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| Number | Title | Issue Date |
| 6958327 | 18 Norsteroids as selectively active estrogens The invention relates to novel 18-norsteroids (gonatrienes) of general formula (I), wherein R1, R2, R3, R6, R7, R8, R9, R11, R11′, R14, R15, R | 10/25/2005 |
| 6953785 | Estra-1,3,5(10)-triene derivatives Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or differen... | 10/11/2005 |
| D506923 | Bottle portion | 07/05/2005 |
| 6784170 | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one Syntheses of steroids such as 3-hydroxy-7α-methyl-21-[2′-methoxy-4′-(diethylaminomethyl)-phenoxy]-19-norpregna-1,3,5(10)triene citrate (“SR 16234”) and analogs thereof are provided, wherein 21-hydroxy-19-norpregna-4-en-3-one serves as a starting material or... | 08/31/2004 |
| 6670347 | 19-nor-17-pregna-1,3,5(10)-trien-17ଲ-ols with a 21,16-lactone ring This invention relates to new 19-nor-17-pregna-1,3,5(10)-trien-17ଲ-ols with a 21,16-lactone ring of formula II, ##STR1## process for their production and pharmaceutical preparations that contain these compounds as well as 17³... | 12/30/2003 |
| 6482813 | Steroids substituted at the 11-position, process for their preparation, their use as medicament and the pharmaceutical compositions containing them Compounds of formula ##STR1## for treating osteoporosis with minimal estrogenic activity are disclosed.... | 11/19/2002 |
| 6448419 | Synthesis of 2-hydroxyestradiol derivatives Disclosed is a method of preparing 2-hydroxy-3,17ଲ-estradiol derivatives wherein 3,17ଲ-estradiol is reacted with an organolithium reagent and reacted with either a boron reagent or a silicon reagent to form either a 2-boronyl or a 2-silyl modi... | 09/10/2002 |
| 6437157 | 20-substituted steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 15 carbon atoms or taken t... | 08/20/2002 |
| 6281205 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5(10)-estratriene nucleus, and are substituted at the C-17 or C-11 position with a mol... | 08/28/2001 |
| 6271220 | Anti-angiogenic agents The application discloses methods of treating mammalian diseases characterized by undesirable angiogenesis by administering compounds including those having the general formulae ##STR1## wherein A is a fused tropone having a general formula: ##STR2##... | 08/07/2001 |
| 6242619 | 19-norpregnane steroids as neurochemical initiators of change in human hypothalamic function Several 19-nor-pregnanes are provided which have the capacity to neurochemically alter the hypothalamic function in an individual through nasal administration. These pharmaceutically active compounds can be administered by themselves or in the form of a p... | 06/05/2001 |
| 6080735 | Estra-1,3,5(10)-trien derivatives, processes for their preparation and pharmaceutical compositions containing these compounds This invention is relating to new estra-1,3,5(10)-trien-sulfamates carrying at the 3-position an R--SO2 --O--group, with R being an R1 R2 N--group in which R1 and R2, independently of each other, repr... | 06/27/2000 |
| 6054446 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecul... | 04/25/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5792757 | 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor pregnane steroid, or a pharmaceutical composition containing a vomeropherin, such that the... | 08/11/1998 |
| 5723638 | Process for 20-oxo-17,21-diol steroids The invention is drawn to a process for the preparation of a steroid of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and theo A, B, C, and D ring system has at ... | 03/03/1998 |
| 5705495 | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds The invention relates to new sulfamate derivatives of 1,3,5(10)-estratriene derivatives of the general formula I ##STR1## wherein the 3-sulfamate moiety is acylated, sulfonated or amidosulfonated. Furthermore, methods for the production of the compou... | 01/06/1998 |
| 5618806 | 17 and 17ଲ-substituted estra-1,3,5(10)-triene-3-carbboxlic acid Invented are 17 and 17ଲ-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is or ଲ ##STR2## in which A ... | 04/08/1997 |
| 5561124 | 17--acyl steroids which inhibit 5--reductase The invention relates to substituted 17-acyl steroidal 5-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for reducing prostate size and treating prostate aden... | 10/01/1996 |
| 5352808 | Process for steroid preparation A process for the preparation of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl a... | 10/04/1994 |
| 5149696 | 19.fwdarw.nor.fwdarw.steroids Novel 19-nor-steroids of the formula ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2## having hormonal properties and their preparation and intermediates.... | 09/22/1992 |
| 5093502 | 14,17-dihydroxy-17ଲ-substituted steroids A process for the preparation of novel 14, 17-dihydroxy-17ଲ-substituted steroids by reacting 14-hydroxy-17-oxo-steroids with metal organic compounds and the use of the said novel steroids in the production of 14, 17&... | 03/03/1992 |
| 4970205 | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to redu... | 11/13/1990 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4954490 | 11 ଲ-substituted progesterone analogs A 11ଲ-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-... | 09/04/1990 |
| 4705783 | 9, 11ଲ-substituted and 11ଲ-substituted estranes 9 alpha, 11 beta and 11 beta-substituted estranes are disclosed which exhibit elevated estrogenic and postcoital contraceptive activities. A process for their manufacture and their use in pharmaceuticals is also disclosed.... | 11/10/1987 |
| 4565656 | Preparation of 17ଲ-hydroxyacetyl-17-ol-steroids A novel process for the preparation of 17ଲ-hydroxyacetyl-17-ol-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or ... | 01/21/1986 |
| 4551278 | Preparation of 20-keto-Ɗ16 -steroids A novel process for the preparation of 20-keto-Ɗ16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an alkylating agent QR4 wherein R4 is an organic group and Q is a group or atom readily displa... | 11/05/1985 |
| 4548749 | Process for the preparation of 21-hydroxy-20-keto-Ɗ16 -steroids and new intermediate compounds formed in this process A novel process for the preparation of 21-hydroxy-20-keto-Ɗ16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an aldehyde and an alcohol to form a 17-(2-alkoxy-3-oxazolin-4-yl)-Ɗ16 -steroid and subjectin... | 10/22/1985 |
| 4547493 | Novel 11ଲ-substituted-19-nor-steroids Novel 19-nor-steroids of the formula ##STR1## wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydro... | 10/15/1985 |
| 4512986 | Progrestationally active steroids Novel steroids having the formula ##STR1## wherein R1 is selected from the group consisting of methyl, ethyl, and propyl; R2 is selected from the group consisting of H and methyl; R3 is selected from the group consisting o... | 04/23/1985 |
| 4501701 | 20-Isocyano-Ɗ17(20) -steroids Novel 20-isocyano-Ɗ17(20) -steroids of the formula ##STR1## wherein R1 is selected from the group consisting of (1) hydrogen, (2) alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halo... | 02/26/1985 |
| 4464302 | 17-[(Hydroxymethyl)formamido-methylene]-steroids Novel 17-[(hydroxymethyl)formamido methylene]-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function... | 08/07/1984 |
| 4424159 | Process for the synthesis of the hydroxyacetyl side-chain of steroids of the pregnane type, novel 21-hydroxy-20-oxo-17-pregnane compounds and pharmaceutical preparations containing them The present invention relates to a novel general process for synthesizing a - or ଲ-oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession with formaldehy... | 01/03/1984 |
| 4272530 | Ɗ1,3,5(10) -Estratrienes Novel 11ଲ -substituted-Ɗ 1,3,5(10) -estratrienes of the formula ##STR1## wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted ary... | 06/09/1981 |
| 4185101 | 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor 1,3,5(10),6,8-19-Nor-pregnapentaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied topically, preferred anti-psoriatic compounds being 1,... | 01/22/1980 |
| 4172132 | 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor 1,3,5(10),6,8,14-19 Nor-pregnahexaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied topically, a preferred anti-psoriatic compound being ... | 10/23/1979 |
| 4155923 | Process for the preparation of 17ଲ-hydroxy-20-alkoxypregnane-21-oic acid derivatives A process for the preparation of 17ଲ-hydroxy-20-alkoxypregnane-21-oic acid derivatives of the formula ##STR1## WHEREIN R1 is methyl or ethyl; R2 is hydrogen or methyl, either being in the -or ଲ-position; R | 05/22/1979 |
| 4152325 | Novel steroids and their use Novel pregnatetraenes of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, tetrahydropyranyl, trityl and trimethylsilyl and intermediates therefore and a process for their preparation and ... | 05/01/1979 |
