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| Number | Title | Issue Date |
| 7994351 | Preparation of bile acids and intermediates thereof Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. ... | 08/09/2011 |
| 7902387 | Preparation of bile acids and intermediates thereof Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided. ... | 03/08/2011 |
| 7355056 | Transfection agents The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents... | 04/08/2008 |
| 7329416 | Method of enhancing absorptions of transmucosal administration formulations Disclosed is a method for enhancing absorption of a medicament that is suitable for administering transmucosally to a subject by providing an environment of the administration with a suitable pH. A medicament of propranolol suitably administered sublingually is prov... | 02/12/2008 |
| 7255973 | Positive resist compositions and patterning process A polymer comprising units derived from an exo-form ester and units derived from an ester having two hexafluoroisopropanol groups is used as a base resin to formulate a positive resist composition which, when exposed and developed by photolithography, is minimized i... | 08/14/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7189493 | Polymer, positive resist composition, and patterning process using the same There is disclosed a polymer which at least has the repeating unit represented by the following general formula (1a), and the repeating unit represented by the following general formula (1b) and/or the repeating unit represented by the following general formula (1c)... | 03/13/2007 |
| 7141559 | Glucocorticoid receptor ligands for the treatment of metabolic disorders This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin... | 11/28/2006 |
| 7030082 | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The f... | 04/18/2006 |
| 7002027 | Compositions and methods for therapeutic use The present invention is directed to compositions and methods of treating cancer by gene therapy using a therapeutic gene formulated in a buffer comprising a delivery-enhancing agent. The delivery-enhancing agents of the invention can be used to formulate therapeuti... | 02/21/2006 |
| 6984634 | Bile-acid conjugates for providing sustained systemic concentrations of drugs This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such comp... | 01/10/2006 |
| 6951654 | Intravaginal drug delivery devices for the administration of an antimicrobial agent An intravaginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device. ... | 10/04/2005 |
| 6803030 | Bile acids conjugates with metal ion chelates and the use thereof Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as “Magnetic Resonance Imaging” (M.R.I.). ... | 10/12/2004 |
| 6793943 | Health food products An object of the present invention is to provide a very effective health food exhibiting the effect near that which has been already achieved by the traditional Chinese medical science. The present invention relates to a health food product comprising cholic acid, e... | 09/21/2004 |
| 6624156 | Methods of making and method of using hybrid cholinergic agents and compositions The present invention provides hybrid molecules and methods of synthesizing such hybrid molecules from a cholinergic agent and a bile acid. The hybrid molecules function as cholinergic agents and may be either cholinergic agonists or cholinergic antagonis... | 09/23/2003 |
| 6589946 | Bile salt conjugates The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called "BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence or recurrence, to their use in reducing or preventing arterio... | 07/08/2003 |
| 6468975 | Liver specific bile acid derivatives of the glucocorticoid antagonist RU486 Novel glucocorticoid receptor ligands and methods of treating diseases such as diabetes, wherein the ligands have general formula (I) ##STR1## wherein the variables are as defined by the present specification.... | 10/22/2002 |
| 6448420 | Acid-decomposable ester compound suitable for use in resist material A novel ester compound having an exo-form 2-alkylbicyclo[2.2.1]heptan-2-yl ester as the acid-decomposable site is used as a dissolution regulator to formulate a resist composition having a high sensitivity, resolution, etching resistance and storage stabi... | 09/10/2002 |
| 6342489 | Bile acid salts of metals with physiological action and the use thereof in therapy Bile acid metal salts of therapeutic interest and pharmaceutical and veterinary composition containing same for the treatment of anemias and other conditions are described.... | 01/29/2002 |
| 6255502 | Pharmaceutical composition containing acid addition salt of basic drug A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal penetration of the basic drug. The acid addition salts, an inclusi... | 07/03/2001 |
| 5610151 | Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS I, in which GS, X and Z have the meanings give... | 03/11/1997 |
| 5559258 | Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors Ethylenically unsaturated bile acid derivatives of the formula I G--X--A I in which G, X and A have the meanings indicated, are described. They are suitable for the preparation of polymeric bile acid derivatives. B... | 09/24/1996 |
| 5541348 | Bile acids for biological and chemical applications and processes for the production thereof Novel bile acids according to the general formula ##STR1## wherein R1 represents a hydroxyl group, R2 and R3 both represent a hydrogen or a hydroxyl group, or R2 represents a hydroxyl group or a ଲ hyd... | 07/30/1996 |
| 5252729 | Extraction of compounds from plant materials using supercritical fluids The present invention is directed toward a process for extracting compounds from plant material, comprising a) contacting hydrolyzed plant material with a supercritical fluid and optionally with a co-solvent and p1 b) recovering the compound from the supe... | 10/12/1993 |
| 4981983 | Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with... | 01/01/1991 |
| 4927921 | Novel 23-keto-steroids A compound of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, and A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group co... | 05/22/1990 |
| 4921848 | Biliary acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them Compounds of formula I ##STR1## wherein: R1 is hydrogen or hydroxy, and the methyl and hydroxy groups at 6- and 7-positions respectively can be either in or ଲ configuration, are useful in human therapy. Compounds I are prepar... | 05/01/1990 |
| 4921999 | Method for making tertiary butyl esters A method is provided for making tertiary butyl esters by effecting reaction between an organic carboxylic acid and isobutylene in the presence of an effective amount of trifluoromethane sulfonic acid at temperatures below about -7° C. Tertiary butyl este... | 05/01/1990 |
| 4917828 | Process for preparing ketocholanates A process for preparing ketocholanate(s) comprises oxidizing cholanic acid compound(s), such as alkyl 3-alkoxycarbonyloxy-7,12- dihydroxycholanates or alkyl 3-acyloxy-7,12-dihydroxycholanates, with an alkali ... | 04/17/1990 |
| 4847014 | Novel steroids A compound of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is methyl or ethyl, the A,B,C and D rings optionally have one or more double bonds and are optionally substituted with one or more members of the group cons... | 07/11/1989 |
| 4834919 | Stereoselective reduction of the keto group at 7-position of a bile keto acid The keto group at the 7-position of a bile keto acid is stereoselectively reduced to a beta-hydroxy group with hydrogen in the presence of nickel, a base (the quantity of which is at least 0.3 mole for each mole of keto acid), and an alcohol having from 3... | 05/30/1989 |
| 4648995 | Chemical synthesis A compound of the formula, ##STR1## wherein R may be H or acyl; X may be H, acyl, or lower alkyl; Z may be H, hydroxy, or acyloxy; Y may be lower alkyl, aryl, alkyl substituted aryl or vinyl; and the non-toxic pharmaceutically acceptable salts thereo... | 03/10/1987 |
| 4592868 | 11-hydroxypregn-4-en-3-one-20-carbaldehyde and a method for its production There is provided the novel compound 11-hydroxypregn-4-en-3-one-20-carbaldehyde, as well as a microbial method for production of the same. This novel compound is of value as a starting material for antiinflammatory corticoids such as hydrocortisone, ... | 06/03/1986 |
| 4565810 | Derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic bile acids having in the side chain in the 19 position a cyclopropane ring are described together with taurine and glycine conjugated derivatives thereof. The compounds of the inv... | 01/21/1986 |
| 4514393 | New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same Derivatives of biliary acids having formula I ##STR1## wherein St has the meaning of the 17-etiocholanyl residue, having two or more hydroxyl groups both in the and ଲ conformation, some of which being optionally replaced by keto groups,... | 04/30/1985 |
| 4499020 | Mixed anhydrides and processes thereof Mixed anhydrides products are described. These mixed anhydrides are produced by reaction of a carboxylic acid-containing steroid with a material having the formula: ##STR1## wherein: X is a halogen Z is an oxygen or sulfur R is a hydrocarbon in an in... | 02/12/1985 |
| 4460509 | Chemical synthesis This invention relates to steroid compounds having a D-ring side chain structure of the formula, ##STR1## wherein R1 may be ##STR2## or --Cn H2n --, wherein n is an integer from 0 to 8; Y may be S, N, or O; ... | 07/17/1984 |
| 4425273 | Process for production of chenodeoxycholic acid A process for producing chenodeoxycholic acid of the following formula ##STR1## which comprises reducing a 12-oxocholanic acid tosylhydrazone compound of the following formula ##STR2## wherein R1 and R2 are identical or dif... | 01/10/1984 |
| 4379093 | Process for preparing high purity ursodeoxycholic acid A process for preparing very pure ursodeoxycholic acid starting from cholic acid (I) by: (a) selectively oxidizing it to 3 alpha, 12 alpha-dihydroxy-7-ketocholanic acid (II) (b) reducing acid (II) to 3 alpha, 7 beta, 12 alpha-trihydroxy-cholanic acid (III... | 04/05/1983 |
| 4279898 | In vivo inhibitors of cholesterol biosynthesis Dialkyl esters of 5-carbo[etiocholane-3'-7', 12'-trihydroxy-17'ଲ(1" methyl-4' butyl]oxy-4-hydroxy-4-methylpentyl-1-phosphonate and 5-carbohexadecyloxy-4-hydroxy-4-methylpentyl-1-phosphonate are shown to inhibit cholesterol ... | 07/21/1981 |
