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| Number | Title | Issue Date |
| 8017793 | Oxidation of alcohol with use of hydrogen peroxide and tungsten catalyst Disclosed is a method for oxidizing an alcohol in an amide solvent using a mixed reagent containing hydrogen peroxide and a tungsten catalyst. ... | 09/13/2011 |
| 7863464 | Triptolide lactone ring derivatives as immunomodulators and anticancer agents Disclosed are compounds based on lactone ring modifications of triptolide and hydroxylated triptolide, for use in therapy, such as antiproliferative, anticancer, and immunosuppressive therapy. ... | 01/04/2011 |
| 7847109 | Triptolide derivatives for modulation of apoptosis and immunosuppression Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful ... | 12/07/2010 |
| 7820834 | Triptolide 5,6-derivatives as immunomodulators and anticancer agents Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the ... | 10/26/2010 |
| 7662976 | Triptolide derivatives for modulation of apoptosis and immunosuppression Variously substituted carbonate and carbamate derivatives of triptolide compounds have good aqueous solubility and convert to biologically active compounds in vivo, at a rate which can be modulated by varying the substitution on the prodrug. The prodrugs are useful ... | 02/16/2010 |
| 7626044 | Triptolide derivatives and their uses Triptolide derivatives of Formula (I), their pharmaceutically acceptable salts and optical isomers, Formula (I): wherein, C5 and C6 are connect with each other by a C-C single bond or double bond; when C5 and C6 are connected... | 12/01/2009 |
| 7417069 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF... | 08/26/2008 |
| 7317113 | Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. ... | 01/08/2008 |
| 7314942 | Methylenelactones syntheses in supercritical fluids Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid. ... | 01/01/2008 |
| 7279501 | Pharmaceutical composition useful in prevention and treatment of beta-amyloid protein-induced disease The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the inventio... | 10/09/2007 |
| 7238514 | Diterpene-producing unicellular organism The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synt... | 07/03/2007 |
| 7232916 | Process for the preparation of a taxane derivative The invention relates to an improved process for the synthesis of 13-(N-Boc-β-isobutylserinyl)-14-β-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and... | 06/19/2007 |
| 7145021 | Analogs of terpene trilactones from and related compounds and uses thereof The subject invention provides compounds having the structure: wherein R1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R2 is H, OH, a photoactivatable ... | 12/05/2006 |
| 7097865 | Inhibition of CYP450 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4 in cryopreserved human hepatocytes by a Tripterygium Wilfordii Hook. F. extract A method of inhibiting chytochrome P450 enzymes selected from the group consisting of CYP1A2, CYP2A6 and CYP3A4 comprises the step of administering an effective inhibition amount of AHT-323A botanical extract to a patient. ... | 08/29/2006 |
| 7098348 | Triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl... | 08/29/2006 |
| 7078432 | Process for the preparation of the 14β-hydroxy-baccatin III-1,14-carbonate A process for the preparation of 14β-hydroxy-baccatin III-1,14-carbonate useful for the preparation of novel taxane derivatives with antitumor activity. ... | 07/18/2006 |
| 7067158 | Preparation for the relief of disease A composition including (a) a Platelet Activating Factor (PAF) Inhibitor and (b) an antioxidant which interferes with the arachidonic acid cascade and also has antioxidant activity. The composition is useful for the treatment or the relief of inflammatory diseases, ... | 06/27/2006 |
| 7048954 | Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles A process for the preparation of an extract of Ginkgo biloba leaves, comprising i. extraction of the dried fragments of Ginkgo biloba leaves in ethanol containing a maximum of 20% by weight of water; ii. concentration of the e... | 05/23/2006 |
| 7041838 | (Meth)acrylate esters, starting alcohols for the preparation thereof, processes for preparing both, polymers of the esters, chemically amplifiable resist compositions, and method for forming patterns A (meth)acrylate represented by the following formula (1): wherein each of R1, R2, R3 and R4 represents a hydrogen atom, a methyl group or an ethyl group; either one of X... | 05/09/2006 |
| 7037995 | Tertiary (meth)acrylates having lactone structure, polymers, resist compositions and patterning process Novel tertiary (meth)acrylate compounds having a lactone structure are polymerizable into polymers having improved transparency, especially at the exposure wavelength of an excimer laser and dry etching resistance. Resist compositions comprising the polymers are sen... | 05/02/2006 |
| 6943259 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CH... | 09/13/2005 |
| 6933395 | PROCESSING FOR PRODUCING OF DROSPIRENONE (6β, 7β, 15β, 16β-DIMETHYLENE-3-OXO-17α-PREGN-4-EN-21, 17-CARBOLACTONE, DRSP) AS WELL AS 7α-(3-HYDOXY-1-PROPLY)-6β, 7β; 15β, 16β-DIMETHYLENE-5β-ANDROSTANE-3β, 5,17β-TRIOL(ZK 92836) AND 6β, 7β; 15β, 16β-DIMETHYLENE-5β-HYDROXY Process for the production of drospirenone (6β,7β; 15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, DRSP) (1) and 7α-(3-hydroxy-1-propyl)-6β,7β; 15β,16β-dimethylene-5β-androstane-3β,5,17β-triol (ZK 92836) and 6β,7β; 15β,16β-dimethylene-... | 08/23/2005 |
| 6887869 | Mikanolide derivatives, their preparation and therapeutic uses The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)1 and (I... | 05/03/2005 |
| 6844451 | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of Ginkgo biloba A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an... | 01/18/2005 |
| 6828347 | Anti-viral multi-quinone compounds and regiospecific synthesis thereof This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of t... | 12/07/2004 |
| 6808724 | Artemisolide compound isolated from the aerial parts of Artemisia sylvatica, isolation method, and use thereof The present invention relates to a novel compound isolated from Artemisia Sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel compound isolated from Artemisia Sylvatica, a method of isolat... | 10/26/2004 |
| 6759065 | Extraction method, pharmaceutical composition and a cosmetic composition A compound is extracted from vegetable material, wherein the vegetable material is reduced and treated with a solvent. According to the invention, the vegetable material is frozen using a liquid nitrogen and in frozen condition reduced in size. According to two impo... | 07/06/2004 |
| 6737534 | Process for the preparation of taxan derivatives A process for the preparation of the compound 13-(N-Boc-β-isobutylisoserinyl)-14β-hydroxybaccatine III 1,14-carbonate. ... | 05/18/2004 |
| 6693091 | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies A compound having the structure: ##STR1## wherein R1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; wherein R2 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiet... | 02/17/2004 |
| 6642217 | Triterpenes having human antifungal and antiyeast activity Methods of treating a fungal or yeast infection and of killing or inhibiting fungi or yeast are disclosed. The methods use derivatives of triterpenes that are abundant in birch bark and other plants. The triterpenes include betulin, allobetulin, and lupeo... | 11/04/2003 |
| 6590109 | Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones usin... | 07/08/2003 |
| 6586601 | Method for producing 2-halopyridine-n-oxide The present invention concerns a process for the preparation of 2-halopyridine N-oxide by reaction of 2-halopyridine with hydrogen peroxide in aqueous solution in the presence of an acid anhydride as catalyst in which, according to the invention, as catal... | 07/01/2003 |
| 6569893 | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents Compounds which are prodrugs of triptolide or its derivatives, containing an amino acid or oligopeptide moiety, are used for anticancer or immunosuppressive treatment. The compounds are of the structure: ##STR1## where X1 is OH or OR1 | 05/27/2003 |
| 6548536 | Agent for inducing apoptosis Agents for inducing apoptosis comprising a tetrocarcin derivative represented by the following formula (I) or a salt thereof as an active ingredient (---- represents a single bond or a double bond; j and k represent 0 or 1; R1 to R3,... | 04/15/2003 |
| 6492533 | Bismethine benzodifuranone derivative colorants Colorants comprising a chromophore having two methine moieties attached to a benzodifuranone backbone, wherein said moieties optionally have at least one poly(oxyalkylene) chain, preferably at least two such chains attached thereto are provided. Such colo... | 12/10/2002 |
| 6476251 | Process for preparing spirocyclic tetronic acid derivatives The present invention relates to a novel process for preparing compounds of the formula (I) ##STR1## by reacting compounds of the formula (II) ##STR2## with a base and compounds of the formula (III) ##STR3## in which X, Y, Z, n, G, A, B, R1 | 11/05/2002 |
| 6376539 | Substituted bicyclic lactones The present invention relates to novel substituted bicyclic lactones, to processes for their preparation and to their use for the prevention and/or treatment of disorders caused by hyper- or hypofunction of the glutamatergic system, in particular of cereb... | 04/23/2002 |
| 6150539 | Triptolide prodrugs having high aqueous solubility Compounds useful in immunosuppressive and anti-inflammatory treatment are described. The compounds are hydrolyzable triptolide analogs with improved water solubility and generally lower toxicity than the parent compound.... | 11/21/2000 |
| 6080741 | Arglabin compounds and therapeutic uses thereof The invention provides various derivatives of arglabin, a sesquiterpene lactone isolated from Artemisia glabella. These compounds are effective for suppressing tumor growth in mammals. A method of suppressing tumor growth in humans is also described.... | 06/27/2000 |
| 6074855 | Process for preparing spirolaxine and spirolaxine methyl ether Processes for preparing spirolaxine and spirolaxine methyl ether, the compounds of formulas (I) and (II) respectively, ##STR1## comprising fermenting fungi selected from the group consisting of Sporotrichum pruinosum FD 29585, ATCC 74327; Sporotrichu... | 06/13/2000 |
