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| Number | Title | Issue Date |
| 7417140 | 7α-Hydroxyacetyl and 7α-Hydroperoxyacetyl-substituted steroid compounds The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 08/26/2008 |
| 7414127 | 7 α-Enedione-substituted steroid compounds The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 08/19/2008 |
| 7153988 | 7α-hydroxy-pregn-4-en-3-one-20-carbaldehyde, process for producing the same, and process for producing 7α, 21-dihydroxy-20-methyl-pregn-4-en-3-one from the same 7α-Hydroxy-pregn-4-en-3-one-20-carbaldehyde, a production method thereof and a method for producing 7α,21 -dihydroxy-20-methyl-pregn-4-en-3-one, which is useful as a synthetic intermediate for pharmaceuticals such as squalamine and the like, efficiently at high pu... | 12/26/2006 |
| 7109360 | 16-hydroxyestratrienes as selectively active estrogens The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rat... | 09/19/2006 |
| 7078396 | Method of treating disorder related to high cholesterol concentration A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and co... | 07/18/2006 |
| 7074778 | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to ... | 07/11/2006 |
| 7037907 | Estradiol conjugates and uses thereof A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent. ... | 05/02/2006 |
| 6992076 | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration This invention is directed to methods for providing sustained systemic concentrations of therapeutic or prophylactic agents such as GABA analogs following oral administration to animals. This invention is also directed to compounds and pharmaceutical compositions th... | 01/31/2006 |
| 6967195 | 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity Compounds of formula (I) in which: R1 represents a hydrogen atom or an O-protecting group; R2 represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R3 represe... | 11/22/2005 |
| 6790970 | (Meth) acrylic acid ester compound The present invention provides a novel (meth)acrylic acid ester compound useful as a resin material for photosensitive compositions, which enables control of the molecular weight of a resin to be prepared. The novel (meth)acrylic acid ester compound is one represent... | 09/14/2004 |
| 6742541 | Linear indicator for a valve A linear actuator monitors and distinguishes between the open and closed states of a valve. The states of the actuator are monitored electrically by two switches and visually via a mechanical indicator. The electrical switches are initialized by an adjustable system... | 06/01/2004 |
| 6689551 | Photographic element, compound, and process Disclosed is a photographic element comprising a light-sensitive silver halide emulsion layer having associated therewith a phenolic "NB magenta coupler" having the formula: ##STR1## wherein: the term "NB magenta coupler" represents a coupler of formula (... | 02/10/2004 |
| 6645955 | 3,6-dihydroxy-24-amidyl steroid derivatives Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.... | 11/11/2003 |
| 6630587 | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein Novel 9-hydroxy steroid compounds, including compounds of Formula IX ##STR1## wherein --A--A--, --B--B--, R1, R3, R8 and R9 are as defined in the specification.... | 10/07/2003 |
| 6555530 | Use of estrogens and delta-gonadien-21-Ol-3,20-diones for treating insulin dependent and non-insulin dependent diabetes Analysis of full-blood glucose, serum insulin, serum triglycerides and total serum cholesterol were performed. Glucose levels in blood samples from the oral glucose tolerance test were used for calculation of the incremental Area Under the Curve (AUC... | 04/29/2003 |
| 6506223 | Pelletizing and briquetting of combustible organic-waste materials using binders produced by liquefaction of biomass A fuel pellet is produced by the combination of organic waste material with a binder obtained by direct liquefaction and/or fast pyrolysis of biomass material. Direct liquefaction and fast pyrolysis are carried out according to known liquefaction processe... | 01/14/2003 |
| 6451781 | Substituted acylguanidines, process for their preparation, their use as medicaments or diagnostics, and medicaments comprising them Substituted acylguanidines and their pharmaceutically tolerable salts and physiologically functional derivatives. Compounds of the formula I ##STR1## in which the radicals have the meanings indicated, and their physiologically tolerable salts, physiologic... | 09/17/2002 |
| 6432938 | 19-nor-cholane steroids as neurochemical initators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the ... | 08/13/2002 |
| 6395722 | Fatty acid derivatives of bile acids and bile acid derivatives The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called "BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence or recurrence, to their use in reducing or preventing arterio... | 05/28/2002 |
| 6365582 | S-substitute 11ଲ-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds Thiol esters of S-substituted 11ଲ-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I ##STR1## their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. ... | 04/02/2002 |
| 6313327 | Carboxylic acid derivatives and their synthesis method This invention relates to novel carboxylic acid derivatives represented by the following formula I and their synthesis: ##STR1## wherein, R1 is an hydrogen atom, an alkyl group or an alkoxy group of 1 to 20 carbon atoms in a linear, branched or... | 11/06/2001 |
| 6180780 | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I ##STR1## wherein the variables are as defined by the specification.... | 01/30/2001 |
| 6177420 | 20-aralkyl-5-pregnane derivatives The invention relates to 20-aralkyl-5-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (H,OR), (H,OSO3 H) or NOR; R is H, (C1-6)alkyl or (C1-6)a... | 01/23/2001 |
| 6166002 | Substituted phenylalkenoylguanidines, process for their preparation, and their use in medicaments and in diagnostics Substituted phenylalkenoylguanidines, processes for their preparation, uses as medicaments or diagnostics, and medicaments containing them are described. The invention relates to substituted phenylalkenoylguanidines and their pharmaceutically tolerable sa... | 12/26/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 6040468 | Method of preparing 16, 17-dialkylated steroids 16, 17-dialkylated steroids are prepared by reacting a 16-alkyl-17(20)-enyl-20-silyl ether with an alkylating agent and an enol silyl ether cleaving agent in a suitable solvent.... | 03/21/2000 |
| 5994333 | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that... | 11/30/1999 |
| 5972922 | Steroids which inhibit angiogenesis Novel angiostatic Ɗ4,9(11) -steroids (I), ##STR1## C21 -oxygenated steroids (II) and other known steroidal compounds have been found to be useful in treating angiogenesis in mammals who have a need for the same. These steroids ... | 10/26/1999 |
| 5866560 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 02/02/1999 |
| 5834452 | 1- or 6-hydroxylated steroids A compound of the formula ##STR1## having progestomimetic activity, wherein the substituents are as defined in the specification and compositions of a compound of formula I and an estrogen compound.... | 11/10/1998 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5705662 | 17-(3-imino-2-alkylpropenyl)-5ଲ, 14ଲ-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same New 17-3-imino-2-alkyl propenyl!-14ଲ-hydroxy-5ଲ-androstane derivatives active on the cardiovascular system by inhibiting Na+,K+-ATPase, a process for their preparation, and to pharmaceutical compositions for the treatment of cardiovascular d... | 01/06/1998 |
| 5641877 | 17- and 17-ଲ substituted acyl-3-carboxy-3, 5-dienes and use in inhibiting 5--reductase Invented are 17 and 17ଲ-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5--reductase. Als... | 06/24/1997 |
| 5641765 | 17-댚nd 17-ଲsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5--reductase Invented are 17 and 17ଲ-substituted acyl-3-carboxy-3,5-diene analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5--reductase. Als... | 06/24/1997 |
| 5618806 | 17 and 17ଲ-substituted estra-1,3,5(10)-triene-3-carbboxlic acid Invented are 17 and 17ଲ-substituted acyl-3-carboxy aromatic A ring analogues of steroidal synthetic compounds. Representative of such compounds include the following ##STR1## wherein Z is or ଲ ##STR2## in which A ... | 04/08/1997 |
| 5561124 | 17--acyl steroids which inhibit 5--reductase The invention relates to substituted 17-acyl steroidal 5-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for reducing prostate size and treating prostate aden... | 10/01/1996 |
| 5541348 | Bile acids for biological and chemical applications and processes for the production thereof Novel bile acids according to the general formula ##STR1## wherein R1 represents a hydroxyl group, R2 and R3 both represent a hydrogen or a hydroxyl group, or R2 represents a hydroxyl group or a ଲ hyd... | 07/30/1996 |
| 5508453 | Intermediate for use in the preparation of taurocholanic acids The present invention relates to intermediates for use in the preparation of taurocholanic acids. The intermediates have the following formula (IV): ##STR1## in which A completes the 5ଲ-cyclopentaneperhydrophenanthrene structure of a cholanic a... | 04/16/1996 |
| 5506221 | Contignasterol, and related 3-alpha hydroxy-6-alpha hydroxy-7-beta hydroxy-15-keto-14-beta steroids useful as anti-inflammatory and anti-thrombosis agents The invention presents compounds useful for the prevention of inflammatory or allergic reaction or the treatment of cardiovascular or haemodynamic disorders having the formula: ##STR1## where R= ##STR2## where R= ##STR3## or pharm... | 04/09/1996 |
| 5478956 | 8-En-19 11 ଲ-bridged steroids, their production and pharmaceutical preparations containing them 8-En-19,11ଲ-bridged steroids of general formula I ##STR1## that have the 8,9-double bond as a new structural feature, and a process for their production are described. The substituents R1 R4 -Y, R4' -Y.sup.', X ... | 12/26/1995 |
