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Patent No. 5970981

Mouthguard made at least partially from an edible candy

A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.

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Class 552/536 - Halogen bonded directly at the 16-position of the cyclopentanohydrophenanthrene ring system


Subclass of Class 552 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein halogen is bonded directly at the 16-position
No. of patents: 26
Last issue date: 09/02/2008


NumberTitleIssue Date
74199722-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of...
09/02/2008
6737417Compounds with hydroxycarbonyl-halogenoalkyl side chain
The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general f...
05/18/2004
6667299Pharmaceutical compositions and treatment methods
The invention provides compositions comprising, 16଱-bromo-3ଲ-hydroxy-5଱-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make im...
12/23/2003
5994333Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that...
11/30/1999
59861157଱-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7଱-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents
This invention describes new, substituted 7଱-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ...
11/16/1999
58665607଱-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7଱-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents
This invention describes new, substituted 7଱-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ...
02/02/1999
5808051Process for preparing neuromuscular blocking agents and intermediates useful therefor
The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R1 is .dbd.O and X is halo; and formula I...
09/15/1998
5804576Derivatives of 5-androsten-17-ones and 5-androstan-17-ones
Steroids of the formula: ##STR1## useful as cancer preventive agents, anti-obesity agents, anti-hyperglycemic agents, anti-aging agents, and anti-hypercholesterolemic agents and anti-auto-immune agents....
09/08/1998
5714481Derivatives of 5-androsten-17 ones and 5-androstan-17-ones
Steroids of the formula: ##STR1## useful as cancer preventive agents, anti-obesity agents, anti-hyperglycemic agents, anti-aging agents, and anti-hypercholesterolemic agents and anti-auto-immune agents....
02/03/1998
5700793Steroids useful as anti-cancer and anti-obesity agents
12/23/1997
5364847Inhibitors of sex steroid biosynthesis and methods for their production and use
Certain steroidal and non-steroidal compounds have been found to inhibit androgen and estrogen formation. Such inhibition may aid in the reduction of the activity of these hormones and may be useful in the treatment of diseases where, for example, inhibit...
11/15/1994
5204337Estrogen nucleus derivatives for use in inhibition of sex steroid activity
Novel compounds for the inhibition of sex steroid activity for the treatment of both androgen-related and estrogen-related diseases include for example 15- and 16-halo substituted compounds such as: ##STR1## The compounds are characterized by an estr...
04/20/1993
489869417-Hydroxy-steroids
Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents....
02/06/1990
4855125Iodinated estradiols, intermediate products and methods of production
A method of preparation of estradiol derivatives labeled by iodine, especially 123 I, substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepared from which either 16-alpha-123 I-17-be...
08/08/1989
4780420Progesterone receptor ligands
Radiodinated and non-radiodinated 16଱-iodo- and 17଱-(2-iodovinyl)-19-nortestosterones are prepared and are used in progesterone receptor assays....
10/25/1988
4659517Halogen labeled compounds including estradiol derivatives, their synthetic intermediates and the syntheses thereof
A method of preparation of halogen labeled organic compounds is described. In particular, estradiol derivatives labeled by halogen substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepared from which eith...
04/21/1987
452954817ଲ-(substituted thio)androstenes
Antiinflammatory activity is exhibited by steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl; R2
07/16/1985
446567616଱ Halogen substituted 3,17ଲ-dihydroxy steroidal estrogens
16଱-Radiohalo-3,17ଲ-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16ଲ-bromo compoun...
08/14/1984
4447363Androstene-17-dithioketals
Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, 6,7-dehydro and 15,16-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, cycloalkyl, aryl, arylalkyl, or --CH2...
05/08/1984
4427592Androstene-17-dithioketals
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the oth...
01/24/1984
4330540Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions
New and pharmacologically useful ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes are disclosed having the formula I: ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, wherein: n=1 or 2, preferably 1 R1 =...
05/18/1982
4215044Synthesis of ଱-fluorocarbonyl compounds
Process for preparing an organic compound of the formula R2 R2 CFC(O)R3, which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF...
07/29/1980
4192871Chemical compounds
Pregnanes and androstanes are described which essentially possess a 3଱-hydroxy group, a 5଱-hydrogen atom or a 4.5- or 5,6-double bond, a 17଱-hydrogen atom and an 11ଲ-aminoester group. Other optional substituents or double bonds may...
03/11/1980
40962531-Oxygenated steroids
1-Oxygenated steroids and a method of preparing same as described. The 1-oxygenated steroids are useful as antifertility agents....
06/20/1978
401626917଱-HYDROXY-1,3,5(10),15-ESTRATETRAENES AND PROCESS FOR THEIR PRODUCTION
Novel estrogenic 17଱-hydroxy-1,3,5(10),15-estratetraenes of the formula ##STR1## wherein R1 is H, lower alkyl or lower acyl, R2 is lower alkyl and R3 is H, lower alkyl, lower acyl or tetrahydropyranyloxy, are ...
04/05/1977
3980681Process for the preparation of 11-ଲ-nitro-oxysteroids
Process for preparing 9 ଱-hydroxy-11 ଲ-nitro-oxysteroids having a aromatic ring A wherein an aromatic A-ring-containing 9, 11-unsubstituted steroid or corresponding 9,11-dehydrosteroid is oxidized with ceric ions in the presence of nitrate ion...
09/14/1976
 
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