Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7432263 | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them Compounds which are amino-phthalazinone derivatives according to formula 1 and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compostions are useful in the treatment of diseases ... | 10/07/2008 |
| 7271273 | Method for the preparation of citalopram The invention provides a new and improved method for the preparation of 5-cyano-phtalid, which is a key intermediate in the preparation of the antidepressant compound citalopram. ... | 09/18/2007 |
| RE39755 | 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof A product corresponding to formula (I) or its ketonic tautomer form (II) which is 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation and use of the product corresponding to formula (I) or its tau... | 07/31/2007 |
| 7235675 | Conjugates of mycophenolic acid The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or olig... | 06/26/2007 |
| 7189758 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutic... | 03/13/2007 |
| 7129270 | Nonsteroidal antiinflammatory agents Compounds of Formula 1 are useful in the treatment of inflammation. ... | 10/31/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7084196 | Flame retardant compositions Polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of (i.) at least one compound selected from the group consisting of nitroxyl stabilizers, hydroxylamine stabilizers... | 08/01/2006 |
| 7026351 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods o... | 04/11/2006 |
| 6989446 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula V wherein ... | 01/24/2006 |
| 6960581 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical com... | 11/01/2005 |
| 6872839 | Benzofuran-2-one Benzofuran-2-ones, compositions comprising benzofuranones, processes for preparing them, and their use as colorants for high or low molecular mass organic material. ... | 03/29/2005 |
| 6868215 | Dye thin film, production method thereof, optical switch, optical distributor, optical modulator and optical switch array A dye thin film containing a dye compound represented by the general formula (I), an optical switch, an optical distributor, an optical modulator and an optical switch array having the dye thin film, as well as a method for producing a dye thin film are provided. Th... | 03/15/2005 |
| 6825363 | Compounds useful in optical switching and manufacturing method thereof A dibenzofuranonylium methylate compound represented by the following formula (I), having maximum absorption wavelength of over 1 μm, high thermal stability and good solubility in organic solvents, and a production method thereof are provided: | 11/30/2004 |
| 6812237 | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ... | 11/02/2004 |
| 6809208 | 3-Arylbenzofuranones with electron-withdrawing substituents as stabilizers The invention describes novel compounds of the formula (I) wherein the general symbols are as defined in claim (1) and R1 is an aromatic radical with electron withdrawing substituents, as stabilizers for protecting organic materials, in particular polymer... | 10/26/2004 |
| 6803378 | HIV integrase inhibitors Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC. ... | 10/12/2004 |
| 6689808 | Substituted phthalides, a process for their preparations and pharmaceutical compositions containing them The invention relates to compounds of formula (I): ##STR1## wherein R1 represents alkyl or ureido, R2 represents alkyl or hydrogen, or R1 and R2 together form a 5- or 6-membered ring, R3 represents CN, NO | 02/10/2004 |
| 6515147 | 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one a process for the preparation thereof and the use thereof A product corresponding to formula (I) or its ketonic tautomer form (II) ##STR1## which is 3-(1-hydroxy-pentylidene)-5-nitro-3H-benzofuran-2-one, a process for the preparation and use of the product corresponding to formula (I) or its tautomeric form (II)... | 02/04/2003 |
| 6417358 | Process for the preparation of 3-aryl-benzofuranones Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim 1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim 1, with carbon monoxide in the ... | 07/09/2002 |
| 6392060 | Method for the preparation of 5-cyanophthalide A method for the preparation of 5-cyanophthalide in which 5-carboxyphthalide is converted to the corresponding amide of Formula (IV) ##STR1## in which R is hydrogen or C1-6 alkyl, which is then reacted with a dehydrating agent thereby obtaining... | 05/21/2002 |
| 6376539 | Substituted bicyclic lactones The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cereb... | 04/23/2002 |
| 6339094 | 2-acylaminopropanamines as tachykinin receptor antagonists This invention provides a series of substituted propanamines useful as tachykinin receptor antagonists. This invention also provides methods employing these substituted propanamines as well as pharmaceutical formulations comprising these compounds.... | 01/15/2002 |
| 6268394 | Farnesyl-protein transferase inhibitors Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described... | 07/31/2001 |
| 6268514 | Use of nitroethane derivatives as microbicides and specific nitroethane derivatives The use of nitroethane derivatives of the formula I ##STR1## where: R1 is hydrogen, unsubstituted or substituted C1 -C6 -alkyl, C3 -C6 -alkenyl, C3 -C6 -alkynyl, halogen, cyano or ... | 07/31/2001 |
| 6262302 | N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid pep... | 07/17/2001 |
| 6153652 | N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid pep... | 11/28/2000 |
| 6143779 | Benzofuranone derivatives and a method for producing them The present invention provides new benzofuranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases. The present invention is a new benzofuranone derivative represente... | 11/07/2000 |
| 5861518 | Phthalide compounds and their production process This invention provides processes for producing phthalide compounds which comprise cultivating Phanerochaete avelutina FERM BP-4787 and then isolating phthalide compounds from the fermentation broth.... | 01/19/1999 |
| 5717098 | Process for the preparation of azanoradamantane benzamides A process for the preparation of a γ-lactone of the formula ##STR1## which can be used to produce a single enantiomer of aminoazanoradamantane which is coupled to aromatic acid moieties to produce compounds useful as 5-HT agonists or antagonists.... | 02/10/1998 |
| 5693829 | Benzofuran-2-ones as stabilizers The invention relates to compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, as stabilizers for protecting organic materials against thermal, oxidative or light-induced degradation.... | 12/02/1997 |
| 5541344 | Intermediates useful in a process for the preparation of azanoradamantane benzamides The present invention is directed to intermediates of the formula ##STR1## which are useful in a process for the preparation of aminoazanoradamanatanes.... | 07/30/1996 |
| 5488117 | 3-(acyloxyphenyl)benzofuran-2-one stabilisers Compounds of the formula (1) ##STR1## in which R2, R3, R4 and R5 independently of one another, are hydrogen, C1 -C25 alkyl, C7 -C9 phenylalkyl, unsubstituted or C... | 01/30/1996 |
| 5430056 | Substituted 2-aminotetralins Optically active or racemic compounds are provided having the formula ##STR1## where R1 is ##STR2## where Y is hydrogen, halogen or C1 to C6 linear or branched alkyl; R6 is C1 to C4 | 07/04/1995 |
| 5428177 | 3-(Dihydrobenzofuran-5-yl)benzofuran-2-ones as stabilizers Novel compounds of formula (1) ##STR1## wherein R1 is hydrogen, alkyl or alkaryl, R2 to R5 are independently hydrogen, chloro, alkyl phenylalkyl, aryl, cycloalkyl, alkoxy, alkylthio, hydroxy, amino or substituted amin... | 06/27/1995 |
| 5384411 | Immobilization of PH-sensitive dyes to solid supports Disclosed are pH dyes containing a suitable compatible substituent which permits binding of the dye to a solid support. Also disclosed are methods for synthesizing such dyes prior to their coupling to the solid supports.... | 01/24/1995 |
| 5360919 | Polycyclic dyes A process for the preparation of a compound of Formula (1): ##STR1## wherein: W1 is aryl; X1 and X2 are each independently selected from --H, --CN, halogen, alkyl, aryl and --COOH; Y is --H; Z is --OH; or Y and Z together ... | 11/01/1994 |
| 5358971 | Substituted 2-aminotetralins Optically active or racemic compounds are provided having the formula ##STR1## where R2, R3 and R4 are selected from the group consisting of H and OA with the provision that at least one of R2, R3 and... | 10/25/1994 |
| 5286702 | Phthalide compound and recording material using the compound The present invention provides a novel phthalide compound represented by the following formula, which rapidly forms blue-blue black color with a developer when it is used as a recording material and, since a color image formed therewith has an intense abs... | 02/15/1994 |
| 5270469 | Process of preparing 3-phenyl-quinoline-5-carboxylic acid A process for preparing 3-phenyl-quinoline-5-carboxylic acid comprising reacting 4-amino-3-hydroxyphthalide with phenylacetaldehyde.... | 12/14/1993 |
