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| Number | Title | Issue Date |
| 7994346 | Intermediates for the preparation of lipoxin Aanalogs This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 an... | 08/09/2011 |
| 7838693 | Process for the preparation of 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-gamma-lactone The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-γ-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepa... | 11/23/2010 |
| 7763743 | Intermediates for the preparation of lipoxin Aanalogs This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 an... | 07/27/2010 |
| 7709665 | Processes for producing a fluorosulfonyl group-containing compound and a compound LED from the fluorosulfonyl group-containing compound A fluorosulfonyl group-containing compound having a high polymerization reactivity, a process for its production, a sulfonyl group-containing polymerizable monomer led from the sulfonyl group-containing compound, and a polymer obtainable by polymerizing the sulfonyl... | 05/04/2010 |
| 7498451 | Obtaining an aliphatic dialdehyde Monoacetal The invention relates to a process for obtaining a pure aliphatic dialdehyde monoacetal by reaction of the corresponding aliphatic dialdehyde or a precursor of the corresponding aliphatic dialdehyde with one or more aliphatic mono- or polyhydric alcohols while disti... | 03/03/2009 |
| 7192968 | Ethylenediamine derivatives The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent H... | 03/20/2007 |
| 6962767 | Acetal compound, polymer, resist composition and patterning process Acetal compounds in which a 5- or 6-membered ring acetal structure is connected to a norbornene structure through a linker represented by —(CH2)m— in which one hydrogen atom may be substituted with a hydroxyl or acetoxy group, and m is from... | 11/08/2005 |
| 6844375 | 4-methylene-1,3-dioxolanes as cross-linking agents The invention relates to: 4-methylene-1,3-dioxolanes of the general formula (I) wherein R1 denotes hydrogen, C5-C6-cycloalkyl or C1-C4-alkyl; m and n, which may be the same o... | 01/18/2005 |
| 6803488 | Process for producing fluorinated ketone The present invention provides a process whereby fluorinated ketones of various structures can be produced by short process steps and which is useful as an industrial production process. Namely, it is a process for producing a fluorinated ketone of the follow... | 10/12/2004 |
| 6753127 | Norbornene-based copolymer for photoresist, preparation method thereof, and photoresist composition comprising the same Disclosed is an norbornene-based copolymer for photoresist, a preparation method thereof, and a photoresist composition comprising the same. The copolymer of the present invention exhibits high transparency to light of 193 nm wavelength and an excellent etching resi... | 06/22/2004 |
| 6624177 | Matrix metalloproteinase inhibitors and their therapeutic uses The present invention relates to a method of inhibiting matrix metalloproteinases using compounds that are dibenzofuran sulfonamide derivatives having the Formula I ##STR1## More particularly, the present invention relates to a method of treating dis... | 09/23/2003 |
| 6610892 | Process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals The invention relates to a process for preparing 2,7-dimethyl-2,4,6-octatrienal monoacetals of the general formula I ##STR1## which comprises a) condensing an ester phosphonium salt of the general formula II or an ester phosphonate of the general form... | 08/26/2003 |
| 6569810 | Cyclopentane-1,3-dione derivatives The present invention relates to novel bicyclic cyclopentane-1,3-dione derivatives of the formula (I) ##STR1## to a process for their preparation and to their use as pesticides and herbicides.... | 05/27/2003 |
| 6515150 | Cyclic acetal compound, polymer, resist composition and patterning process Cyclic acetal compounds of formula (1) wherein k=0 or 1 and n is an integer of 0 to 6 are novel. Using the cyclic acetal compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy... | 02/04/2003 |
| 6486331 | Substituted alkylketo compounds and process Substituted alkylketo compounds of the formula ##STR1## can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds... | 11/26/2002 |
| 6462076 | Beta-amino acid nitrile derivatives as cathepsin K inhibitors The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated wi... | 10/08/2002 |
| 6395911 | Process for cis-1{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine This invention provides an improved process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy] ethyl}pyrrolidine which is an intermediate for the preparation of (-)cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5,6,7,8-tet... | 05/28/2002 |
| 6388104 | 4-methylene-1,3-dioxolanes having functional groups Novel 4-methylene-1,3-dioxolanes of the general formula I ##STR1## in which R1 denotes hydrogen or alkyl, X denotes a single bond, C1 -C18 alkylene, cycloalkylene, arylalkylene, --CH2 (OCH2 CH2)n... | 05/14/2002 |
| 6376683 | Process for the preparation of (4R,6S)-4-hydroxy-6-hydroxymethyl-tetrahydropyran-2-one The present invention relates to an improved, efficient and enantio-selective process for the synthesis of (4R, 6S)-4-hydroxy-6-hydroxymethyl tetrahydropyran-2-one, employing the Sharpless asymmetric dihydroxylation and regiospecific nucleophilic hyd... | 04/23/2002 |
| 6355812 | Methods for the synthesis of dioxoalkanoic acid compounds The invention relates to improved methods of producing aryl dioxoalkanoic acid compounds and derivatives useful as intermediates for diarylpyrrole therapeutic agents by the alcoholysis of benzoylcyclohexanone ketal compounds.... | 03/12/2002 |
| 6251937 | 5,6-0-alkylidene glucono-1(4)-lactones and derivatives, processes for their preparation and uses thereof The invention relates to cleavable surfactants of formula: ##STR1## in which R' and R, which may be identical or different, represent a hydrogen atom or a linear or branched, saturated or unsaturated alkyl radical, the sum of the carbon atoms of R' and R ... | 06/26/2001 |
| 6214859 | Ethylamine derivatives Ethylamine derivatives of the formula (I): ##STR1## (wherein R1 is hydrogen, hydroxyl, lower alkoxy or halogen; R2 is alkyl having 2 to 5 carbon atoms; R3 is hydrogen, alkyl having 2 to 5 carbon atoms, alkylcarbonyl having... | 04/10/2001 |
| 6184376 | Synthesis of acyclic nucleoside derivatives Methods and novel intermediates of the formula: ##STR1## wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are --CH2 CH2 --, --CH2 CH2 CH2 | 02/06/2001 |
| 6051711 | Synthesis of swainsonine salts A method for synthesizing swainsonine salts and intermediates thereof comprising subjecting a compound of the formula I ##STR1## wherein R2 and R2' are the same or different and represent alkyl, halogen, alkenyl, alkoxy, cycloa... | 04/18/2000 |
| 6001994 | Process for making gemcitabine hydrochloride An improved process to make gemcitabine hydrocrhloride, the improvement consisting essentially of making the lactone intermediate, 2-deoxy-2,2-difluoro-D-erythro-pentafuranose-1 ulose-3,5-dibenzoate: ##STR1## from D-erythro-2-Deoxy-2,2-difluoro 4,5-O... | 12/14/1999 |
| 6001535 | Monomers with cyclic carbonate groups Monomers with cyclic carbonate groups of the formula I are suitable for the production of photosensitive recording materials, for example for the production of offset printing plates ##STR1## in which A means an (n+m)-valent hydrocarbon residue with ... | 12/14/1999 |
| 5998633 | Process for the synthesis of protected esters of (S)-3,4-dihydroxybutyric acid The invention is an improved process for the preparation of a compound of formula I wherein R and R1 are each independently alkyl of from 1 to 3 carbon atoms; and R2 is alkyl of from 1 to 8 carbon atoms. ##STR1##... | 12/07/1999 |
| 5994379 | Bisaryl COX-2 inhibiting compounds, compositions and methods of use The present invention relates to inhibitors of COX-2, compositions which contain such compounds and methods of use. The compounds are represented by formula I: ##STR1## and include pharmaceutically acceptable salts and esters thereof.... | 11/30/1999 |
| 5942632 | Solid phase synthesis method A solid phase synthesis method and intermediates useful in the process are disclosed for the preparation of diamino diol and diamino alcohol inhibitors of HIV protease.... | 08/24/1999 |
| 5925759 | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the novel inventive int... | 07/20/1999 |
| 5912366 | , -Difluoro-ଲ-hydroxy thiol esters and their synthesis ,-Difluoro-ଲ-hydroxy thiol esters of Formula (III): ##STR1## wherein: Rc and Rd are independently selected from the group consisting of H, C1 -C6 alkyl, substituted C1 -C6 | 06/15/1999 |
| 5837725 | Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R1, R2, R3, R4, R5 and n are as defined herein. The novel compounds are useful for modulating gene expression of ... | 11/17/1998 |
| 5824484 | RXR homodimer formation The invention provides a method of screening a substance for the ability to effect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the presence of homodimer... | 10/20/1998 |
| 5801258 | Amide derivatives and dermatologic preparations containing the same The amide derivative of the present invention is one represented by the following general formula (I) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R1 represents a strai... | 09/01/1998 |
| 5756775 | Process to make ,-difluoro-ଲ-hydroxyl thiol esters A process to make ,-difluoro-ଲ-hydroxy thiol esters of formula (IIIA) ##STR1## comprising reacting a difluoroethanethioate of formula (IVA) ##STR2## with a second reactant selected from the group consisting of aldehydes, ... | 05/26/1998 |
| 5741810 | Cyclopentane heptan(ene)oic acid, 2- heteroarylalkenyl derivatives as therapeutic agents The present invention provides to cyclopentane heptanoic acid, 2 heteroaryl alkyl or alkenyl derivatives which may be substituted in the 1-position with hydroxyl, alkyloxy, amino and amido groups, e.g. 1-OH cyclopentane heptanoic acid, 2 heteroarylalkenyl... | 04/21/1998 |
| 5739376 | Fullerene derivatives, methods of preparing them and their use Fullerene derivatives, methods of preparing the same and methods of using the same, wherein the fullerene derivatives are of the formula I ##STR1##... | 04/14/1998 |
| 5659052 | Amide derivatives and dermatologic preparations containing the same The amide derivative of the present invention is one represented by the following general formula (II) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R11 represents a str... | 08/19/1997 |
| 5602262 | Process for the preparation of 2-deoxy-2,2-difluoro-ଲ-D-ribo-pentopyranose A process for producing intermediate compounds 2-deoxy 2,2-difluoro-ଲ-D-ribo-pentopyranose (III) from 3,3-difluoro-4,5,6-O-trihydroxy-5,6-O-(1-ethylpropylidene)hexene (I). The process of preparing intermediate compound (I) involves reacting D-g... | 02/11/1997 |
| 5585373 | 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a b... | 12/17/1996 |