Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7910755 | Stem cell expansion and uses The invention relates to methods to prevent, treat, ameliorate or slow the progression of one or more of a blood cell deficiency, unwanted inflammation, allergy, immune suppression condition, immunosenescence, autoimmune disorder, infection, neurological disorder, c... | 03/22/2011 |
| 7868193 | 16,17-carbocyclic condensed steroid compounds having selective estrogenic activity The invention discloses a steroid compound having the formula (1), wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C | 01/11/2011 |
| 7435757 | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C | 10/14/2008 |
| 7390875 | Method for binding, in solution, a peptide and a lipophilic vector and uses thereof The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the l... | 06/24/2008 |
| 7388003 | Δ-D-Homosteroids with androgenic action The invention relates to Δ15-D-homosteroids of general formula (I) process for their production and pharmaceutical compositions that contain these compounds. The compounds of general formula I according ... | 06/17/2008 |
| 7358379 | Steroid conjugates, preparation thereof and the use thereof Conjugates comprising one or more steroids conjugated with one or more mammalian proteins are disclosed. The conjugates are useful for diagnosis or treatment of solid cancer and hematological malignancies. Further the conjugates exhibit a synergistic action together... | 04/15/2008 |
| 7214384 | Lipid-conjugated polyamide compounds In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologica... | 05/08/2007 |
| 7169611 | Programmable genotoxic agents and uses therefor The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cell... | 01/30/2007 |
| 7112670 | Crystal form The present invention involves a novel crystal form of 17β-hydroxy-7α-(5′-methyl-2′-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, γ-lactone, having the formula which is an intermediate useful in pre... | 09/26/2006 |
| 7067504 | Di-steroidal prodrugs of ethinyl estradiol The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I: ... | 06/27/2006 |
| 7067505 | Di-steroidal prodrugs of estradiol The present invention is a di-steroidal prodrug of estradiol having the following formula: ... | 06/27/2006 |
| 7038041 | Selective nuclear receptor-targeted systems for delivery of cytotoxins to cancer cells for targeted photodynamic therapy An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The meth... | 05/02/2006 |
| 6982092 | Method of complexing a nucleic acid with a lipid-conjugated polyamide In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologica... | 01/03/2006 |
| 6888014 | Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sap... | 05/03/2005 |
| 6881728 | 14-β, 17-α-hydroxymethylandrostane derivatives as androgens Androgenic steroids having a (14β,17α-)-17-(hydroxymetheyl) configuration, useful for the preparation of male contraceptives and pharmaceutical formulations for the treatment of androgen insufficiency. ... | 04/19/2005 |
| 6844456 | Modified, hydroxy-substituted aromatic structures having cytoprotective activity The present invention is directed to modified, hydroxy-bearing aromatic ring structures having cytoprotective activity. More specifically, in a first embodiment the present invention is directed to phenolic compounds, and in particular steriods (e.g., estrogens), wh... | 01/18/2005 |
| 6753414 | Process for preparing saponin compounds A process for preparing compounds of formula (1): including the convergent steps as defined in the specification, and wherein R groups have any of the values defined in the specification. The invention also provides proc... | 06/22/2004 |
| 6670348 | Methods and compositions for destruction of selected proteins Compounds having an ansamycin anitibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic leading to the deg... | 12/30/2003 |
| 6664391 | N-fluorotriazinium fluorinating agents Novel N-fluorotriazinium electrophilic fluorinating agents have the Formula I: ##STR1## wherein three A moieties are independently CR, where each R is, independently, hydrogen, halogen, hydroxyl, (primary, secondary or tertiary) amino, amino, cyano, ... | 12/16/2003 |
| 6660725 | Method and composition for modulating amyloidosis Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include ... | 12/09/2003 |
| 6610866 | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces ... | 08/26/2003 |
| 6596885 | 19-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions Novel compounds having a formula selected from the group consisting of ##STR1## wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-prolife... | 07/22/2003 |
| 6572881 | Lipid-conjugated polyamide compounds and related compositions and methods thereof In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for deliverin... | 06/03/2003 |
| 6569450 | Lipid-conjugated polyamide compounds and related compositions and methods thereof In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for deliverin... | 05/27/2003 |
| 6500669 | Programmable genotoxic agents and uses therefor The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts dam... | 12/31/2002 |
| 6468981 | Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors A water soluble delivery system for nucleic acids to cells having androgen receptors, preferably prostate cells, is provided comprising a steroid moiety capable of binding to said receptors, said steroid moiety being covalently linked to a polycationic ma... | 10/22/2002 |
| 6407270 | Methods for manufacturing betulinic acid The present invention provides a method for preparing an ester of betulin at the 3-position, e.g., betulin-3-acetate, including the selective alcoholysis of a betulin-3,28-diester, e.g., betulin-3,28-diacetate; a method for preparing betulin-3-acetate inc... | 06/18/2002 |
| 6322784 | Adipogenic differentiation of human mesenchymal stem cells A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into t... | 11/27/2001 |
| 6313327 | Carboxylic acid derivatives and their synthesis method This invention relates to novel carboxylic acid derivatives represented by the following formula I and their synthesis: ##STR1## wherein, R1 is an hydrogen atom, an alkyl group or an alkoxy group of 1 to 20 carbon atoms in a linear, branched or... | 11/06/2001 |
| 6303589 | Pentacyclic triterpenes The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.... | 10/16/2001 |
| 6232481 | Method for manufacturing betulinic acid The present invention provides a method for preparing betulin-3-acetate including alcoholyzing betulin 3,28-dibenzoate; a process for preparing betulin-3-acetate including: (1) acylating betulin to provide betulin 3,28-dibenzoate and (2) alcoholyzing betu... | 05/15/2001 |
| 6197332 | Lipid-conjugated polyamide compounds and related compositions and methods thereof In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for deliverin... | 03/06/2001 |
| 6177417 | Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof The present invention relates to a cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the following formula 1, process for preparation and use thereof. The cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the present invent... | 01/23/2001 |
| 6175035 | Method of producing betulinic acid A method of producing betulinic acid from the bark of plane trees by fractional extraction with a solvent of medium polarity and subsequent recrystallization out of methanol.... | 01/16/2001 |
| 6174665 | Hormone replacement therapy monitoring The present invention provides methods for monitoring the effectiveness of hormone replacement therapy in a perimenopausal, early menopausal, or late menopausal woman, comprising testing for hormonal levels in a body fluid of the woman at intervals depend... | 01/16/2001 |
| 6127140 | Assay for quantitative measurement of analytes in biological samples A method for determining concentration of an analyte in a biological sample comprising the steps of: (a) combining the biological sample, at least one oxidizing enzyme for the analyte of interest, nicotinamide adenine dinucleotide (hereinafter NAD+ | 10/03/2000 |
| 6087090 | Methods for predicting drug response Methods are provided for formulating models for predicting whether subjects will respond to a particular drug or treatment regimen. Biochemical profiles are obtained (by measuring a variety or biochemical parameters) for a test group before and after trea... | 07/11/2000 |
| 6046186 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use Novel compounds useful as inhibitors of estrone sulfatase are provided. The compounds have the structural formula (I) wherein r1 is an optional double bond, R1 and R2 are selected from the group consisting of hydrogen and lower alky,... | 04/04/2000 |
| 6043026 | Combination therapy for the prevention and treatment of osteoporosis The combination of an estrogen receptor modulator and a growth hormone secretagogue is useful in the treatment or prevention of diseases involving bone resorption, especially osteoporosis.... | 03/28/2000 |
| 6025332 | Method for treating low circulating levels of sex hormone steroids associated with aging using IGF or IGF/IGFBP-3 Methods are provided for treating or alleviating the symptoms of subjects with psychological disorders, metabolic disorders, chronic stress-related disorders, sleep disorders, conditions associated with sexual senescence, aging, or premature aging by trea... | 02/15/2000 |
