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| Number | Title | Issue Date |
| 7595409 | 3,4-diamino-3-cyclobutene-1,2-dione derivatives as potassium channel openers The present invention is directed to novel 3,4-diamino-3-cyclobutene-1,2-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel. ... | 09/29/2009 |
| 7323577 | Process for producing benzofuran derivative A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, o... | 01/29/2008 |
| 7102465 | Frequency discrete LC filter bank An inductive (“L”)-capacitive (“C”) filter bank has application for use in a television receiver. The LC filter includes inductors configured in at least one inductive (“L”) bank, and capacitors configured in at least one capacitive (“C”) bank. The i... | 09/05/2006 |
| 6921774 | Compounds and their use as glycine transport inhibitors The invention provides novel compounds of the formula I below: wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the ... | 07/26/2005 |
| 6716987 | Derivatives of benzofuran or benzodioxazole compounds An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1 | 04/06/2004 |
| 6683709 | Photochromic pyran compounds Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By int... | 01/27/2004 |
| 6602901 | Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR) The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, Ar, X, Q, A, Y and Z are as defined in the specification. These ... | 08/05/2003 |
| 6514996 | Derivatives of benzofuran or benzodioxole An oxygen-containing heterocyclic compound represented by following Formula (I): ##STR1## wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, --(CH2)n --E1 --CO--G1 (whe... | 02/04/2003 |
| 6331625 | Photochromic spirofluorenopyran compounds Photochromic spirofluorenopyran compounds corresponding to the general formula (I): ##STR1## in which B, B', R1 to R4 and G have the meanings defined herein. The compounds of the invention are useful in the production of photoch... | 12/18/2001 |
| 6225466 | Photochromic spirofluorenopyran compounds Photochromic spirofluorenopyran compounds corresponding to the general formula (I): ##STR1## in which B, B', R1 to R4 and G have the meanings defined herein. The compounds of the invention are useful in the production of photoch... | 05/01/2001 |
| 6133279 | Therapeutic agents for renal diseases and organ preservatives Herein disclosed are therapeutic agents for renal diseases and organ preservatives containing a compound represented by the general formula (1): ##STR1## wherein X represents an oxygen atom or a group represented by the general formula (2): ... | 10/17/2000 |
| 6121274 | Dihydrobenzofurane The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors.... | 09/19/2000 |
| 6054475 | Substituted dihydrobenzofuran-based phosphodiesterase 4 inhibitors useful for treating airway disorders Compounds of formula (I) ##STR1## and the salts of these compounds, are efficacious PDE (phosphodiesterase) inhibitors.... | 04/25/2000 |
| 5902824 | Phenyldihydrobenzofuranes Compounds of formula I are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV). They and pharmaceutical compositions in which they are active ingredients are useful as bronchial therapeutics, for elimination of erectile dysf... | 05/11/1999 |
| 5882881 | Inhibition of cyst formation by cytoskeletal specific drugs The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent i... | 03/16/1999 |
| 5877191 | Phenyl spiroethercycloalkyl tachykinin receptor antagonists The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12 | 03/02/1999 |
| 5854036 | Sesquiteterpenic dervatives The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the... | 12/29/1998 |
| 5808109 | Compounds that inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain... | 09/15/1998 |
| 5789189 | Inhibition of cyst formation by cytoskeletal specific drugs The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent i... | 08/04/1998 |
| 5686471 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl or aralkyl having from ... | 11/11/1997 |
| 5684041 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisiting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carb... | 11/04/1997 |
| 5684002 | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) W is --C(X')--NRR' or --NR--C(X')R'; (b) X and X' are independently O or S; (c) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms, or the tw... | 11/04/1997 |
| 5684031 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 ... | 11/04/1997 |
| 5672620 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2 ; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbo... | 09/30/1997 |
| 5663373 | 4-alkoxy-2, 6-di-t-butylphenol derivatives Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R1 is a hydrogen atom or an acyl group; R2 is a lower alkyl group; R3 is a hydrogen atom or a low... | 09/02/1997 |
| 5656661 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents A compound having the structure: ##STR1## wherein (a) X is oxygen or sulfur; (b) each Y is independently hydrogen or unsubstituted straight, branched or cyclic alkanyl having from 1 to about 3 carbon atoms,. or the two Y's are bonded to form an alkan... | 08/12/1997 |
| 5656659 | Compounds which inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectivly inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain ... | 08/12/1997 |
| 5637709 | Photochromatic substances Polychromatic compounds of pyrans having a substituted adamantane or a polycyclic ring system, with the exception of adamantane, in the 2-position of the pyran ring, having the structure ##STR1## whereby the residues R1 -R4 are ... | 06/10/1997 |
| 5612370 | Phenylglycine and phenylalaninen amido benzopyran derivatives Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein a, b and d are all carbon atoms or one of a, b and d is a nitrogen atom or --N(O)-- and the others are carbon atoms; Y is a single bond, --CH2 --, ... | 03/18/1997 |
| 5536833 | Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives A process for preparing compounds of the formula ##STR1## where a, b, c, R1, R2, and R3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3... | 07/16/1996 |
| 5506247 | Compounds that inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain... | 04/09/1996 |
| 5453421 | Aryl and heterocyclic substituted propenamide derivatives Novel compounds useful, for example, for the treatment of ischemic conditions and arrhythmia are disclosed. The compounds have the formula ##STR1## wherein X is oxygen or sulfur and the R groups are as defined herein.... | 09/26/1995 |
| 5418254 | Substituted cyclopentadienyl compounds for the treatment of inflammation A class of 2,3-substituted cyclopenta-2,4-dienyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R1 and R... | 05/23/1995 |
| 5403846 | Spirocycles Compounds of the general formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form enantiomer, diastereomer or mixtures thereof are Class III antiarrhythmic agents.... | 04/04/1995 |
| 5401767 | Compounds which inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain... | 03/28/1995 |
| 5366986 | Compounds which inhibit complement and/or suppress immune activity The present invention is directed to compounds which suppress immune responses and/or selectively inhibit complement. These compounds contain an aromatic ring and are substituted dihydrobenzofurans, spirobenzofuran-2(3H)-cycloalkanes, and their open chain... | 11/22/1994 |
| 5276168 | Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents A new method for the treatment of ischemic conditions and arrhythmia is disclosed. The method uses compounds of the formula ##STR1## wherein A can be --CH2 --, --O--, --NR9 --, --S--, --SO--, --SO2 --; X can be oxygen... | 01/04/1994 |
| 5273998 | Process for making an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coron... | 12/28/1993 |
| 5232944 | Chroman derivatives Novel chroman derivatives of the formula I ##STR1## in which X is O or NR11, Z is CH2, O, S or CHHal, R1 and R5 are each A, R2 is H or A, R1 and R2 together are also alkylene having 3... | 08/03/1993 |
| 5194637 | Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives Methods are provided for producing isomerically enriched camphorsulfonates, and in particular a diastereomerically enriched glycidyl camphorsulfonate by bromide-casylate exchange between an alkyl casylate and the bromide analog of the desired casylate, fo... | 03/16/1993 |
