Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7390613 | Photoactive compounds The present application relates to a compound of formula Ai Xi Bi where Ai and Bi are each individually an organic onium cation; and Xi is anion of the formula −O3S—CF2CF2OCF2CF2—SO3 | 06/24/2008 |
| 7384974 | 4,5-dihydronaphtho[1,2-b]thiophene derivative A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 a... | 06/10/2008 |
| 7332615 | Hydrophilic analogs of 4,8-dihydrobenzodithiophene-4,8-diones as anticancer agents The present invention discloses hydrophilic derivatives of 4,8-dihydrobenzodithiophene-4,8-diones, which are active as anticancer agents, along with pharmaceutical formulations containing the same. ... | 02/19/2008 |
| 7101905 | Pharmaceutically active compounds and methods of use New fused thiophene compounds are provided and methods of using those compounds for a variety of therapeutic indications. Compounds of the invention are particularly useful for treatment of neuropathic pain. ... | 09/05/2006 |
| 6693136 | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) ##STR1## are novel P2X3 and P2X2 /P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.... | 02/17/2004 |
| 6605632 | Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them The invention concerns compounds of formula (I): R--A--R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the desc... | 08/12/2003 |
| 6602901 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ... | 08/05/2003 |
| 6509499 | Nitromethylthiobenzene derivatives as inhibitors of aldose reductase The invention concerns novel compound of general formula (1) in which: P, T1, T2, X and n are as defined in claim 1, their tautomeric forms, and their additive salts with pharmaceutically acceptable bases. The invention also concerns... | 01/21/2003 |
| 6423870 | Tricyclic compounds, preparation method and pharmaceutical compositions containing same The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4 ; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2... | 07/23/2002 |
| 6403809 | Compounds for electronic devices The present invention provides a compound or complex comprising at least two moieties, each moiety being comprised of two or more thiophenes fused directly to each other. Also provided is a method for the production of the compounds of the present inventi... | 06/11/2002 |
| 6337346 | Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents Compounds useful as cytotoxic agents are selected from the group consisting of compounds of Formula I and compounds of Formula II: ##STR1## wherein: R1, R2, R3 and R4 are each independently selected from the gro... | 01/08/2002 |
| 6174913 | Naphtho- and dihydrobenzo-thiophene derivatives as cytotoxic antitumor agents Compounds useful as cytotoxic agents are selected from the group consisting of compounds of Formula I and compounds of Formula II: ##STR1## wherein: R1, R2, R3 and R4 are each independently selected from the gro... | 01/16/2001 |
| 6156787 | Substituted thienlycyclohexanone derivatives for enhancing cognition The present invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof: ##STR1## where A is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, arylC1-6 alkyl, ... | 12/05/2000 |
| 6071946 | Tricyclic urea compounds A compound selected from those of formula (I): ##STR1## in which A, Y, R1, R2 and R3 are as defined in the Specification, and pharmaceutical compositions containing the same, which are useful for treating a mammal aff... | 06/06/2000 |
| 6037361 | Fluorinated butyric acids and their derivatives as inhibitors of matrix metalloproteinases Fluorinated butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase)... | 03/14/2000 |
| 5998461 | Tricyclic amide compounds This invention relates to benzofuran/pyran derivatives of a new tricyclic amide compound, their composition and method of use for treating disorders of the melatoninergic system.... | 12/07/1999 |
| 5977074 | Inhibitors of ଲ-amyloid protein production This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it ... | 11/02/1999 |
| 5849781 | Tricyclic amides The invention relates to a compound selected from these of formula (I): ##STR1## in which R7, R8, Y, n and A are as defined in the description, and medicinal product containing the same useful for treating a disorder of the mela... | 12/15/1998 |
| 5763609 | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3, R4 are the same or different and represent hydrogen, C1 -C | 06/09/1998 |
| 5578252 | Photochromic substituted naphthopyran compounds Described are novel reversible photochromic 3H-naphtho[2,1-b]pyran compounds, examples of which are substituted with an oxy-bearing substituent at the number 8 carbon atom and with either an alkyl group at the number 7 carbon atom or with a carbonyl beari... | 11/26/1996 |
| 5569771 | (Haloalkyl) dibenzooniumsulfonate and its production methods; and a haloalkylating agent and haloalkylating methods (Haloalkyl)dibenzooniumsulfonate represented by the following general formula (I): ##STR1## By using this compound as the haloalkylating agent, haloalkylated organic compounds being non-water-soluble as the objective product can very easily be s... | 10/29/1996 |
| 5532254 | Modulation of calcium channels using benzothiophenes A method for modulating calcium channels, increasing the density of calcium channels in vascular and cardiac tissue with no changes in inotropic or pressor response, comprising administering to a warm-blooded animal in need thereof a pharmaceutically-effe... | 07/02/1996 |
| 5530139 | Condensed heterocyclic compound with a sulfonic acid group and process for producing the same A condensed heterocyclic compound having a structure represented by formula (I): ##STR1## wherein the substituents are as defined in the specification herein.... | 06/25/1996 |
| 5334333 | Electroactive compounds, compositions and devices and methods of making the same The present invention relates to electroactive compounds capable of undergoing a change in light absorption and refraction due to an applied electric field and a permanent change in refraction due to exposure to predetermined bands of optical radiation. T... | 08/02/1994 |
| 5292894 | Preparation of benzo[b]thiophenes A process for the preparation of benzo[b]thiophenes of the general formula I ##STR1## in which R1, R2, R3, R4 independently denote hydrogen, C1 -C4 alkyl, C1 -C4 ... | 03/08/1994 |
| 5169861 | Benzothiophene compounds A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R1 to R3 ... | 12/08/1992 |
| 5151528 | Charge transfer complex formed between benzoquinone derivative and electron donor and process for producing the same A charge transfer complex formed between a benzoquinone derivative represented by formula ##STR1## wherein at least one of the rings A and B represents a heterocyclic ring as defined in the specification, and an electron donor, and a salt of an ... | 09/29/1992 |
| 5136099 | Golfomycin derivatives: fused ring cyclodecadiyne derivatives having DNA-cleaving properties and antitumor activity 5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods of making and usi... | 08/04/1992 |
| 5130058 | Photochromic compound, process for production thereof, use thereof and composition containing said photochromic compound A photochromic compound represented by the following general formula [I] ##STR1## wherein ##STR2## represents a divalent aromatic hydrocarbon group or a divalent heterocyclic group each of which may have a substituent, R1 represents ... | 07/14/1992 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 5047554 | 3-substituted-2-oxindole derivatives This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H | 09/10/1991 |
| 5011845 | Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds Compounds of the formula ##STR1## wherein R5 represents C1 to C6 -alkyl or the group--(CH2)n --Z--(CH2)m --Ar wherein Z represents O, S or --CH2 --and Ar is pheny... | 04/30/1991 |
| 5011967 | Method for preparing aromatic bischloroformate compositions Bischloroformate oligomer compositions are prepared by passing phosgene into a heterogeneous aqueous-organic mixture containing at least one dihydroxyaromatic compound, with simultaneous introduction of a base at a rate to maintain a specific pH range and... | 04/30/1991 |
| 4960886 | Charge transfer complex formed between benzoquinone derivative and electron donor and process for producing the same A charge transfer complex formed between a benzoquinone derivative represented by formula ##STR1## wherein at least one of the rings A and B represents a heterocyclic ring as defined in the specification, and an electron donor, and a salt of an ... | 10/02/1990 |
| 4952602 | Phenyl benzothiophene hypolipidemic derivatives Biphenyl derivative of the formula: ##STR1## wherein R1 is hydrogen atom or a lower alkoxycarbonyl group and R2 is a lower alkoxycarbonyl group, or R1 and R2 are combined together to form a group of the for... | 08/28/1990 |
| 4864033 | Novel liquid crystalline compounds and polymers The present invention relates to novel liquid crystalline compounds having the following formula: ##STR1## In the above formula, a is 1 or 2, or R1 and R2 may be virtually any chemical groups which will maintain the liquid cryst... | 09/05/1989 |
| 4831042 | Tricyclic-substituted piperidine antihistamines Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ... | 05/16/1989 |
| 4826977 | Photochromic spiropyran compounds A series of novel photochromic spiropyrans are disclosed in which a spiro-adamantane group is introduced into the 2-position of the benzopyran or naphthopyran ring. The spiropyran compounds of the invention exhibit heliochromic properties, i.e. they color... | 05/02/1989 |
| 4797414 | Naphthothiophene derivatives and their use as respiratory enhancing agents Pharmaceutical preparations containing compounds of formula I ##STR1## wherein ring A is unsubstituted or substituted, R1 and R2, independently of one another, each represents hydrogen, lower alkyl, aryl or heteroaryl, or R... | 01/10/1989 |
