Class 552/550 - Halogen, nitrogen, or sulfur containing (e.g., glycocholic acids, taurocholic acids, etc.)

Subclass of Class 552 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain halogen, nitrogen or sulfur.
No. of patents: 40
Last issue date: 12/05/2006

Number	Title	Issue Date
7144877	Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs Disclosed are methods for providing enhanced systemic blood concentrations of orally delivered drugs that are incompletely translocated across the intestinal wall of an animal. Also disclosed are methods for the sustained release of drugs, whether poorly or readily ...	12/05/2006
6900192	Bile-acid conjugates for providing sustained systemic concentrations of drugs This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such comp...	05/31/2005
6767904	Steroid derived antibiotics A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin. ...	07/27/2004
6624155	Hybrid cholinergic agents and compositions The present invention provides hybrid molecules and methods of synthesizing such hybrid molecules from a cholinergic agent and a bile acid. The hybrid molecules function as cholinergic agents and may be either cholinergic agonists or cholinergic antagonis...	09/23/2003
6589946	Bile salt conjugates The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called "BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence or recurrence, to their use in reducing or preventing arterio...	07/08/2003
6468975	Liver specific bile acid derivatives of the glucocorticoid antagonist RU486 Novel glucocorticoid receptor ligands and methods of treating diseases such as diabetes, wherein the ligands have general formula (I) ##STR1## wherein the variables are as defined by the present specification....	10/22/2002
6388108	Aminosterol compounds and uses thereof Newly isolated aminosterol compounds and pharmaceutical compositions based on the aminosterol compounds are described. Methods for the treatment of various disorders, for example, a microbial infection, are also described....	05/14/2002
6342489	Bile acid salts of metals with physiological action and the use thereof in therapy Bile acid metal salts of therapeutic interest and pharmaceutical and veterinary composition containing same for the treatment of anemias and other conditions are described....	01/29/2002
6255502	Pharmaceutical composition containing acid addition salt of basic drug A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal penetration of the basic drug. The acid addition salts, an inclusi...	07/03/2001
6177417	Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof The present invention relates to a cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the following formula 1, process for preparation and use thereof. The cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the present invent...	01/23/2001
5679690	Concentrated aqueous solutions of argatroban Concentrated aqueous solutions of argatroban containing argatroban, a micelle-forming agent and a lipoid substance....	10/21/1997
5646272	Bile acid conjugates of proline hydroxylase inhibitors Bile acid derivatives of the formula I W--X--G in which G is a bile acid radical, W is an active compound moiety of a medicament and X is a bonding member between a bile acid radical and active compound moiety, are outstandingly suitable for introducing active...	07/08/1997
5637691	Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants Compounds having a broad range of antimicrobial activity generally have a structure including asteroid nucleus with a cationic, preferably polyamine, side chain (X) and an anionic side chain (Y). The invention is also directed to compounds of the Formula ...	06/10/1997
5610151	Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS I, in which GS, X and Z have the meanings give...	03/11/1997
5559258	Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors Ethylenically unsaturated bile acid derivatives of the formula I G--X--A I in which G, X and A have the meanings indicated, are described. They are suitable for the preparation of polymeric bile acid derivatives. B...	09/24/1996
5260462	Purification of tauroursodesoxycholic acid dihydrate Process for purification of tauroursodesoxycholic acid dihydrate prepared through reaction between taurine and mixed anhydride of ursodesoxycholic acid with an alkylcholoroformate using ion exchange resins....	11/09/1993
5061701	Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them A compounds of general formula I ##STR1## wherein R1 is hydrogen or hydroxy, and the hydroxy group at the 7-position can be either in ଱ or ଲ configuration, are valuable in human therapy. Compounds I can be prepared by fluorinat...	10/29/1991
5057302	Bifunctional chelating agents The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions....	10/15/1991
4950428	Novel steroids A novel process for the preparation of 20-keto-pregnanes....	08/21/1990
4927921	Novel 23-keto-steroids A compound of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, and A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group co...	05/22/1990
4921848	Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them Compounds of formula I ##STR1## wherein: R1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in ଱ or ଲ configuration, are useful in human therapy. Compounds I are prepar...	05/01/1990
4847014	Novel steroids A compound of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, the A,B,C and D rings optionally have one or more double bonds and are optionally substituted with one or more members of the group cons...	07/11/1989
4834919	Stereoselective reduction of the keto group at 7-position of a bile keto acid The keto group at the 7-position of a bile keto acid is stereoselectively reduced to a beta-hydroxy group with hydrogen in the presence of nickel, a base (the quantity of which is at least 0.3 mole for each mole of keto acid), and an alcohol having from 3...	05/30/1989
4810422	Bile acid derivatives, their salts and production thereof A bile acid derivative of the following formula (I): ##STR1## wherein: X is a halogen atom; R1 is a hydrogen atom or a lower alkyl group; Y is ##STR2## (wherein n is an integer of from 0 to 5); each of R2 and R3 ...	03/07/1989
4793948	Bile acid derivatives and production thereof A bile acid derivative having carcinostatic activity represented by the following formula (1): ##STR1## wherein each of R1 and R2 is a hydrogen atom or a hydroxyl group, R3 is a hydroxyl group, benzyloxyl group or --N...	12/27/1988
4681876	Antifungal utility of bile acids A valuable alternative antifungal antibiotic, for treatment especially of candidiasis, particularly vaginal candidiasis, is proposed. The antibiotic is a bile acid or simple derivative (salt or conjugate) thereof. Cholic, deoxycholic, chenodeoxycholic and...	07/21/1987
4648995	Chemical synthesis A compound of the formula, ##STR1## wherein R may be H or acyl; X may be H, acyl, or lower alkyl; Z may be H, hydroxy, or acyloxy; Y may be lower alkyl, aryl, alkyl substituted aryl or vinyl; and the non-toxic pharmaceutically acceptable salts thereo...	03/10/1987
4592868	11-hydroxypregn-4-en-3-one-20-carbaldehyde and a method for its production There is provided the novel compound 11-hydroxypregn-4-en-3-one-20-carbaldehyde, as well as a microbial method for production of the same. This novel compound is of value as a starting material for antiinflammatory corticoids such as hydrocortisone, ...	06/03/1986
4499020	Mixed anhydrides and processes thereof Mixed anhydrides products are described. These mixed anhydrides are produced by reaction of a carboxylic acid-containing steroid with a material having the formula: ##STR1## wherein: X is a halogen Z is an oxygen or sulfur R is a hydrocarbon in an in...	02/12/1985
4460509	Chemical synthesis This invention relates to steroid compounds having a D-ring side chain structure of the formula, ##STR1## wherein R1 may be ##STR2## or --Cn H2n --, wherein n is an integer from 0 to 8; Y may be S, N, or O; ...	07/17/1984
4372888	Nondenaturing zwitterionic detergents A nondenaturing zwitterionic detergent for proteins which, for example, consists of an effective amount of 3-[(3-chloamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). This detergent is of extreme interest in the biological study of proteins due ...	02/08/1983
4264514	Method and reagents for measuring the level of conjugated bile acids A method and novel reagents useful for measuring the level of specific immunoreactive conjugated bile acids in a sample using labeled conjugated bile acid derivatives are disclosed....	04/28/1981
4220598	Method and reagents for measuring the level of conjugated bile acids A method and novel reagents useful for measuring the level of specific immunoreactive conjugated bile acids in a sample using labeled conjugated bile acid derivatives are disclosed....	09/02/1980
4207308	Process for purifying iodinated bile acid conjugates Iodinatable bile salt derivatives are obtained by providing bile salts and their glycine and taurine conjugates with iodinatable groups. The radioiodinated compounds are useful in the radioimmunoassay of bile salts and in physiological studies. The prefer...	06/10/1980
4180504	Method for the preparation of esters This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent....	12/25/1979
4172085	Labelled bile acids The present invention provides compounds having the general formula ##STR1## wherein R is ##STR2## and A is 0 or 1, B is 0 to 4, C is 0 to 4, Z is Se or Te, R6 is --OH or an amino acid residue, R7 is hydrogen or saturated C...	10/23/1979
4107188	Pregnanes The compound 5(3,12-dihydroxy-pregnan-20-yl)-pentanoic acid and 7-(3,12-dihydroxy-pregnan-20-yl)-heptanoic acid as well as ester and unsaturated derivatives thereof useful for decreasing the level of lipids such as cholesterol and triglycerides....	08/15/1978
4072710	Process for preparing acid chlorides A process for preparing acid chlorides, wherein a silyl ester having an aliphatic, aromatic, alkanoaromatic or heterocyclic group which may support substituents, and having a low molecular weight alkyl or phenyl group is reacted with thionyl chloride in a...	02/07/1978
3998859	Introducing Ɗ¹¹ unsaturation into steroid compounds A process for the introduction of Ɗ11 unsaturation into steroid compounds having a C-12 sulfonate ester group is described. Dehydrosulfonation is carried out by reacting the sulfonate with a hexaalkylphosphoric triamide. The process is particu...	12/21/1976
3989711	Soft quaternary surface active agents exhibiting antibacterial activity Soft quaternary surface active agents having the formula: ##EQU1## wherein ##EQU2## represents a tertiary open chain or cyclic aliphatic amine; wherein ##EQU3## represents an aromatic amine; wherein R represents a member selected from ...	11/02/1976

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Class 552/550 - Halogen, nitrogen, or sulfur containing (e.g., glycocholic acids, taurocholic acids, etc.)