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| Number | Title | Issue Date |
| 7956201 | Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula by employing a dialkylmalonate of the formula wherein R... | 06/07/2011 |
| 7619101 | Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2H-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the for... | 11/17/2009 |
| 7414139 | Catalytic antioxidants and methods of use The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some em... | 08/19/2008 |
| 7316884 | 5-methylene-1,3-dioxolan-4-one derivatives, process for their production, polymers of the derivatives, resist compositions, and pattern formation process A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): ... | 01/08/2008 |
| 7195719 | High polarization ferroelectric liquid crystal compositions The invention relates to chiral nonracemic liquid crystal compounds having achiral tails comprising a perfluoroalkyl terminal portion which are useful as components in liquid crystal to impart high polarization to the mixture. The materials of this invention can be ... | 03/27/2007 |
| 7071339 | Process for preparing functionalized γ-butyrolactones from mucohalic acid A process for preparing functionalized γ-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meaning... | 07/04/2006 |
| 6960573 | Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following for... | 11/01/2005 |
| 6958145 | Synthesis of cyclic compounds A method for the preparation of a compound of formula (II) wherein R1 and R2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, stra... | 10/25/2005 |
| 6433197 | Substituted oxygen alicyclic compounds, including methods for synthesis thereof The invention provides new methods for preparation of cyclic oxygen compounds, including 2,5-disubstituted tetrahydrofurans, 2,6-disubstituted tetrahydropyrans, 2,7-disubstituted oxepanes and 2,8-oxocanes. The invention also provides new cyclic oxygen com... | 08/13/2002 |
| 6346629 | Method for producing butyrolactones Process for producing butyrolactones of the general formula I ##STR1## where R1 and R2 are each hydrogen, alkyl, hydroxyalkyl, substituted or unsubstituted aryl or substituted or unsubstituted trialkylsilyl, by reacting alkynes of th... | 02/12/2002 |
| 6309561 | Liquid crystal compounds having a chiral fluorinated terminal portion Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion comprising (i) at least one chiral center, which can optionally be heteroatom-substituted; (ii) a terminal fluoroalkyl, fluoroether, perfluoroalkyl,... | 10/30/2001 |
| 6140515 | Process of making 3-aryloxy, 4-aryl furan-2-ones useful as inhibitors of COX-2 Described is a process of preparing 3-aryl, 4-aryloxy furan-5-ones which are useful as inhibitors of cyclooxygenase-2 (COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a tris... | 10/31/2000 |
| 6066667 | Substituted furanones, compositions and antiarthritic use The invention provides substituted furanone antiarthritic and analgesic pharmaceutical agents defined by Formula I, ##STR1## wherein: R1 is selected from the group consisting of (a) S(O)2 CH3, (b) S(O)2 NH2... | 05/23/2000 |
| 6034255 | Inhibitors of cholesterol esterase The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholest... | 03/07/2000 |
| 6028033 | N-aminopyridone derivatives and their use as herbicides There are described N-aminopyridone derivatives of the formula I: ##STR1## where the substituents R1 to R12 have the meanings given in claim 1, a process for their preparation, and their use for controlling undesirable vegetatio... | 02/22/2000 |
| 5998468 | Furanone endothelin antagonists Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, my... | 12/07/1999 |
| 5986112 | Vitamin D3 derivative and production process thereof A vitamin D3 derivative represented by the following formula: wherein, R is, independently, a hydrogen atom, tri(C1 to C7 hydrocarbon)silyl group, C2 to C8 acyl group, or group forming an acetal bond ... | 11/16/1999 |
| 5981577 | -methylene peperomins and halogenated derivatives thereof A compound of formula I, ##STR1## wherein R1, R2, R3, R1 ', R2 ', and R3 ' are independently the same or different and each represent hydrogen, hydroxy, or lower alkoxy, or any vicinal... | 11/09/1999 |
| 5972241 | Liquid crystal compounds having a chiral fluorinated terminal portion Fluorine-containing, chiral liquid crystal compounds comprise (a) a chiral fluorochemical terminal portion containing at least one methylene group and optionally containing at least one catenary ether oxygen atom; (b) a saturated, chiral or achiral, hydro... | 10/26/1999 |
| 5849217 | Optically active compound, liquid crystal composition containing the same, liquid crystal device using the same, liquid crystal apparatus and display method An optically active compound represented by the formula R1 --A1 --A2 --X1 --A3 --(CH2)p --L--A4 --R2, in which R1 is F, CN or straight chain, branched... | 12/15/1998 |
| 5747505 | Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compoun... | 05/05/1998 |
| 5670661 | Process for producing lactones and lactones obtained with this process The present invention relates to a process for producing lactones starting from cyclic ketones which comprises an oxidation reaction which is performed in the presence of an optionally substituted cycloaliphatic peracid or of an optionally substituted ali... | 09/23/1997 |
| 5486622 | Process and intermediate products for the production of 5-oxaspiro [2.4]heptan-6-one 5-Oxaspiro[2.4]heptan-6-one: ##STR1## is obtained from [3-(hydroxymethyl)oxetan-3-yl]acetonitrile by reaction with hydrogen bromide and then cyclizing the intermediate product 4,4-bis(bromomethyl)dihydro-2-furanone with zinc. 5-Oxaspiro[2.4]hept... | 01/23/1996 |
| 5453516 | Preparation of 5-membered ring heterocycles A process for preparing 5-membered ring heterocycles of the general formula I ##STR1## where R1 is methyl or hydroxyethyl, R2,R3,R4,R5 and R6 are hydrogen, C1 - to C12 | 09/26/1995 |
| 5371106 | 3,4-diaryl-5(H)-furan-2-one based compounds with fungicidal activity Compounds based on 3,4-diaryl-(5H)-furan-2-one, with fungicidal activity, having the general formula (I): ##STR1##... | 12/06/1994 |
| 5278321 | Process for simultaneously producing lactone and aromatic carboxylic acid A process for simultaneously producing a lactone and an aromatic carboxylic acid, which comprises oxidizing a cyclic ketone and an aromatic aldehyde wherein: the cyclic ketone/aromatic aldehyde molar ratio is set at 1.1:1 to 20:1 and the throughput of the... | 01/11/1994 |
| 5254697 | Process for the preparation of haloalkyllactones The invention provides a novel process for the manufacture of enantiomerically-pure halolactones of the formula I which are useful for the production of certain 5-amino-4-hydroxyvaleric acid derivatives, themselves valuable intermediates in the production... | 10/19/1993 |
| 5169976 | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents Variously substituted 4-(biphen-2-ylmethylcarbamoyl)-3-hydroxybutyric acids and esters, also named as N-(biphen-2-yl)-3-hydroxyglutaramic acid derivatives, are blood cholesterol lowering agents and so are useful in the prevention and treatment of cardiova... | 12/08/1992 |
| 4954623 | Recovery of difluoro sugar A process for recycling the difluoro sugar in the synthesis of 2,2-difluoronucleosides proceeds by removing the base moiety of -difluoronucleosides by reduction and hydrolysis, followed by oxidation to put the difluro sugar in a form conventiently ... | 09/04/1990 |
| 4935530 | Process for preparing 5-substituted-3-furaldehydes A process for preparing 5-substituted-3-furaldehydes which comprises reacting 3-furaldehyde with lithium morpholide, followed by sec-butyl lithium, followed by an electrophile.... | 06/19/1990 |
| 4898977 | Processes for the preparation of 5-amino-4-hydroxyvaleric acid derivatives The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower... | 02/06/1990 |
| 4855460 | Process for perfluoroalkylation of acid anhydrides A process for the preparation of perfluoroalkylated ketones and/or perfluoroalkylated alcohols, comprising the step of contacting a perfluoroalkyl iodide or perfluoroalkyl bromide with an acid anhydride, in the presence of a metal chosen from zinc and cad... | 08/08/1989 |
| 4831166 | Preparation of alpha-substituted upsilon-butyrolactones γ-butyrolactones of the general formula I ##STR1## where R1 is hydrogen or alkyl of 1 to 4 carbon atoms which may be substituted by lower alkoxy or acyloxy and R2 is hydrogen or straight-chain or branched alkyl which is unsubst... | 05/16/1989 |
| 4777288 | Process for preparing a 4,4-diphenylbutanoic acid derivative A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the inter... | 10/11/1988 |
| 4686300 | Polyfluoro gamma-ketoesters and 5-hydroxy gamma lactone analogues thereof Polyfluoro γ-ketoester compounds are obtained by reaction of ethylenic monoolefins, a metal or quaternary ammonium cyanide, and a fluoroester. These compounds, which have a general formula RF C(O)CFYCF2 CO2 R1,... | 08/11/1987 |
| 4508913 | Dialkoxymethyl-butyrolactones The following process steps are shown: ##STR1## Intermediates I, II, and VI are new. End product IV is a known intermediate in the preparation of known pyrethroid-like cyclopropanecarboxylic acid ester insecticides.... | 04/02/1985 |
| 4508914 | 3H-Furanones There are disclosed substituted lactones of the formula ##STR1## wherein A stands for --CH--CH2 X (X being Cl, Br or OH), --CHY--CHY-- (Y being Cl or Br), or ##STR2## and R1, R2 and R3 are the same or ... | 04/02/1985 |
| 4458090 | Method of producing cyclopropanecarboxylic acids and esters Novel γ-lactone derivatives are provided. These lactone derivatives, when reacted with hydrogen halide in alcohol, yield γ-halogeno-δ-unsaturated carboxylic acid esters. This ring-opening process is useful for the purpose of increasing the yield of ... | 07/03/1984 |
| 4410711 | Method for the synthesis of lepiochlorin, an antibiotic A method for the synthesis of lepiochlorin, an antibiotic.... | 10/18/1983 |
| 4351839 | Fungicidal 2-aryl-2-1-H-azoyl-(alkyl)-gamma-butyrolactones This invention relates to 2-aryl-2-1-H-azoyl-(alkyl)gamma-butyrolactone of the formula: ##STR1## wherein Z is optionally substituted aryl; R is hydrogen, alkyl, alkenyl, alkynyl, optionally substituted aryl or optionally substituted aralkyl; Azo is 1... | 09/28/1982 |
