|8575370||Method for manufacturing neuraminic acid derivatives|
Methods for manufacturing neuraminic acid compounds and synthetic intermediates of neuraminic acid compounds, including a method for manufacturing a compound represented by wherein R2 represents a C1-C...
|8148554||Methods and compositions for use in treating cancer|
The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer, and intermediates for the synthesis of such compositions. ...
|7868191||Preparation and purification of mupirocin calcium|
The present invention relates to methods for the preparation and purification of mupirocin calcium. The process comprises adsorbing mupirocin to a hydrophobic adsorbent resin, exposing the bound mupirocin to a calcium-containing solution, washing impurities from the...
|7619102||Purification of mupirocin|
A method for purification of the antibiotic mupirocin (pseudomonic acid A) which comprises: a) Causing or allowing precipitation of mupirocin from an aqueous solution thereof; b) Recovering the precipitate; c) Dissolving the recovered precipitate in an organic solve...
|7442793||Peptide deformylase inhibitors|
Novel PDF inhibitors and novel methods for their use are provided. ...
|7351730||Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)|
This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8,...
|7230114||Intermediates for preparing neuraminidase inhibitor conjugates|
Compounds of formula (I), methods for their preparation and their use in the manufacture of neuraminidase inhibitor conjugates. Wherein R represents as carboxylic acid protecting group; P1 and P2 can be the same or different and are selected fr...
Naturally occurring stolonoxide compounds, and derivatives thereof, have antitumor activity. Typical compounds are of the formula (I) or a derivative thereof ...
|7045535||Compounds useful for inhibiting paramyxovirus neuraminidase|
Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas: ...
The invention relates to compounds of formula wherein R is phenyl, unsubstituted or substituted by halogen or —CH2N(CH3)(CH2)nOCH3
|6939886||Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor Type-1 (PAI-1)|
This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are each H, alkyl, alkanoyl, halo, OH, aryl optionally substituted with R8
A liquid-crystalline mediums which contain one or more compounds of the formula A and at least one compound of the formula B wherein compounds of formula A contain at lea...
The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B. ...
|6869696||Organic red electro-luminescent device including a heterocyclic emitter|
The invention concerns an electro-luminescent device in which the luminescent layer contains a compound of general formula I as doping agent or as luminescent compound, whereby the radicals R1 to R12 are identical or are different, and mean hyd...
|6835845||Methine compound, material for organic luminescence element, and organic luminescence element using the same|
A is a novel methine compound, for example, which is represented by the following formula (I): wherein R1, R2, R3, R4 and R5 each represents a hydrogen atom or a s...
|6800654||Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)|
This invention provides PAI-1 inhibiting compounds of Formula I: wherein: R1, R2, R3, and R4 are eachH, alkyl,, alkanoyl, halo, OH, aryl optionally substituted with R8
|6740649||Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)|
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected fro...
|6677355||Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors|
Compounds of the formula; ##STR1## are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such ...
|6642395||Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative|
There are provided an acetalsulfonate derivative useful as an intermediate for medicines and agricultural chemicals, a process for industrially producing the derivative, and a process for industrially producing a styrene oxide derivative from the acetalsu...
|6613743||Sulfonamide inhibitors of aspartyl protease|
The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy...
|6599925||Substituted naphthyl benzofuran derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)|
This invention provides compounds which act as inhibitors of plasminogen activator inhibitor-1 (PAI-1) of the formula: ##STR1## wherein: R, R1, R2, and R3 are H, alkyl, cycloalkyl, --CH2 -(cycloalkyl), alkanoyl,...
|6500958||Carboxylic acid derivatives and process for producing the same|
The present invention relates to compounds which are useful for efficient synthesis of 2-amino-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acids. The compounds according to the present invention comprise 2-oxobicyclo[3.1.0]hexane-6-carboxylic acid derivatives r...
|6469182||Intermediates in the preparation of macrocyclic analogs|
Novel intermediates of the formula ##STR1## They are used in the preparation of macrocyclic analogs....
2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-indeno[5,6-b]fura ns are valuable novel woody fragrances for the preparation of perfume oils....
|6413947||Anilide derivative, production and use thereof|
This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-membered arom...
|6403777||Metalloligands for cleaving nucleic acids|
Transition metal complexes, referred to hereinafter as "metalloligands", that catalyze the degradation of DNA and the cleavage of RNA at select sites are provided. In one embodiment, the metalloligand has the following structure: ##STR1## wherein R1 ...
|6403636||Xanthone compounds, their preparation and use as medicament|
This invention relates to novel xanthone compounds, their preparation and use as medicament. More particularly this invention is directed to the isolation of the novel xanthone natural product sootepenseone from Dasymaschalon sootepense Craib, Annonaceae,...
|6399786||Nonacyclic nodulisporic acid derivatives|
The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents....
|6365751||Antibiotic oxazolidinone derivatives|
The invention concerns a compound of the formula (I): ##STR1## wherein, for example: R1 is of the formula --NHC(.dbd.O)Rb wherein Rb is, for example, (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; R2
|6365759||Intermediate compounds for preparing macrocylcic analogs|
Intermediate compounds of the formulas ##STR1## for use in the preparation of macrocyclic analogs....
|6331563||N-Hydroxy-2-(Alkyl, Aryl, or Heteroaryl, Sulfanyl, Sulfinyl or Sulfonyl)-3-Substituted Alkyl, Aryl or Heteroarylamides as Matrix Metalloproteinase inhibitors|
Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenase...
|6319946||Inhibitors of aspartyl protease|
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical ...
|6306893||Taxoid derivatives and process for producing the same|
An object of the invention is to develop galactose or mannose derivatives of docetaxel, etc. having improved solubility and physiological activity, to alleviate burden imposed on patients and to provide effective therapeutic drug for tumors. The present i...
This invention describes the new, nonsteroidal gestagens of general formula I ##STR1## in which A, B, Ar, R1, R2 and R3 have the meanings that are indicated in more detail in the description. The new compounds show a very ...
|6150532||Modulators of proteins with phosphotyrosine recognition units|
The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human an...
|6133442||Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists|
Compounds of formula I ##STR1## wherein R1 signifies phenyl, substituted phenyl or heterocyclyl; R2 signifies phenyl or substituted phenyl; R3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, su...
The present invention provides a coating suitable for coating woods, and the coating is obtained by dissolving proanthocyanidine into water or a water-containing alcohol....
A photochromic article that includes a host material and a photochromic amount of a benzopyran compound, the benzopyran compound represented by one of the formulas: ##STR1## wherein R1, R2, R3, R4, R5
|6057342||Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof|
The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH2 a...
|6054475||Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders|
Compounds of formula (I) ##STR1## and the salts of these compounds, are efficacious PDE (phosphodiesterase) inhibitors....