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| Number | Title | Issue Date |
| 8357810 | 3.2.1-bicyclo-octane compounds The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.1-bicyclo-octane compounds of the present invention are represented by formula: wherein R is selec... | 01/22/2013 |
| 8067620 | Dispiro 1,2,4-trioxolane antimalarials A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side ... | 11/29/2011 |
| 7786314 | Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes. ... | 08/31/2010 |
| 7417153 | Method for the production of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol derivatives A method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl) cyclopenlane-1,2-diols of formula (I): (and/or the enantiomer), where R1 is H, C1-6-alkyl, C3-8-cycloalkyl or b... | 08/26/2008 |
| 7407984 | Tetraoxaspriro anti-malarials The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not... | 08/05/2008 |
| 7385067 | Process for the preparation of compounds having a CFO bridge The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the... | 06/10/2008 |
| 7371778 | Spiro and dispiro 1,2,4-trioxolane antimalarials A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side ... | 05/13/2008 |
| 7365113 | Phosphate ester flame retardants from resorcinol-ketone reaction products Flavan-based and spirodichroman compound-based phosphate esters prepared by reacting flavans and spirodichroman compounds with phosphorus oxychloride, monophenyl dichlorophosphate, or diphenyl chlorophosphate compounds are described. The flavans and spirodichroman c... | 04/29/2008 |
| 7319155 | 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds useful in the synthesis of non-steroidal analogues of vitamin D Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D. ... | 01/15/2008 |
| 7230144 | Methods of making intermediates from polyhydroxyalkanoates Methods of forming intermediates from PHAs are disclosed. ... | 06/12/2007 |
| 7175297 | In-grade light fixture with leveling and alignment mechanisms, installation features and anti-condensation valve An in-grade light fixture, comprising a below grade light fixture having a light opening substantially at grade level. An optical chamber is arranged within the light fixture housing and holding a light source generating light that passes through the light opening. ... | 02/13/2007 |
| 7169941 | Photochromic composition A photochromic composition and a coating composition comprising a molecular compound of a chromene compound and an aromatic compound. The photochromic composition provides a photochromic optical material as a cured product and the coating composition is applied to a... | 01/30/2007 |
| 7157589 | One step process for the preparation of anticonvulsant derivatives The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R | 01/02/2007 |
| 7034166 | Process for producing benzofuran derivative A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a sal... | 04/25/2006 |
| 6908918 | Antitumor agents The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in... | 06/21/2005 |
| 6906098 | Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1 wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or isopropyl; R2 is H, methyl, or ... | 06/14/2005 |
| 6777441 | Triptolide analogs for the treatment of autoimmune and inflammatory disorders The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune... | 08/17/2004 |
| 6737438 | Substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof In the present invention relates to a novel series of antimalarial 1,2,4-trioxanes analogues of general formula 7, wherein R represents cycloalkyl groups selected from the groups consisting of cyclopentyl, cyclohexyl, cy... | 05/18/2004 |
| 6716832 | Arylphenyl-substituted cyclic ketoenols The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl,... | 04/06/2004 |
| 6680332 | Substituted 5-oxo-5,6,7,8-tetrahydro-4H-1-benzopyrans and benzothiopyrans and the use thereof as potentiators of AMPA Disclosed is a method for treating a disorder responsive to the positive modulation of AMPA receptors in animals suffering therefrom, comprising administering to an animal in need thereof a compound of Formula I: ##STR1## or a pharmaceutically acceptable ... | 01/20/2004 |
| 6673937 | Syntheses and methods of use of new antimitotic agents Oxidative cyclization of bis-naphthyl ethers allows concise total syntheses of palmarumycin CP1 and deoxypreussomerin A in 8-9 steps and 15-35% overall yield from 5-hydroxy-8-methoxy-1-tetralone. A small library of palmarumycin analogs was crea... | 01/06/2004 |
| 6528538 | Cyclic compounds useful in the treatment of dyslipidaemia, atherosclerosis and diabetes, pharamaceutical compositions and preparation process The present invention relates to cyclic compounds which are of the class of compounds of formula I wherein X and Y represent an oxygen atom and to processes for preparing such compounds. The compounds are useful in the treatment of dyslipidemia, atheroscl... | 03/04/2003 |
| 6384251 | Process for effecting allylic oxidation using dicarboxylic acid imides and chromium reagents A procedure for oxidizing organic compounds having allylic hydrogen atom(s) involving the steps of reactively contacting the organic compound with a combination of an N-hydroxy dicarboxylic acid imide and a chromium-containing oxidant. The reaction can co... | 05/07/2002 |
| 6315928 | Spirofluorenopyrans The present invention relates to specific photochromic 3H-naphtho[2,1-b]pyran derivatives and to their use in plastics of all types, especially for ophthalmic purposes. In particular, the present invention relates to spiro compounds derived from naphthopy... | 11/13/2001 |
| 6194586 | Selective sulphonation of the primary alcohol of a diol containing both primary and secondary alcohols This invention discloses an efficient process for selectively sulfonating the primary alcohol of a diol containing both primary and secondary alcohols.... | 02/27/2001 |
| 6100268 | Vasoconstrictive dihydrobenzopyran derivatives The present invention is concerned with compounds of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6 alkyl; R2 | 08/08/2000 |
| 6075155 | Radiation-curable cycloaliphatic epoxy compounds, uses thereof, and compositions containing them Disclosed are compounds of the formulas ##STR1## which are useful as monomers in photopolymerizable compositions. Also disclosed are methods of polymerizing these monomers, and polymers produced thereby.... | 06/13/2000 |
| 5908944 | Methylation or ethylation agent and process for 1,4-addition of a methyl or ethyl group to an , ଲ-unsaturated keto compound This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compound... | 06/01/1999 |
| 5789604 | Isolation, characterization and structures of new antibiotic components produced by fungal culture 07F275 New antibacterial agents produced by fungal culture 07F275, of which the compound designated 07F275 alpha having the following structure: ##STR1## is representative. Methods for the fermentation, recovery and purification from crude solutions are als... | 08/04/1998 |
| 5710288 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, are capable of lowering intraocular pressure in the eye of a mammal.... | 01/20/1998 |
| 5670501 | N-substituted 9-alkyladenines Optically active or racemic compounds represented by the formula ##STR1## where R1 is C1 to C4 straight chain or branched alkyl; R2 is selected from the group consisting of H, --OR1, --SR1 | 09/23/1997 |
| 5670664 | Photosensitive organic compounds that release carbon monoxide upon illumination The present invention relates to acetal derivatives of bicyclo2.2.1!hepta-2,5-diene-7-one (norbornadienone) which are capable of releasing carbon monoxide upon irradiation with ultraviolet light, and a method for producing carbon monoxide employing the ... | 09/23/1997 |
| 5648505 | Method for the preparation of a novel C-ring precursor for taxoids and novel intermediates The present invention relates to a process for the preparation of a compound of the formula (VIII) or (IX) useful as precursor for the C-ring in taxanes ##STR1## wherein R' is a C1 -C6 -alkyl. The invention further relates to ... | 07/15/1997 |
| 5608086 | Process for the preparation of intermediates for the synthesis of glucose-6-phosphatase inhibitors, and novel intermediates Cyclohexane derivatives of the formula I ##STR1## in which the radicals are as defined in the description, and processes for the preparation of these compounds, are described. Also described are novel intermediates for the preparation of the compound... | 03/04/1997 |
| 5591848 | Spiroconjugated charge-transfer dyes for optical applications New intramolecular charge-transfer organic dyes are described. The design of these molecules is based on the phenomenon of spiroconjugation, and it provides a modular approach to the preparation of unique materials with interesting optical properties. In ... | 01/07/1997 |
| 5574178 | 4,6-Di-t-butyl-dihydrobenzofuran-5-ol and its derivatives Compounds represented by the general formula as well as intermediates for the synthesis of thereof: ##STR1## where R1 is a hydrogen atom or an acyl group; R2 is a lower alkyl group; R3 is a hydrogen atom or a lower al... | 11/12/1996 |
| 5463087 | Substituted derivatives of deoxymyoinositol, process for their preparation and their use in medicaments A process for the preparation of a compound. That compound is converted to a novel compound of the formula ##STR1## in which R1, R2 and R5 each independently is alkyl of 3 to 14 carbon atoms, which is used to make nov... | 10/31/1995 |
| 5446174 | 1-댧,8-trihydroxy vitamin D2, 1댧,8-trihydroxy vitamin D.sub . There are disclosed novel compounds that can be used to derive therefrom a fragment that corresponds to an A-ring which is to he combined with fragments which respectively correspond to C- and D-rings in synthetic formation of vitamin D3 deriva... | 08/29/1995 |
| 5434274 | Benz(epsilon)indene compounds Neuroactive benz[e]indene compounds ##STR1## are prepared by a total synthesis from the following three starting materials ##STR2##... | 07/18/1995 |
| 5407902 | Methoxyiminoacetic acid derivative and agricultural/horticultural fungicide containing the same as active ingredient A methoxyiminoacetic acid derivative represented by the following formula (I): ##STR1## wherein X represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; A represents a... | 04/18/1995 |
