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| Number | Title | Issue Date |
| 8158809 | Podophyllotoxin derivatives 4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer. ... | 04/17/2012 |
| 8148552 | Process for the synthesis of anticancer (poly) aminoalkylaminoacetamide derivatives of epipodophyllotoxin The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of condensation of a primary-amine-c... | 04/03/2012 |
| 7582778 | Podophyllotoxin The invention relates to podophyllotoxins, uses thereof and methods of their production. ... | 09/01/2009 |
| 7348358 | Use of cyclolignans The invention refers to the use of specific cyclolignans, wherein the carbon atoms in positions 9 and 9′ have cis configuration, for inhibition of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, suc... | 03/25/2008 |
| 7342114 | Podophyllotoxin derivatives 4-O esters of podophyllotoxin and 4′-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4′-demethylepipodophyllotoxin. The compounds are useful for treating cancer. ... | 03/11/2008 |
| 7192682 | Unsaturated monomers, polymers, chemically-amplified resist composition, and process of pattern formation There is provided a chemically-amplified resist composition having high transparency to light having a wavelength of 220 nanometers or smaller, excellent resistance to etching, and excellent adhesion to a substrate. The chemically-amplified resist composition is pre... | 03/20/2007 |
| 7186495 | (Meth) acrylate derivative, polymer and photoresist composition having lactone structure, and method for forming pattern by using it There are here disclosed a photoresist material for lithography using a light of 220 nm or less which comprises at least a polymer represented by the following formula (2) and a photo-acid generator for generating an acid by exposure: ... | 03/06/2007 |
| 7176236 | Water-soluble etoposide analogs and methods of use thereof Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-fluoroanilino)-4-desoxy-podophyllotoxin (9) ... | 02/13/2007 |
| 7098348 | Triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl... | 08/29/2006 |
| 7097865 | Inhibition of CYP450 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4 in cryopreserved human hepatocytes by a Tripterygium Wilfordii Hook. F. extract A method of inhibiting chytochrome P450 enzymes selected from the group consisting of CYP1A2, CYP2A6 and CYP3A4 comprises the step of administering an effective inhibition amount of AHT-323A botanical extract to a patient. ... | 08/29/2006 |
| 7094805 | Total synthesis of merrilactone A This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides intermediates for use in the synthesis of Merrilactone and its analogues.... | 08/22/2006 |
| 7087641 | 4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents The present invention provides a new class of compounds 4β-1″-[{2″-benzoyl substituted}anilino] podophyllotoxin exhibiting anti cancer activity and a process for preparing the same. ... | 08/08/2006 |
| 7019151 | Triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R... | 03/28/2006 |
| 6903133 | Anticancer compounds This invention features compounds having formula (I): wherein, R1, R2, R3, R4, R5, R6, R7, T, X, and Y are as defined herein. This invention ... | 06/07/2005 |
| 6887869 | Mikanolide derivatives, their preparation and therapeutic uses The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I... | 05/03/2005 |
| 6878746 | Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocy... | 04/12/2005 |
| 6872838 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals. ... | 03/29/2005 |
| 6861537 | Tricyclic and tetracyclic taxane intermediates The synthesis of taxol and other tricyclic and tetracyclic taxanes. ... | 03/01/2005 |
| 6844451 | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of Ginkgo biloba A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an... | 01/18/2005 |
| 6713454 | Prodrugs of etoposide and etoposide analogs The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nerv... | 03/30/2004 |
| 6693091 | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies A compound having the structure: ##STR1## wherein R1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; wherein R2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiet... | 02/17/2004 |
| 6590109 | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones usin... | 07/08/2003 |
| 6566393 | Etoposide analogs and methods of use thereof Etoposide analogs such as 4'-O-demethyl-4ଲ-[4"-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy -podophyllotoxin (12) and 4'-O-demethyl-4ଲ-[4"-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-deso xypodophyllotoxin (13) are described, along with... | 05/20/2003 |
| 6476251 | Process for preparing spirocyclic tetronic acid derivatives The present invention relates to a novel process for preparing compounds of the formula (I) ##STR1## by reacting compounds of the formula (II) ##STR2## with a base and compounds of the formula (III) ##STR3## in which X, Y, Z, n, G, A, B, R1 | 11/05/2002 |
| 6441198 | Podophyllotoxin dimer as DNA topoisomerase II inhibitors, and a process for the preparation therefore The present invention discloses novel podophyllotoxin dimers having structural formula I ##STR1## wherein R is H or CH3 and Z is aryl or subsituted aryl compound selected form the group counting of phenylene, naphthalene, p-terpbhnyl, dime... | 08/27/2002 |
| 6395711 | Macrolides with antitumor activity The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The... | 05/28/2002 |
| 6392059 | Hydronaphtho[2,3-c]furan derivatives and process for the preparation thereof Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: ##STR1## wherein R1 | 05/21/2002 |
| 6387948 | 8-Acetylarteminolide and process for preparing same 8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention and treatment of various cancers and angiogenesis-related ... | 05/14/2002 |
| 6380257 | Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical The present invention relates to new aromatic di-keto derivatives and to their pharmaceutically acceptable salts, esters, ethers and other chemical equivalents. The derivatives are glucose-6-phosphate translocase inhibitors and can be used in the treatmen... | 04/30/2002 |
| 6300371 | Rameswaralide and rameswaralide derivatives A diterpene derivative compound, having the formula I, II, or III, compositions, and therapeutic compositions containing the compounds are disclosed. Also disclosed are methods for treating an inflammatory disorder by providing an inflammatory inhibiting ... | 10/09/2001 |
| 6281198 | 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-[3',4': 6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one compounds Compound of formula (I): ##STR1## wherein: R represents: a group of formula (i): ##STR2## wherein X, Y and W are as defined in the description, or a group of formula (ii): --A--G (ii) wherein: A represents a single bond or an optionally substituted alkylene ... | 08/28/2001 |
| 6242617 | Method and device for production of lyophilized hydrochloride-1ଲ, 10ଲ-epoxy-13-dimethylamino-guaia-3(4)-en-6,12-olide Method of producing an antitumor preparation of natural origin lyophilized arglabin 1ଲ, 10ଲ-epoxy-13-dimethylamino-guaia-3(4)-en-6, 12-olide hydrochloride includes resin extraction from a natural material, its purification from worthless subst... | 06/05/2001 |
| 6225339 | Terpenoid lactone compounds and their production process This invention provides terpenoid lactone compounds, and processes for producing the terpenoid lactone compounds, which comprise cultivating Oidiodedron griseum FERM BP-5778 and then isolating the terpenoid lactone compounds from the fermentation broth. T... | 05/01/2001 |
| 6207673 | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors The present invention provides covalent conjugates of topoisomerase I and topoisomerase II inhibitors. Such compounds have a structure according to formula I: TI --L--TII (I) wherein: TI is a topoisomerase I inhibitor such as ... | 03/27/2001 |
| 6204257 | Water soluble prodrugs of hindered alcohols The present invention is directed to novel water-soluble prodrugs of aliphatic or aromatic hindered hydroxyl group containing pharmaceuticals.... | 03/20/2001 |
| 6197767 | Arglabin compounds and therapeutic uses thereof The invention provides various derivatives of arglabin, a sesquiterpene lactone isolated from Artemisia glabella. These compounds are effective for suppressing tumor growth in mammals. A method of suppressing tumor growth in humans is also described.... | 03/06/2001 |
| 6153645 | Heterocycles as antimicrobial agents Methods for treating infection and related compositions, compounds of formula I as defined in the application and methods for preparing same, are provided. In general, the compounds inhibit transfer ribonucleic acid (tRNA) synthetase and are useful as ant... | 11/28/2000 |
| 6083980 | Furanyl, tetracyclic triterpene derivatives with immunosuppressant activity The compounds of Formula I ##STR1## are useful as immunosuppressive agents.... | 07/04/2000 |
| 6051721 | Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis A process of preparing ring E-modified analogues of (-)-podophyllotoxin as potential new chemotherapeutic agents. The process generates corresponding analogues of (-)-podophyllotoxin, itself, and allows new molecular interactions in the southern hemispher... | 04/18/2000 |
| 6008382 | Method for preparing 4'-Demethylepipodophyllotoxin from podophyllotoxin A method for synthesizing a 4'-demethylepipodophyllotoxin of formula (II) from a podophyllotoxin of formula (I) by treating it with a pair of reagents, i.e. a strong acid and an aliphatic, aromatic or functionalized sulphide, in the present of an organic ... | 12/28/1999 |
