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| Number | Title | Issue Date |
| 7371741 | Estradiol derivatives and pharmaceutical compositions using same Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ... | 05/13/2008 |
| 7365218 | Process for preparing guggulsterones The present invention provides an improved process for the preparation of Guggulsterones which comprises epoxidising 16-dihydropegnenolone acetate (16 DPA) by reacting 16DPA with hydrogen peroxide reagent adduct in the presence of a co-base in a polar solvent to obt... | 04/29/2008 |
| 7235539 | 6-Hydroxyequilenins as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of... | 06/26/2007 |
| 6855836 | 17-Methylene steroids, process for their production and pharmaceutical compositions that contain these compounds The invention relates to 17-methylene steroids, process for their production and pharmaceutical compositions that contain these compounds. The compounds according to the invention have a hybrid-type profile of action in the sense that they act as inhibitors o... | 02/15/2005 |
| 6717002 | Method of producing steroid derivatives A method of producing 3-alkoxy-1,3,5(10)-triene-6-one-steroid derivatives having, in the steroid skeleton thereof, a partial structure of A- and B-rings represented by formula (2): (wherein R represents an alkyl group, a... | 04/06/2004 |
| 6673783 | Fusidic acid derivatives Novel 17,20-methanofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 01/06/2004 |
| 6653491 | Method for producing 4,4-dimethyl-3ଲ-hydroxypregna-8, 14-diene-21-carboxylic acid esters and intermediate products obtained by said method The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use of 4,4-dimethyl-3... | 11/25/2003 |
| 6593319 | Fusidic acid derivatives Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 07/15/2003 |
| 6579864 | 3-methylene steroid derivatives The invention concerns a 3-methylene steroid derivative having general formula (1) wherein R1 is H or together with R3 forms a ଲ-epoxide or R1 is absent if there is a 5-10 or 4-5 double bond; R2 is (C... | 06/17/2003 |
| 6548491 | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use Novel anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependent disorders. Preferred compounds have a 1,3,5(10)-estratriene nucleus, and are substituted at the C-17 or C-11 position with a mol... | 04/15/2003 |
| 6432938 | 19-nor-cholane steroids as neurochemical initators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the ... | 08/13/2002 |
| 6413951 | 20-fluoro-17(20)-vinyl steroids The invention relates to 20.xi.-fluoropregna-4,17(20)-dien-3-on-21-oic acid ethyl ester, 20.xi.-fluoro-3ଲ-hydroxypregna-5,17(20)-dien-21-oic acid ethyl ester, 20.xi.-fluoro-21-hydroxypregna-4,17 (20)-dien-3-one, 20.xi.-fluoropregna-5,17(20)-dien-3&#... | 07/02/2002 |
| 6242619 | 19-norpregnane steroids as neurochemical initiators of change in human hypothalamic function Several 19-nor-pregnanes are provided which have the capacity to neurochemically alter the hypothalamic function in an individual through nasal administration. These pharmaceutically active compounds can be administered by themselves or in the form of a p... | 06/05/2001 |
| 6177418 | Tetracyclic triterpenes as cholesterol-lowering and anti-atherosclerosis agents The invention is directed to compounds, compositions and method of preparation of compounds of formulae I and II: ##STR1## wherein X, Q1, Q2, R1 and R2 are as defined by the specification. The compounds are disc... | 01/23/2001 |
| 6136800 | 17-Difluoromethylene-estratrienes This invention describes the new 17-difluoromethylene-estratrienes of general formula I ##STR1## in which R1 is a hydrogen atom or a C1 -C10 alkyl group, R5 is a methyl or ethyl group, and R2 is a hyd... | 10/24/2000 |
| 6046185 | 6,7-oxygenated steroids and uses related thereto Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substituti... | 04/04/2000 |
| 6043236 | Estrogens Compounds of the formula I ##STR1## a process for their preparation, their use in the treatment of autoimmune disorders as well as new intermediates for their preparation.... | 03/28/2000 |
| 6018062 | 17-difluoromethylene-estratrienes This invention describes the new 17-difluoromethylene-estratrienes of general formula I ##STR1## in which R1 means a hydrogen atom or a C1 -C10 alkyl group, R5 means a methyl or ethyl group, and R2 me... | 01/25/2000 |
| 5633392 | Estrenes for inducing hypothalamic effects The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.... | 05/27/1997 |
| 5480913 | Anti-androgen compounds Disclosed are novel classes of anti-androgens including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.... | 01/02/1996 |
| 5449795 | Process for synthesis of steroidal allylic tert. alcohols A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is to the sulfoxide, in an inert solven... | 09/12/1995 |
| 5252729 | Extraction of compounds from plant materials using supercritical fluids The present invention is directed toward a process for extracting compounds from plant material, comprising a) contacting hydrolyzed plant material with a supercritical fluid and optionally with a co-solvent and p1 b) recovering the compound from the supe... | 10/12/1993 |
| 5194602 | 9-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids New 9-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9-hydroxyandrost-4-ene-3, 17-dione. The resulting compounds are useful starting compounds in the synthesis of corticosteroids.... | 03/16/1993 |
| 5124321 | 17-halomethylene estratrienes 17-halomethylene estratrienes of Formula I ##STR1## wherein R1 is hydrogen, a methyl or acyl group, and R2 is a halogen atom, show low affinity to the estrogen receptor and bring about a cellular membrane and blood/lymphatic vessel p... | 06/23/1992 |
| 5086047 | Novel steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, option... | 02/04/1992 |
| 5084584 | Process for producing an -acyloxy-,ଲ-unsaturated carbonyl compound and a 20-acyloxy-17(20)-methylen-21-al-steroid compound There are disclosed a process for producing an -acyloxy-,ଲ-unsaturated carbonyl compound represented by the general formula (VI): ##STR1## wherein R1, R2 and R4 are independently hydrogen atoms or ... | 01/28/1992 |
| 5081114 | Steroids A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, ##STR2## alkyl and alkoxy of 1 to 12 carbon atoms, aryl and aryloxy of 6 to 12 carbon atoms and aralkyl and aralkoxy of 7 to 12 carbon atoms, R1... | 01/14/1992 |
| 5032586 | 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase. ... | 07/16/1991 |
| 4432905 | Simplified process for the degradation of steroid-C-22-carboxylic acids The degradation of steroid-C22-carboxylic acids to the C20-carbonyl steroids is carried out in simplified form and preferably without isolating intermediate reaction products by using 17(20)-steroid-22-carboxylic acids as starting material and directly ... | 02/21/1984 |
| 4416822 | 17ଲ-Difluoromethyl steroids 17ଲ-Difluoromethyl steroids are disclosed which have progestational, antiprogestational activity and which are useful as and male and female contraceptive agents.... | 11/22/1983 |
| 4405525 | Composition of matter and process The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.... | 09/20/1983 |
| 4333880 | 3-Oxo-pregna-1,14,17-trien-20-carboxylates and process A Ɗ1,4,17 -BNC compound having the formula: ##STR1## wherein X is a substituent selected from the group consisting of OH and OCH3 ; as well as its process of production by microbiological side-chain splitting of a 17-C-side-cha... | 06/08/1982 |
| 4255344 | 9--Hydroxy steroids 9-hydroxy-3-oxopregna-4,17(20)-diene-20-carboxylic acid and its methyl ester, and methods of microbiological production thereof, one comprising cultivating a Rhodococcus species in the presence of the corresponding 3-oxopregna-4,17(20)-diene-20-car... | 03/10/1981 |
| 4255345 | Steroid production The present invention discusses the production of useful steroids through starting with a steroid which has an acid side chain attached to the steroid ring structure. The present invention also describes and claims several novel compounds obtained through... | 03/10/1981 |
| 4252732 | Processing of steroids containing amino functionality The present invention describes the conversion of steroids having a 20-amino functionality to progesterone and other useful steroids.... | 02/24/1981 |
| 4252719 | Steroid conversion method and products produced thereby Method for the removal of selected tertiary hydrogen atoms from 5 -steroids of the cholestane, androstane and pregnane series by chlorination of 5 -steroids esterified with selected iodoaryl substituted esterifying agents which direct a chlo... | 02/24/1981 |
| 4252731 | Preparation of steroidal carbamates The present invention describes a process for converting the amides of certain steroids to the corresponding carbamates of the steroid.... | 02/24/1981 |
| 4251450 | Nitrogen transhalogenation process The present invention describes the transhalogenation of amido compounds to obtain the corresponding N-haloamide through the use of an N-haloimide.... | 02/17/1981 |
| 4197296 | Androstanes Steroids of the androstane series are described which possess a 3-hydroxy group, a 5- or 5ଲ- hydrogen atom, a 10- methyl group, an 11- substituted amino group. The 17-position may be unsubstituted or substituted by a methyl or e... | 04/08/1980 |
| 4119717 | 16-S-acyl derivatives of fusidic acid The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds, the new fusidic acid derivative... | 10/10/1978 |
