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| Number | Title | Issue Date |
| 7371741 | Estradiol derivatives and pharmaceutical compositions using same Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ... | 05/13/2008 |
| 6653491 | Method for producing 4,4-dimethyl-3ଲ-hydroxypregna-8, 14-diene-21-carboxylic acid esters and intermediate products obtained by said method The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use of 4,4-dimethyl-3... | 11/25/2003 |
| 6413951 | 20-fluoro-17(20)-vinyl steroids The invention relates to 20.xi.-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20.xi.-fluoro-3ଲ-hydroxypregna-5,17(20)-dien-21-oic acid ethyl ester, 20.xi.-fluoro-21-hydroxypregna-4,17 (20)-dien-3-one, 20.xi.-fluoropregna-5,17(20)-dien-3&#... | 07/02/2002 |
| 5994333 | Pregnane and cholane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that... | 11/30/1999 |
| 5480913 | Anti-androgen compounds Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.... | 01/02/1996 |
| 5449795 | Process for synthesis of steroidal allylic tert. alcohols A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is to the sulfoxide, in an inert solven... | 09/12/1995 |
| 5084584 | Process for producing an -acyloxy-,ଲ-unsaturated carbonyl compound and a 20-acyloxy-17(20)-methylen-21-al-steroid compound There are disclosed a process for producing an -acyloxy-,ଲ-unsaturated carbonyl compound represented by the general formula (VI): ##STR1## wherein R1, R2 and R4 are independently hydrogen atoms or ... | 01/28/1992 |
| 5041433 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5--reductase Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase.... | 08/20/1991 |
| 4954490 | 11 ଲ-substituted progesterone analogs A 11ଲ-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-... | 09/04/1990 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4720357 | New process for manufacturing derivatives of 17 alpha-hydroxy 19-nor progesterone and novel intermediates for use therein A process for making a known 6-methyl, 19-nor-pregna-4, 6-diene, 3.20-dione which begins with formylating a 3-alcoxy, 19-nor-pregna-3,5,17(20)-triene at the 6 position. The 6-formylated derivative is reduced to yield a 6-hydroxy methylated derivative, whi... | 01/19/1988 |
| 4530795 | Process for preparation of 16 -methyl corticoids from Ɗ16 -steroids This invention discloses a general process for the production of corticoids from respective steroid-type compounds having a double bond from C-16 to C-17. The invention provides a viable alternative synthesis of 17-hydroxy-progesterones and like co... | 07/23/1985 |
| 4424218 | Novel 3 -amino steroids A 3-amino-steroid of the formula ##STR1## wherein W is selected from the group consisting of hydrogen and --OH and taken together with X is ethylidene, X is selected from the group consisting of ethyl, ##STR2## the wavy line indicates the s... | 01/03/1984 |
| 4370271 | Process for the partial reduction of C21-steroid carboxylic acids and their esters to C21-steroid alcohols and new C21-steroid alcohols A process for the partial reduction of C21-steroid carboxylic acids and their esters to C21-steroid alcohols and new C21-steroid alcohols Ɗ4,17(20)-C21-steroid carboxylic acids optionally containing further double bonds in the 1- and/or 9(11)-position and the... | 01/25/1983 |
| 4360470 | Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid The present disclosure is directed to a process for the synthesis of chenodeoxychloic acid, 25-hydroxycholesterol and 1,25-dihydroxycholesterol from 17-keto steroids. A cholic acid side chain is stereospecifically introduced by reaction of the appr... | 11/23/1982 |
| 4310467 | Process and intermediates for the synthesis of vitamin D3 metabolites The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via interme... | 01/12/1982 |
| 4272444 | Dehydroformylation of steroidal aldehydes The invention relates to a process for dehydroformylation of dinorcholanaldehydes and dinorcholenaldehydes to form 17(20)-pregnenes or 20-pregnenes. The dehydroformylation is carried out using a noble metal catalyst, and preferably carried out in the pres... | 06/09/1981 |
| 4255344 | 9--Hydroxy steroids 9-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester, and methods of microbiological production thereof, one comprising cultivating a Rhodococcus species in the presence of the corresponding 3-oxopregna-4,17(20)-diene-20-car... | 03/10/1981 |
| 4216159 | Synthesis of 16-unsaturated pregnanes from 17-keto steroids 17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially important substit... | 08/05/1980 |
| 4197296 | Androstanes Steroids of the androstane series are described which possess a 3-hydroxy group, a 5- or 5ଲ- hydrogen atom, a 10- methyl group, an 11- substituted amino group. The 17-position may be unsubstituted or substituted by a methyl or e... | 04/08/1980 |
| 4155923 | Process for the preparation of 17ଲ-hydroxy-20-alkoxypregnane-21-oic acid derivatives A process for the preparation of 17ଲ-hydroxy-20-alkoxypregnane-21-oic acid derivatives of the formula ##STR1## WHEREIN R1 is methyl or ethyl; R2 is hydrogen or methyl, either being in the -or ଲ-position; R | 05/22/1979 |
| 4150044 | Process for the manufacture of 17-hydroxy-21-acetoxy-progesterone The present invention relates to a process for the manufacture of 17 -hydroxy-21-acyloxy-progesterone, in particular of 17-hydroxy-21-acetoxy-progesterone (Reichstein's substance S acetate) which is of great importance as a starting material... | 04/17/1979 |
| 4092310 | Difluorosteroids and processes for their manufacture A novel group of 18,18-difluorosteroids of the general formula ##STR1## wherein St, R1 and R2 have the meanings given hereinafter is produced by a chemically novel process characterized in that a corresponding 18-oxo compound is... | 05/30/1978 |
| 4059575 | Process for the preparation of 17(20)ene-21-steroid aldehydes There is disclosed a process for the efficient conversion of 17--ethynyl 17-ଲ- hydroxy steroids into the corresponding 17(20) ଲ-unsaturated 21-steroid aldehydes. The process comprises the sequential steps of reacting the ethynyl ... | 11/22/1977 |
| 4055603 | Alkinyl terminating groups in biogenetic-like cyclizations to steroids Polyenine compounds are provided having the naturally occurring geometry and a group which in the presence of acid initiates a carbocation cyclization to a steroid or A-nor-steroid structure, particularly the pregnane parent structure. The compounds are f... | 10/25/1977 |
| 4031080 | 16-Alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-derivatives There is disclosed 16 alpha-methyl-17 alpha-bromo-1,4-pregnadiene-21-ol-3,20-dione-type compounds of the formula ##STR1## where R is hydrogen or acyl; X is hydrogen, bromine, or fluorine; Y is hydrogen or oxygen; and Z is hydrogen or - or �... | 06/21/1977 |
| 4022892 | 17ଲ-Ethynyl-3,17-estradiol and derivatives thereof 17ଲ-ethynyl-3,17-estradiol and derivatives thereof are prepared by epimerization of 17-acyl esters of 17-ethynyl-3,17ଲ-estradiol 3-ethers. 17-ethynyl-3,17-estradiol and its derivatives are active as post-coital... | 05/10/1977 |
| 3983112 | 17ଲ-Ethynyl-3,17-estradiol and derivatives thereof 17ଲ-ethynyl-3,17-estradiol and derivatives thereof are prepared by epimerization of 17-acyl esters of 17-ethynyl-3,17ଲ-estradiol 3-ethers. 17ଲ-ethynyl-3,17댞stradiol and its derivatives are active as post-coital ... | 09/28/1976 |
| 3946052 | 19-Norpregna- 1,3,5(10)-trien-3-ol and loweralkyl homologs thereof having postcoital antifertility activity 19-Norpregna-1,3,5(10)-trien-3-ol and loweralkyl homologs thereof wherein the alkyl group attached in the 17ଲ position contains from 2 to 7 carbon atoms. Said compounds, along with the corresponding known 17ଲ-methyl derivative, are found to ha... | 03/23/1976 |
