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| Number | Title | Issue Date |
| 7427610 | 2-substituted estra-1,3,5(10)-triene-3-yl sulfamate with an anti-tumour action Disclosed are compounds of formula I and use thereof in a method of treating a tumor disease that can be influenced positively by the inhibition of tubulin polymerization. ... | 09/23/2008 |
| 7371741 | Estradiol derivatives and pharmaceutical compositions using same Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ... | 05/13/2008 |
| 6673783 | Fusidic acid derivatives Novel 17,20-methanofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 01/06/2004 |
| 6596885 | 19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions Novel compounds having a formula selected from the group consisting of ##STR1## wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-prolife... | 07/22/2003 |
| 6548491 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5(10)-estratriene nucleus, and are substituted at the C-17 or C-11 position with a mol... | 04/15/2003 |
| 6054446 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5-estratriene nucleus, and are substituted at the C-17 or C-11 position with a molecul... | 04/25/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 5916975 | Process for epoxidising prochiral olefins and a catalyst therefor and intermediates for making the catalyst A process for enantioselectively epoxidising a prochiral olefin, which process comprises reacting a prochiral olefin with a source of oxygen in the presence of a salen catalyst and a source of an electron donating ligand, characterized in that the donor l... | 06/29/1999 |
| 5770748 | Intermediate steroid compound A novel process for the preparation of oxoetiocholenic acid of the formula ##STR1## and intermediates therefore.... | 06/23/1998 |
| 5650526 | Process for the preparation of an oxoetiocholenic acid The invention is drawn to a process for the preparation of oxoetiocholenic acid of the formula I ##STR1## by reacting a compound of the formula II ##STR2## with a halonitrile in the presence of a base followed by formation of a 3-ketone gro... | 07/22/1997 |
| 5449795 | Process for synthesis of steroidal allylic tert. alcohols A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is to the sulfoxide, in an inert solven... | 09/12/1995 |
| 5086047 | Novel steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, option... | 02/04/1992 |
| 5081114 | Steroids A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, ##STR2## alkyl and alkoxy of 1 to 12 carbon atoms, aryl and aryloxy of 6 to 12 carbon atoms and aralkyl and aralkoxy of 7 to 12 carbon atoms, R1... | 01/14/1992 |
| 5041433 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5--reductase Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase.... | 08/20/1991 |
| 5032586 | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase. ... | 07/16/1991 |
| 4970205 | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to redu... | 11/13/1990 |
| 4954490 | 11 ଲ-substituted progesterone analogs A 11ଲ-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5, wherein R5 is C2-... | 09/04/1990 |
| 4668437 | Novel 20 benzcylamino pregnene derivatives and process for preparing same The invention relates to new pregnene derivatives of the general formula (I), ##STR1## wherein R1 stands for a C1-4 alkyl group; R2 stands for a hydrogen atom or a C2-4 alkanoyl group; R3 stands for a... | 05/26/1987 |
| 4647410 | Novel 17-substituted steroids Novel 17-(formamidosulfonylmethylene)-steroids of the formula ##STR1## useful as intermediates for the novel 17-(isocyanosulfonylmethylene)-steroids of the formula ##STR2## which are useful intermediates for 21-hydroxy-20-keto-Ɗ16 ... | 03/03/1987 |
| 4601854 | Process for the production of prednisone 17.21-diacylates A novel process for the preparation of prednisone derivatives of the formula ##STR1## wherein R1 is alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 8 carbon atom... | 07/22/1986 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-Ɗ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4565656 | Preparation of 17ଲ-hydroxyacetyl-17-ol-steroids A novel process for the preparation of 17ଲ-hydroxyacetyl-17-ol-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or ... | 01/21/1986 |
| 4551278 | Preparation of 20-keto-Ɗ16 -steroids A novel process for the preparation of 20-keto-Ɗ16 -steroids comprising reacting a 17-(isocyanosulfonylmethylene)-steroid with an alkylating agent QR4 wherein R4 is an organic group and Q is a group or atom readily displa... | 11/05/1985 |
| 4530795 | Process for preparation of 16 -methyl corticoids from Ɗ16 -steroids This invention discloses a general process for the production of corticoids from respective steroid-type compounds having a double bond from C-16 to C-17. The invention provides a viable alternative synthesis of 17-hydroxy-progesterones and like co... | 07/23/1985 |
| 4501701 | 20-Isocyano-Ɗ17(20) -steroids Novel 20-isocyano-Ɗ17(20) -steroids of the formula ##STR1## wherein R1 is selected from the group consisting of (1) hydrogen, (2) alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halo... | 02/26/1985 |
| 4490296 | Compositions and method A novel nitromethylation composition comprising nitromethane and a catalytic amount of a bifunctional basic catalyst, optionally in an organic solvent, a method of nitromethylating ketonic compounds with said compositions and novel steroids of the formula... | 12/25/1984 |
| 4464302 | 17-[(Hydroxymethyl)formamido-methylene]-steroids Novel 17-[(hydroxymethyl)formamido methylene]-steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function... | 08/07/1984 |
| 4432905 | Simplified process for the degradation of steroid-C-22-carboxylic acids The degradation of steroid-C22-carboxylic acids to the C20-carbonyl steroids is carried out in simplified form and preferably without isolating intermediate reaction products by using 17(20)-steroid-22-carboxylic acids as starting material and directly ... | 02/21/1984 |
| 4412955 | Preparation of corticoids from 17-keto steroids Disclosed is a 20,21-dihalo steroid (VII) and a steroidal sulfoxide (VIII) as well as processes to produce them. The 20,21-dihalo steroid (VII) and sulfoxide (VIII) are intermediates useful in the preparation of pharmaceutically useful corticoids.... | 11/01/1983 |
| 4389345 | 3-Oxoestra-17-acetonitrile and unsaturated analogs This invention relates to cyano steroids of formula I. These compounds exhibit progestational activity.... | 06/21/1983 |
| 4357279 | Preparation of corticoids from 17-keto steroids A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).... | 11/02/1982 |
| 4342702 | Metallated halogenated acetylene corticoid synthesis A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C17 side chain rearrangement.... | 08/03/1982 |
| 4310467 | Process and intermediates for the synthesis of vitamin D3 metabolites The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via interme... | 01/12/1982 |
| 4255345 | Steroid production The present invention discusses the production of useful steroids through starting with a steroid which has an acid side chain attached to the steroid ring structure. The present invention also describes and claims several novel compounds obtained through... | 03/10/1981 |
| 4252730 | Hydrolysis of steroidal carbamates The present invention describes a process for converting the carbamate of a steroidal amino compound to the corresponding hydrohalide.... | 02/24/1981 |
| 4252732 | Processing of steroids containing amino functionality The present invention describes the conversion of steroids having a 20-amino functionality to progesterone and other useful steroids.... | 02/24/1981 |
| 4252731 | Preparation of steroidal carbamates The present invention describes a process for converting the amides of certain steroids to the corresponding carbamates of the steroid.... | 02/24/1981 |
| 4251450 | Nitrogen transhalogenation process The present invention describes the transhalogenation of amido compounds to obtain the corresponding N-haloamide through the use of an N-haloimide.... | 02/17/1981 |
| 4216159 | Synthesis of 16-unsaturated pregnanes from 17-keto steroids 17-Keto steroids (I) in their protected form (IIa or IIb) are reacted with a metalated olefin (VI) to give a 21-aldehyde (IV) which is readily transformed to a 16-unsaturated pregnane (V) which is useful in the production of commercially important substit... | 08/05/1980 |
| 4119717 | 16-S-acyl derivatives of fusidic acid The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds, the new fusidic acid derivative... | 10/10/1978 |
