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| Number | Title | Issue Date |
| 7205287 | Platinum complexes having antitumor activity A platinum complex having antitumor activity in which the metal ligands are dehydrocholic acid and phosphine. ... | 04/17/2007 |
| 7122533 | Cosalane compounds and methods for their use The present invention relates to methods, compounds and compositions for inhibiting effective binding of a chemokine to its cellular receptor. In one form of the invention, a method includes contacting a cellular population with an effective amount of cosalane or an... | 10/17/2006 |
| 6388108 | Aminosterol compounds and uses thereof Newly isolated aminosterol compounds and pharmaceutical compositions based on the aminosterol compounds are described. Methods for the treatment of various disorders, for example, a microbial infection, are also described.... | 05/14/2002 |
| 6140518 | Steroid bisphosphonates Bisphosphonate derivatives of hydroxy steroids which are bone resorption inhibitors or bone formation stimulators, the derivatives having at least one group A in place of a hydroxy group on the steroid molelcule, where A is a group of forumla (A) where X ... | 10/31/2000 |
| 5861390 | Steroid sulphatase inhibitors Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase inhibitors are phosphonate esters of formula (I) ##STR1## where... | 01/19/1999 |
| 5849724 | Microorganism of genus chrysosporium for use in preparing farnesyl transferase inhibitors A Chrysosporium strain No. CBS 123.95, mutants and derivatives thereof, and a method for preparing non-peptide compounds using said strain, are disclosed. Novel compounds of general formula (I), pharmaceutical compositions containing same, and the use of ... | 12/15/1998 |
| 5637691 | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants Compounds having a broad range of antimicrobial activity generally have a structure including asteroid nucleus with a cationic, preferably polyamine, side chain (X) and an anionic side chain (Y). The invention is also directed to compounds of the Formula ... | 06/10/1997 |
| 5610151 | Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives, processes for their preparation and the use of these compounds as medicaments Monomeric bile acid derivatives of the formula I Z--X--GS I, in which GS, X and Z have the meanings give... | 03/11/1997 |
| 5561124 | 17--acyl steroids which inhibit 5--reductase The invention relates to substituted 17-acyl steroidal 5-reductase inhibiting compounds. The invention also relates to pharmaceutical compositions containing these compounds and their use for reducing prostate size and treating prostate aden... | 10/01/1996 |
| 5541348 | Bile acids for biological and chemical applications and processes for the production thereof Novel bile acids according to the general formula ##STR1## wherein R1 represents a hydroxyl group, R2 and R3 both represent a hydrogen or a hydroxyl group, or R2 represents a hydroxyl group or a ଲ hyd... | 07/30/1996 |
| 5486603 | Oligonucleotide having enhanced binding affinity The present invention relates to an oligonucleotide or analog thereof conjugated to a molecule comprising a structure, which structure (a) is of substantially fixed conformation; (b) contains, is directly attached to, or is attached to a carbon atom that ... | 01/23/1996 |
| 5439899 | Cosalane and related compounds having activity against aids and aids-related infections Novel compounds having anti-HIV activity are disclosed along with formulations and methods for treating human immunodeficiency viral infections employing these compounds.... | 08/08/1995 |
| 5428181 | Bisphosphonate derivative A compound represented by the general formula: ##STR1## wherein A-O-denotes a residue of a compound having an estrogenic activity; R1 denotes H or a C1 -C6 alkyl group; X denotes a single bond, a C1 -C... | 06/27/1995 |
| 5391776 | Steroid derivatives Asteroid derivative of the general formula: ##STR1## wherein X--O-- represents a residue of steroid compound and --A-- represents --CO[NH(CHR1)y --(Y)p --CO]m NH--, --CO--(R2)x --(Z) | 02/21/1995 |
| 5232915 | 9-hydroxy-19,11ଲ-bridged steroids, their production and pharmaceutical preparations containing these steroids 9-Hydroxy-19,11ଲ-bridged steroids of general formula I ##STR1## are described. The more detailed meaning of A, B, R1, R2, G, Z, R4 --Y and R4' --Y' follows from the description. The steroids of... | 08/03/1993 |
| 5229376 | Encapsulated plant-derived phosphatidylinositol (PI) compositions for the prevention of mitogenically induced cell proliferation Encapsulated PI compositions such as liposomes containing plant PI and th use to prevent mitogenic transformation of normal splenic lymphoid cells (including lymphocytes transformed induced by treatment of cells with lipid A) by exposing the cells theret... | 07/20/1993 |
| 5215972 | Steroids Steroids of the formula ##STR1## wherein R1 to R4, X and n have the significance given in the description, which lower the intestinal resorption of cholesterol and plasma cholesterol and a process of making same from correspondi... | 06/01/1993 |
| 5183815 | Bone acting agents Described are new agents for treating bone disorders associated with a reduction in bone mass and abnormalities in bone resportion or bone formation including osteoporosis. Paget's disease, bone metastases and malignant hypercalcemia. The agents are hydro... | 02/02/1993 |
| 5116830 | Stereoisomerically pure 17-ethynyl-estra-2-en-17ଲ-ol and the 17ଲ esters thereof, methods of preparation and uses This invention relates to a stereoisomerically pure Ɗ2 compound of the formula (I): ##STR1## wherein: R1 is hydrogen or --(C.dbd.O)--R2, wherein: R2 is an organic substituent selected from the group consisting ... | 05/26/1992 |
| 5106963 | Phospholipid conjugates and their preparation Phospholipid conjugate compounds derived from cardiac glycosides and sters useful in liposome immunoassays are disclosed as well as their method of preparation.... | 04/21/1992 |
| 5026882 | Phosphinic acid substituted steroids as inhibitors of steroid 5-reductase The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-reductase.... | 06/25/1991 |
| 5002936 | Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds The present invention provides a composition with the structure (L)m (E)n wherein (L)m and (E)n are bound as a complex, wherein L is a lipophilic compound; wherein E is a nonlipophilic, ionic, inorganic ester of an o... | 03/26/1991 |
| 4999344 | Phosphatidyl treatment of rapidly proliferating cells Diacyl phosphatides having a polyunsaturated carboxylic acid at the 2 position are found to have cytotoxic effect against tumor cells. Subject compositions may be employed in vivo or in vitro for inhibiting tumor cell growth, either by themselves or in co... | 03/12/1991 |
| 4946834 | Phosphonic acid substituted steroids as steroid 5-reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-reductase. Also invented are intermediates used in prepari... | 08/07/1990 |
| 4937237 | Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase Invented are phosphinic acid substituted analogues of steroidal synthetic compounds, pharamaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5--reductase, including using these compounds to r... | 06/26/1990 |
| 4873233 | 17-Substituted androsta-1,4-dien-3-one derivatives The invention relates to new 17-hydroxy androsta-1,4-diene-3-one derivatives of the following formula ##STR1## wherein each of R and R3, independently, is hydrogen or C1 -C6 alkyl; R1 is hydrogen, halogen o... | 10/10/1989 |
| 4780455 | Lipophilic complexes of pharmacologically active organic compounds The present invention provides a composition with the structure wherein m and n are each integers, and m and n are different or the same; L is an ampholytic lipid or polymer, or a nonampholytic lipid with hydrophobic properties; E is a nonlipophilic ionic inor... | 10/25/1988 |
| 4680290 | Steroids for the treatment of hypercholesterolemia Steroids of the formula ##STR1## wherein n represents the number 2, 3 or 4; R1 represents hydrogen, lower-alkyl or lower-alkylidene; R2, R3 and R4 represent hydrogen or lower-alkyl and the dotted C--C bonds... | 07/14/1987 |
| 4659516 | Steroid derivatives A steroid derivative of the formula: wherein ST is a 7-linked steroid nucleus of the general formula: ##STR1## wherein the double bond(s) between carbon atoms 6 and 7 and/or carbon atoms 8 and 9 are optional; wherein the aromatic ring A may optiona... | 04/21/1987 |
| 4634695 | Steroid derivatives Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 01/06/1987 |
| 4602008 | Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent 16-Alkylated and 16-alkylated-7-hydroxy 5ଲ-androstan-3-ol-17-one, and the esters and ethers thereof, are used as an anti-diabetic, anti-obesity and erythropoietic agent in mammals.... | 07/22/1986 |
| 4592869 | Selective acylation process This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent being a carbamoyl halogenide, a 4-(tertiary amino)-pyridine, o... | 06/03/1986 |
| 4584136 | Process for preparing Estracyt compounds having a carcinostatic bound thereto An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH2 and OH, either directly or after reaction with an amine to... | 04/22/1986 |
| 4560557 | Silicon and sulfur steroids as irreversible inhibitors of hormone biosynthesis The compounds of the present invention are irreversible and highly selective inhibitors of the cytochrome P-450 cholesterol side chain cleavage (P-450scc) enzyme responsible for the first and rate limiting step of steroid hormone biosynthesis by the adren... | 12/24/1985 |
| 4550163 | Ligand analog-irreversible enzyme inhibitor conjugates The present invention encompasses a method for determining ligands in test samples comprising intermixing with the test sample a ligand analog-irreversible enzyme inhibitor conjugate and a binding protein bindable to the ligand and the ligand analog-irrev... | 10/29/1985 |
| 4525303 | Process for preparation of steroids A novel process for preparing a steroid of the following formula (to be referred to as compound .circle.13 ) is provided. ##STR1## This compound is known to have marked anti-inflammatory and anti-rheumatoid arthritic activity with very much reduced ... | 06/25/1985 |
| 4519946 | Steroids Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbons atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with th... | 05/28/1985 |
| 4501695 | Spironalactone process The present invention relates to processes for the conversion of a 3-protected steroidal 17-ketone to a 17-spiro-γ-lactone having the appropriate 17-stereochemistry for spironolactone. Novel intermediates (II, II', II", II'", IIa, IIb | 02/26/1985 |
| 4447424 | Steroid derivatives Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 05/08/1984 |
| 4438033 | Steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used New steroidal chiral phosphines of formula ##STR1## wherein R represents a phosphorated group selected between ##STR2## methods for their preparation; catalytic systems comprising metal complexes and the above steroidal chiral phosphines; asymme... | 03/20/1984 |
