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| Number | Title | Issue Date |
| 8183391 | Process for preparing dorzolamide A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide campho... | 05/22/2012 |
| 7385066 | Thiophene sulfoximines, compositions thereof, and methods of treating complement-mediated diseases and conditions Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. The compounds are of Formula I or a solvate, hydrate, pharmaceutically acceptabl... | 06/10/2008 |
| 7354936 | 2-phenylpyran-4-one derivatives The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses. ... | 04/08/2008 |
| 7205440 | Method of producing amines The invention relates to a special two-step method for producing amines on the basis of amides by reacting them with halides or hypohalites in an aqueous solution in a Hofmann degradation reaction. The amide is reacted in an alkaline solution and/or suspension with ... | 04/17/2007 |
| 7012094 | Substituted furans and furanones for the treatment of inflammation A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin... | 03/14/2006 |
| 6924276 | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors The invention provides dicarboxylic acid-substituted heteroaryl derivatives of the formula G1-(C(R1)R2)n-Q1-B-Q2-(C(R3)R4)m-G2 I or... | 08/02/2005 |
| 6878723 | LTA4 hydrolase inhibitors The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications. ... | 04/12/2005 |
| 6797723 | Heterocycle substituted diphenyl leukotriene antagonists The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases. ... | 09/28/2004 |
| 6734207 | Cytotoxic compounds Compounds are described that bind to tubulin causing tubulin depolymerization and inhibiting tubulin polymerization. The compounds of the invention are therapeutically effective to inhibit cellular proliferation, for example, as effective anti-cancer agents. The com... | 05/11/2004 |
| 6686478 | Thienylsulphonylamino(thio)carbonyl compounds The invention relates to novel thienylsulphonylamino(thio)carbonyl compounds of the formula (I), ##STR1## in which Q represents oxygen or sulphur, R1 represents cyano, halogen or in each case optionally cyano-, halogen- or C1 -C... | 02/03/2004 |
| 6670485 | Prostanoic acid derivatives as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; ... | 12/30/2003 |
| 6642180 | Biphenyl-substituted cyclic ketoenols as pesticides The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which W represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, X repre... | 11/04/2003 |
| 6566375 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula ##STR1## wherein: R | 05/20/2003 |
| 6566366 | Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists Compounds of the formula ##STR1## and salts thereof wherein the substituents are defined as in accordance with the specification useful for the treatment of tumor growth, osteoporosis, inflammation and cardiovascular disorders.... | 05/20/2003 |
| 6482947 | Substituted (hetero) aryl compounds, process for their preparation, agents containing them and their use as safeners Compounds of the formula I and their salts, as defined in claim 1, are suitable as safeners for protecting crop plants against the phytotoxic side-effects of herbicides.... | 11/19/2002 |
| 6465060 | Tetrahydrothiophene derivatives, and their use in liquid-crystalline mixtures Tetrahydrothiophene derivatives of the formula (I) R1 --X--(A1 --M1)a --(A2 --M2)b --A3 --Y--T--Z--R2 (I) where the symbols and indices have the following meanings, ... | 10/15/2002 |
| 6455573 | Glycosidase inhibitors and methods of synthesizing same A method for synthesizing Salacinol, its stereoisomers, and non-naturally occurring selenium and nitrogen analogues thereof having the general formula (I): ##STR1## The compounds are potentially useful as glycosidase inhibitors. The synthetic schemes... | 09/24/2002 |
| 6376682 | Compound with -glucosidase inhibiting action and method for producing the same A compound expressed by chemical structural formula: ##STR1## having the characteristic of specifically inhibiting the activity of -glucosidase (an enzyme that breaks down disaccharides, etc.) at the intestinal level. The compound is obtained by ex... | 04/23/2002 |
| 6333346 | Ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H)-thiophenones as antitumor agents The present invention relates to ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H0-thiophenones for the treatment of tumors.... | 12/25/2001 |
| 6323315 | Dolastatin peptides The present invention provides compounds of the formula ##STR1## where R1 -R5 are each, independently, a hydrogen atom or a normal or branched C1 -C6 -alkyl group; A is a methionyl, phenylalanyl or phenylglycyl ... | 11/27/2001 |
| 6310067 | Urocanic acid derivatives Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R2 denotes hydrogen or lower alkyl, R3 denotes nitro, amino, cyano or C... | 10/30/2001 |
| 6303569 | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: ##STR1## wherein: B is H, OH, OSiR13, a residue of an amine-containing target moiety or a resi... | 10/16/2001 |
| 6262101 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovis replication, asthma, and inflammatory condi... | 07/17/2001 |
| 6248773 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-heteroarylalk(en)yl derivatives as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: ##STR1## wherein the hatch... | 06/19/2001 |
| 6166074 | Pharmaceutical compositions Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and -alkoxyarylidene e... | 12/26/2000 |
| 6156788 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 12/05/2000 |
| 6121202 | Thienyloxypyridines and-pyrimidines useful as herbicidal agents The present invention provides a herbicidal compound of formula I, methods for the preparation thereof and intermediates useful therefor. ##STR1## wherein X and Y are each independently O or S; Z is N or CR4.... | 09/19/2000 |
| 6068834 | Skin lightening compositions This invention relates to compositions, compounds and methods for lightening skin, using active compounds having the structure: ##STR1## wherein: (i) each X is, independently, selected from the group consisting of halo, alkyl, substituted alkyl, aryl... | 05/30/2000 |
| 6060493 | Phenyl benzyl ethers, process for producing them and their use as pesticide and fungicide A compound of the general formula I ##STR1## where the indices and the substituents have the following meanings: R1 is C(CO2 CH3).dbd.CHOCH3, C(CO2 CH3).dbd.NOCH3, N(OCH | 05/09/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 6051679 | Self-acid-doped highly conducting polythiophenes The invention relates to thiophenes bearing (ω-sulfonate)alkoxy or (ω-sulfonic acid)alkoxy groups and water-soluble polythiophenes bearing (ω-sulfonic acid)-alkoxy side-chains prepared therefrom. The invention also relates to methods for the preparatio... | 04/18/2000 |
| 6048895 | Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R1, R2, R3, R4, X, and Z are as de... | 04/11/2000 |
| 6040328 | Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use The objects of the present invention are: novel organoselenium compounds: aromatic diselenides and selenosulphides; the use of said novel compounds as antioxidant agents; pharmaceutical compositions containing them; a method of preparation of said novel compounds. Said ... | 03/21/2000 |
| 6030993 | 2-hydroxypropionic acid derivative and its manufacturing method This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so that the derivative ... | 02/29/2000 |
| 6004948 | Derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II ##STR1##... | 12/21/1999 |
| 6004994 | Heterocyclic diarylmethylene derivatives, methods of preparing them and their uses in therapeutics The present invention relates to compounds of the formula: ##STR1## and their use in therapeutics, especially as medicaments with anti-inflammatory and analgesic properties.... | 12/21/1999 |
| 5981496 | -pyrones for treating -pyrone responsive states Novel -pyrones are described. The -pyrones are useful in a method for controlling -pyrone responsive states in a mammal. The method includes administering to a mammal a therapeutically effective amount of an -pyrone such that c... | 11/09/1999 |
| 5977173 | Aromatic C16 -C20 -substituted tetrahydro prostaglandins useful as FP agonists The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R1, R2, R3, R4, X, Y, and Z are de... | 11/02/1999 |
| 5972950 | 1,2-diarylmethylene derivatives, their methods of preparation and their uses in therapeutics The present invention relates to the derivatives of formula: ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.... | 10/26/1999 |
| 5945444 | 3-aryl-4-hydroxy-Ɗ3 -dihydrothiophenone derivatives The present invention relates to novel 3-aryl-4-hydroxy-Ɗ3 -dihydrothiophenone derivatives of the formula (I) ##STR1## in which A, B, G, S, X, Y, Z and n have the meaning given in the description, to processes for their preparation, to no... | 08/31/1999 |
