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| Number | Title | Issue Date |
| 8168810 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. ... | 05/01/2012 |
| 8106225 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precu... | 01/31/2012 |
| 7705168 | Manufacturing process for tigecycline Disclosed herein is a manufacturing process for the preparation of tigecycline suitable for intravenous infusion. ... | 04/27/2010 |
| RE40183 | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula wherein R, X, R5 and R6 are defined in the specification. The compounds of the invention ... | 03/25/2008 |
| 7214669 | Tetracycline derivatives and methods of use thereof A treatment for inhibiting microbial or tumor growth is disclosed, which comprises adding to a subject in need of treatment an effective amount of one or more tetracycline derivatives. ... | 05/08/2007 |
| 7208482 | 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): ... | 04/24/2007 |
| 7132111 | Odorless formulation for treating mucosal discontinuities The present invention includes a method for making a formulation for treating mucosal discontinuities, comprising: providing phenolic compounds and treating the purified phenolic compounds with sulfuric acid to make sulfonic acids and sulfonate salts. The present in... | 11/07/2006 |
| 7067681 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reac... | 06/27/2006 |
| 7067505 | Di-steroidal prodrugs of estradiol The present invention is a di-steroidal prodrug of estradiol having the following formula: ... | 06/27/2006 |
| 7067504 | Di-steroidal prodrugs of ethinyl estradiol The present invention is a di-steroidal prodrug of ethinyl estradiol according to formula I: ... | 06/27/2006 |
| 7056902 | 4-dedimethylamino tetracycline compounds The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well a... | 06/06/2006 |
| 7001918 | 7-pyrrolyl tetracycline compounds and methods of use thereof A compound of Formula (I): wherein variables R, R1, R2, R3 and A are as defined in the ... | 02/21/2006 |
| 6946453 | 4-dedimethylaminotracycline derivatives The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include ... | 09/20/2005 |
| 6894036 | 4-dedimethylaminotetracycline derivatives The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include ... | 05/17/2005 |
| 6818635 | 7-substituted tetracycline compounds The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known ap... | 11/16/2004 |
| 6683068 | 7, 9-substituted tetracycline compounds The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applicat... | 01/27/2004 |
| 6638922 | 4-dedimethylaminotetracycline derivatives The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compoun... | 10/28/2003 |
| 6617318 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to 7-phenyl substituted tetracycline derivatives and compositions thereof.... | 09/09/2003 |
| 6165999 | Tetracycline derivatives The present invention relates to novel tetracycline derivatives, to intermediates used in their preparation, to pharmaceutical compositions containing them and to their medicinal use.... | 12/26/2000 |
| 6028207 | Bone resorption inhibition/osteogenesis promotion compound A compound represented by the following formula (I): X--Y--Z (I) where Y is represented by the following formulae: ##STR1## X is a monovalent group of a tetracycline type compounds and Z is a monoent gro... | 02/22/2000 |
| 5932437 | Control of lyme disease spirochete A method is described for controlling the spread of Lyme Disease spirochete from rodents which have been infected. The method involves orally administering to the rodents a composition which includes an antibiotic (e.g., tetracycline) which is capable of ... | 08/03/1999 |
| 5641762 | Bone targeted inhibitors of carbonic anhydrase The present invention relates to novel compounds useful for the treatment and prophylaxis of degenerative bone disorders and to the preparation thereof. These compounds are particularly characterized by two active moieties, the first of which possesses "b... | 06/24/1997 |
| 5538954 | Salts of tetracyclines A salt of sucrose-octa-O-sulfonic acid and a tetracycline useful in inhibiting protein synthesis of bacteria.... | 07/23/1996 |
| 5495031 | Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with ... | 02/27/1996 |
| 5494903 | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula ##STR1## wherein R, X, R5 and R6 are defined in the specification. The compounds of the invention are useful a... | 02/27/1996 |
| 5495032 | Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R3, R4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted w... | 02/27/1996 |
| 5488119 | Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R1 to R4 are H or a substituent such as phenylthio, and one of the substituents R1, R2, R3 and R4... | 01/30/1996 |
| 5387703 | Process and intermediate for the purification of oxytetracycline The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is suspended under stirring oxytetracycline hydrochloride, or ... | 02/07/1995 |
| 5202449 | Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline A process for purifying 7-dimenthylamino-6-demethyl-6-deoxytetracycline represented by the following formula, ##STR1## which comprises dissolving 7-dimethylamino-6-demethyl-6-deoxytetracycline or its hydrochloride having a lower purity in a mixed sol... | 04/13/1993 |
| 5003097 | Method for the sulfurization of phosphorous groups in compounds A method is disclosed for the sulfurization of a phosphorus containing compound, which comprises: solubilizing the phosphorous containing compound and then contacting the phosphorous containing compound, with a sulfur containing compound of the solution f... | 03/26/1991 |
| 5001243 | Substituted naphthacene-5, 12-diones Naphthacene-5,12-diones which are substituted by at least one organic thio radical are not only photoinitiators for the photopolymerization but also sensitizers for the photodimerization of ethylenically unsaturated compounds. Compositions made of these n... | 03/19/1991 |
| 4990636 | Process for the production of alpha-6-deoxytetracyclines and hydrogenation catalyst useful therein A coordination compound useful as a hydrogenation catalyst, having the formula: ##STR1## wherein Ph is phenyl; R is hydrogen or C1 -C4 alkyl; and X is chloro, bromo or iodo. This compound is particularly useful as a homogen... | 02/05/1991 |
| 4743699 | Homogeneous catalytic system and a process for the preparation of same A homogeneous stereospecific rhodium complex hydrogenation catalyst is prepared using a degassed organic solvent and eventually water.... | 05/10/1988 |
| 4581166 | Method for isolating and purifying antibiotics A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0° to 40° C. and at a pressure which lies between the critical pressure and ... | 04/08/1986 |
| 4550096 | Homogeneous catalytic system comprising rhodium, hydrazine and phosphine and a process for the preparation of same Stable homogeneous hydrogenation catalysts are prepared by reacting a rhodium salt or complex with a hydrazine in the presence or absence of a tertiary phosphine.... | 10/29/1985 |
| 4418060 | Therapeutically active complexes of tetracyclines Tri-tetracyclines are complexes of tetracyclines with an amino compound containing per molecule at least a tris (hydroxyalkyl) group and at least a primary or secondary amino group in a molar excess in respect to the tetracycline compound. The complexes h... | 11/29/1983 |
| 4160783 | 4-Dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines Novel 4-dedimethylamino-4-arylsulfonamido-5a,6-anhydrotetracyclines of the general formula I ##STR1## wherein R stands for C1 -C3 -alkyl, halogen or --NHCOR1, R1 being C1 -C3 -alkyl.... | 07/10/1979 |
| 4060605 | Water-soluble derivative of 6-deoxy-tetracyclines This invention relates to a novel water soluble derivatives of 6-deoxy-tetracyclines, particularly of doxycycline, in which a methionine group is linked to the tetracycline group through a methylene bridge, thus obtaining a derivative which is not only wa... | 11/29/1977 |
| 3993694 | Tetracycline derivatives and process for preparing them Antibacterially-active tetracyclines, substituted at the amide group, and physiologically-tolerable salts thereof, said tetracyclines having the formula ##SPC1## Methods of making the same; pharmaceutical compositions containing the same.... | 11/23/1976 |
| 3991111 | N-alkenyltetracycline derivatives N-alkenyltetracycline derivatives, for example, N-(1-methyl-2--naphthylethenyl)tetracycline represented by the formula ##SPC1## The compounds have excellent antibacterial action as compared with tetracycline.... | 11/09/1976 |
