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| Number | Title | Issue Date |
| 7419972 | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of... | 09/02/2008 |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 6756366 | Orally active androgens Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the gro... | 06/29/2004 |
| 6673783 | Fusidic acid derivatives Novel 17,20-methanofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 01/06/2004 |
| 6593319 | Fusidic acid derivatives Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 07/15/2003 |
| 6562805 | Cosalane compounds and methods for their use The present invention relates to methods, compounds and compositions for inhibiting effective binding of a chemokine to its cellular receptor. In one form of the invention, a method includes contacting a cellular population with an effective amount of cos... | 05/13/2003 |
| 6541465 | Orally active androgens Novel, orally active androgens are 7-substituted Ɗ14 -nandrolone derivatives. The compounds satisfy the general formula: ##STR1## wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C... | 04/01/2003 |
| 6534490 | Unsaturated 14, 15-cyclopropanoandrostanes, method for the production thereof and pharmaceutical preparations containing said compounds Described are new, unsaturated 14,15-cyclopropano-androstanes of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are characterized ... | 03/18/2003 |
| 6388109 | 14,15-cyclopropano steroids of the 19-norandrostane series, method for the production thereof and pharmaceutical preparations containing said compounds Described are new 14,15-cyclopropano steroids of the 19-norandrostane series of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are... | 05/14/2002 |
| 5916975 | Process for epoxidising prochiral olefins and a catalyst therefor and intermediates for making the catalyst A process for enantioselectively epoxidising a prochiral olefin, which process comprises reacting a prochiral olefin with a source of oxygen in the presence of a salen catalyst and a source of an electron donating ligand, characterized in that the donor l... | 06/29/1999 |
| 5892069 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found belo... | 04/06/1999 |
| 5801165 | Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids Compounds of formula I ##STR1## where R1, R2, R3, R4, R5, R6, n, and are as defined herein, their use as antiinflammatory, immunosuppressive, and antiallergic agents, pharmaceutical c... | 09/01/1998 |
| 5439899 | Cosalane and related compounds having activity against aids and aids-related infections Novel compounds having anti-HIV activity are disclosed along with formulations and methods for treating human immunodeficiency viral infections employing these compounds.... | 08/08/1995 |
| 4970205 | Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5--reductase Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to redu... | 11/13/1990 |
| 4753932 | Novel 10-substituted steroids A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or --S-- and R is optionally substituted carbocyc... | 06/28/1988 |
| 4529547 | 17-(substituted thio)-17-(substituted dithio)androstenes Topical antiinflammatory activity is by steroids having the formula ##STR1## and the 1,2-dehydro derivatives thereof wherein R1 and R2 are the same or different and each is alkyl, aryl, arylalkyl or cycloalkyl; R3 is carbo... | 07/16/1985 |
| 4529548 | 17ଲ-(substituted thio)androstenes Antiinflammatory activity is exhibited by steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl; R2 | 07/16/1985 |
| 4528138 | 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro derivative thereof, wherein R1 is alkyl, mono-, di- or trifluoroalkyl, ##STR2## aryl or alkylthioalkyl, wherein R6 is alkyl ... | 07/09/1985 |
| 4499021 | 17ଲ(Substituted thio)-16-ketoandrostene-17..-carboxylic acid derivatives Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro derivative thereof wherein R1 is alkyl, cycloalkyl, aryl, alkanoyloxyalkyl or arylcarbonyloxyalkyl; R2 is alkoxy, aryloxy... | 02/12/1985 |
| 4481144 | 17-Substituted thia-17-alkyl(or alkenyl or alkynyl)androstenes Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro derivatives thereof, wherein R is hydrogen, alkyl, or aryl; R1 is hydrogen, alkyl, ##STR2## alkylthio, alkoxy, fluoro, hydroxyalkyl, c... | 11/06/1984 |
| 4447363 | Androstene-17-dithioketals Antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, 6,7-dehydro and 15,16-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, cycloalkyl, aryl, arylalkyl, or --CH2... | 05/08/1984 |
| 4446071 | Intermediates useful in the preparation of 17,17-bis(substituted thio) androstenes Androstenes having the formula ##STR1## wherein R1 hydrogen and R2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarbonylalkyl, carboxyalkyl, or arylalkyl, or R1 | 05/01/1984 |
| 4435326 | Intermediates useful in the preparation of 17,17-bis(substituted thio)androstenes Androstenes having the formula ##STR1## wherein R1 hydrogen and R2 is alkyl, cycloalkyl, aryl, arylalkyl, alkylthioalkyl, alkoxyalkyl, alkanoyloxyalkyl, aroyloxyalkyl, alkoxycarobnylalkyl, carboxyalkyl, or arylalkyl, or R1 | 03/06/1984 |
| 4427592 | Androstene-17-dithioketals Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the oth... | 01/24/1984 |
| 4420428 | 16-Ketoandrostene-17-dithioketals Steroids having the formual ##STR1## and the 1,2-dehydro and 6,7-dehydro derivatives thereof, wherein R1 and R2 are the same or different and each is alkyl, cycloalkyl or aryl; R3 is carbonyl, ଲ-hydroxymethylene... | 12/13/1983 |
| 4361559 | Antiinflammatory 17,17-bis (substituted thio) androstenes 3-Ketoandrostenes having in the 17-position the substituents R1 --S-- and R2 --S-- wherein R1 and R2 are the same or different and each is alkyl, cycloalkyl or aryl, have antiinflammatory activity.... | 11/30/1982 |
| 4315004 | Fusidic acid derivatives A method for treating arthritis which comprises administering to a subject in need of such treatment an effective amount of a fusidic acid derivative selected from compounds of the formula I: ##STR1## in which R1 stands for a straight or b... | 02/09/1982 |
| 4265815 | 17-(Substituted thio)androst-4-ene[16,17,-b]-[1,4]benzodioxin-3-ones Steroids having the formula ##STR1## are useful intermediates for the preparation of novel antiinflammatory agents having the formula ##STR2## In the above formulas, X is S, ##STR3## R1 is alkyl, aryl, arylalkyl or acyloxyal... | 05/05/1981 |
| 4252719 | Steroid conversion method and products produced thereby Method for the removal of selected tertiary hydrogen atoms from 5 -steroids of the cholestane, androstane and pregnane series by chlorination of 5 -steroids esterified with selected iodoaryl substituted esterifying agents which direct a chlo... | 02/24/1981 |
| 4252733 | 17-Substituted sulfonyl-16,16-disubstituted androstenes Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## wherein X is oxygen or sulfur; R1 is alkyl or aryl; R2 is alkyl or arylalkyl, or together the R2 groups are --(CH2) | 02/24/1981 |
| 4183924 | 17-Chloro-17ଲ-hydrocarbonsulfinyl-1,4-androstadienes and the corresponding 17ଲ-hydrocarbonsulfonyl derivatives and their use as anti-acne agents Novel 17-chloro-17ଲ-hydrocarbonsulfinyl and 17-chloro-17ଲ-hydrocarbonsulfonyl derivatives of 3-oxo-1,4-androstadienes and their use as anti-acne agents are described.... | 01/15/1980 |
| 4162259 | Fusidic acid derivatives Fusidic acid derivatives which possess anti-bacterial, antimicrobial and pharmacokinetic properties. These derivatives include, for example, 3,11-dihydroxy-16ଲ-(2'-methlyphenyl) thiofusida-13(17),24-dien-21-oic acid and pharmaceuticall... | 07/24/1979 |
| 4146538 | 17-Alkylthio (and arylthio) androsteno[17,16-b]benzopyran-3-ones and [16,17]naphthopyran-3-ones Steroids having the formula ##STR1## wherein X is -S-, ##STR2## R1 is alkyl, aryl or acyloxyalkyl; R2 is carbonyl or ଲ-hydroxymethylene; R3 is hydrogen or halogen; R4 is hydrogen, fluorine o... | 03/27/1979 |
| 4133811 | 13-Alkylthio (and arylthio)-11,17-epoxy-17-methyl-18-norandrostenes Steroids having the formula ##STR1## wherein X is --S--, ##STR2## R1 is alkyl or aryl; R2 is hydrogen or halogen; and R3 is hydrogen, fluorine or methyl; can be used as antiinflammatory agents.... | 01/09/1979 |
| 4119717 | 16-S-acyl derivatives of fusidic acid The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds, the new fusidic acid derivative... | 10/10/1978 |
| 4100276 | Fusidic acid derivatives The invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolyzable esters thereof, to the preparation of these compounds and to pharmaceutical compositions containing the compounds, the new compounds having the general for... | 07/11/1978 |
| 4091036 | 17-Alkylthio (and arylthio)-1',2',3',4'-tetrahydroandrosteno [16 , 17 -b]naphthalenes and derivatives pg,1 Steroids having the formula ##STR1## wherein X is ##STR2## R1 is alkyl, aryl or acyloxyalkyl; R2 and R3 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, ##STR3## hydr... | 05/23/1978 |
| 4060606 | 16-Ethers of fusidic acid derivatives The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds. The new compounds have the gene... | 11/29/1977 |
