Did You Know...
...that the Eveready Battery began as an invention called the "electric flowerpot," which was a tube with a battery and light bulb inside? The idea was to fasten this gizmo to the side of a flowerpot so it would illuminate the flowers from the bottom. The idea died on the vine and the businessman who licensed the flower pot, Conrad Huber, was left with a pile of useless tubes -- until he found a way to market them as batteries to light the world!
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| Number | Title | Issue Date |
| 7365087 | Oxazole derivatives of tetracyclines This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents. ... | 04/29/2008 |
| 7214669 | Tetracycline derivatives and methods of use thereof A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives. ... | 05/08/2007 |
| 7067681 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reac... | 06/27/2006 |
| 6562615 | Apparatus for the preparation of chlortetracycline-containing animal feed compositions The present invention provides improved chlortetracycline-containing animal feed compositions and processes and apparatuses for their preparation. In certain embodiments, raw fermentation broth comprising chlortetracycline is divided into two portions. Th... | 05/13/2003 |
| 5594158 | Processes for producing doxorubicin, daunomycinone, and derivatives of doxorubicin Daunomycinone is a known precursor of the well known antibiotic and antineoplastic, doxorubicin. Daunomycinone may be synthesized by preparing mono ketal of a 1,4-naphthoquinone as the precursor of the CD rings of daunomycinone followed by preparing a pre... | 01/14/1997 |
| 5495032 | Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R3, R4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted w... | 02/27/1996 |
| 5495031 | Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with ... | 02/27/1996 |
| 5488119 | Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R1 to R4 are H or a substituent such as phenylthio, and one of the substituents R1, R2, R3 and R4... | 01/30/1996 |
| 5401863 | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines Novel 9-amino-7-(substituted amino)-6-demethyl-6-deoxytetracyclines having activity against a wide spectrum of organisms including organisms which are resistant to tetracyclines are disclosed. Also disclosed are intermediates and methods for making the no... | 03/28/1995 |
| 5387703 | Process and intermediate for the purification of oxytetracycline The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is suspended under stirring oxytetracycline hydrochloride, or ... | 02/07/1995 |
| 5218130 | 4-substituted anthracyclinones and their preparation 4-substituted anthracyclinones of formula (I) ##STR1## wherein R represents a hydrogen atom or a straight or branched alkyl, alkenyl or alkynyl group having from 1 to 10 carbon atoms, are intermediates in the preparation of antitumor anthracycline gl... | 06/08/1993 |
| 5202449 | Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline A process for purifying 7-dimenthylamino-6-demethyl-6-deoxytetracycline represented by the following formula, ##STR1## which comprises dissolving 7-dimethylamino-6-demethyl-6-deoxytetracycline or its hydrochloride having a lower purity in a mixed sol... | 04/13/1993 |
| 5180758 | Process for preparing anthracyclinones 4-substituted anthracyclinones of general formula (I): ##STR1## wherein R represents a hydrogen atom or a COOR1 group in which R1 may be a hydrogen atom or an optionally substituted C1 -C10 alkyl group, whi... | 01/19/1993 |
| 5049683 | Process for the production of alpha-6-deoxytetracyclines A process for the preparation of alpha-6-deoxytetracyclines from the corresponding 6-methylenetetracyclines is described using a silica-supported heterogeneous rhodium catalyst: ##STR1## The process stereospecifically produces the alpha epimers at hi... | 09/17/1991 |
| 5015745 | Process for the preparation of 4-demethoxydaunomycinone, the aglycone of 4-demethoxy-daunorubicin 4-Demethoxy-daunomycinone I: ##STR1## the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyl-daunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound with an amine, removi... | 05/14/1991 |
| 4997959 | Process for the production of alpha-6-deoxytetracyclines A process for the hydrogenation of a 6-methylenetetracycline in the production of alpha-6-deoxytetracycline, particularly the antibiotic doxycycline, in the presence of a transition metal complex of the formula MClx (PPh3)y | 03/05/1991 |
| 4960913 | Process for the preparation of pharmaceutical compositions The invention relates to a process for the preparation of tetracycline derivatives of the formula ##STR1## and acid addition salts thereof --wherein R stands for --CH3 or .dbd.CH2 --by dehalogenating and hydrogenating chlorometh... | 10/02/1990 |
| 4939282 | The process for preparing 6-deoxynthracyclines A new process for the preparation of 6-deoxyanthracyclinones of general formula I: ##STR1## wherein R represents a hydrogen atom, a hydroxy group or a lower alkoxy group is described. The process provides a total synthesis of the 6-deoxyanthracy... | 07/03/1990 |
| 4918208 | Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline A process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) which comprises treating the reaction liquid containing minocycline and formaldehyde with hydroxylamine or urea, the reaction liquid being obtained after reductive methyl... | 04/17/1990 |
| 4680338 | Bifunctional linker A selective bifunctional sequential linker has the formula wherein Q is a homoaromatic or heteroaromatic ring system; A is a single bond or an unsubstituted or substituted divalent C1-30 bridging group; Y is O or S; and Z is Cl, Br, I, N3... | 07/14/1987 |
| 4584135 | Process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth The invention relates to a process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth. By the process according to the invention the valuable antibiotic oxytetracycline may be separated from the fermentation broth i... | 04/22/1986 |
| 4579686 | Process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride The invention relates to a new process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride. According to the process of the invention, the crude, dry or filter-wet oxytetracyclin hydrochloride consisting of needle-shaped crystals i... | 04/01/1986 |
| 4418060 | Therapeutically active complexes of tetracyclines Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar excess in respect to the tetracycline compound. The complexes h... | 11/29/1983 |
| 4066694 | 4-Hydroxy-4-dedimethylamino-tetracyclines 4-Dedimethylaminotetracyclines and the corresponding 5a,6-anhydro derivatives having an oxo, hydroxy, substituted imino, amino or substituted amino group other than dimethylamino at the C.multidot.4-position useful as antimicrobial agents. The 4-oxo-... | 01/03/1978 |
| 4061676 | Recovery of doxycycline and products thereof The present invention provides a process for the recovery of doxycycline and products thereof.... | 12/06/1977 |
| 3993694 | Tetracycline derivatives and process for preparing them Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## Methods of making the same; pharmaceutical compositions containing the same.... | 11/23/1976 |
| 3986927 | Process for the purification and sterilization of acidophilic biologicals by extreme acidification at cold temperatures Methods of sterilizing biologicals in which the biologicals are acidified to a pH of not higher than about 1.0, preferably 0.75 to about 0.5, and the acidified biologicals are stored at cold temperatures for a perod of time sufficient to inactivate microb... | 10/19/1976 |
| 3947517 | Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic ... | 03/30/1976 |
