparations containing ... | 12/01/1998 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5567694 | 17-Aryl and 17-heterocyclyl-5ଲ,14ଲ-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 17-aryl and heterocyclyl-5ଲ,14ଲ-androstane compounds having the formula (I) ##STR1## wherein R is an aryl ring or a saturated or unsaturated heterocyclic ring are active on the cardiovascular system and are useful in treating cardiov... | 10/22/1996 |
| 5565588 | 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing said steroids New 9-alpha-hydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.... | 10/15/1996 |
| 5502183 | Steroid intermediates and processes for their preparation Novel steroids having a 9-hydroxy or a 9-carbonate substituent can be prepared from 9-hydroxyandrostenedione and can be utilized in the synthesis of commercially valuable corticosteroids such as betamethasone. The 9-carbonates ... | 03/26/1996 |
| 5424304 | 17-aryl-substituted steroidal compounds active on the cardiovascular system Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R1, R2, R3, R4, R5, R6 and R7 have the meanings shown in the description, and pharmaceutical compositio... | 06/13/1995 |
| 5359054 | Initial compounds for the production of 10ଲ-H-steroids and a process for the production of these initial compounds The invention includes compounds of the following formula ##STR1## where A and B either A and B form an additional double bond and D is a hydrogen atom or B and D form an additional double bond and A is a hydrogen atom and the other variables are as ... | 10/25/1994 |
| 5352809 | 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids New 9-alphahydroxy steroids are prepared by the introduction of substituents on the D-ring of 9-alpha-hydroxy-androst-4-ene-3,17-dione. The resulting compounds are useful intermediates in the synthesis of corticosteroids.... | 10/04/1994 |
| 5182381 | Intermediates for 3-keto-19-nor-Ɗ4,9 -steroids Novel 3-keto-19-nor-Ɗ4,9 -steroids of the formula ##STR1## and their non-toxic, pharmaceutically acceptable acid addition salts possessing a remarkable antiglucocorticoidal activity.... | 01/26/1993 |
| 4996335 | Soft steroids having anti-inflammatory activity The invention provides novel soft steroidal anti-inflammatory agents, pharmaceutical compositions containing said agents, and methods of administering same to mammals in the treatment of inflammation. Preferred compounds of the invention include haloalkyl... | 02/26/1991 |
| 4921845 | 11-arylsteroid compounds The invention relates to new 11-arylsteroid compounds, having a strong antiprogestin and a weak or nonexistent antiglucocorticoid activity, to processes for preparing said compounds and also to pharmaceutical preparations which contain these derivatives a... | 05/01/1990 |
| 4898694 | 17-Hydroxy-steroids Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 02/06/1990 |
| 4874754 | Novel 19-nor-steroids Novel 19-nor-steroids of the formula ##STR1## wherein the A ring is either ##STR2## Re is selected from the group consisting of hydrogen, acyl and optionally substituted alkyl of 1 to 6 carbon atoms, R is methyl or ethyl, R1 is s... | 10/17/1989 |
| 4871724 | Novel 11-aryloestrane and 11-arylpregnane derivatives The present invention is concerned with 11-aryloestrane and 11-arylpregnane derivatives, characterized in that these derivatives have the following structure: ##STR1## wherein R1 is an aryl group with an ##STR2## group as substit... | 10/03/1989 |
| 4808710 | 18-Phenyloestrane derivatives A novel class of steroids having pregnancy-terminating and/or pregnancy-preventing activity and a very low antiglucocorticoid activity have been found. The compounds have the general formula: ##STR1## wherein R1 and R2 each sepa... | 02/28/1989 |
| 4753932 | Novel 10-substituted steroids A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or --S-- and R is optionally substituted carbocyc... | 06/28/1988 |
| 4719054 | Process for the production of 17-ethynyl-17ଲ-hydroxy-18-methyl-4,15-estradien-3-one, and novel 3,5-estradien-17-one starting compounds for this process A process and novel starting materials for the production of 17-ethynyl-17ଲ-hydroxy-18-methyl-4,15-estradien-3-one of Formula I ##STR1## are disclosed. Novel 17-ketone starting materials have the Formula II ##STR2## wherein R i... | 01/12/1988 |
| 4661295 | Novel radioactive estradienes Novel radioactive estradienes labelled with tritium of the formula ##STR1## wherein 3 H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carb... | 04/28/1987 |
| 4634695 | Steroid derivatives Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 01/06/1987 |
| 4603013 | Estrane derivatives Estrane derivatives of the general formula I ##STR1## wherein one of the substituents X or Z signifies a hydrogen atom and the other together with Y represents a carbon-carbon bond, or wherein the substituents X and Z represent hydrogen atoms and Y r... | 07/29/1986 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-Ɗ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4519946 | Steroids Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with th... | 05/28/1985 |
| 4501695 | Spironalactone process The present invention relates to processes for the conversion of a 3-protected steroidal 17-ketone to a 17-spiro-γ-lactone having the appropriate 17-stereochemistry for spironolactone. Novel intermediates (II, II', II", II'", IIa, IIb | 02/26/1985 |
| 4473564 | 19-Thio-androstane derivatives The invention relates to novel 19-thio-androstane derivatives having the general formula: ##STR1## and the 4,5-dihydro analogues thereof, wherein R1 =H, hydrocarbyl(1-4C), aralkyl(7-9C), aryl(6-9C) or acyl derived from an organic carb... | 09/25/1984 |
| 4464365 | 11ଲ-Chloro-Ɗ15 -steroids, a process for their preparation and pharmaceutical preparations containing them 11ଲ-Chloro-Ɗ15 -steroids of Formula I ##STR1## wherein R1 is hydrogen or acyl and R2 is ethynyl, chloroethynyl, or propynyl have strong progestational activity.... | 08/07/1984 |
| 4451404 | 16ଲ-Methyl steroid process Ɗ4 -3-keto, Ɗ1,4 -3-keto and 3ଲ-hydroxy 17-keto steroids (I) are transformed into the corresponding 16-ଲ-methyl-17-keto steroids (IV) by first activating the C-16 position, then methylating. By protecting the C-3 positi... | 05/29/1984 |
| 4447424 | Steroid derivatives Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 05/08/1984 |
| 4386085 | Novel steroids Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 05/31/1983 |
| 4383947 | Introduction of a fluorine atom Perchloryl fluoride when reacted with the appropriately protected 9-hydroxyandrostenedione stereoselectively produces the corresponding 6ଲ-fluoro steroid.... | 05/17/1983 |
| 4357279 | Preparation of corticoids from 17-keto steroids A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).... | 11/02/1982 |
| 4325879 | Amino-14 steroid derivatives and process for preparation of the same The invention relates to medicinally useful steroid derivatives, particularly amino-14 steroids substituted at the 17-position by a functional group represented by the general formula: ##STR1## wherein R1 is a hydroxy, hydroxyalkyl, alkoxy... | 04/20/1982 |
