Famous Patents
The ice cream cone was invented at the St. Louis Worlds Fair by Ernest Hamwi in 1904. His waffle booth was next to an ice cream vendor who ran short of dishes. Hamwi rolled a waffle to hold ice cream and the cone was born.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6915962 | Apparatus for providing aerosol for medical treatment and methods Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an open... | 07/12/2005 |
| 6589588 | Phytosterol compositions This invention relates to phytosterols and phytostanols, in particular to fatty acid esters of phytosterols and phytostanols with a specified fatty acid composition. The invention further relates to methods for preparation of the phytosterol and phytostan... | 07/08/2003 |
| 6040468 | Method of preparing 16, 17-dialkylated steroids 16, 17-dialkylated steroids are prepared by reacting a 16-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent.... | 03/21/2000 |
| 5994333 | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that... | 11/30/1999 |
| 5994335 | 17-azolyl steroids useful as androgen synthesis inhibitors Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.... | 11/30/1999 |
| 5827842 | 14, 17-C2 -bridged norprogesterone derivatives The invention describes 14,17-C2 -bridged steroids of general formula (I), ##STR1## wherein the various R groups are as defined in the specification, and wherein said steroids are, in contrast with the disclaimed compound 14,17-ethano... | 10/27/1998 |
| 5824670 | 17-deoxycorticosteroid-21-O!carboxylic esters, processes for their preparation and pharmaceuticals containing these compounds 17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH3 ; R(1) is aryl or hetaryl and R(2) is H or methyl.... | 10/20/1998 |
| 5792759 | 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl cyclopentaneperhydrophenanthrene derivatives active on the cardiovascular system, a process for their preparation and pharmaceutical compositions containing the same Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl steroids of the general formula (I) ##STR1## where A, R1 and R2 are defined in the specification are disclosed. The compounds have cardiovascular activity. Pharmaceutic... | 08/11/1998 |
| 5610152 | Anti-obesity agent 4-cholesten-3-one The present invention provides an anti-obesity agent comprising 4-cholesten-3-one represented by the following formula: ##STR1## as an effective component. The anti-obesity agent of the present invention is useful because of inhibition effect of body... | 03/11/1997 |
| 5608093 | Corticosteroid 17-alkyl carbonate 21-[0]-carboxylic and carbonic esters, and pharmaceuticals containing these compounds Corticoid 17-alkyl carbonate 21-carboxylic and carbonic esters of the formula I ##STR1## are described in which A is CHOH and CHCl, CH2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH3 ; R(1) is aryl or heta... | 03/04/1997 |
| 5561124 | 17--acyl steroids which inhibit 5--reductase The invention relates to substituted 17-acyl steroidal 5-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for reducing prostate size and treating prostate aden... | 10/01/1996 |
| 5420121 | Use of 4-cholesten-3-one as an anti-obesity agent The present invention provides a method for using the anti-obesity agent comprising 4-cholesten-3-one represented by the following formula: ##STR1## as an effective component. The anti-obesity agent of the present invention is useful because of inhib... | 05/30/1995 |
| 5352808 | Process for steroid preparation A process for the preparation of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl a... | 10/04/1994 |
| 5264427 | 20-substituted pregnene derivatives and their use as androgen synthesis inhibitors Novel 20-substituted-pregnene derivatives, compositions containing such derivatives and methods for their use and manufacture are disclosed. The 20-substituted-pregnene derivatives inhibit the androgen biosynthesis enzymes 17(alpha)-hydroxylase/C17 | 11/23/1993 |
| 5248773 | 16-methyl-Ɗ1,4-pregnadiene-3,20-diones A compound of the formula ##STR1## in which ##STR2## is either a 3-keto-Ɗ4-system or a 3-keto -Ɗ1,4-system or a 3-OR4 -Ɗ5-system in which R4 is hydrogen or a protector group of hydroxy, R is methyl, --CH2... | 09/28/1993 |
| 5194602 | 9-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids New 9-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9-hydroxyandrost-4-ene-3, 17-dione. The resulting compounds are useful starting compounds in the synthesis of corticosteroids.... | 03/16/1993 |
| 5169966 | Process for producing an -acyloxy-, ଲ-unsaturated carbonyl compound and a 20-acyloxy-17(20)-methylen-21-al-steroid compound There are disclosed a process for producing an -acyloxy-,ଲ-unsaturated carbonyl compound represented by the general formula (VI): ##STR1## wherein R1, R2 and R4 are independently hydrogen atoms or ... | 12/08/1992 |
| 5137882 | Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors Invented are 3-acetic acid-steroidal compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-reductase including using these compounds to reduce prostate size and to treat prostatic... | 08/11/1992 |
| 5120724 | Aldosterone biosynthesis inhibitor Aldosterone biosynthesis inhibitors having substantially no intrinsic antiandrogenic activity are disclosed as well as pharmaceutical compositions containing such compounds and methods of treatment utilizing these compositions.... | 06/09/1992 |
| 4920114 | 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors 19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pat... | 04/24/1990 |
| 4913852 | Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Ɗ-4-pregnene-3,20-dione or with derivatives of Ɗ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucoco... | 04/03/1990 |
| 4870069 | 11ଲ-alkynyl-estrenes and -estradienes, their production and pharmaceutical preparations containing them 11ଲ-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pentagonal ... | 09/26/1989 |
| 4668437 | Novel 20 benzcylamino pregnene derivatives and process for preparing same The invention relates to new pregnene derivatives of the general formula (I), ##STR1## wherein R1 stands for a C1-4 alkyl group; R2 stands for a hydrogen atom or a C2-4 alkanoyl group; R3 stands for a... | 05/26/1987 |
| 4609496 | Steroid esters of N-(2-halogenoethyl)-N-nitroso-carbamoyl-amino acids and peptides thereof, as well as methods for preparing them Steroid-N-(2-halogen ethyl)-N-nitroso-carbamoyl-amino acid or peptide esters of the general formula: ##STR1## where R1 and R2, which may be identical or different, mean the radical of an amino acid beyond the C atom in the beta ... | 09/02/1986 |
| 4588718 | Carboxy containing ester prodrugs of corticosteroids A compound of the formula ##STR1## wherein St represents a corticosteroid moiety bonded to the carbonyl via the 21-hydroxy group of said corticosteroid; wherein Z is a bond or --O--; wherein n is an integer from 4 to 9; wherein Q is (1) Y--CH2 ... | 05/13/1986 |
| 4537722 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in h... | 08/27/1985 |
| 4472392 | Sulfonate containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1## and their salts.... | 09/18/1984 |
| 4469689 | Sulfonate containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1## and their salts.... | 09/04/1984 |
| 4464302 | 17-[(Hydroxymethyl)formamido-methylene]-steroids Novel 17-[(hydroxymethyl)formamido methylene]-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function... | 08/07/1984 |
| 4456602 | Amine containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1##... | 06/26/1984 |
| 4443440 | Amine containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1##... | 04/17/1984 |
| 4424159 | Process for the synthesis of the hydroxyacetyl side-chain of steroids of the pregnane type, novel 21-hydroxy-20-oxo-17-pregnane compounds and pharmaceutical preparations containing them The present invention relates to a novel general process for synthesizing a - or ଲ-oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession with formaldehy... | 01/03/1984 |
| 4423208 | Affinity gel-adsorbent An improved affinity gel-adsorbent for use in an improved method of purifying glucocorticoid receptor by affinity chromatography and having the formula: ##STR1## R1 : H or OH or .dbd.O R2 : H or F R3 : H or F R4 | 12/27/1983 |
| 4321208 | Preparation of directly iodinated steroid hormones and related compounds A process for the direct iodination of steroids and steroid hormones in the presence of hydrogen peroxide or chloramine-T is disclosed. The antigenicity and the specific receptor binding of directly iodinated estradiol 17-beta is identical to tritiated es... | 03/23/1982 |
| 4318908 | Methylated prostaglandin derivatives Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as (Me)2 --PGE2 --E (Me)2 --PGE2 --E--2AC (Me)2 --PGE2 --E--BA (Me)2 | 03/09/1982 |
| 4293548 | 18-Substituted pregn-4-ene-3,20-diones Progesterone derivatives having a vinylidene or a 1-alkynyl substituent at the 18-position and further optionally hydroxylated at the 11-position and the 21-position are described herein. Compounds having both an ethynyl substituent and a hydroxy substitu... | 10/06/1981 |
| 4263290 | Novel 19-nor-steroids Novel 19-nor-steroids of the formula ##STR1## wherein R1 and R2 taken together form a cycloalkyl of 3 to 8 carbon atoms or are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl... | 04/21/1981 |
| 4223030 | Novel delta 4,9 pregnane derivatives New and useful steroids of the pregnane series and compositions therefor are disclosed of the formula: ##STR1## wherein R1 is selected from the group consisting of H, F, OH, and OR2, and R2 is carbacyl of one to eight... | 09/16/1980 |
| 4198405 | Prostaglandine derivatives Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group. The prostaglandine derivatives have extraordinarily reduced side-effect and superior physiological activity, particularly effect of abortion in ... | 04/15/1980 |
| 4181669 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 01/01/1980 |
