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| Number | Title | Issue Date |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| 7368572 | Acetylene derivatives as inhibitors of histone deacetylase The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparin... | 05/06/2008 |
| 7230028 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, ph... | 06/12/2007 |
| 7223790 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C2–C8 alkyl C3-8 cycloalk... | 05/29/2007 |
| 7214707 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, option... | 05/08/2007 |
| 7157494 | Dimeric compounds and their use as anti-viral agents The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; R2 is acetyl or trifluoroacetyl; X is CONH, SO2NH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to ... | 01/02/2007 |
| 7053229 | Process for the production of 4-(17α-alkoxymethyl-17β-substituted 3-oxoestra-4,9-dien-11β-yl) benzaldehyde-(1E)-oxime derivatives This invention relates to a process for the production of 4-(17α-alkoxymethyl-17β-substituted-3-oxoestra-4,9-dien-11β-yl)benzaldehyde-(1E)-oxime derivatives of general formula (I) in which R means an amino gro... | 05/30/2006 |
| 7045535 | Compounds useful for inhibiting paramyxovirus neuraminidase Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas: ... | 05/16/2006 |
| 7019003 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 03/28/2006 |
| 6905786 | Light emitting device material, light emitting device using thereof, and amine compound A compound represented by the following formula (I): wherein R1, R2 and R3each represents an aryl group, a heterocyclic group or an aliphatic hydrocarbon group, provided that at least o... | 06/14/2005 |
| 6900341 | Substituted phenylketoenols The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) in which A, B, G, X, Y, Z and W are each as defined in the description, to proce... | 05/31/2005 |
| 6849660 | Antimicrobial biaryl compounds Provided are antibacterial compounds having Formula I: In such compositions, X is O or S; Y is CH2; n is 0 or 1. One of R1 and R1′ is —C(O)NR5R5′ | 02/01/2005 |
| 6849733 | Neuropeptide-Y ligands There are disclosed novel neuropeptide Y ligands having the general formula I Wherein the symbols W, A, D, R1, R2, R3, R4 are further defined in the description. Compounds of... | 02/01/2005 |
| 6844363 | Hydrates of a neuraminic acid compound and crystalline forms thereof Hydrates of the compound of formula (I) and crystalline forms thereof have excellent storage stability and are useful medicaments. ... | 01/18/2005 |
| 6762178 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and de... | 07/13/2004 |
| 6670488 | Substituted phenylketoenols The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which A, B, G, X, Y, Z and W are each as defined in the description, to processes and intermediates for their preparation and to their use as pestici... | 12/30/2003 |
| 6486343 | Substituted phenyl keto enols as pesticides and herbicides The present invention relates to novel compounds of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, an... | 11/26/2002 |
| 6451766 | Neuraminic acid derivatives, their preparation and their medical use Compounds of formula (I) or their salts or esters: ##STR1## [wherein R1 is alkyl or haloalkyl; R2 and R3 each represents hydrogen or aliphatic acyl; X is hydroxy, halogen, alkoxy, or a group of formula Ra O--, w... | 09/17/2002 |
| 6376468 | Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell proliferation, and in supressing aberrant high signal trans... | 04/23/2002 |
| 6376536 | Quaternary ammonium salts and their use This invention is to provide a compound for antagonizing CCR5, said compound being represented by the formula: ##STR1## wherein R1 is an optionally substituted phenyl or an optionally substituted thienyl; Y is --CH2 --, --S-- or --O-... | 04/23/2002 |
| 6331650 | Method for manufacturing aminoalcohol An aminoalcohol is synthesized by reacting a cyclic hemiacetal expressed by Formula 1 ##STR1## (where n is 0 or 1; R1 and R2 are each a hydrogen atom, a monovalent saturated hydrocarbon group which is optionally substituted, or ... | 12/18/2001 |
| 6310245 | 3-aminocarbonyl/3-aminothiocarbonyl-substituted 2-benzoyl-cyclohexan-1,3-diones with herbicidal effect The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I ##STR1## where R1, R2 are hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, --OR5, --OCOR6, ... | 10/30/2001 |
| 6294572 | Crystalline N-acetyl neuraminic acid derivatives and process for their preparation Two useful crystal hydrates of 5-acetamido-2,3,4,5-tetradeoxy-4-guanidino-D-glycero-D-galacto-non-2-enopy ranosonic acid have either a low or high aspect ratio. These crystalline N-acetyl neurominic acid derivatives are favored for pharmaceutical form... | 09/25/2001 |
| 6242582 | Method of detection of influenza virus and compounds for use therein The invention provides a method of detection of influenza virus which utilizes compounds able to bind specifically to the active site of influenza virus neuraminidase, and novel compounds for use in the method.... | 06/05/2001 |
| 6229025 | Process for alkylating hindered sulfonamides The present invention relates to a process for alkylating hindered sulfonamides by Michael addition to propiolates, and to novel intermediates prepared in said process. The products of these reactions can be converted into pharmaceutical compounds useful ... | 05/08/2001 |
| 6225341 | Compounds and methods for synthesis and therapy Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the inventi... | 05/01/2001 |
| 6218519 | Compounds and methods for the selective treatment of cancer and bacterial infections The present invention relates to compounds containing an anthracyclinone group such as doxorubicin, daunorubicin or a derivative thereof. The compounds of the invention also contain ester, glycoside or glucuronide structures which are hydrolyzed by the co... | 04/17/2001 |
| 6214872 | Aryloxyarylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein X, Y, R1 and R2 are as defined above, useful in the treatment of arthritis or cancer and other diseases involving selective inhibition of matrix metaloproteinase-13.... | 04/10/2001 |
| 6197810 | 3-(arylsulfonylamino)-tetrahydropyran-3-carboxylic acid hydroxamides A compound of the formula ##STR1## wherein R1, R2, R3, R4 and Q are as defined above, are useful in the treatment of arthritis (including osteoarthritis and rheumatoid arthritis), cancer and other diseases. In a... | 03/06/2001 |
| 6166074 | Pharmaceutical compositions Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and -alkoxyarylidene e... | 12/26/2000 |
| 6166006 | Anilide derivative, production and use thereof This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-mem... | 12/26/2000 |
| 6156741 | Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 12/05/2000 |
| 6153604 | Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 11/28/2000 |
| 6147063 | Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines of the following Formula: ##STR1## and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines.... | 11/14/2000 |
| 6107337 | Arylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein n, X, R3, R4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal dise... | 08/22/2000 |
| 6087392 | (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides A compound of the formula ##STR1## wherein Q is as defined above, are useful in the treatment of a condition selected from the group consisting of arthritis (including osteoarthritis and rheumatoid arthritis), inflammatory bowel disease, Crohn's dise... | 07/11/2000 |
| 6057342 | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a... | 05/02/2000 |
| 5990156 | 6-Carboxamido dihydropyran derivatives Compounds of formula (I), ##STR1## wherein R1 represents OR5, SR5, NR5 R6, N(OR5)R6 or N(NR5 R6)R6 ; X represents OH, N3, NR... | 11/23/1999 |
| 5985880 | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds A method of reducing, treating or preventing drug-mediated respiratory depression in an animal, incident to the administration to said animal of a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effecti... | 11/16/1999 |
| 5948816 | 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds Compounds represented by general formula (I) and salts thereof useful as non-tolerance-inducing antiviral agents, wherein A is O, CH2 or S; R1 is lower alkoxycarbonyl, or the like; R2 is H, OR6, F, Cl, Br, CN, N... | 09/07/1999 |
