"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 7432232 | Compound 2-oxabicyclo[2,2,2]octane,1-methyl-4-(1,2,2-trimethylbicyclo[3,1,0]hex-3-yl)- and its uses in fragrance applications The compound 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo[3,1,0]hex-3-yl)— and its uses in fragrance applications. ... | 10/07/2008 |
| 7057057 | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene e... | 06/06/2006 |
| 6962768 | Ether monomers and polymers having multi-ring structures, and photosensitive polymers and resist compositions obtained from the same Provided are a variety of monomers suitable of producing photosensitive polymers, that are in turn, useful in photoresist compositions, through radical (cationic) polymerization including at least one multi-ring alkenyl ethers and one α-fluorinated acrylate. The re... | 11/08/2005 |
| 6908637 | Process for debittering peanut hearts The present invention involves methods for preparing a processed peanut product containing high levels of peanut hearts material, with the peanut heart material being substantially stripped of bitter taste so as to provide debittered peanut hearts of comparable tast... | 06/21/2005 |
| 6894073 | Use of diterpene compound as a therapeutic agent of inflammation, immune disease or cancer The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exi... | 05/17/2005 |
| 6872840 | Synthesis of 8-membered carbocyclic compound having diexomethylene groups The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by... | 03/29/2005 |
| 6849746 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 02/01/2005 |
| 6750364 | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport This invention provides compounds of the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; R1 and R2 are H, halogen, hydroxy, ... | 06/15/2004 |
| 6713228 | Ether monomers and polymers having multi-ring structures, and photosensitive polymers and resist compositions obtained from the same Provided are alkenyl ether-based monomers having multi-ring structure, and photosensitive polymers and resist compositions obtained from the same. The photosensitive polymer includes a monomer unit represented by the following formula: | 03/30/2004 |
| 6599553 | Dry drink mix and chocolate flavored drink made therefrom A dry drink mix which is rich in cocoa polyphenols such as catechin, epicatechin, and cocoa procyanidins contains a cocoa polyphenol rich cocoa powder, an alkalized cocoa powder, and a sweetener. The dry mix contains other conventional ingredients such as... | 07/29/2003 |
| 6517841 | Solid compositions and liquid preparations for oral administration which contain cocoa polyphenols Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions contai... | 02/11/2003 |
| 6420334 | Tetracyclic acetals 2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-indeno[5,6-b]fura ns are valuable novel woody fragrances for the preparation of perfume oils.... | 07/16/2002 |
| 6399139 | Food products having enhanced cocoa polyphenol content and processes for producing the same The invention provides food products, including confectioneries and chocolates, having conserved concentrations of polyphenols, and in particular cocoa polyphenols. The method of this invention avoids the significant and detrimental losses of polyphenols ... | 06/04/2002 |
| 6399653 | Ring fused dihydropyrans, process for preparation and use thereof The invention relates to compounds of the formula I ##STR1## in which the radicals R1, R2, R3 and A have the meaning mentioned in the description. The invention further relates to a process for the preparation of the compo... | 06/04/2002 |
| 6312753 | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods o... | 11/06/2001 |
| 6258838 | Compounds The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.... | 07/10/2001 |
| 6194020 | Process for preparing food products containing cocoa polyphenols The invention provides food products, including confectioneries and chocolates, having conserved concentrations of polyphenols, and in particular cocoa polyphenols. The method of this invention avoids the significant and detrimental losses of polyphenols ... | 02/27/2001 |
| 6127415 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especiall... | 10/03/2000 |
| 6015913 | Method for producing fat and/or solids from cocoa beans The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing pro... | 01/18/2000 |
| 5990104 | Polycyclic alcaloid-derivatives as NMDA-receptor antagonists Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, --C(NH)--NH2, ... | 11/23/1999 |
| 5811313 | Identification test for highly refined sesame oil A method for confirming the presence of highly refined sesame oil in pharmaceuticals. By extracting, concentrating and detecting sesamin and epi-sesamin, through the method disclosed in the present invention, highly refined sesame oil can be identified. T... | 09/22/1998 |
| 5451689 | Method of preparing epoxide There is provided a method of preparing an epoxide (1a) or (1b) shown below: ##STR1## where R1, R2, R3, and R4 represent a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an alkoxy group, an... | 09/19/1995 |
| 5407901 | Herbicidal oxatricyclic ethers This patent application relates to Certain tricyclic ether herbicidal compounds and their use to control a broad spectrum of undesirable plant growth.... | 04/18/1995 |
| 5374653 | Iridoid derivatives and the use thereof as a drug Iridoid derivatives synthesized using genipin, which is an aglycon of geniposide, as the starting material are useful as an anti-hyperlipemia agent and as a cholagogue.... | 12/20/1994 |
| 5344942 | Reagents for racmate resolution (R) and (S) enantiomers of the formula ##STR1## in which n is 1 or 2, W is as defined in the specification which are characterized in that X is halogen, SO3 H, SO2 Cl or SO2 NR1 R2 where R1... | 09/06/1994 |
| 5288731 | 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any significant D2 receptor binding affini... | 02/22/1994 |
| 5189183 | Aromatic amine derivatives Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.... | 02/23/1993 |
| 5041566 | Method of preparing levoglucosenone Levoglucosenone is prepared by reaction sequence using 1,6-anhydro-ଲ-D-galactopyranose as a starting material. First, the starting material is reacted with ortho formate, obtaining an ortho ester of said starting material. Then, the ortho ester is p... | 08/20/1991 |
| 5011950 | Aromatic amine derivatives Novel aromatic amine derivatives of specific structure are useful intermediates for herbicides. The aromatic amine compounds have the structure shown by formula [I]: ##STR1## wherein Ar and A are as defined herein.... | 04/30/1991 |
| 4992563 | Benzopyran intermediates for use in manufacturing thromboxane A2 antagonists This invention relates to several intermediates useful in preparing thromboxane A2 inhibiting (b1;)7-[3-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-1.alpha ., 4-bicyclo[2.2.1]hept-2ଲ-yl]-heptenoic acids and useful ... | 02/12/1991 |
| 4942256 | Novel intermediates in the manufacture of novel thromboxane A2 antagonists This invention relates to several novel intermediates useful in the manufacture of thromboxane A2 inhibiting 7-[3--[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids.... | 07/17/1990 |
| 4859664 | Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula ##STR1## have useful pharmaceutical properites. They are prepared from ketones of the formula ##STR2## via a lactone intermediate. In th... | 08/22/1989 |
| 4841078 | Benzopyrans Bicyclic fused benzenoid compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6 ; R6 is hydrogen, formyl, carbobenzyloxy or certain carboal... | 06/20/1989 |
| 4838924 | Aromatic urea derivatives and their use as herbicide This invention relates to novel compounds of formula [I], a process for their production, and their use as a herbicide. ##STR1## wherein A represents the bond ##STR2## in which X is a hydrogen atom, a chlorine atom, a nitro group or a trif... | 06/13/1989 |
| 4739082 | Enantiomerically pure mono acetal-protected diols, their preparation and use Enantiomerically pure mono acetal-protected diols of the formula ##STR1## wherein A, B, C and D are hydrogen or a methyl group in any combination, M and N are aliphatic or araliphatic hydrocarbons, m and n are the numbers 0, 1 or 2, whereby the total... | 04/19/1988 |
| 4670041 | Oxabicycloalkane herbicides Compounds of the formula ##STR1## wherein X is (--CR4 R4 --)m in which m is 0 or 1; Y is (--CR5 R6 --)n in which n is 0, 1 or 2; Z is (--CR7 R7 --)p in which p i... | 06/02/1987 |
| 4548929 | Insecticidal and nematocidal heterobicyclic hydroximinates, thiohydroximidates, and carbamate esters, composition, and method of use thereof Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. ##STR1##... | 10/22/1985 |
| 4515972 | Intermediates and method for producing intermediates useful in the preparation of 7-oxabicycloheptane prostaglandin derivatives A method is provided for preparing intermediates for use in preparing 7-oxabicycloheptane prostaglandin derivatives which method includes the steps of reducing (exo)hexa hydro-4,5-epoxyisobenzofuran-1,3-dione to the corresponding diol, subjecting the diol... | 05/07/1985 |
| 4497960 | Chiral, optically active compounds useful as protective groups for hydroxy, thiol and amino compounds The invention declares new chiral, optically active compounds of the general formula ##STR1## wherein a 5 or 6 membered lactol ring (E), with X and Y meaning (CR1 R2)n, with n=0 to 2 and R1, R2 =... | 02/05/1985 |
| 4438023 | Oxygenated tricyclic derivatives of norbornane and use of same as perfuming ingredients Oxygen containing tricyclic derivatives of norbornane of formula ##STR1## wherein symbol X represents a divalent radical of formula ##STR2## possess valuable organoleptic properties and consequently can be used as perfuming ingredients.... | 03/20/1984 |