Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7880021 | Compounds and kits for the detection and the quantification of cell apoptosis 3-hydroxyflavone derivatives are useful in the detection and the quantification of cell apoptosis. Such derivatives are also useful as fluorescent probes in studying lipid asymmetry of cell plasma membrane and in detecting apopoptic cells. The derivatives can be use... | 02/01/2011 |
| 7396856 | Benzopyran analogs and their use for the treatment of glaucoma Novel benzopyran analogs are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present... | 07/08/2008 |
| 7345090 | Galenical formulation The invention relates to compounds of the formula I where R1, R2, R3, R4 and R5 have the meanings given in claim 1. The compound is suitable in particular for use in sk... | 03/18/2008 |
| 7282598 | Synthetic methods for preparing procyanidin oligomers Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially pro... | 10/16/2007 |
| 7268240 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 09/11/2007 |
| 7244855 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins Various processes are disclosed for preparing procyanidin oligomers having (4,8)-interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or -catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activated-epicatechin or -catechin... | 07/17/2007 |
| 7226644 | Chroman derivative and liquid-crystal composition containing the compound The present invention relates to a liquid crystal compound which has negative dielectric anisotropy and a large absolute value thereof; and a liquid crystal display element which contains the compound as a constituent element and has a negative value of dielectric a... | 06/05/2007 |
| 7067679 | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest Various processes are disclosed for preparing protected epicatechin oligomers having (4β,8)-interflavan linkages. In one process, a tetra-O-protected epicatechin monomer or oligomer is coupled with a protected, C-4 activated epicatechin monomer in the presence of a... | 06/27/2006 |
| 7056952 | Isoflavone metabolites There are disclosed compounds of formulae (I) or (II) in which A is selected from the group consisting of (1), (2), (3) and (4); OH, and one of R1 and R2 is selected from H, OH and OCH3, and the other of R1 and R2 | 06/06/2006 |
| 7012149 | Process for the production of (−)-epigallocatechin gallate A process is provided for making (−)-epigallocatechin gallate (EGCG) by subjecting a green tea extract to chromatography on a macroporous polar resin, eluting EGCG from the resin with a polar elution solvent, optionally concentrating the eluate, optionally regener... | 03/14/2006 |
| 6916831 | Flavone acetic acid analogs and methods of use thereof Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n... | 07/12/2005 |
| 6908942 | 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives and their construction by parallel synthesis on solid-phase The present invention provides (i) 6-amino-2,2-dimethyl-3,4,6-trisubstituted benzopyran derivatives; (ii) a process for synthesizing benzopyran derivatives with high efficiency by parallel synthesis on a solid-phase as one of combinatorial chemical synthesis technol... | 06/21/2005 |
| 6849746 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 02/01/2005 |
| 6803129 | Organic light emitting diode and organic luminescent materials thereof The present invention relates to an organic light emitting diode (OLED) device, comprising an anode disposed on a substrate, an organic EL layer disposed on the anode and a cathode disposed on the organic EL layer. The material of the organic EL layer comprises a co... | 10/12/2004 |
| 6790967 | Process for the preparation of vitamin E The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol. ... | 09/14/2004 |
| 6737439 | Aromatase inhibitors from Broussonetia papyrifera A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammal... | 05/18/2004 |
| 6720353 | Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with p-type fimbriae to surfaces The present invention is directed to isolation and identification of plant proanthocyanidin extracts and particular proanthocyanidin compounds for prevention and treatment of urinary tract infections caused by P-type Escherichia coli. These extracts can be ob... | 04/13/2004 |
| 6677371 | 4-oxybenzopyran derivative This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C | 01/13/2004 |
| 6670390 | Cocoa extract compounds and methods for making and using the same Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a po... | 12/30/2003 |
| 6645997 | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d... | 11/11/2003 |
| 6608102 | Plant proanthocyanidin extract effective at inhibiting adherence of bacteria with P-type fimbriae to surfaces The present invention is directed to isolation and identification of plant proanthocyanidin extracts and particular proanthocyanidin compounds for prevention and treatment of urinary tract infections caused by P-type Escherichia coli. These extracts can b... | 08/19/2003 |
| 6555574 | 4-oxybenzopyran derivative This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or a C | 04/29/2003 |
| 6531617 | Process for preparing hydroxychomanones and cis-aminochromanols Enantiomerically enriched hydroxychromanones are obtained by the AlCl3 -catalyzed intramolecular Friedel-Crafts acylation of the corresponding 3-phenoxy-2-alkylcarbonyloxy-propionic acid followed by cleavage of the carboxylate in the presence o... | 03/11/2003 |
| 6528664 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionali... | 03/04/2003 |
| 6479671 | Process for producing optically active chromene derivative A process for producing a compound of the formula (II): ##STR1## (wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl, alkoxy or the like, R5 is alkyl or alkoxyalkyl, A is O or S, Ar is a... | 11/12/2002 |
| 6420572 | Synthetic methods for preparation of protected proanthocyanidin(s) A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionali... | 07/16/2002 |
| 6291518 | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof The present invention relates to novel hydroxy and polyhydroxy derivatives of coumarin fused with dialdehydes and aldehyde acids of the general formulae I, II, III and IV: ##STR1## wherein R1 =R2 =4-hydroxycoumarin; R1 =R | 09/18/2001 |
| 6215007 | Recombinant production of novel polyketides Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn ca... | 04/10/2001 |
| 6207842 | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives A process is disclosed for the production of polyphenol oligomers having n polyphenol monomers, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized pol... | 03/27/2001 |
| 6194450 | Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structura... | 02/27/2001 |
| 6130342 | CYP2D fluorescent assay reagents Novel fluorescent substrates of the human P450 enzyme CYP2D6 are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing CYP2D6 enzyme activity and in selecting compounds which inhibit CYP2D6 enzyme acti... | 10/10/2000 |
| 6080780 | Use of nitroflavonoids for the treatment of anxiety Methods of treating anxiety with flavonoid compounds according to Formula (I) and dimers thereof, compounds of Formula (I) and dimers thereof, use of compounds of Formula (I) and pharmaceutical formulations comprising flavonoids of Formula (I) and dimers ... | 06/27/2000 |
| 6071938 | Benzopyrans A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein X, O R, R1, R2, R3, and R4 are defined in the specification; compositions containing such compounds; intermediates ... | 06/06/2000 |
| 6051601 | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4 (LTB4) antagonists This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds or a pharmaceutically acce... | 04/18/2000 |
| 6034121 | Chromone fungicides Compounds of the formula ##STR1## where one of Z and Y is CO and the other is C--W--R2 and the dotted line indicates a double bond is present where necessary to meet valency requirements, W is O, S(O)n, N(R3), N(R | 03/07/2000 |
| 6004998 | Flavonoid and biflavonoid derivatives, their pharmaceutical compositions, their anxiolytic activity Certain flavonoids, notably derivatives of flavone, chrysin and apigenin, together with dimers thereof such as amentoflavone, have been found to possess anxiolytic properties (i.e., anxiety reducing properties) without exhibiting a sedative effect. Novel ... | 12/21/1999 |
| 6001821 | Dioxane-substituted cyclodextrin macromolecules and inclusion complexes The preparation of compositions containing cyclodextrin moieties which are modified by fusing 1,4 dioxane rights to glucopyranosyl residues is described. These compositions are suited as carrier for pharmaceuticals, agricultural chemicals and... | 12/14/1999 |
| 5977167 | Benzopyran and benzoxazine derivatives Novel benzopyran and benzoxazine derivatives represented by the general formula: wherein R1 and R2 represent a lower haloalkyl group, R3 represents a hydrogen atom, etc., R4 represents a heterocyclic group or A-... | 11/02/1999 |
| 5939452 | Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists The invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists of formula I and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds, and to a meth... | 08/17/1999 |
| 5861430 | Benzopyran phenol derivates for use as antibacterial, antiviral or immunostimulating agents A method of inhibiting microorganisms, including bacteria, using benzopyran phenol derivates from propolis. Propolis is extracted with an alcohol, and the resulting compounds are effective as antibacterial, antiviral or immunostimulating agents.... | 01/19/1999 |
