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| Number | Title | Issue Date |
| 7365132 | Monomers containing polyoxyalkylenes and polymer supports therefrom A polymer support is provided which comprises protected hydroxypolyC2-4 alkyleneoxy chains attached to a cross-linked polymer wherein the protected hydroxypolyC2-4 alkyleneoxy chain contains from 2 to 10 C2-4 alkyleneoxy groups and w... | 04/29/2008 |
| 7173125 | Triphosphate oligonucleotide modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligon... | 02/06/2007 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 6031117 | Boronic acid containing phosphoramidite reagents The present invention provides arylboronic acid reagents useful for incorporation into modified oligonucleotides and polynucleotides. The modified oligonucleotides and polynucleotides thus produced are useful in bioconjugation reactions for the immobiliza... | 02/29/2000 |
| 6028103 | Triaryl methane compounds and analogues thereof useful for the treatment or prevention of sickle cell disease or diseases characterized by abnormal cell proliferation The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted triaryl methane co... | 02/22/2000 |
| 5922890 | Organic compounds New trityl linkers for use in solid phase synthesis comprise compounds of formula II ##STR1## wherein R4 is alkyl (e.g. C1-4 alkyl), halogen, NO2, or hydrogen; Z is a coupling group chosen from acylamido, acyloxy, ami... | 07/13/1999 |
| 5726329 | Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R1 and R2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined togeth... | 03/10/1998 |
| 5665877 | Synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 09/09/1997 |
| 5614647 | Intermediates for the synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 03/25/1997 |
| 5557002 | Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin... | 09/17/1996 |
| 5541347 | Synthesis of bisindolylmaleimides The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because i... | 07/30/1996 |
| 5391785 | Intermediates for providing functional groups on the 5' end of oligonucleotides Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R1 and R2 are individually alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, or aryl of 6 to 20 carbon atoms or are joined togeth... | 02/21/1995 |
| 5359100 | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays which comprise (1) at least one first single-stranded oligonucleotide unit that is complementary to a single-stranded oligonucleotide sequence of interest, and (2) a m... | 10/25/1994 |
| 5332845 | Phosphorylating reagents Novel phosphorylating reagents are provided which are useful in DNA synthesis and purification procedures. The reagents are substituted phosphines which are particularly useful in the phosphorylation of nucleoside and solid supported oligonucleotides at t... | 07/26/1994 |
| 5306837 | Intermediates for an optically active cyclobutane nucleoside Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1,2ଲ,3)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one are described.... | 04/26/1994 |
| 5256806 | Intermediates for the preparation of optically active cyclobutane nucleoside Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1,2ଲ,3)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one are described.... | 10/26/1993 |
| 5252760 | Method of using colored phosphorylating reagents A method of phosphorylating a nucleoside or an oligonucleotide chain having a free 2', 3' or 5' hydroxyl moiety is provided. The method involves the use of a phosphorylating reagent which is selected such that the extent of phosphorylation can be monitore... | 10/12/1993 |
| 5189188 | Bis(triarylmethane) compounds Compounds of the general formula ##STR1## in which the symbols have the meaning given in the description, are highly suitable as color formers in recording materials based on acid developers. They give deep blue, green-blue, green, violet or red shad... | 02/23/1993 |
| 5189164 | Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium... | 02/23/1993 |
| 4983759 | Process for the production of 3,5,6-trihydroxyhexanoic acid derivative A compound of a 3,5,6-trihydroxyhexanoic acid derivative of the formula: ##STR1## wherein P1 and P2 are independently hydrogen atoms or hydroxy-protecting groups, or together form a ring, and R is an alkyl group is effectively p... | 01/08/1991 |
| 4923641 | Highly concentrated stable solutions of color-forming agent: for pressure-sensitive recording materials Highly concentrated stable solutions of color-forming agents of the general formula ##STR1## wherein x denotes hydroxyl, alkoxy, alkenyloxy, aralkoxy, cycloalkoxy, aryloxy, acyloxy, alkylamino, dialkylamino, acylamino, aralkylamino or arylamino ... | 05/08/1990 |
| 4870199 | Processes for the synthesis of diprotected R[R*,S*]-3,5-dihydroxy-6-oxohexanoate esters Process for the synthesis of compounds of the formula ##STR1## in R[R*,S*] enantiomeric form, wherein each P1 is independently an hydroxy group-protecting group, and R2z is C1-4 alkyl, benzyl or allyl, comprising, as a key... | 09/26/1989 |
| 4783196 | Highly concentrated stable solutions of color-forming agents: for pressure-sensitive recording materials Highly concentrated stable solutions of color-forming agents of the general formula ##STR1## wherein x denotes hydroxyl, alkoxy, alkenyloxy, aralkoxy, cycloalkoxy, aryloxy, acyloxy, alkylamino, dialkylamino, acrylamino, aralkylamino or arylamino... | 11/08/1988 |
| 4734225 | D-mannite derivatives as starting products for the synthesis of phospholipids The mannite derivatives have the formula (1) wherein R' and R2, idenal or different, represent when they are identical a straight or branched alkyl, alkenyl or alkynyl group containing from 5 to 24 atoms of carbon which may be substituted by a... | 03/29/1988 |
| 4666633 | Process for preparing triarylmethyl methacrylate A triarylmethyl methacrylate is produced by reacting methacrylic acid with a triarylmethylating agent in an inert, organic solvent containing therein an excess amount of an amine or in the presence of an anion exchanger.... | 05/19/1987 |
| 4658044 | Intermediates for uracil derivatives Compounds of formula (C) ##STR1## where either RD represents a hydroxymethyl group and RE represents a hydroxyl group or RD represents a protected hydroxymethyl group and RE represents a protected hydroxyl ... | 04/14/1987 |
| 4622180 | Derivatives of glycerophosphocholine and glycerophosphoethanolamine, their preparation and their use The invention relates to new triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine of the general formula ##STR1## in which T denotes a triphenylmethyl group which is unsubstituted or monosubstituted or ... | 11/11/1986 |
| 4598160 | Intermediate phenolic compounds for the catalytic synthesis of chromans A catalytic synthesis of chromans in racemic or optically active forms, including intermediates thereto; the synthesis employs an asymmetric palladium (II) catalyzed oxidative cyclization of a 2-homoallylphenol and provides intermediates useful in making ... | 07/01/1986 |
| 4439365 | Novel hydroxy substituted prostanoic acids, esters, congeners, intermediates and process This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.... | 03/27/1984 |
| 4410720 | 16-Fluoro prostaglandins 11-Unsubstituted 16-fluoro-prostaglandin E2 useful as blood pressure lowering agents.... | 10/18/1983 |
| 4405530 | Process for preparing fluorinated amino-nitriles Certain -(fluoromethyl or difluoromethyl)--aminoacetonitriles are prepared by treating the appropriate -(fluoromethyl or difluoromethyl) ketimine magnesium halide with hydrogen cyanide or with an alkali metal cyanide or ammonium cyani... | 09/20/1983 |
| 4396775 | Homoserine aldehyde derivatives for mugineic acids synthesis This invention is related to homoserine aldehyde derivatives represented by the formula (I) which is important intermediate for producing mugineic acid, 2'-deoxymugineic acid, avenic acid A and homologue. ##STR1##... | 08/02/1983 |
| 4390721 | 3-Endo-protected hydroxyl-tricyclo[3,2,0,02,7 ]heptan-6-ones A novel 3-endo-protected hydroxyl-tricyclo[3,2,0,02,7 ]heptan-6-one is described which can be alkylated stereospecifically to give a 5-endo-protected hydroxyl-bicyclo[2,2,1]heptan-2-one which may then be converted via a sequence of reactions in... | 06/28/1983 |
| 4296042 | Preparation of unsaturated aliphatic insect pheromones using cyclic phosphonium ylids This process relates to the synthesis of unsaturated aliphatic esters useful as insect sex attractants, including gossyplure, the insect sex pheromone of the pink bollworm moth, Pectinophora gossypiella, and intermediates therefor. The process utilizes a ... | 10/20/1981 |
| 4246426 | 11-Substituted prostaglandins 11-Substituted prostaglandins E1, E2 and F2 useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.... | 01/20/1981 |
| 4227019 | 11-Substituted prostaglandins 11-Substituted prostaglandins E1, E2 and F2 useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.... | 10/07/1980 |
| 4211436 | Pressure-sensitive recording material A pressure-sensitive and heat-sensitive recording material contains color-forming agents of the formula ##STR1## wherein R1 denotes hydrogen or a non-ionic radical which is free from amino groups, R2 denotes hydroxyl, alkylamino... | 07/08/1980 |
| 4187381 | 16-Substituted prostaglandins A process for producing optically active 16-substituted prostaglandins and new 16-substituted prostaglandins produced thereby which are useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnan... | 02/05/1980 |
| 4179451 | Novel hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters This disclosure describes certain hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters useful as hypotensive agents, anti-ulcer agents, bronchodilators, anti-microbial agents, anticonvulsants, or as intermediates.... | 12/18/1979 |
| 4165331 | 11-(2-Hydroxyethylthio)prostenoic acid E series derivatives This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.... | 08/21/1979 |
