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| Number | Title | Issue Date |
| 8153823 | 2-alkenyl-3-aminothiophene derivative and process for producing thereof Disclosed is a method for commercially producing 2-alkenyl-3-aminothiophene derivatives, which are useful as intermediates for agricultural chemicals, at low cost. Specifically disclosed is a method for introducing alkenyl groups into the 2-position of 3-aminothioph... | 04/10/2012 |
| 7923571 | Process for preparing substituted 2-alkoxycarbonyl-3-aminothiophenes The present invention relates to a process for preparing 4-alkoxycarbonyl-3-aminothiophenes of the general formula (I) and/or their hydrochlorides of the formula (I)′ | 04/12/2011 |
| 7799935 | Crystalline duloxetine hydrochloride Crystalline duloxetine hydrochloride, compositions containing the same and methods for the production thereof. ... | 09/21/2010 |
| 7795455 | Crystalline duloxetine hydrochloride Crystalline duloxetine hydrochloride, compositions containing the same and methods for the production thereof. ... | 09/14/2010 |
| 7795454 | Crystalline duloxetine hydrochloride Crystalline duloxetine hydrochloride, compositions containing the same and methods for the production thereof. ... | 09/14/2010 |
| 7524973 | Nitrate esters of phenylaminothiophenacetic acid derivatives The compounds of formula I in which R1, R2, R3, R4 and R5 have the meanings as given in the description are novel effective antiinflammatory compounds. ... | 04/28/2009 |
| 7423170 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 09/09/2008 |
| 7423061 | Substitute thiophenes and uses thereof This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cancer. ... | 09/09/2008 |
| 7388012 | (Hydrazido)(amino)thiophene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, ... | 06/17/2008 |
| 7351841 | Heterocyclic compounds and thrombopoietin receptor activators A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C | 04/01/2008 |
| 7300956 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analog... | 11/27/2007 |
| 7192535 | Conjugated molecule and electroluminescent device thereof and electronic device having the electroluminescent device It is intended to provide a novel material having no absorption or low absorption intensity in the visible region and to provide an electroluminescent device excellent in hole injection characteristic by using the novel material. A novel organic material wherein two... | 03/20/2007 |
| 7179836 | Chemical compounds Thiophene derivatives are described herein. The described invention also includes methods of making such thiophene derivatives as well as methods of using the same in the treatment of diseases. ... | 02/20/2007 |
| 7173030 | Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and fo... | 02/06/2007 |
| 7166639 | NF-κB inhibitors The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-κB in ... | 01/23/2007 |
| 7153980 | Thiophene-containing compound and thiophene-containing compound polymer The present invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are useful for organo-electronic devices such as electrophotographic photoreceptors (photosensitive elements), organic electroluminescent elements and ... | 12/26/2006 |
| 7129363 | Conductive compound, electrode and sensor containing the same, and target molecule detection method using the sensor A conductive compound of formula (I) below, an electrode coated with the conductive compound, a sensor including the electrode, and a target molecule detection method using the sensor are provided: wherein Y is a... | 10/31/2006 |
| 7126013 | Mono-, oligo- and polymers comprising fluorene and aryl groups Mono-, oligo- or polymers comprising at least one 9-H,H-fluorene group and at least one arylene group are suitable for use as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors, electrolum... | 10/24/2006 |
| 7102016 | Preparation of 2,2′-di(3,4-ethylenedioxythiophene)s The invention relates to a process for preparing compounds of the general formula (I) to novel compounds of this substance class and also to their use as important precursors or for preparing important precursors... | 09/05/2006 |
| 7084178 | Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's... | 08/01/2006 |
| 7084171 | Compounds and therapies for the prevention of vascular and non-vascular pathologies The invention provides a method of treating a mammal having, or at risk of, an indication associated with a TGF-beta deficiency comprising administering one or more agents that is effective to elevate the level of TGF-beta. The invention also provides novel compound... | 08/01/2006 |
| 7064122 | Pancreatic lipase inhibitor compounds, their synthesis and use The subject invention features compounds having the structure: wherein X is O, S, CH2 or NR5; Y is O or S; R1 is H, substituted or unsubstituted C1-C15 alkyl, C | 06/20/2006 |
| 7026094 | Substituted oxime derivatives and the use thereof as latent acids New oxime sulfonate compounds of the formula (I) and (II), wherein R1 is C1-C12alkyl, C1C4haloalkyl, hydrogon, OR9, NR10R11, SR12 or is phenyl which is unsubstituted o... | 04/11/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 7012094 | Substituted furans and furanones for the treatment of inflammation A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin... | 03/14/2006 |
| 6984737 | Di(het)arylaminothiophene derivatives The invention relates to novel 2-(N,N-di(het)arylamino)-thiophene derivatives of formula (I), wherein R1, R2, R3, R4 and R5 are, independently each of other, each a monofunctional (het)aryl system and wherein R | 01/10/2006 |
| 6962929 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/08/2005 |
| 6881735 | Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically a... | 04/19/2005 |
| 6858223 | Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS) A composition comprising a combination of a compound of formula I in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt thereof, and lung surfactant is useful for treating patien... | 02/22/2005 |
| 6849738 | Processes for the production of thienopyrimidine derivatives The present invention provides a process for producing an intermediate for thienopyrimidine derivatives having the GnRH antagonistic activity at an industrial large scale. The process for production of the present invention relates to a process for producing ... | 02/01/2005 |
| 6841669 | Functionalized thiophene oligomers and their use as fluorescent markers Thiophene oligomers which are excitable in the visible and ultraviolet region and each having at least one functional group able to form a covalent bond with organic and/or biological molecules, so as not to alter either the fluorescence properties of the oligomers ... | 01/11/2005 |
| 6840965 | P-aminophenols and colorants containing said compounds The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination co... | 01/11/2005 |
| 6835745 | Phenyl substituted thiophenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specificat... | 12/28/2004 |
| 6822118 | Process for the hydrogenation of imines A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts and with or without an inert solvent, wherein the reaction mixture contains an ammonium or metal chloride, bromide or iodide and additionally an acid... | 11/23/2004 |
| 6818775 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 11/16/2004 |
| 6794521 | Process for the preparation of 2-nitrothiophene selectively from thiophene using metal exchanged clay catalysts The present invention provides an ecofriendly process for the preparation 2-nitrothiophenes selectively from thiophene, using metal exchanged clay catalysts and nitric acid, dispensing with the use of acetic anhydride. ... | 09/21/2004 |
| 6680337 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl de... | 01/20/2004 |
| 6677341 | (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and m... | 01/13/2004 |
| 6660769 | N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of γ-aminobutyric acid activity and for treating nervous disorders and preparation method The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO2, an SO, ... | 12/09/2003 |
| 6620767 | Pesticidal n-heteroaryl alpha-alkoximino-carboxamides The invention relates to compounds of the general formula ##STR1## wherein R1 is hydrogen, halogen, C1 -C6 -alkyl, C1 -C6 -alkoxy, C1 -C6 -haloalkyl or unsubstituted or mono- to ... | 09/16/2003 |
