Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7342004 | Thioether sulphamate steroids as steroid inhibitors and anti-cancer compounds There is provided use of a compound of Formula XI: wherein R3 is a sulphamate group and at least of R1 or R2 is a thioether group as disclosed by the present specification, capable of inhibi... | 03/11/2008 |
| 6673783 | Fusidic acid derivatives Novel 17,20-methanofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 01/06/2004 |
| 6593319 | Fusidic acid derivatives Novel 17,20-dihydrofusidic acid derivatives are used in pharmaceutical compositions for the treatment of infections, in particular in topical compositions for the treatment of skin or eye infections.... | 07/15/2003 |
| 6534490 | Unsaturated 14, 15-cyclopropanoandrostanes, method for the production thereof and pharmaceutical preparations containing said compounds Described are new, unsaturated 14,15-cyclopropano-androstanes of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are characterized ... | 03/18/2003 |
| 6388109 | 14,15-cyclopropano steroids of the 19-norandrostane series, method for the production thereof and pharmaceutical preparations containing said compounds Described are new 14,15-cyclopropano steroids of the 19-norandrostane series of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are... | 05/14/2002 |
| 6355630 | Estra-1,3,5(10)-triene-7-thioethers This invention provides estrogens and antiestrogens of formula I having the structure ##STR1## wherein X, Y, Z, and R are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof.... | 03/12/2002 |
| 6326503 | 16-ENE-vitamin D derivatives A compound having the formula (4): wherein ##STR1## X is oxygen or sulfur, R9 and R10 are each a hydrogen or a protecting group, and R11 is an aliphatic hydrocarbon, a --COR12 group where R12 is alkyl... | 12/04/2001 |
| 6143737 | Progesterone analogs to reverse multidrug resistance The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.... | 11/07/2000 |
| 5892069 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found belo... | 04/06/1999 |
| 5646316 | Bile acid inhibitors of metalloproteinase enzymes The present invention relates to a bile acid derivative, which comprises a bile acid derivatized at the carboxyl group with a hydroxamic acid or hydroxamate ester. The carboxyl group in the bile acid compound can also be derivatized with an amino acid or ... | 07/08/1997 |
| 5321019 | Bile acid sulfurated derivatives Compounds of formula I: ##STR1## in which the various R groups have the meanings defined in the disclosure are useful as medicaments for the treatment of hepatobiliary diseases.... | 06/14/1994 |
| 5093507 | 10ଲ,11ଲ-bridged steroids 10ଲ,11ଲ-bridged steroids of Formula I ##STR1## wherein R1 is H or methyl; R2 is H, a cyanide residue, a heteroaryl residue, a straight-chain or branched aliphatic, e.g., alkyl group of up to 20 carbon atoms, optionally ... | 03/03/1992 |
| 5086047 | Novel steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, option... | 02/04/1992 |
| 5034548 | Steroid derivatives useful as hypocholesterolemics Lanosterols substituted in the 14 and/or 15 position(s) which are active in inhibiting lanosta-8,24-dien-3ଲ-ol 14-methyl-demethylase activity, suppressing 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity, decreasing cholesterol... | 07/23/1991 |
| 4988684 | Novel 4-alkylthio-steroids A compound of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R1 is alkyl of 1 to 6 carbon atoms unsubstituted or substituted with at leas... | 01/29/1991 |
| 4987128 | Novel 10ଲ-alkynyl-steroids Novel 10ଲ-alkynyl-steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally substituted alkyl and alkoxy of 1 to 8 carbon atoms, optionally substituted alkenyl and alkynyl of 2 to 8 carbon atoms, o... | 01/22/1991 |
| 4913852 | Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with pregnane derivatives Compounds obtained from the associative synthesis of sulfur-containing or sulfur-free amino acids with derivatives of Ɗ-4-pregnene-3,20-dione or with derivatives of Ɗ-1,4-pregnadiene-3,20-dione of the general formulas (I), (II) and (III), having glucoco... | 04/03/1990 |
| 4822528 | 4-substituted 6-alkylidenandrosteine-3,17-dione derivatives and process for their preparation The invention relates to 4-substituted 6-alkylidenandrostene-3,17-dione derivatives of the following formula ##STR1## wherein each of R1, R2 and R3 is, independently, hydrogen or C1 -C6 alkyl; R | 04/18/1989 |
| 4753932 | Novel 10-substituted steroids A novel steroid of the formula ##STR1## wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or --S-- and R is optionally substituted carbocyc... | 06/28/1988 |
| 4745109 | Suicide inhibitors of aromatase Thiol-substituted synthetic steriod hormones or androgens having a testosterone ring system backbone are used to inhibit aromatase's catalyzed conversion of C19 androgens having a A4,3-ketone group to estrogens in the treatment of es... | 05/17/1988 |
| 4701449 | Novel 10-substituted steroids and their use in the induction of aldosterone antagonistic activity Novel 10-substituted steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl and substituted alkyl of 1 to 8 carbon atoms, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl of 2 to 8 carbon atom... | 10/20/1987 |
| 4603128 | Mineralocorticoid hormone antagonists 7-acylthio-4-pregnene-3,20-diones, active as mineralocorticoid hormone antagonists, of the formula: ##STR1## in which R1 is hydrogen, hydroxyl or acyloxy --OR2, R2 is an acyl group derived from a straight or br... | 07/29/1986 |
| 4502989 | Aldosterone-antagonistic steroids Novel spironolactone derivatives characterized by the C11 -C12 double bond which have a potent aldosterone-antagonistic activity without causing potassium loss, used alone in diagnosis and improvement of condition of primary aldoster... | 03/05/1985 |
| 4309423 | Compounds of the pregnane series with an oxygen function in the 19-position, processes for their manufacture and pharmaceutical preparations containing these compounds 19-Oxygenated steroid compounds of the pregnane series of the formula I ##STR1## in which R1 represents a hydrogen atom, and R2 represents an -oriented lower alkanoylthio group, or R1 and R2 together represent... | 01/05/1982 |
| 4261985 | Novel diuretics An advantageous diuretic action by excretion of water, sodium and chloride ions, with reduced excretion of potassium ions, is effected by combined administration of a 19-oxygenated steroid compound of the pregnane series of the formula ##STR1## ... | 04/14/1981 |
| 4192802 | Process for the manufacture of steroid carboxylic acid lactones An advantageous method for the manufacture of steroidal lactones of the spironolactone and canrenone type involves the following reaction sequence: bromination of a 3ଲ ,17-dihydroxy-17 -pregn-5-en-21-carboxaldehyde in basic or neutral medium,... | 03/11/1980 |
| 4192871 | Chemical compounds Pregnanes and androstanes are described which essentially possess a 3-hydroxy group, a 5-hydrogen atom or a 4.5- or 5,6-double bond, a 17-hydrogen atom and an 11ଲ-aminoester group. Other optional substituents or double bonds may... | 03/11/1980 |
| 4190593 | Cortisol radioimmunoassay method and cortisol derivatives useful therefor The cortisol compound of the formula (E) ##STR1## wherein R represents a hydroxy group, a tyrosine lower alkyl ester residue, a tyramine residue, a histamine residue, a 7-aminoheptanoyl-tyrosine lower alkyl ester residue, a radioiodinated tyrosi... | 02/26/1980 |
| 4180570 | 17ଲ-Hydroxy-4-androsten-3-ones and process for the preparation thereof Compounds of the formula I ##STR1## wherein R2 is hydrogen or an organic acid residue; R3 is methyl or ethyl; R4 is hydrogen or methyl; ##STR2## wherein R1 is lower alkyl; and ##STR3## and when ... | 12/25/1979 |
| 4150127 | Novel steroid compounds having an oxygen function in the 19-position Novel 19-oxygenated steroids of the 20-spiroxane series of the formula ##STR1## in which R3 is a lower alkyl radical carrying an oxygen-containing functional group and R4 is two hydrogen atoms or an oxo group, and which carry a ... | 04/17/1979 |
| 4118488 | 4-Androsten-3-ones and process for the preparation thereof 4-Androsten-3-ones of the formula ##STR1## wherein R1 is hydrogen or the acyl radical of an organic or inorganic acid, R2 is hydrogen, alkyl, or the acyl radical of an organic or inorganic acid, R3 is methyl or ethyl,... | 10/03/1978 |
| 4078059 | Novel 2,2-dimethyl steroids Novel 2,2-dimethyl steroids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, --OH and ##STR2## R1 is selected from the group consisting of hydrogen and hydrocarbon of 1 to 17 carbon atoms Z is selec... | 03/07/1978 |
| 4055603 | Alkinyl terminating groups in biogenetic-like cyclizations to steroids Polyenine compounds are provided having the naturally occurring geometry and a group which in the presence of acid initiates a carbocation cyclization to a steroid or A-nor-steroid structure, particularly the pregnane parent structure. The compounds are f... | 10/25/1977 |
| 4033988 | Derivatives of 17-hydroxy, 19-norpregn-4-ene-3,20-dione Derivatives of 3,20-diketo-17-hydroxy-19-norpregnene-4 and their method of preparation is described. These compounds are useful as progestationals, pituitary-suppresants, contraceptives, anti-androgens, anti-estrogens, anti-seborrehoeics and inhibi... | 07/05/1977 |
| 4031117 | Testosterone derivatives Testosterone-15 or ଲ-carboxyethyl thioether, 5-, dihydrotestosterone-15 or ଲ-carboxyethyl thioether related compounds and intermediates for preparation thereof. The compounds are conjugated to an immunological protein and ... | 06/21/1977 |
| 3989686 | Anaesthetic steroids of the androstane series and process for preparing same Anaesthetic steroids of the androstane and 19-norandrostane series are described, the steroids possessing a 3-hydroxy group, a 17-hydrogen atom and at the 17ଲ-position a --COSH or esterified --COSH group.... | 11/02/1976 |
| 3983111 | Steroidal anaesthetics of the pregnane and 19-norpregnane series Steroid anaesthetics of the pregnane and 19-norpregnane series are described, the steroids having a 3-hydroxy group, a 17-hydrogen atom, a 20-oxo group and at the 21-position a cyano, azido or basic amino group.... | 09/28/1976 |
| 3971777 | Novel steroids and their use Novel (17)-steroids derivatives optical active isomers or mixtures thereof of the formula ##SPC1## Wherein R is selected from the group consisting of hydrogen and methyl, R1 is alkyl of 1 to 4 carbon atoms, Z is selected from the group ... | 07/27/1976 |
| 3969345 | 20ଲ,21-Epoxy-3-hydroxy-5-pregnanes and derivatives thereof The invention provides 3-oxygenated pregnane 21-ethers possessing a hydroxy group in the 3-position; a hydrogen atom or a methyl group at the 10-position; a hydrogen atom in the 17-position; a keto group in the 20-position; and an eth... | 07/13/1976 |
| 3939260 | Therapeutic and cosmetic compositions Lyophilised oil-in-water emulsions and suspensions are useful as compositions for dermatological, cosmetological, buccal, and dental use having the advantage over conventional compositions of lower bulk and better storage stability.... | 02/17/1976 |
