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| Number | Title | Issue Date |
| 7361685 | Compounds for use in the treatment of skin conditions The present invention provides compounds of formula (I) and analogues or derivatives thereof for the treatment of skin conditions, such as Vitiligo, which are treatable by the stimulation of melanocyte proliferation and also for treating skin cancer. The compounds m... | 04/22/2008 |
| 7345068 | Aromatic amino acid derivatives and medicinal compositions 1. An aromatic amino acid derivative represented by the formula (I) or its pharmacologically acceptable salt: wherein, R1 is a hydrogen atom or an amino-protecting group, ... | 03/18/2008 |
| 7169907 | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 01/30/2007 |
| 7122561 | Treatment of skin conditions The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives the... | 10/17/2006 |
| 7060847 | Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA im... | 06/13/2006 |
| 7033401 | 3-Aminophenol derivatives substituted in the 2-position, and dyes containing these compounds The 3-aminophenol derivatives of formula (I), or the physiologically compatible, water-soluble salts thereof: wherein R1 represents a group of formula (II) or a group of formula (III): | 04/25/2006 |
| 7019024 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof. ... | 03/28/2006 |
| 7019028 | Endiandric acid H and its derivatives, process for their preparation and use thereof The invention relates to compounds of the formula (I) process for their preparation starting from the plant Beilschmiedia fulva, PLA 101037, and the use thereof for producing a medicament, in particular for the t... | 03/28/2006 |
| 6890955 | Aryloxypropanolamine derivatives, method of preparation and applications thereof The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with th... | 05/10/2005 |
| 6787559 | Sulfonamide compounds This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds. ... | 09/07/2004 |
| 6780998 | Substituted 2-aminoalkyl-1,4-diaminobenzene compounds and oxidation dye precursor compositions containing same The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substitu... | 08/24/2004 |
| 6680391 | Treatment of skin conditions The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or deri... | 01/20/2004 |
| 6677456 | Pentacyclic taxan compound This invention is to provide a novel taxol derivative useful as an antitumor compound having respective substituent groups, represented by the following formula (I) which can be orally administered ##STR1##... | 01/13/2004 |
| 6492394 | Sulfonamide hydroxamates A compound of the Formula (I): ##STR1## wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceu... | 12/10/2002 |
| 6342532 | Inorganic ion receptor active compounds The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium o... | 01/29/2002 |
| 6319944 | Aryl amidines, compositions containing such compounds and methods of use Compounds represented by formula I: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof, are disclosed. Pharmaceutical compositions and methods of treatment are also included.... | 11/20/2001 |
| 6274613 | Cyclic imines as pesticides The invention relates to novel cyclic imines of the formula (I) ##STR1## in which Ar1 and Ar2 each represent substituted phenyl and n represents 1, to a process for their preparation and to their use as pesticides.... | 08/14/2001 |
| 6255528 | Process for preparing phenethylamines and novel chemical compounds Fluorine-containing phenethylamines are obtained in an advantageous manner by reacting fluorine-containing bromobenzenes with acrylamide in the presence of a palladium catalyst, hydrogenating the resulting arylacrylamides catalytically and then rearrangin... | 07/03/2001 |
| 6232475 | Process for preparing fluorine-containing phenethylamines and novel fluorine-containing ଲ-iminovinyl-and ଲ-iminoethylbenzenes The present invention relates to a process for preparing fluorine-containing phenethylamines which is characterized in that, in a first step, a substituted bromobenzene is reacted with an N-vinylimide in the presence of a palladium catalyst, in a second s... | 05/15/2001 |
| 6162810 | Inadone and tetralone compounds for inhibiting cell proliferation A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationa... | 12/19/2000 |
| 6001884 | Calcium receptor-active molecules The present invention features molecules which can modulate one or activities of an inorganic ion receptor. Preferably, the molecule can mimic or block the effect of extracellular Ca2+ on a calcium receptor. The preferred use of such molecules... | 12/14/1999 |
| 5998410 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 12/07/1999 |
| 5955492 | Carboxylic acid indole inhibitors of chemokines This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 09/21/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5932749 | Asymmetric synthesis of R--propyl-piperonyl amine and its analogs Processes for the preparation of R--propyl-piperonyl amine and its analogs, such compounds being useful intermediates in the preparation of elastase inhibitors, and intermediates useful for making R--propyl-piperonyl amine are described.... | 08/03/1999 |
| 5739166 | Substituted terphenyl compounds for the treatment of inflammation A class of terphenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R2 and R3 is independently sel... | 04/14/1998 |
| 5723473 | Propenoic acid derivatives useful as fungicides A fungicidal compound of formula (I): ##STR1## wherein A is hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4 alkoxycarbony... | 03/03/1998 |
| 5686474 | Acetylene derivatives and crop protection agents containing them Acetylene derivatives of the general formula I ##STR1## where U, V and W are hydrogen, halogen, nitro, cyano, alkyl or alkoxy, A is alkylidene, alkoxymethylidene, alkylthiomethylidene or alkoximino, B is OH, alkoxy or alkylamino and R is hydrogen, halogen, cya... | 11/11/1997 |
| 5686633 | Inks, particularly for ink jet printing Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R1, R2, R3, R4, R3 ' and R4 ' are as defined in claim... | 11/11/1997 |
| 5536853 | Opiate receptor ligands Compounds of Formula 1 bind opioid receptors: ##STR1## wherein X and Y are each independently ##STR2##... | 07/16/1996 |
| 5493032 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R1 -Z1 in which Z1 is a leaving group, or with an aldehyde produces compounds of formula I ##S... | 02/20/1996 |
| 5480908 | ଲ3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions The invention is antiobesity/antidiabetes beta-3 agonists of the formula: ##STR1## wherein Ar, X, R2, R3, Y and n are as defined in the specification.... | 01/02/1996 |
| 5451596 | Cycloalkyl amine bis-aryl squalene synthase inhibitors This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol... | 09/19/1995 |
| 5420273 | Condensed heterocyclic compounds The invention relates to compounds of the formula ##STR1## wherein R1 is hydrogen, acyl, lower-alkyl or --CHO, --CH2 OR10, --COR7 or OR13 ; R2, R3 and R4 are, ind... | 05/30/1995 |
| 5393774 | Phenylethanolamines, pharmaceutical compositions containing these compounds and process for preparing them The invention relates to phenylethanolamines of general formula ##STR1## wherein R1 and R2 are defined as in claim 1, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, not only ... | 02/28/1995 |
| 5380878 | Benzo[b]thiophen-5-yl derivative and process for producing the same This invention relates to a process for producing a compound represented by formula (6a) or (6b): ##STR1## wherein R2 represents a hydrogen atom or a hydroxyl-protecting group and R4 and R5, which may be the same or d... | 01/10/1995 |
| 5356924 | Pesticidal benzodioxole Compounds of the general formula: ##STR1## wherein R1 and R2 each independently represents a halogen atom or an alkyl, alkoxy, haloalkyl, haloalkoxy, alkoxycarbonyl, alkenoxy, cyano or nitro group; R3 and R4 | 10/18/1994 |
| 5302724 | Antitumor compositions and methods of treatment This invention provides certain sulfonamide compounds, formulations and method of use of certain sulfonamide compounds in treating susceptible neoplasms.... | 04/12/1994 |
| 5294638 | Phenyalkylaminoalkyl compounds and pharmaceutical compositions containing them Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4, n represents 2-5, R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and... | 03/15/1994 |
| 5194628 | Process for the preparation of substituted difluorobenzo-1,3-dioxoles The reaction of 2,2-difluorobenzo-1,3-dioxole with (a) an alkali metal or an alkali metal compound and then (b) a compound R1 -Z1 l in which Z1 is a leaving group, or with an aldehyde produces compounds of formula I #... | 03/16/1993 |
