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| Number | Title | Issue Date |
| 8071795 | HIF inhibitors HIF-1 inhibitors and methods of use thereof are provided. ... | 12/06/2011 |
| 8030503 | Process for the preparation of epothilones Intermediates in the preparation of epothilones and epothilone analogs are provided along with synthetic methods useful in the synthesis of epothilone compounds. ... | 10/04/2011 |
| 7781601 | Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters A method for the production of 6,6,6-trihalo-3,5-dioxohexanic acid esters of formula (I): in addition to the enols thereof and E and Z isomers, wherein X independently represents fluorine, chlorine or bromine ... | 08/24/2010 |
| 7678928 | Process for manufacture of simvastatin An improved method for manufacture of simvastatin of formula (I) in high purity. The process for preparation of compound (I) comprises the steps of agitating a compound of formula (II), | 03/16/2010 |
| 7678927 | Process for lactonization in the preparation of statins The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hyd... | 03/16/2010 |
| 7566792 | Method for the manufacture of Lovastatin A method for the manufacture of Lovastatin of formula (I) is disclosed. The method comprises of: A. lactonisation of Mevinolinic acid (II) and isolation of impure Lovastatin (I), B. purification of impure Lovastatin (I), C. optionally, repurification of pure Lovasta... | 07/28/2009 |
| 7528265 | Process for the preparation of simvastatin Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecti... | 05/05/2009 |
| 7439046 | Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one α-hydrogen atom and a substituted or unsubstituted aldehyde i... | 10/21/2008 |
| 7423162 | Process for the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives The invention relates to a process for the preparation of (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile from 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one, wherein X stands for a leaving group, by reacting 6-X-substituted-methyl-4-hydroxy-tetrahydro... | 09/09/2008 |
| 7414074 | Antiinflammatory lactones Lactones of Formula (I) which are pharmaceutically active in diseases associated with inflammation ... | 08/19/2008 |
| 7368585 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. ... | 05/06/2008 |
| 7342124 | Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided. ... | 03/11/2008 |
| 7323592 | Methods for crystallization of hydroxycarboxylic acids The invention aims at producing high-purity crystals of a hydroxycarboxylic acid represented by the following formula (1): in high yield. Provided are a method for crystallization of a compound (1) which ... | 01/29/2008 |
| 7304091 | Statin-like compounds The present invention relates to compounds with structures resembling natural statins isolated from Penicillium sp. (Formula I); where R1 represents OH, C6H5COO, R6COO and R6 represents C1–C | 12/04/2007 |
| 7273948 | Process of preparing esters and ethers of probucol and derivatives thereof A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ... | 09/25/2007 |
| 7214708 | Synthetic discodermolide analogs Synthetic discodermolide analogs having utility as antiproliferative agents, having a structure represented by formula A where RA through RE and XA are as defined herein. ... | 05/08/2007 |
| 7205415 | Process for the preparation of simvastatin A process for manufacturing simvastatin is provided using novel intermediates. Thus, for example, lovastatin is reacted with methoxyethylamine, alpha methylated 2-methylbutyryl side chain of the amide formed, hydrolyzed and lactonized to produce finally simvastatin ... | 04/17/2007 |
| 7205309 | Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The... | 04/17/2007 |
| 7199243 | Piperidine compounds useful as PPAR activators PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol ... | 04/03/2007 |
| 7189558 | Process for producing pravastatin sodium salt using dsm 14455 In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens. ... | 03/13/2007 |
| 7157255 | Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises ei... | 01/02/2007 |
| 7151105 | Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected... | 12/19/2006 |
| 7141681 | Continuous process for preparing dihydropyrones The invention relates to a continuous process for preparing dihydropyrones of general formula I, wherein the groups R1 and R2 have the meanings described herein. ... | 11/28/2006 |
| 7141602 | Process for obtaining HMG-CoA reductase inhibitors of high purity Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d... | 11/28/2006 |
| 7109341 | Therapeutic amides The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions ... | 09/19/2006 |
| 7101867 | Benzofuran derivatives, their production and use Compounds represented by the formula: wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carb... | 09/05/2006 |
| 7101912 | Carbidopa prodrugs and derivatives, and compositions and uses thereof Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed... | 09/05/2006 |
| 7094912 | Process for the preparation of 4-oxytetrahydropyran-2-ones A process for the preparation of inhibitors of HMG-CoA reductase, such as simvastatin, from 4-silyloxytetrahydropyran-2-ones with triethylamine trihydrofluoride being used as the desilylation reagent is described. The reaction is performed in organic solvents, a mix... | 08/22/2006 |
| 7087558 | Process for reacting large hydrophobic molecules with small hydrophilic molecules A process for reacting relatively small hydrophilic carboxylic molecules with relatively large, hydrophobic hydrocarbon based molecules, said process comprising conducting the reacting in the presence of a sulfonic acid catalyst having solubilizing properties. In a ... | 08/08/2006 |
| 7081347 | Method for predicting cardiovascular events A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations.... | 07/25/2006 |
| 7074826 | R-NSAID esters and their use The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition c... | 07/11/2006 |
| 7038075 | Production method of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid C1-6 alkyl ester The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) ... | 05/02/2006 |
| 7038064 | Process for producing hydroxylactones A process of the present invention produces a hydroxylactone by subjecting an unsaturated carboxylic acid having a double bond not conjugated to a carboxyl group or an ester thereof to (i) a reaction with hydrogen peroxide in the presence of a metallic compound cont... | 05/02/2006 |
| 7026351 | Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods o... | 04/11/2006 |
| 7002017 | Enantioselective hydrogenation of intermediates in the synthesis of tipranavir The invention relates to a process for preparing the compounds of general formula I by enantioselective hydrogenation of the compounds of formula II in the presence of spec... | 02/21/2006 |
| 7001531 | Sustained release coolant additive composition A coolant additive composition comprising a sustained release component and an additive component, the additive component is effective to provide at least one benefit to a coolant when released into the coolant, the sustained release component includes a polymeric m... | 02/21/2006 |
| 6995277 | Process for preparing simvastatin having controlled ranges of simvastatin dimer content The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to abou... | 02/07/2006 |
| 6972292 | Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds ... | 12/06/2005 |
| 6960573 | Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following for... | 11/01/2005 |
| 6951844 | Phenyl naphthol ligands for thyroid hormone receptor New thyroid receptor ligands are provided which have the general formula I wherein R1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or ... | 10/04/2005 |
