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| Number | Title | Issue Date |
| 7897793 | Process for preparation of 13,14-dihydro-PGF2 alpha derivatives The invention relates to a process for the preparation of 13,14-dihydro-PGF2α derivatives of R or S configuration at carbon 15, represented by the general formula (I), wherein the identity of the substituents is defined in the description. Compounds of t... | 03/01/2011 |
| 7687645 | Intermediates for the preparation of citalopram and escitalopram Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram. ... | 03/30/2010 |
| 7683188 | Process for preparation of mycophenolic acid and ester derivatives thereof Provided are processes for preparation of mycophenolic acid. ... | 03/23/2010 |
| 7488836 | Costunolide derivatives A compound of the following formula: wherein X, Y, and Z are as defined herein. Also disclosed are methods for inhibiting TNFα expression, IL-1β expression, iNOS expression, and NF-κB activity and methods for treating au... | 02/10/2009 |
| 7427684 | Process for the production of lactams A homogeneous process for the hydrogenation of dicarboxylic acid and/or derivative thereof with an amine in the presence of a catalyst comprising: (a) ruthenium or osmium; and (b) an organic phosphine; and wherein the hydrogenation is carried out in the presence of ... | 09/23/2008 |
| 7345051 | Mucin synthesis inhibitors The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds of Formula II in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and... | 03/18/2008 |
| 7307175 | Process for the preparation of 7-substituted 3-alkyl-3H-isobenzofuran-1-one derivatives Process for the preparation of compounds of formula (I) wherein R is halogen, R1O1R1S(O)n or (R1)2NC(X)O; R1 is C1-C8alkly, aryl-C1-C8alkyl, C | 12/11/2007 |
| 7276533 | Compositions useful for the treatment of pathologies responding to the activation of PPAR-gamma receptor This invention features the use of the spirolaxine of formula (I) for the treatment of those pathologies responding to the activation of the PPARγ receptor, such as the Type 2 insulin-resistant diabetes. This invention also features a pharmaceutical composition in ... | 10/02/2007 |
| RE39754 | Benzamide derivatives and pharmaceutical compositions containing same The novel benzamide derivative represented by formula (1) and the novel anilide derivative represented by formula (13) of this invention has differentiation-inducing effect, and are, therefore, useful a therapeutic or improving agent for malignant tumors, autoimmune... | 07/31/2007 |
| 7087548 | Preparation and use of a heterogeneous rhodium catalyst for the hydrogenation of a double bond of an α-β-unsaturated carbonyl compound A process for preparing an Rh-based catalytic system heterogenized on an organic or mineral support, characterized in that: a) a rhodium derivative with a valency state>0 is reduced in an ether or aromatic solvent and in the presence of a compound chosen from the gr... | 08/08/2006 |
| 7084196 | Flame retardant compositions Polymeric substrates, for example polyolefins such as polypropylene, can be made flame retardant by the incorporation therein of a synergistic mixture of (i.) at least one compound selected from the group consisting of nitroxyl stabilizers, hydroxylamine stabilizers... | 08/01/2006 |
| 7049459 | 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and a process for preparing the same This invention relates to 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone. This compound is convertible into 4-(4-methyl thio phenyl)-3-phenyl-2 (5H)-furanone by an economically viable process. This substituted furanone is an intermediate or starting compoun... | 05/23/2006 |
| 6964784 | METHOD OF PREPARATION AND COMPOSITION OF A WATER SOLUBLE EXTRACT OF THE BIOACTIVE COMPONENT OF THE PLANT SPECIES UNCARIA FOR ENHANCING IMMUNE, ANTI-INFLAMMATORY, ANTI-TUMOR AND DNA REPAIR PROCESSES OF WARM BLOODED ANIMALS A method for isolating the bioactive component of the water-soluble extract of Uncaria tomentosa known as C-MED-100®, comprising (i) precipitating the spray drying carrier from C-MED-100®; (ii) using the resulting C-MED-100® to obtain a spotting mixture fo... | 11/15/2005 |
| 6960394 | Fabric reinforced cement A cement panel that is reinforced with a fabric made of nucleated polypropylene fibers. The cement panel includes a core layer that is made of a lightweight cement composition. This core layer is covered with a layer of reinforcing nucleated polypropylene fabric on ... | 11/01/2005 |
| 6872839 | Benzofuran-2-one Benzofuran-2-ones, compositions comprising benzofuranones, processes for preparing them, and their use as colorants for high or low molecular mass organic material. ... | 03/29/2005 |
| 6784302 | Method of producing optically active lactone compound and complex used in the method An optically active lactone compound is produced by using a Zr(salen) complex of the following formula (I) or its enantiomer as a catalyst and subjecting a cyclic ketone compound to a Baeyer-Villiger reaction with at least one oxidizer selected from hydrogen peroxid... | 08/31/2004 |
| 6762327 | Selective oxidation process with enhanced safety A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(C2-C4 alkanoyloxy-1,1-dihydro-1,2-benziodoxol-3(... | 07/13/2004 |
| 6689891 | 2-bromomethyl-6-methyl-benzoic acid and a process for the preparation thereof A process for the preparation of 2-bromomethyl-6-methyl-benzoic acid (I) and derivatives thereof by selective bromination of 2,6-dimethylbenzoic acid (II) with sodium bromate and hydrobromic acid in the presence of light.... | 02/10/2004 |
| 6586606 | Process for the preparation of 3-aryl-benzofuran-2-ones The instant invention discloses a process for the preparation of compounds of formula I ##STR1## wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V ##STR2## wherein the general symbols a... | 07/01/2003 |
| 6414165 | Preparation of cis-6, 6-dimethyl-3-oxa-bicyclo[3.1.0]hexan-2-one A process for the preparation of cis-6,6-dimethyl-3-oxa-bicyclo[3.1.0]hexan-2-one which comprises either: 1) reacting a sulphonic ester of ଲ,ଲ-dimethyl-γ-(hydroxymethyl)-γ-butyrolactone with a compound of formula M(C1-6 alkox... | 07/02/2002 |
| 6391365 | Use of 3,6-dimethyl-2(3H)-benzofuranone as flavor material and new process for its preparation 3,6-Dimethyl-2(3H)-benzofuranone is a new, valuable flavor material. A process for its industrial-scale preparation was developed.... | 05/21/2002 |
| 6376539 | Substituted bicyclic lactones The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cereb... | 04/23/2002 |
| 6323267 | Isoxindigos useful as colorants and preparation thereof The present invention relates to a process for coloration of a high molecular weight material by admixing said high molecular weight organic or inorganic material, preferably high molecular weight organic material, prior to processing with at least one co... | 11/27/2001 |
| 6114545 | Inhibitors of cholesterol esterase The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholest... | 09/05/2000 |
| 5986130 | Process for the preparation of cyclopropane carboxylic acids and intermediates therefor The compounds 3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethyl-(1R,cis)-cyc lopropane carboxylic acid, cis-3-(2,2-dichloro-3,3,3-trifluoro-1-hydroxypropyl)-2,2-dimethyl-cyclopro pane carboxylic acid and (1R,5S)-4-(1,1-dichloro-2,2,2-t... | 11/16/1999 |
| 5814657 | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents Compounds of the formula ##STR1## wherein the variables are defined as in the specification, are capable of lowering introaocular pressure in the eye of a mammal.... | 09/29/1998 |
| 5717112 | Benzofuranone and benzodifuranone compounds Benzodifurantriones of Formula (1): ##STR1## in which W is unsubstituted or substituted aryl, a process for their preparation via dioxo intermediates and processes for their conversion into benzodifuranone dyes and compounds of Formula (7): ##ST... | 02/10/1998 |
| 5556994 | Cyclopropane derivatives and method of preparing the same A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. In addition another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cy... | 09/17/1996 |
| 5498734 | Preparation and use of (2-butene-1,4-diyl)magnesium complexes in organic synthesis The magnesium complexes of cyclic hydrocarbons containing conjugated dienes, such as 1,2-dimethylenecycloalkanes, and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4 diyl)magnesium reag... | 03/12/1996 |
| 5488117 | 3-(acyloxyphenyl)benzofuran-2-one stabilisers Compounds of the formula (1) ##STR1## in which R2, R3, R4 and R5 independently of one another, are hydrogen, C1 -C25 alkyl, C7 -C9 phenylalkyl, unsubstituted or C... | 01/30/1996 |
| 5464824 | Use of furanones as perfuming ingredients The furanones of formula ##STR1## wherein symbols R1 and R2, taken separately, are identical and represent each a methyl radical, or are different and represent each a hydrogen atom or a methyl radical, or, taken together, repre... | 11/07/1995 |
| 5407961 | -substituted benzenemethanamine derivatives and pharmaceutical use The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and processes of preparing said compounds and compositions... | 04/18/1995 |
| 5401858 | Preparation of quinic acid derivatives 3- or 4-mono-, 1,3- or 1,4- or even 3,4-disubstituted derivatives of quinic acid are produced by reaction of a hydroxycinnamic acid derivative, of which the phenol group(s) is/are protected with a quinic acid derivative, to form an ester and the different... | 03/28/1995 |
| 5395950 | Production of quinic acid derivatives 1-, 5-O-mono- and 3,4-0-bis-substituted derivatives of quinic acid are prepared by reacting a derivative of a hydroxycinnamic acid of which the hydroxyl group(s) is/are protected with a quinic acid derivative to form an ester and the protective groups are... | 03/07/1995 |
| 5308539 | Ferroelectric liquid crystal composition and liquid crystal device using the same A ferroelectric liquid crystal composition including: at least one optically active compound of the formula (I): ##STR1## where R1 and R2 are, the same or different, a straight or branched chain alkyl group having 1 to 15 carbon... | 05/03/1994 |
| 5276167 | Process for the preparation of the lactone of 1R, cis 2,2-dimethyl-3-formyl-cyclopropane-1-carboxylic acid A process for preparation of a compound of the formula ##STR1##... | 01/04/1994 |
| 5219743 | Method for optical resolution of Corey lactone diols The primary hydroxy group of Corey lactone diols is optically selectively acylated to obtain the desired optically active ester and/or diol. The mixture of Corey lactone diols of formulae (Ia) and (Ib): ##STR1## is reacted with an acylating agent opt... | 06/15/1993 |
| 5175311 | Method of enantioselective cyclopropanation using chiral catalysts A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands... | 12/29/1992 |
| 5136050 | Process for resolving amino acids using substituted lactones Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturation... | 08/04/1992 |
| 5034541 | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z A method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-Z and key intermediates therefor are disclosed. This method is characterized by the following successive steps: opening of the 1-phenyl-2-oxo-3-oxa-bicyclo(3:1:0)-hexane by ... | 07/23/1991 |
