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| Number | Title | Issue Date |
| 7368442 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 05/06/2008 |
| 7205288 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 04/17/2007 |
| 7196075 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 03/27/2007 |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 7160871 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 01/09/2007 |
| 7157450 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 01/02/2007 |
| 7056905 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 06/06/2006 |
| 6780854 | Orally active androgens Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1... | 08/24/2004 |
| 6713465 | Pregnanes This invention provides a pharmaceutically acceptable salt of 5α-pregn-16-en-3β-ol-20-one 3-sulfate ester, which is useful as a progestational agent. ... | 03/30/2004 |
| 5910478 | Peptidomimetics inhibiting the oncogenic action of p21 ras The present invention provides peptides, cyclized peptides and peptidomimetics which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the ras-inhibiting peptides, cyclized pe... | 06/08/1999 |
| 5824669 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a ଲ-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production... | 10/20/1998 |
| 5710293 | Method of preparation of ester derivatives of steroids The present invention relates to a method of using a perchloric acid catalyzed reaction to make acyl derivatives of norprogesterone compounds and, in particular, 16-methylene-17-hydroxy-19-norpregn-4-ene-3,20-dione.... | 01/20/1998 |
| 5567830 | Process for synthesis of acetylenic carbinols A method for the preparation of an acetylenic alcohol by reaction of 1,2-dibromoethylene with an alkyl, aryl an heteroaryl lithium in an inert solvent, followed by reaction with a carbonyl-containing compound to give an acetylenic alcohol is disclosed.... | 10/22/1996 |
| 5352808 | Process for steroid preparation A process for the preparation of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl a... | 10/04/1994 |
| 5250711 | Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfato-ethyl) amides Amine salts of alkane-1,n-dicarboxylic acid mono-(2-sulfatoethyl)amides of the Formula I HOC(O)--(CH2)n --C(O)--N(R1)--CH2 CH2 SO3--+ HN(R2)3 ... | 10/05/1993 |
| 4948533 | 11a-hydroxy steroid diester The present invention relates to 21-(3-carboxy-1-oxopropoxy) -17-hydroxy-11-(3,3-dimethyl-1-oxobutoxy)pregna-1,4-diene-3, 20 dione and pharmaceutically acceptable salts thereof which are useful steroid prodrugs.... | 08/14/1990 |
| 4933331 | Hydrocortisone 17-oxo-21-thioesters and their uses as medicaments 3,20-dione-11ଲ-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11ଲ-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.... | 06/12/1990 |
| 4913852 | Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Ɗ-4-pregnene-3,20-dione or with derivatives of Ɗ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucoco... | 04/03/1990 |
| 4762919 | Anti-inflammatory carboxy pregnane derivatives Compounds of the formula: ##STR1## wherein one X is COOR, CH2 COOR, CH(COOR)2, CONHR, CH2 CONHR, or CN remaining X's are H, F, CH3, OH, COOR, CH2 COOR, CH(COOR)2, CONHR, CH2... | 08/09/1988 |
| 4609496 | Steroid esters of N-(2-halogenoethyl)-N-nitroso-carbamoyl-amino acids and peptides thereof, as well as methods for preparing them Steroid-N-(2-halogen ethyl)-N-nitroso-carbamoyl-amino acid or peptide esters of the general formula: ##STR1## where R1 and R2, which may be identical or different, mean the radical of an amino acid beyond the C atom in the beta ... | 09/02/1986 |
| 4602009 | Corticoid derivatives and process for production thereof Novel corticoid 17-alkoxycarbonyl carboxylate derivatives are disclosed. These derivatives have strong topical anti-inflammatory activity and extremely weak systemic adverse reactions and are useful for the treatment of acute and chronic eczema, ec... | 07/22/1986 |
| 4588530 | Anti-inflammatory prednisolone steroids Derivatives of prednisolone of the formula ##STR1## wherein CR1 is C.dbd.O, -HCOH, ଲ-HCOH, or a mixture of -HCOH and ଲ-HCOH CR2 is HC(OH) OR6 or HCO when CR1 is C.dbd.O; CR2 | 05/13/1986 |
| 4588718 | Carboxy containing ester prodrugs of corticosteroids A compound of the formula ##STR1## wherein St represents a corticosteroid moiety bonded to the carbonyl via the 21-hydroxy group of said corticosteroid; wherein Z is a bond or --O--; wherein n is an integer from 4 to 9; wherein Q is (1) Y--CH2 ... | 05/13/1986 |
| 4537722 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in h... | 08/27/1985 |
| 4525303 | Process for preparation of steroids A novel process for preparing a steroid of the following formula (to be referred to as compound .circle.13 ) is provided. ##STR1## This compound is known to have marked anti-inflammatory and anti-rheumatoid arthritic activity with very much reduced ... | 06/25/1985 |
| 4511511 | Prednisolone derivatives Novel prednisolone derivatives modified at C-17,C-20 and/or C-21 positions. Many of the compounds are anti-inflammatory agents which do not significantly suppress the pituitary-adrenal axis.... | 04/16/1985 |
| 4472392 | Sulfonate containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1## and their salts.... | 09/18/1984 |
| 4469689 | Sulfonate containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1## and their salts.... | 09/04/1984 |
| 4456602 | Amine containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1##... | 06/26/1984 |
| 4444689 | 17-Acyloxy-5ଲ-corticoids and 17-acyloxy-5-corticoids 17-Acyloxy-5ଲ-pregnanes (I) and 17-acyloxy-5-pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.... | 04/24/1984 |
| 4443440 | Amine containing ester prodrugs of corticosteroids Novel solution stable ester prodrugs of corticosteroids of the formula ##STR1##... | 04/17/1984 |
| 4404141 | Ɗ9(11) - And Ɗ16 -21-chloro-20-keto steroids of the pregnane and D-homopregnane series, their preparation and use as intermediates for the synthesis of highly effective corticoids Ɗ16 - and Ɗ17 -21-chloro-20-keto steroids of the formula ##STR1## wherein n is 1 or 2, C1 C2 and C9 C11 represent a CC-single or CC-double bond, R1 is H or OH, R2 | 09/13/1983 |
| 4381307 | Soft tertiary amine esters of bio-affecting carboxylic acids Novel derivatives of known bio-affecting carboxylic acids R-COOH are disclosed, said derivatives having the structural formula ##STR1## wherein Y and Y' are each H or C1 -C4 alkyl; n is 0 or 1; R1 and R2 ar... | 04/26/1983 |
| 4377575 | Corticoid-17-(alkyl carbonates) and process for their manufacture What is disclosed are steroid-21-halogeno-17-(alkyl carbonates), useful as medicaments for the treatment of inflammatory dermatoses, and a method for making them.... | 03/22/1983 |
| 4336200 | 17-Acyloxy-5ଲ-corticoids 17-Acyloxy-5ଲ-pregnanes (I) and 17-acyloxy-5-pregnanes (IV) have an excellent activity split providing high topical antiinflammatory activity with very low systemic side effects.... | 06/22/1982 |
| 4330541 | Novel corticoid 17-thioacetals, their preparation and use Novel corticoid 17-thioacetals of the formula: ##STR1## wherein X is hydrogen, fluorine or methyl, R1 is hydrogen or C1 -C6 alkyl, and R2 is hydrogen or the acyl group of a C1-16 - hydrocarbon carboxy... | 05/18/1982 |
| 4318853 | 9ଲ,11ଲ-Epoxy-5ଲ-corticoids 17-Acyloxy-5-pregnanes (I) and 17-acyloxy-5-pregnanes (IV) have an excellent activity split providing high topical anti-inflammatory activity with very low systemic side effects.... | 03/09/1982 |
| 4296109 | Corticoid 21-sulfopropionates and the salts thereof, a process for the production thereof and pharmaceutical preparations thereof Corticoid 21-sulfopropionates of the formula ##STR1## wherein St is a steroid nucleus of a corticoid having anti-inflammatory activity, and the salts thereof with physiologically acceptable bases, simultaneously form stable, sterilizable and storable... | 10/20/1981 |
| 4264585 | Hydrocortisone esters, pharmaceutical formulations containing these and processes for their preparation Hydrocortisone esters of the formula ##STR1## wherein R1 is H, formyl or acetyl and R2 is H or CH3 are antiphlogistically active.... | 04/28/1981 |
| 4260605 | Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R1 =alkyl (1-4 C); R2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with... | 04/07/1981 |
